Comment diagnostiquer une surdose de 4-hydroxycoumarines ?
Le diagnostic repose sur des tests de coagulation et l'évaluation des symptômes cliniques.
AnticoagulantsSurdosage
#2
Quels tests sont utilisés pour surveiller le traitement par 4-hydroxycoumarines ?
Le temps de prothrombine (TP) et l'INR sont les tests principaux pour surveiller l'efficacité.
Temps de prothrombineINR
#3
Quels symptômes indiquent une complication du traitement ?
Des saignements inhabituels, des ecchymoses ou des douleurs abdominales peuvent indiquer une complication.
SaignementComplications
#4
Comment évaluer l'efficacité des 4-hydroxycoumarines ?
L'efficacité est évaluée par la réduction des événements thromboemboliques et les résultats des tests de coagulation.
ThromboseÉvaluation
#5
Quels signes cliniques nécessitent une évaluation urgente ?
Des signes de saignement grave, comme des hémorragies cérébrales ou gastro-intestinales, nécessitent une évaluation urgente.
HémorragieUrgence
Symptômes
5
#1
Quels sont les effets secondaires courants des 4-hydroxycoumarines ?
Les effets secondaires incluent des saignements, des nausées et des douleurs abdominales.
Effets secondairesNausées
#2
Comment reconnaître une réaction allergique aux 4-hydroxycoumarines ?
Des éruptions cutanées, des démangeaisons ou un gonflement peuvent indiquer une réaction allergique.
Réaction allergiqueÉruption cutanée
#3
Quels symptômes peuvent indiquer une thrombose malgré le traitement ?
Des douleurs, un gonflement ou une rougeur dans une jambe peuvent indiquer une thrombose persistante.
ThromboseSymptômes
#4
Quels signes indiquent une surdose de 4-hydroxycoumarines ?
Des saignements excessifs, des ecchymoses et des douleurs abdominales peuvent indiquer une surdose.
SurdosageSaignement
#5
Quels symptômes nécessitent un ajustement de la dose ?
Des saignements fréquents ou des résultats d'INR élevés peuvent nécessiter un ajustement de la dose.
Ajustement de doseINR
Prévention
5
#1
Comment prévenir les complications des 4-hydroxycoumarines ?
Une surveillance régulière de l'INR et une éducation des patients sont essentielles pour prévenir les complications.
PréventionSurveillance
#2
Quelles précautions prendre lors de l'utilisation de 4-hydroxycoumarines ?
Éviter les activités à risque de blessure et informer les professionnels de santé de l'utilisation.
PrécautionsAnticoagulants
#3
Comment éduquer les patients sur les 4-hydroxycoumarines ?
Informer sur les effets secondaires, l'importance des tests de coagulation et les signes d'alerte.
Éducation des patientsAnticoagulants
#4
Quels aliments éviter avec les 4-hydroxycoumarines ?
Éviter les aliments riches en vitamine K, comme les légumes à feuilles vertes, pour maintenir l'efficacité.
AlimentationVitamine K
#5
Comment gérer les interactions médicamenteuses ?
Consulter un professionnel de santé avant de prendre d'autres médicaments pour éviter les interactions.
Interactions médicamenteusesConsultation
Traitements
5
#1
Comment traiter une surdose de 4-hydroxycoumarines ?
Le traitement inclut l'administration de vitamine K et la surveillance des paramètres de coagulation.
SurdosageVitamine K
#2
Quels médicaments interagissent avec les 4-hydroxycoumarines ?
Des antibiotiques, des anti-inflammatoires et certains antifongiques peuvent interagir avec ces anticoagulants.
Interactions médicamenteusesAnticoagulants
#3
Quelle est l'alternative aux 4-hydroxycoumarines ?
Les anticoagulants directs comme le rivaroxaban ou l'apixaban sont des alternatives possibles.
AnticoagulantsAlternatives
#4
Comment ajuster la dose de 4-hydroxycoumarines ?
La dose est ajustée en fonction des résultats de l'INR et des facteurs de risque individuels.
Ajustement de doseINR
#5
Quels sont les traitements de soutien lors d'une surdose ?
Des transfusions de plaquettes et des soins intensifs peuvent être nécessaires en cas de surdose sévère.
TransfusionSurdosage
Complications
5
#1
Quelles sont les complications possibles des 4-hydroxycoumarines ?
Les complications incluent des hémorragies, des thromboses et des réactions allergiques.
ComplicationsHémorragie
#2
Comment gérer une hémorragie due aux 4-hydroxycoumarines ?
La gestion inclut l'arrêt du médicament, l'administration de vitamine K et des soins médicaux appropriés.
HémorragieVitamine K
#3
Quels facteurs augmentent le risque de complications ?
L'âge avancé, les maladies hépatiques et l'utilisation concomitante d'autres anticoagulants augmentent le risque.
