Titre : Carence en vitamine B12

Carence en vitamine B12 : Questions médicales fréquentes

Termes MeSH sélectionnés :

Complement Pathway, Alternative
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tests réguliers sont-ils recommandés ?\nLes maladies digestives augmentent-elles le risque ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+Pathway,+Alternative&page=4#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Carence en vitamine B12", "description": "Comment traiter une carence en vitamine B12 ?\nQuelle est la durée du traitement ?\nLes aliments peuvent-ils aider à corriger la carence ?\nLes personnes végétariennes sont-elles à risque ?\nLes traitements sont-ils différents pour les enfants ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+Pathway,+Alternative&page=4#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Carence en vitamine B12", "description": "Quelles complications peuvent survenir ?\nLa carence peut-elle entraîner des problèmes cognitifs ?\nY a-t-il un risque accru de maladies cardiovasculaires ?\nLes complications sont-elles réversibles ?\nLa carence en B12 peut-elle affecter la grossesse ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+Pathway,+Alternative&page=4#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Carence en vitamine B12", "description": "Qui est le plus à risque de carence en B12 ?\nLes maladies auto-immunes augmentent-elles le risque ?\nLes médicaments peuvent-ils influencer le risque ?\nLes troubles digestifs sont-ils un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+Pathway,+Alternative&page=4#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une carence en vitamine B12 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un diagnostic se fait par des analyses sanguines mesurant les niveaux de vitamine B12." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour confirmer la carence ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests incluent la mesure de la vitamine B12, de l'homocystéine et de la méthylmalonyl-CoA." } }, { "@type": "Question", "name": "Quels signes cliniques indiquent une carence ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des signes comme l'anémie, la fatigue, et des troubles neurologiques peuvent indiquer une carence." } }, { "@type": "Question", "name": "La carence en B12 peut-elle être asymptomatique ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines personnes peuvent avoir une carence sans présenter de symptômes visibles." } }, { "@type": "Question", "name": "Quel rôle joue l'historique médical dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'historique médical aide à identifier des facteurs de risque comme des troubles d'absorption." } }, { "@type": "Question", "name": "Quels sont les symptômes courants de la carence en B12 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, faiblesse, engourdissements et troubles de l'humeur." } }, { "@type": "Question", "name": "La carence en B12 peut-elle causer des problèmes neurologiques ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des troubles neurologiques comme des démences ou des neuropathies." } }, { "@type": "Question", "name": "Comment la carence affecte-t-elle la peau ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut provoquer des changements cutanés comme une pâleur ou des lésions cutanées." } }, { "@type": "Question", "name": "Y a-t-il des symptômes digestifs associés ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme des nausées, des diarrhées ou des troubles digestifs peuvent survenir." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent être plus prononcés chez les personnes âgées en raison de l'absorption réduite." } }, { "@type": "Question", "name": "Comment prévenir la carence en vitamine B12 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée incluant des sources de B12 et des suppléments si nécessaire aide." } }, { "@type": "Question", "name": "Les personnes âgées doivent-elles prendre des suppléments ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes âgées peuvent avoir besoin de suppléments en raison d'une absorption réduite." } }, { "@type": "Question", "name": "Les végétaliens peuvent-ils éviter la carence ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Ils doivent prendre des suppléments de B12 ou consommer des aliments enrichis pour éviter la carence." } }, { "@type": "Question", "name": "Les tests réguliers sont-ils recommandés ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests réguliers sont conseillés pour les personnes à risque de carence." } }, { "@type": "Question", "name": "Les maladies digestives augmentent-elles le risque ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme la maladie de Crohn peuvent affecter l'absorption de la vitamine B12." } }, { "@type": "Question", "name": "Comment traiter une carence en vitamine B12 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement inclut des suppléments oraux ou des injections de vitamine B12 selon la gravité." } }, { "@type": "Question", "name": "Quelle est la durée du traitement ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "La durée dépend de la gravité, mais peut durer de quelques mois à plusieurs années." } }, { "@type": "Question", "name": "Les aliments peuvent-ils aider à corriger la carence ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, consommer des aliments riches en B12 comme la viande, le poisson et les produits laitiers aide." } }, { "@type": "Question", "name": "Les personnes végétariennes sont-elles à risque ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent être à risque en raison d'un apport alimentaire limité en vitamine B12." } }, { "@type": "Question", "name": "Les traitements sont-ils différents pour les enfants ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements sont similaires, mais les doses peuvent varier selon l'âge et le poids." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent l'anémie mégaloblastique, des troubles neurologiques et des problèmes cardiaques." } }, { "@type": "Question", "name": "La carence peut-elle entraîner des problèmes cognitifs ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une carence prolongée peut causer des troubles cognitifs et des pertes de mémoire." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de maladies cardiovasculaires ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une carence en B12 peut augmenter le risque de maladies cardiovasculaires en élevant l'homocystéine." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non." } }, { "@type": "Question", "name": "La carence en B12 peut-elle affecter la grossesse ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des complications pendant la grossesse, comme des malformations congénitales." } }, { "@type": "Question", "name": "Qui est le plus à risque de carence en B12 ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les personnes âgées, les végétariens, et ceux ayant des troubles d'absorption sont à risque." } }, { "@type": "Question", "name": "Les maladies auto-immunes augmentent-elles le risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme la gastrite atrophique peuvent affecter l'absorption de la B12." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils influencer le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments comme les inhibiteurs de la pompe à protons peuvent réduire l'absorption." } }, { "@type": "Question", "name": "Les troubles digestifs sont-ils un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles comme la maladie cœliaque peuvent nuire à l'absorption de la vitamine B12." } }, { "@type": "Question", "name": "Les antécédents familiaux jouent-ils un rôle ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de carence peuvent augmenter le risque chez certains individus." } } ] } ] }

