Titre : Carence en vitamine B12

Carence en vitamine B12 : Questions médicales fréquentes

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diagnostiquer une carence en vitamine B12 ?\nQuels tests sont utilisés pour confirmer la carence ?\nQuels signes cliniques indiquent une carence ?\nLa carence en B12 peut-elle être asymptomatique ?\nQuel rôle joue l'historique médical dans le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D014806?page=6#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Carence en vitamine B12", "description": "Quels sont les symptômes courants de la carence en B12 ?\nLa carence en B12 peut-elle causer des problèmes neurologiques ?\nComment la carence affecte-t-elle la peau ?\nY a-t-il des symptômes digestifs associés ?\nLes symptômes varient-ils selon l'âge ?", "url": "https://questionsmedicales.fr/mesh/D014806?page=6#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Carence en vitamine B12", "description": "Comment prévenir la carence en vitamine B12 ?\nLes personnes âgées doivent-elles prendre des suppléments ?\nLes végétaliens peuvent-ils éviter la carence ?\nLes tests réguliers sont-ils recommandés ?\nLes maladies digestives augmentent-elles le risque ?", "url": "https://questionsmedicales.fr/mesh/D014806?page=6#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Carence en vitamine B12", "description": "Comment traiter une carence en vitamine B12 ?\nQuelle est la durée du traitement ?\nLes aliments peuvent-ils aider à corriger la carence ?\nLes personnes végétariennes sont-elles à risque ?\nLes traitements sont-ils différents pour les enfants ?", "url": "https://questionsmedicales.fr/mesh/D014806?page=6#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Carence en vitamine B12", "description": "Quelles complications peuvent survenir ?\nLa carence peut-elle entraîner des problèmes cognitifs ?\nY a-t-il un risque accru de maladies cardiovasculaires ?\nLes complications sont-elles réversibles ?\nLa carence en B12 peut-elle affecter la grossesse ?", "url": "https://questionsmedicales.fr/mesh/D014806?page=6#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Carence en vitamine B12", "description": "Qui est le plus à risque de carence en B12 ?\nLes maladies auto-immunes augmentent-elles le risque ?\nLes médicaments peuvent-ils influencer le risque ?\nLes troubles digestifs sont-ils un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?", "url": "https://questionsmedicales.fr/mesh/D014806?page=6#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une carence en vitamine B12 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un diagnostic se fait par des analyses sanguines mesurant les niveaux de vitamine B12." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour confirmer la carence ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests incluent la mesure de la vitamine B12, de l'homocystéine et de la méthylmalonyl-CoA." } }, { "@type": "Question", "name": "Quels signes cliniques indiquent une carence ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des signes comme l'anémie, la fatigue, et des troubles neurologiques peuvent indiquer une carence." } }, { "@type": "Question", "name": "La carence en B12 peut-elle être asymptomatique ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines personnes peuvent avoir une carence sans présenter de symptômes visibles." } }, { "@type": "Question", "name": "Quel rôle joue l'historique médical dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'historique médical aide à identifier des facteurs de risque comme des troubles d'absorption." } }, { "@type": "Question", "name": "Quels sont les symptômes courants de la carence en B12 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, faiblesse, engourdissements et troubles de l'humeur." } }, { "@type": "Question", "name": "La carence en B12 peut-elle causer des problèmes neurologiques ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des troubles neurologiques comme des démences ou des neuropathies." } }, { "@type": "Question", "name": "Comment la carence affecte-t-elle la peau ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut provoquer des changements cutanés comme une pâleur ou des lésions cutanées." } }, { "@type": "Question", "name": "Y a-t-il des symptômes digestifs associés ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme des nausées, des diarrhées ou des troubles digestifs peuvent survenir." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent être plus prononcés chez les personnes âgées en raison de l'absorption réduite." } }, { "@type": "Question", "name": "Comment prévenir la carence en vitamine B12 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée incluant des sources de B12 et des suppléments si nécessaire aide." } }, { "@type": "Question", "name": "Les personnes âgées doivent-elles prendre des suppléments ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes âgées peuvent avoir besoin de suppléments en raison d'une absorption réduite." } }, { "@type": "Question", "name": "Les végétaliens peuvent-ils éviter la carence ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Ils doivent prendre des suppléments de B12 ou consommer des aliments enrichis pour éviter la carence." } }, { "@type": "Question", "name": "Les tests réguliers sont-ils recommandés ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests réguliers sont conseillés pour les personnes à risque de carence." } }, { "@type": "Question", "name": "Les maladies digestives augmentent-elles le risque ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme la maladie de Crohn peuvent affecter l'absorption de la vitamine B12." } }, { "@type": "Question", "name": "Comment traiter une carence en vitamine B12 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement inclut des suppléments oraux ou des injections de vitamine B12 selon la gravité." } }, { "@type": "Question", "name": "Quelle est la durée du traitement ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "La durée dépend de la gravité, mais peut durer de quelques mois à plusieurs années." } }, { "@type": "Question", "name": "Les aliments peuvent-ils aider à corriger la carence ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, consommer des aliments riches en B12 comme la viande, le poisson et les produits laitiers aide." } }, { "@type": "Question", "name": "Les personnes végétariennes sont-elles à risque ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent être à risque en raison d'un apport alimentaire limité en vitamine B12." } }, { "@type": "Question", "name": "Les traitements sont-ils différents pour les enfants ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements sont similaires, mais les doses peuvent varier selon l'âge et le poids." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent l'anémie mégaloblastique, des troubles neurologiques et des problèmes cardiaques." } }, { "@type": "Question", "name": "La carence peut-elle entraîner des problèmes cognitifs ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une carence prolongée peut causer des troubles cognitifs et des pertes de mémoire." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de maladies cardiovasculaires ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une carence en B12 peut augmenter le risque de maladies cardiovasculaires en élevant l'homocystéine." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non." } }, { "@type": "Question", "name": "La carence en B12 peut-elle affecter la grossesse ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des complications pendant la grossesse, comme des malformations congénitales." } }, { "@type": "Question", "name": "Qui est le plus à risque de carence en B12 ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les personnes âgées, les végétariens, et ceux ayant des troubles d'absorption sont à risque." } }, { "@type": "Question", "name": "Les maladies auto-immunes augmentent-elles le risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme la gastrite atrophique peuvent affecter l'absorption de la B12." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils influencer le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments comme les inhibiteurs de la pompe à protons peuvent réduire l'absorption." } }, { "@type": "Question", "name": "Les troubles digestifs sont-ils un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles comme la maladie cœliaque peuvent nuire à l'absorption de la vitamine B12." } }, { "@type": "Question", "name": "Les antécédents familiaux jouent-ils un rôle ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de carence peuvent augmenter le risque chez certains individus." } } ] } ] }