Facteurs de risqueAnticoagulants
#4
Comment prévenir les thromboses sous traitement ?
Maintenir un suivi régulier et ajuster la dose en fonction des résultats de l'INR pour prévenir les thromboses.
PréventionThrombose
#5
Quels signes indiquent une complication grave ?
Des douleurs thoraciques, des difficultés respiratoires ou des saignements importants indiquent une complication grave.
ComplicationsSaignement
Facteurs de risque
5
#1
Quels sont les facteurs de risque pour les complications des 4-hydroxycoumarines ?
Les antécédents de thrombose, l'âge avancé et les maladies hépatiques sont des facteurs de risque.
Facteurs de risqueThrombose
#2
Comment l'alimentation influence-t-elle l'efficacité des 4-hydroxycoumarines ?
Une alimentation riche en vitamine K peut réduire l'efficacité des 4-hydroxycoumarines.
AlimentationVitamine K
#3
Quels médicaments augmentent le risque de saignement ?
Les anti-inflammatoires non stéroïdiens (AINS) et certains antibiotiques peuvent augmenter le risque de saignement.
MédicamentsSaignement
#4
Comment l'âge affecte-t-il le traitement par 4-hydroxycoumarines ?
Les personnes âgées peuvent avoir une sensibilité accrue et nécessiter un ajustement de la dose.
ÂgeAjustement de dose
#5
Quels antécédents médicaux sont préoccupants ?
Des antécédents de maladies hépatiques ou de troubles de la coagulation sont préoccupants lors du traitement.
Antécédents médicauxCoagulation
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"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antibiotiques, des anti-inflammatoires et certains antifongiques peuvent interagir avec ces anticoagulants."
}
},
{
"@type": "Question",
"name": "Quelle est l'alternative aux 4-hydroxycoumarines ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les anticoagulants directs comme le rivaroxaban ou l'apixaban sont des alternatives possibles."
}
},
{
"@type": "Question",
"name": "Comment ajuster la dose de 4-hydroxycoumarines ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La dose est ajustée en fonction des résultats de l'INR et des facteurs de risque individuels."
}
},
{
"@type": "Question",
"name": "Quels sont les traitements de soutien lors d'une surdose ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des transfusions de plaquettes et des soins intensifs peuvent être nécessaires en cas de surdose sévère."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles des 4-hydroxycoumarines ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des hémorragies, des thromboses et des réactions allergiques."
}
},
{
"@type": "Question",
"name": "Comment gérer une hémorragie due aux 4-hydroxycoumarines ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut l'arrêt du médicament, l'administration de vitamine K et des soins médicaux appropriés."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de complications ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, les maladies hépatiques et l'utilisation concomitante d'autres anticoagulants augmentent le risque."
}
},
{
"@type": "Question",
"name": "Comment prévenir les thromboses sous traitement ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un suivi régulier et ajuster la dose en fonction des résultats de l'INR pour prévenir les thromboses."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une complication grave ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des douleurs thoraciques, des difficultés respiratoires ou des saignements importants indiquent une complication grave."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les complications des 4-hydroxycoumarines ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents de thrombose, l'âge avancé et les maladies hépatiques sont des facteurs de risque."
}
},
{
"@type": "Question",
"name": "Comment l'alimentation influence-t-elle l'efficacité des 4-hydroxycoumarines ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en vitamine K peut réduire l'efficacité des 4-hydroxycoumarines."
}
},
{
"@type": "Question",
"name": "Quels médicaments augmentent le risque de saignement ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les anti-inflammatoires non stéroïdiens (AINS) et certains antibiotiques peuvent augmenter le risque de saignement."
}
},
{
"@type": "Question",
"name": "Comment l'âge affecte-t-il le traitement par 4-hydroxycoumarines ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées peuvent avoir une sensibilité accrue et nécessiter un ajustement de la dose."
}
},
{
"@type": "Question",
"name": "Quels antécédents médicaux sont préoccupants ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antécédents de maladies hépatiques ou de troubles de la coagulation sont préoccupants lors du traitement."
}
}
]
}
]
}
Department of Drug Metabolism, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. sdemami12@gmail.com.
Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, PR China; Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, Liaocheng University, Liaocheng 252059, PR China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China.
Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo, Zhejiang 315832, China.
Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Meishan Campus, Ningbo University, Ningbo, Zhejiang 315832, China.
We present five studies aimed at developing an L1 vocabulary test for English-speaking university students. Such a test is useful as an indicator of crystallized intelligence and because vocabulary si...
Large language models (LLMs) have shown remarkable abilities recently, including passing advanced professional exams and demanding benchmark tests. This performance has led many to suggest that they a...
The aim of this research note is to encourage child language researchers and clinicians to give careful consideration to the use of domain-specific tests as a proxy for language; particularly in the c...
We report on data leveraged through the prospective Raine Study cohort. Participants included 1626 children aged 10 years (...
