Carence en vitamine B12 : Questions médicales fréquentes
Nom anglais: Vitamin B 12 Deficiency
Descriptor UI:D014806
Tree Number:C18.654.521.500.133.699.923
Termes MeSH sélectionnés :
Intestinal Failure
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Carence en vitamine B12 : Questions médicales les plus fréquentes",
"headline": "Carence en vitamine B12 : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Carence en vitamine B12 : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-03-25",
"dateModified": "2025-03-20",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Carence en vitamine B12"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Carence en vitamines B",
"url": "https://questionsmedicales.fr/mesh/D014804",
"about": {
"@type": "MedicalCondition",
"name": "Carence en vitamines B",
"code": {
"@type": "MedicalCode",
"code": "D014804",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "C18.654.521.500.133.699"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Anémie pernicieuse",
"alternateName": "Anemia, Pernicious",
"url": "https://questionsmedicales.fr/mesh/D000752",
"about": {
"@type": "MedicalCondition",
"name": "Anémie pernicieuse",
"code": {
"@type": "MedicalCode",
"code": "D000752",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "C18.654.521.500.133.699.923.280"
}
}
}
],
"about": {
"@type": "MedicalCondition",
"name": "Carence en vitamine B12",
"alternateName": "Vitamin B 12 Deficiency",
"code": {
"@type": "MedicalCode",
"code": "D014806",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Dorota Gryko",
"url": "https://questionsmedicales.fr/author/Dorota%20Gryko",
"affiliation": {
"@type": "Organization",
"name": "Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland. dorota.gryko@icho.edu.pl."
}
},
{
"@type": "Person",
"name": "Jacob Selhub",
"url": "https://questionsmedicales.fr/author/Jacob%20Selhub",
"affiliation": {
"@type": "Organization",
"name": ""
}
},
{
"@type": "Person",
"name": "Setareh Shahab-Ferdows",
"url": "https://questionsmedicales.fr/author/Setareh%20Shahab-Ferdows",
"affiliation": {
"@type": "Organization",
"name": "Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, United States."
}
},
{
"@type": "Person",
"name": "Daniela Hampel",
"url": "https://questionsmedicales.fr/author/Daniela%20Hampel",
"affiliation": {
"@type": "Organization",
"name": "Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, United States; Department of Nutrition, University of California, Davis, CA, United States."
}
},
{
"@type": "Person",
"name": "Lindsay H Allen",
"url": "https://questionsmedicales.fr/author/Lindsay%20H%20Allen",
"affiliation": {
"@type": "Organization",
"name": "Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, United States."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Overview of Physical, Neurocognitive, and Psychosocial Outcomes in Pediatric Intestinal Failure and Transplantation.",
"datePublished": "2022-08-30",
"url": "https://questionsmedicales.fr/article/36040624",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s11894-022-00848-3"
}
},
{
"@type": "ScholarlyArticle",
"name": "Characteristics of chronic intestinal failure in the USA based on analysis of claims data.",
"datePublished": "2022-07-24",
"url": "https://questionsmedicales.fr/article/35726729",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/jpen.2426"
}
},
{
"@type": "ScholarlyArticle",
"name": "Effects of resistance training on sarcopenia in patients with intestinal failure: A randomized controlled trial.",
"datePublished": "2023-07-16",
"url": "https://questionsmedicales.fr/article/37625319",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.clnu.2023.07.013"
}
},
{
"@type": "ScholarlyArticle",
"name": "Efficacy of same venous route Hickman catheter replacement in patients with intestinal failure.",
"datePublished": "2022-10-28",
"url": "https://questionsmedicales.fr/article/37096641",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jfma.2022.10.003"
}
},
{
"@type": "ScholarlyArticle",
"name": "Body Composition and Physical Activity in Pediatric Intestinal Failure On and Off Parenteral Nutrition.",
"datePublished": "2023-07-12",
"url": "https://questionsmedicales.fr/article/37434279",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1097/MPG.0000000000003884"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Maladies métaboliques et nutritionnelles",
"item": "https://questionsmedicales.fr/mesh/D009750"
},
{
"@type": "ListItem",
"position": 3,
"name": "Troubles nutritionnels",
"item": "https://questionsmedicales.fr/mesh/D009748"
},
{
"@type": "ListItem",
"position": 4,
"name": "Malnutrition",
"item": "https://questionsmedicales.fr/mesh/D044342"
},
{
"@type": "ListItem",
"position": 5,
"name": "Maladies de carence",
"item": "https://questionsmedicales.fr/mesh/D003677"
},
{
"@type": "ListItem",
"position": 6,
"name": "Avitaminoses",
"item": "https://questionsmedicales.fr/mesh/D001361"
},
{
"@type": "ListItem",
"position": 7,
"name": "Carence en vitamines B",
"item": "https://questionsmedicales.fr/mesh/D014804"
},
{
"@type": "ListItem",
"position": 8,
"name": "Carence en vitamine B12",
"item": "https://questionsmedicales.fr/mesh/D014806"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Carence en vitamine B12 - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Carence en vitamine B12",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-11",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Carence en vitamine B12",