Sources (10000 au total)

Vitamin B12 deficiency may play an etiological role in atrophic glossitis and its grading: A clinical case-control study.

Existing studies have reported the significant association between atrophic glossitis (AG) and hematinic deficiencies, including iron, folate and vitamin B12 deficiency. However, these findings were i... 236 AG patients and 208 sex- and age-matched healthy controls were enrolled in this study. Hematological tests including complete blood count, and serum levels of folate, ferritin and vitamin B12 were... Compared with the healthy controls, AG patients had significantly higher frequencies of vitamin B12 deficiency (68.22%), ferritin deficiency (13.98%) and anemia (21.61%). The differences in hematinic ... AG could be an important clinical indicator for potential vitamin B12 deficiency, especially when the degree of tongue atrophy more than 50% and complete atrophy. Vitamin B12 deficiency might play an ...

Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency.

Risk factors for vitamin B12 deficiency in infants are not fully understood. The aim of the study was to assess predictors of total homocysteine and methylmalonic acid analysed in newborn screening dr... In a Norwegian case control study, we analysed total homocysteine and methylmalonic acid in newborn screening dried blood spots of 86 infants clinically diagnosed with vitamin B12 deficiency during 20... Both total homocysteine and methylmalonic acid were significantly higher on newborn screening dried blood spots in infants later clinically diagnosed with vitamin B12 deficiency than controls. Multipl... Nitrous oxide dose during labour was a predictor for total homocysteine and may impact the interpretation of total homocysteine analysis in newborn screening. Nitrous oxide is suggested as a contribut...

Prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin, a cross-sectional study in primary healthcare.

Several studies documented that metformin use contributes to vitamin B12 deficiency in patients with type 2 diabetes mellitus (T2DM). However, there has been a lack of data assessing this issue in Jor... Assess the vitamin B12 serum levels, frequency of vitamin B12 deficiency, and related factors among Jordanian patients with T2DM patients treated with metformin.... a total of 447 subjects attending a primary health care center were included in this cross-sectional study consisting of T2DM patients who use metformin and a control group of non-diabetics. Serum B12... There was no significant difference in serum B12 levels nor the frequency of vitamin B12 deficiency between T2DM metformin-treated patients and control groups. Among metformin-treated patients there w... The prevalence of vitamin B12 deficiency among T2DM patients on metformin treatment in this study was high (48.9%). However, the treatment with metformin and the dose of metformin use was not associat...

Nutritional vitamin B12 deficiency-associated Infantile epileptic spasms syndrome: Clinico-neurophysiological presentation, response to treatment, and neurodevelopmental outcome.

Nutritional vitamin B12 deficiency has been shown to cause Infantile epileptic spasms syndrome (IESS) in infants in anecdotal studies.... In this retrospective cohort study, we intended to study the clinical presentation, neurophysiological, laboratory abnormalities, treatment, and neurodevelopmental outcome at 6-months in infants prese... Data from 162 infants with IESS (21 caused by NVBD) were included in our study. The NVBD group had more patients residing in the rural region, with lower socioeconomic status, vegetarian mothers and p... Nutritional vitamin B12 deficiency may cause IESS in infants. Hence, vitamin B12 deficiency needs to be ruled out in patients with IESS without any definite etiology....

