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"description": "Comment diagnostiquer la leucémie myéloïde chronique ?\nQuels tests sont utilisés pour confirmer la présence du chromosome de Philadelphie ?\nQuels signes cliniques indiquent une LMC ?\nQuel rôle joue l'hémogramme dans le diagnostic ?\nQuand faut-il suspecter une LMC ?",
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"headline": "Symptômes sur Philadelphie",
"description": "Quels sont les symptômes courants de la LMC ?\nLa splénomégalie est-elle un symptôme de la LMC ?\nLes sueurs nocturnes sont-elles liées à la LMC ?\nComment la LMC affecte-t-elle l'énergie du patient ?\nLes infections fréquentes sont-elles un symptôme de la LMC ?",
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"name": "Prévention",
"headline": "Prévention sur Philadelphie",
"description": "Peut-on prévenir la LMC ?\nQuels facteurs de risque sont associés à la LMC ?\nLe tabagisme influence-t-il le risque de LMC ?\nLes antécédents familiaux jouent-ils un rôle ?\nComment réduire le risque de LMC ?",
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"name": "Traitements",
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"description": "Quels traitements sont disponibles pour la LMC ?\nQuel est le rôle des inhibiteurs de tyrosine kinase ?\nLa greffe de moelle osseuse est-elle une option ?\nQuels effets secondaires peuvent survenir avec le traitement ?\nComment surveiller l'efficacité du traitement ?",
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"headline": "Complications sur Philadelphie",
"description": "Quelles complications peuvent survenir avec la LMC ?\nQu'est-ce qu'une crise blastique ?\nLa résistance au traitement est-elle une complication ?\nComment les complications affectent-elles le pronostic ?\nLes complications peuvent-elles être gérées ?",
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"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Philadelphie",
"description": "Quels sont les principaux facteurs de risque de la LMC ?\nL'âge influence-t-il le risque de LMC ?\nLes maladies génétiques augmentent-elles le risque ?\nLe sexe joue-t-il un rôle dans le risque de LMC ?\nLes infections virales sont-elles un facteur de risque ?",
"url": "https://questionsmedicales.fr/mesh/D015143?mesh_terms=Language+Development+Disorders&page=4#section-facteurs de risque"
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"@type": "Question",
"name": "Comment diagnostiquer la leucémie myéloïde chronique ?",
"position": 1,
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"text": "Le diagnostic se fait par un test sanguin et une analyse cytogénétique pour détecter le chromosome de Philadelphie."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour confirmer la présence du chromosome de Philadelphie ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests de fluorescence in situ hybridation (FISH) et la PCR sont utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une LMC ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, perte de poids, sueurs nocturnes et splénomégalie sont des signes courants."
}
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{
"@type": "Question",
"name": "Quel rôle joue l'hémogramme dans le diagnostic ?",
"position": 4,
"acceptedAnswer": {
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"text": "L'hémogramme révèle une augmentation des globules blancs, un indicateur clé de la LMC."
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"name": "Quand faut-il suspecter une LMC ?",
"position": 5,
"acceptedAnswer": {
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"text": "En cas de symptômes persistants et d'anomalies dans les tests sanguins, la LMC doit être suspectée."
}
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{
"@type": "Question",
"name": "Quels sont les symptômes courants de la LMC ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, fièvre, douleurs osseuses et saignements fréquents."
}
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{
"@type": "Question",
"name": "La splénomégalie est-elle un symptôme de la LMC ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la splénomégalie est fréquente et peut causer des douleurs abdominales."
}
},
{
"@type": "Question",
"name": "Les sueurs nocturnes sont-elles liées à la LMC ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les sueurs nocturnes sont un symptôme courant chez les patients atteints de LMC."
}
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{
"@type": "Question",
"name": "Comment la LMC affecte-t-elle l'énergie du patient ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients peuvent ressentir une fatigue intense due à l'anémie et à la maladie elle-même."
}
},
{
"@type": "Question",
"name": "Les infections fréquentes sont-elles un symptôme de la LMC ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les infections fréquentes peuvent survenir en raison d'une immunité affaiblie."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la LMC ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention spécifique pour la LMC, car elle est souvent liée à des facteurs génétiques."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés à la LMC ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition aux radiations et certains produits chimiques augmentent le risque de LMC."
}
},
{
"@type": "Question",
"name": "Le tabagisme influence-t-il le risque de LMC ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme est un facteur de risque potentiel, bien que moins étudié que d'autres facteurs."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers hématologiques peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque de LMC ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'exposition aux produits chimiques nocifs et aux radiations peut aider à réduire le risque."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour la LMC ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent les inhibiteurs de tyrosine kinase, la chimiothérapie et la greffe de moelle."
}
},
{
"@type": "Question",
"name": "Quel est le rôle des inhibiteurs de tyrosine kinase ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils ciblent spécifiquement les cellules cancéreuses et bloquent leur croissance."
}
},
{
"@type": "Question",
"name": "La greffe de moelle osseuse est-elle une option ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la greffe peut être envisagée pour les cas avancés ou résistants au traitement."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires peuvent survenir avec le traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires incluent nausées, fatigue, et risque accru d'infections."
}
},
{
"@type": "Question",
"name": "Comment surveiller l'efficacité du traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins réguliers et des examens de suivi sont nécessaires pour évaluer la réponse."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la LMC ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections, des saignements et des crises blastiques."