"description": "Comment diagnostiquer une carence en vitamine B12 ?\nQuels tests sont utilisés pour confirmer la carence ?\nQuels signes cliniques indiquent une carence ?\nLa carence en B12 peut-elle être asymptomatique ?\nQuel rôle joue l'historique médical dans le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Intestinal+Failure&page=3#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Carence en vitamine B12",
"description": "Quels sont les symptômes courants de la carence en B12 ?\nLa carence en B12 peut-elle causer des problèmes neurologiques ?\nComment la carence affecte-t-elle la peau ?\nY a-t-il des symptômes digestifs associés ?\nLes symptômes varient-ils selon l'âge ?",
"url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Intestinal+Failure&page=3#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Carence en vitamine B12",
"description": "Comment prévenir la carence en vitamine B12 ?\nLes personnes âgées doivent-elles prendre des suppléments ?\nLes végétaliens peuvent-ils éviter la carence ?\nLes tests réguliers sont-ils recommandés ?\nLes maladies digestives augmentent-elles le risque ?",
"url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Intestinal+Failure&page=3#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Carence en vitamine B12",
"description": "Comment traiter une carence en vitamine B12 ?\nQuelle est la durée du traitement ?\nLes aliments peuvent-ils aider à corriger la carence ?\nLes personnes végétariennes sont-elles à risque ?\nLes traitements sont-ils différents pour les enfants ?",
"url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Intestinal+Failure&page=3#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Carence en vitamine B12",
"description": "Quelles complications peuvent survenir ?\nLa carence peut-elle entraîner des problèmes cognitifs ?\nY a-t-il un risque accru de maladies cardiovasculaires ?\nLes complications sont-elles réversibles ?\nLa carence en B12 peut-elle affecter la grossesse ?",
"url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Intestinal+Failure&page=3#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Carence en vitamine B12",
"description": "Qui est le plus à risque de carence en B12 ?\nLes maladies auto-immunes augmentent-elles le risque ?\nLes médicaments peuvent-ils influencer le risque ?\nLes troubles digestifs sont-ils un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?",
"url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Intestinal+Failure&page=3#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une carence en vitamine B12 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic se fait par des analyses sanguines mesurant les niveaux de vitamine B12."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour confirmer la carence ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent la mesure de la vitamine B12, de l'homocystéine et de la méthylmalonyl-CoA."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une carence ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes comme l'anémie, la fatigue, et des troubles neurologiques peuvent indiquer une carence."
}
},
{
"@type": "Question",
"name": "La carence en B12 peut-elle être asymptomatique ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines personnes peuvent avoir une carence sans présenter de symptômes visibles."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'historique médical dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'historique médical aide à identifier des facteurs de risque comme des troubles d'absorption."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes courants de la carence en B12 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, faiblesse, engourdissements et troubles de l'humeur."
}
},
{
"@type": "Question",
"name": "La carence en B12 peut-elle causer des problèmes neurologiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des troubles neurologiques comme des démences ou des neuropathies."
}
},
{
"@type": "Question",
"name": "Comment la carence affecte-t-elle la peau ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut provoquer des changements cutanés comme une pâleur ou des lésions cutanées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes digestifs associés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme des nausées, des diarrhées ou des troubles digestifs peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent être plus prononcés chez les personnes âgées en raison de l'absorption réduite."
}
},
{
"@type": "Question",
"name": "Comment prévenir la carence en vitamine B12 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée incluant des sources de B12 et des suppléments si nécessaire aide."
}
},
{
"@type": "Question",
"name": "Les personnes âgées doivent-elles prendre des suppléments ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir besoin de suppléments en raison d'une absorption réduite."
}
},
{
"@type": "Question",
"name": "Les végétaliens peuvent-ils éviter la carence ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils doivent prendre des suppléments de B12 ou consommer des aliments enrichis pour éviter la carence."
}
},
{
"@type": "Question",
"name": "Les tests réguliers sont-ils recommandés ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests réguliers sont conseillés pour les personnes à risque de carence."