Bidirectional association between diabetic peripheral neuropathy and vitamin B12 deficiency: Two longitudinal 9-year follow-up studies using a national sample cohort.

This study aims to investigate the association among metformin use, vit B12 deficiency, and DPN occurrence in diabetes.... This retrospective, propensity-matched cohort study was performed using National Health Insurance Service database - National Sample Cohort in South Korea. Study 1 analyzed DPN incidence according to ... In study 1, DPN incidence per 10000 person-year (PY) was 179.7 and 76.6 in the vit B12 and non-vit B12 deficiency groups, respectively. The adjusted HR was 1.32 (95% CI; 1.21-1.44, P < 0.05) and metfo... DPN occurrence increased in diabetes with vit B12 deficiency and the incidence of vit B12 deficiency was also high in DPN patients. However, metformin showed opposite effects in both cohorts. Further ...

The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study.

To evaluate the prevalence of vitamin B12 deficiency in Chinese patients with type 2 diabetes mellitus receiving metformin treatment and to investigate the effects of metformin daily dose and treatmen... In this multicenter cross-sectional study, 1027 Chinese patients who had been taking ≥1000 mg/day metformin for ≥1 year were enrolled using proportionate stratified random sampling based on daily dose... The prevalence of vitamin B12 deficiency, borderline deficiency, and PN were 2.15%, 13.66%, and 11.59%, respectively. Patients receiving ≥1500 mg/day metformin had significantly higher prevalence of b... High daily dosage (≥1500 mg/day) played an important role in metformin-associated vitamin B12 deficiency while not contributing to the risk of PN....

The effects of prenatal and postnatal high-dose vitamin B-12 supplementation on human milk vitamin B-12: a randomized, double-blind, placebo-controlled trial in Tanzania.

Vitamin B-12 status in human milk (HM) has critical implications for infant growth and development. Few studies have separately evaluated the effects of prenatal and postnatal maternal high-dose vitam... This randomized controlled trial aimed to assess the effects of prenatal and postnatal vitamin B-12 supplementation on HM vitamin B-12 at 6 wk and 7 mo postpartum.... Pregnant women were enrolled in Dar es Salaam, Tanzania, between 2001 and 2004. From recruitment (12-27 weeks of gestation) through 6 wk postpartum, participants were randomly assigned to daily oral m... The prevalence of HM vitamin B-12 of <310 pmol/L was 73.3% and 68.4% at 6 wk and 7 mo postpartum, respectively. Prenatal supplementation increased HM vitamin B-12 concentration (percent difference: 34... Prenatal maternal vitamin B-12 supplementation has benefits on short-term HM status, and postnatal maternal vitamin B-12 supplementation has benefits on long-term HM status. This trial was registered ...

High Serum Folate Concentration, Vitamin B12 Deficiency, and Anthropometric Nutritional Status in Brazilian Children Aged 6-59 Months: Data from the Brazilian National Survey of Child Nutrition.

Vitamin B12 and folate are key nutrients that help children reach their full potential in growth and development; however, little is known about the status of these vitamins in Brazilian children.... To describe the serum concentrations of vitamin B12 and folate, to investigate the association between high folate concentration (HFC) and vitamin B12 deficiency, and to evaluate the association betwe... Data from 7417 children aged 6-59 mo collected during the Brazilian National Survey on Child Nutrition were used. Serum concentrations of vitamin B12 of <150 pmol/L and folate of <10 nmol/L were class... In Brazil, 14.2% (95% CI: 12.2, 16.1) of children aged 6-59 mo had vitamin B12 deficiency, 1.1% (95% CI: 0.5, 1.6) had folate deficiency, and 36.9% (95% CI: 33.4, 40.3) had HFC. Vitamin B12 deficiency... Vitamin B12 deficiency is a public health problem among Brazilian children aged <2 y with vulnerable socioeconomic status. HFC was inversely associated with vitamin B12 deficiency, and lower odds of s...

Vitamin B12 reference intervals.

P-Vitamin B12 is a commonly used biochemical test. Evaluation of test results and diagnosis of vitamin B12 deficiency are challenging, and the role of different biochemical methods remains unclear.... The aim of this study was to establish reference intervals for plasma vitamin B12 concentration using different immunoassays (method 1: Alinity, Abbott Laboratories; method 2: Cobas 6000, Roche Diagno... Direct reference intervals (2.5-97.5 percentiles) were as follows for method 1: 168-553 pmol/l; method 2: 202-641 pmol/l; and method 3: 211-551 pmol/l. Indirect reference intervals were as follows for... Measurement of plasma vitamin B12 concentration using different immunoassays revealed results and reference intervals that were not interchangeable. Clinical guidelines for the diagnosis of vitamin B1... None.... None....