Children with DLD performed within the average range on a measure of non-verbal intelligence (...
Domain-specific language assessments, particularly those testing receptive vocabulary, may overestimate the language ability of children with DLD. Caution is urged when using such tests by clinicians ...
There is a lack of standardized assessment tools for poststroke aphasia in Brazil, particularly bedside screenings for early identification of patients with suspected language disorders. The Language ...
This study aimed to translate, culturally adapt, and validate the LAST into Brazilian Portuguese....
Following a systematic, multistep approach to translation and cultural adaptation of language instruments, this study developed the two parallel versions of the Brazilian Portuguese LAST (pLAST) Versi...
Findings showed that the two versions (A and B) of the pLAST were equivalent (intraclass correlation coefficient = .91;...
The Brazilian Portuguese version of the LAST is a valid, simple, easy, and rapid test to screen poststroke aphasia in hospital settings....
https://doi.org/10.23641/asha.23548911....
The current study aimed to validate the Cantonese version of the Amsterdam-Nijmegen Everyday Language Test (CANELT), a functional communication assessment tool for Cantonese speakers with aphasia. A q...
CANELT was translated from its English version with cultural adaptations. The performance on the 20-item CANELT collected from 56 PWA and 100 neurologically healthy Cantonese-speaking controls aged 30...
An age effect was found in neurologically healthy controls, and therefore z scores were used for subsequent comparisons between neurologically healthy controls and PWA. The test showed strong evidence...
Measures on validity and reliability yielded promising results, suggesting CANELT as a useful and reliable functional communication assessment for PWA. Its application in managing PWA and potential ar...
This study compares the home language environments of children with (a suspicion of) developmental language disorder (DLD) with that of children with typical development (TD). It does so by adopting n...
Ninety-nine 2- to 4-year-old toddlers participated: 59 with (a suspicion of) DLD and 40 with TD. LENA metrics on adult word count, conversational turn count, and child vocalization count were obtained...
We found lower adult word count, conversational turn count, and child vocalization count in the DLD group, independent of multilingualism but not of parental education. In the DLD group, receptive voc...
Toddlers with (a suspicion of) DLD vocalize less at home than children with TD. They also hear fewer adult words and experience fewer conversational turns. Children with DLD's language outcomes are to...
It is challenging to reliably assess the language comprehension of children with severe motor and speech impairments using traditional assessment tools. The Computer Based instrument for Low motor Lan...
A qualitative approach including semi-structured individual interviews with 15 clinicians (speech-language pathologists, neuropsychologists, and one teacher, counsellor, and vision specialist) was use...
Several meaningful barriers and facilitators were identified across the data. Clinicians used the C-BiLLT with two distinct groups of clients: (1) the population it was originally developed for, and (...
This study provides timely insights into the capability, opportunity, and motivation factors important for creating and sustaining assessment behaviour change in clinicians who used or attempted to us...
Children's vocabulary and syntactic skills vary upon school entry in depth and breadth, persistently influencing academic performance, including reading. Enhancing early communicative abilities throug...
Language skills were examined in a pre- to posttest design in which 43 typically developing participants, ages 3-5 years, were randomly assigned to clay-based (...
Receptive and expressive vocabulary knowledge for items introduced in the language stimulation program, mean length of utterance (MLU), and conversational initiations improved for participants in the ...
A language-to-action link is created when children engage with open-ended materials, such as clay, as they craft target objects hands on and step by step, affording additional opportunities for langua...
https://doi.org/10.23641/asha.24093780....
Semantic tasks evaluate dimensions of children's lexical-semantic knowledge. However, the relative ease of semantic task completion depends on individual differences in developmental and language expe...
Participants included 232 Spanish-English bilingual children in second through fifth grade with (...
Results showed that language ability and grade level drive semantic task difficulty for all task types, and children with DLD experienced greater difficulty on all task types compared to their typical...
This study clarifies developmental profiles of lexical-semantic performance in bilingual children with and without DLD and supports clinical decision-making regarding children's English language learn...
Early and effective treatment for children with developmental language disorder (DLD) is important. Although a growing body of research shows the effects of interventions at the group level, clinician...
To assess changes in the language domains: expressive morphosyntax; receptive and expressive vocabulary; and comprehension, in children in special needs education for DLD. To explore if differences in...
We extracted data from school records of 154 children (4-6 years old) in special needs education offering a language and communication-stimulating educational environment, including speech and languag...
Overall, the children showed significant improvements in expressive morphosyntax, expressive vocabulary and language comprehension. Baseline scores and gains were lowest for expressive morphosyntax. D...
Children with DLD in special needs education showed gains in language performance during one school year. There was, however, little change in morphosyntactic scores, which supports previous studies c...
What is already known on the subject Intervention studies indicate that intervention can be effective, but not for all children with DLD, and not in all language domains. Longitudinal studies on langu...