}
},
{
"@type": "Question",
"name": "Les maladies digestives augmentent-elles le risque ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme la maladie de Crohn peuvent affecter l'absorption de la vitamine B12."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en vitamine B12 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des suppléments oraux ou des injections de vitamine B12 selon la gravité."
}
},
{
"@type": "Question",
"name": "Quelle est la durée du traitement ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La durée dépend de la gravité, mais peut durer de quelques mois à plusieurs années."
}
},
{
"@type": "Question",
"name": "Les aliments peuvent-ils aider à corriger la carence ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, consommer des aliments riches en B12 comme la viande, le poisson et les produits laitiers aide."
}
},
{
"@type": "Question",
"name": "Les personnes végétariennes sont-elles à risque ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent être à risque en raison d'un apport alimentaire limité en vitamine B12."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils différents pour les enfants ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements sont similaires, mais les doses peuvent varier selon l'âge et le poids."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent l'anémie mégaloblastique, des troubles neurologiques et des problèmes cardiaques."
}
},
{
"@type": "Question",
"name": "La carence peut-elle entraîner des problèmes cognitifs ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence prolongée peut causer des troubles cognitifs et des pertes de mémoire."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de maladies cardiovasculaires ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence en B12 peut augmenter le risque de maladies cardiovasculaires en élevant l'homocystéine."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non."
}
},
{
"@type": "Question",
"name": "La carence en B12 peut-elle affecter la grossesse ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des complications pendant la grossesse, comme des malformations congénitales."
}
},
{
"@type": "Question",
"name": "Qui est le plus à risque de carence en B12 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées, les végétariens, et ceux ayant des troubles d'absorption sont à risque."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes augmentent-elles le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme la gastrite atrophique peuvent affecter l'absorption de la B12."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils influencer le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments comme les inhibiteurs de la pompe à protons peuvent réduire l'absorption."
}
},
{
"@type": "Question",
"name": "Les troubles digestifs sont-ils un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme la maladie cœliaque peuvent nuire à l'absorption de la vitamine B12."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de carence peuvent augmenter le risque chez certains individus."
}
}
]
}
]
}
Intestinal failure and transplantation may significantly impact physical, neurocognitive, and psychosocial development in pediatric patients. Currently, there is a paucity of literature on the effects...
Psychological disorders, neurodevelopmental delay, and social maladaptation are frequently encountered in this patient population. While the main focus is often on medical management, equal emphasis s...
This study investigated the prevalence, characteristics, and management of patients with chronic intestinal failure (CIF) in the United States in 2012-2020, based on parenteral support (PS) prescripti...
Patients with CIF were identified from the Integrated DataVerse® claims database if they had at least two PS prescriptions within 6 months and a relevant diagnosis. Analysis included prevalence and ch...
Up to 24,048 patients with CIF were identified, equivalent to 75 patients per million. CIF affected people of all ages, being more prevalent in women than in men. Many providers signed PS orders for s...
Healthcare disparities for patients with CIF have likely been obscured by the lack of CIF-specific diagnostic and procedure codes, obliging providers to code for their patients under other codes. Effe...
The potential effects of resistance training on sarcopenia in patients with intestinal failure (IF) are not fully elucidated. This study aimed to explore the efficacy of a resistance training program ...
A single-center randomized controlled trial was conducted in a Chinese tertiary teaching hospital. Patients with IF exhibiting sarcopenia were randomly assigned to the exercise group or control group....
A total of 60 participants (control group 30, age 51.2 ± 12.9 years, women 43.3%; exercise group 30, age 53.9 ± 14.5 years, women 56.7%) completed the 4-week intervention trial. For the primary outcom...
In this randomized clinical trial, we observed that 4 weeks of resistance training was associated with improved ASMI, physical performance, biochemical parameters (including IGF-1, prealbumin, and hem...
www.chictr.org.cn, identifier: ChiCTR2100051727....
Periodical replacement of venous Hickman catheters is required for the nutritional care of patients with intestinal failure. The conventional de novo operation (DN-OP) involves inserting the catheter ...
We conducted a retrospective study to compare the efficacy of Hickman catheters and the survival of venous vessels using two different operative strategies....
Overall, 181 catheters were inserted, 109 using DN-OP and 72 using SR-OP. The mean catheter duration was 11.9 ± 8.8 months in the DN-OP group and 10.5 ± 5.6 months in the SR-OP group; the infection ra...
Application of SR-OP in Hickman catheter replacement significantly extended the working duration of venous access by re-using the same venous route without compromising catheter efficacy in patients w...