Sources (10000 au total)

Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection.

Mortalin/GRP75 is a ubiquitous mitochondrial chaperone related to the cytosolic heat shock protein 70. It protects cells from various types of damages and from senescence. Our goal was to determine wh... Mortalin was determined by ELISA in the sera of 83 COVID-19 patients enrolled in the study. Patients were categorized into 4 groups: critical patients who died (FATAL) or required intensive care and s... The mortalin concentration in the serum of all COVID-19 patients in the cohort was 194-2324 pg/mL. A comparison of the mortalin levels by peak severity among the various patient groups showed a highly... This is the first report on circulating mortalin in COVID-19 patients. Higher mortalin levels were associated with more severe illnesses and a higher risk of death. We claim that quantifying the blood...

Targeting the Alternative Complement Pathway With Iptacopan to Treat IgA Nephropathy: Design and Rationale of the APPLAUSE-IgAN Study.

Targeting the alternative complement pathway (AP) is an attractive therapeutic strategy because of its role in immunoglobulin A nephropathy (IgAN) pathophysiology. Iptacopan (LNP023), a proximal compl... APPLAUSE-IgAN (NCT04578834) is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study enrolling approximately 450 adult patients (aged ≥18 years) with biopsy-confir... APPLAUSE-IgAN will evaluate the benefits and safety of iptacopan, a novel targeted therapy for IgAN, in reducing complement-mediated kidney damage and thus slowing or preventing disease progression....

Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis.

IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.... to assess the underlying molecular mechanisms in the pathogenesis of IgAV using an untargeted proteomics approach.... Thirty-seven IgAV patients and five healthy controls were enrolled. Plasma samples were collected on the day of diagnosis before any treatment was initiated. We used nano-liquid chromatography-tandem ... Among the 418 proteins identified in the nLC-MS/MS analysis, 20 had significantly different expressions in IgAV patients. Among them, 15 were upregulated and 5 were downregulated. According to the KEG... Our results clearly suggest the role of the lectin and alternate complement pathways in IgAV. The proteins defined in the pathways of cell adhesion may serve as biomarkers. Further functional studies ...

Alternative Complement Pathway Inhibition With Iptacopan for the Treatment of C3 Glomerulopathy-Study Design of the APPEAR-C3G Trial.

Complement 3 glomerulopathy (C3G) is a rare kidney disease characterized by dysregulation of the alternative pathway (AP) of the complement system. About 50% of patients with C3G progress to kidney fa... APPEAR-C3G (NCT04817618) is a randomized, double-blind, and placebo-controlled Phase III study to evaluate the efficacy and safety of iptacopan in C3G patients, enrolling 68 adults with biopsy-confirm... This study aims to demonstrate the clinical benefits of AP inhibition with iptacopan in C3G....