Data on the relationship between body composition (BC) and physical activity (PA) in children with intestinal failure (IF) are lacking. The objectives were to collect data on PA and BC in children wit...
Cross-sectional study in children 5-18 years with IF including those receiving parenteral nutrition (PN) and those fully enterally fed. PA levels were measured using accelerometry. BC was measured by ...
Fifty-eight children with IF (38 males), mean (SD) age of 10.0 (3.5) years, 20 dependent on PN were included. Patients with IF had significantly fewer steps per day ( P ≤ 0.001) compared with literatu...
Children with IF, those receiving PN and those fully enterally fed, are at risk of decreased PA and altered BC. PA should be part of ongoing rehabilitation and management to optimize outcomes....
There is a subset of intestinal failure patients with associated chronic intestinal inflammation resembling inflammatory bowel disease. This study aimed to evaluate factors associated with chronic int...
This was a single-center retrospective case-control study of children <18 years old with intestinal failure. Cases were defined by abnormal amounts of chronic intestinal inflammation on biopsies. Chil...
Thirty cases were identified and matched to 60 controls. On univariate analysis, longer parenteral nutrition (PN) duration (1677 vs 834 days, P = 0.03), current PN use (33.3% vs 20.0%, P = 0.037), and...
PN dependence and intestinal dysbiosis are associated with chronic intestinal inflammation in children with intestinal failure. Severity of inflammation is associated with escalation of therapy. Furth...
Intestinal dysmotility (ID) problems are common in patients with pediatric-onset intestinal failure (IF) and short bowel syndrome (SBS), leading to significant morbidity and delays in the advancement ...
Retrospective chart review of all children with IF and/or SBS who required parenteral nutrition (PN) > 6 weeks or small-intestinal resection ≥ 50%. Patients were divided into SBS and non-SBS groups. S...
A total of 42 children with IF were treated in our institution during 2003-2022. In non-SBS group (n = 10), ID was the most common cause of IF (80%). SBS-group included 32 children; 18 children (56%) ...
ID is the most common complication of SBS and is the most common cause of IF in non-SBS patients. ID has a high morbidity rate and various clinical manifestations. Successful treatment of these infant...
With increasing number of children with intestinal failure (IF) on long-term parenteral nutrition (PN), this study assesses the impact of IF on muscle strength, speed, and agility and body composition...
Cross-sectional study in children 5-18 years with IF on PN. Assessments included Bruininks-Oseretsky Test of Motor Proficiency-2 strength and agility subtest (BOT-2), and grip strength. BC data from d...
Twenty-one children with IF (14 males), median age 8.33 (IQR: 6.96-11.04) years and 33 controls (20 males), 8.25 (6.67-10.79) years were included. Strength and agility ( P < 0.001) and grip strengt...
Children with IF are at risk of decreased muscle strength and agility, along with altered BC. Ongoing medical, nutritional, and rehabilitation intervention is vital to optimize outcomes....
Patients with intestinal failure (IF) are often dependent on PN for provision of calories and nutrients for survival. Similar to chronic intestinal failure (CIF) patients, those who have AIF are also ...
The primary objective of this study was to determine the incidence of IFALD in AIF patients on short-term PN. Secondary objectives were to analyse patient and PN risk factors of IFALD, and clinical ou...
This was a retrospective cross-sectional cohort study of hospitalised adult patients with AIF prescribed with short-term PN. All adult patients aged 21 years and above who received PN for at least 5 c...
A total of 171 patients were enrolled in this study, with 77 (45%) having deranged LFTs at the end of PN therapy and categorised under the IFLAD group. The patient cohort was predominantly male (92 [5...
In this study, IFALD is a common phenomenon in AIF and the incidence was found to be an estimated 50% amongst patients on short-term PN with similar clinical outcomes between the two groups....
This post-hoc analysis evaluated the effect of teduglutide treatment on diarrhea in patients with short bowel syndrome-associated intestinal failure (SBS-IF)....
Data from 2 open-label, multicenter, phase 3 pediatric SBS-IF clinical trials of teduglutide (NCT01952080 and NCT02682381) were pooled where possible. The primary objective was to evaluate the change ...
Overall, 101 patients were analyzed. Among the total teduglutide group (n = 87), there were significant changes from baseline to weeks 12 and 24 in mean (standard error) Bristol Stool Form Scale (BSFS...
In this post-hoc analysis, short-term treatment with teduglutide was associated with improved stool consistency, as well as trends towards reductions in PN/IV requirements and advancements in enteral ...