}
},
{
"@type": "Question",
"name": "Qu'est-ce qu'une crise blastique ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "C'est une progression de la LMC vers une forme plus agressive, ressemblant à une leucémie aiguë."
}
},
{
"@type": "Question",
"name": "La résistance au traitement est-elle une complication ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains patients peuvent développer une résistance aux inhibiteurs de tyrosine kinase."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles le pronostic ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent aggraver le pronostic et nécessiter des traitements plus intensifs."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être gérées ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la gestion des complications est essentielle pour améliorer la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque de la LMC ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition aux radiations, certains produits chimiques et des antécédents familiaux sont des facteurs clés."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de LMC ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la LMC est plus fréquente chez les adultes âgés de 50 à 70 ans."
}
},
{
"@type": "Question",
"name": "Les maladies génétiques augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies génétiques, comme le syndrome de Down, peuvent augmenter le risque de LMC."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque de LMC ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les hommes sont légèrement plus susceptibles de développer la LMC que les femmes."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales, comme le virus d'Epstein-Barr, peuvent être associées à un risque accru."
}
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Public awareness of Developmental Language Disorder (DLD) is lower than other neurodevelopmental disorders, despite its high prevalence of 7.6%. This lower awareness means recruitment for DLD research...
This paper aims to describe the families of children with DLD and adults with DLD in the database thus far....
E-DLD members sign up via our website, reporting demographic characteristics as part of this procedure. We request all E-DLD members subsequently fill in a yearly survey. The content of the yearly sur...
The database currently consists of 196 parents of children with DLD and 20 individuals over the age of 16 with DLD or suspected DLD across a range of socioeconomic status (SES) backgrounds. Our initia...
The findings indicate that a participant database for DLD research is feasible and useful. The rates of emotional, behavioural and sleep difficulties among the child probands are higher than reported ...
What is already known on this subject Developmental Language Disorder (DLD) is characterised by expressive and/or receptive language difficulties in the absence of another biomedical condition that co...
To prevent or mitigate long-lasting learning problems and emotional, behavioral, and social-adaption difficulties associated with language disorders, age-appropriate German language competence at scho...
To develop a screening instrument to identify increased risk of LD and to evaluate its validity and feasibility within the constraints of regular universal pre-school language screening....
A two-component screening instrument including direct assessment of expressive and receptive grammar was used in a sample of 374 children with German as their dominant language attending a public pre-...
The combination of the expressive and receptive grammar scales demonstrated excellent accuracy (area under the curve score 0.928). A cut-off of 18 resulted in a failing rate of 21.8% and showed good s...
The differential diagnosis of developmental language disorder (DLD) in bilingual children represents a unique challenge due to their distributed language exposure and knowledge. The current evidence i...
Eighty-four Spanish-English bilingual second graders with (...
Results demonstrated moderate overall item-by-item scoring agreement (...
This study provides preliminary support for the technical feasibility of ASR as a bilingual expressive language assessment tool....
https://doi.org/10.23641/asha.20249994....
Language sample analysis is widely regarded as the gold standard of language assessment. However, the uncertainty regarding the optimal length of sample and the limited availability of developmental l...
The study involved 30 typically developing Afrikaans-speaking children aged between 3;6 and 9;6 (years;months). A descriptive research design was used to transcribe and analyze 1-hr interactions colle...
Results indicated that mean length of utterance in words per minute, number of different words per minute, and total number of words per minute stabilized at 30 min and no significant differences were...
The study concluded that a 30-min interaction segment provides a representative language sample for Afrikaans-speaking children who are between 3;6 and 9;6. It provides promising preliminary developme...
While it has been posited that young people with language needs may be viewed more negatively (e.g., as more rude, less cooperative) than those without language needs, the impact of knowing about a pe...
To examine whether the presence of a developmental language disorder (DLD) diagnosis in a defendant's information would affect mock juror ratings of guilt, sentence length, credibility and blameworthi...
A total of 143 jury eligible participants read a vignette of a non-violent crime. Half of the participants (N = 73) were told the defendant has a diagnosis of DLD, while half (N = 70) were not told....
Preregistered analyses found that DLD information affected ratings of credibility and blameworthiness, though not judgements of guilt or sentence length. Unregistered content analyses were applied to ...
Unlike in previous studies of the impact of autism information, information about a defendant's DLD did not affect mock jurors' likelihood of finding them guilty, or lead participants to give longer s...
What is already known on the subject There is already evidence that some conditions that affect communication, specifically autism, also affect juror perceptions. Research also shows that knowing whet...
Many mental disorders (MD) share common etiology, fuelling debates about the specificity of clinical categories and whether the presence of specific risk factors (RF) can distinguish among them. The s...
Developmental language disorder (DLD) has clear functional ramifications in the areas of social competency, emotion recognition, emotional well-being and literacy skill, which have been found to persi...
To investigate the association between psychosocial domains, literacy skill and concerns about school during the transition to secondary school for adolescents with DLD, LL and their TD peers. The fir...
Participants (aged 10-11 years) with DLD (n = 30), LL ((n = 29) and TD (n = 42) were recruited for this longitudinal study from eight UK primary schools. Standardized language and psychosocial assessm...
Regression analyses showed pre-transition school concern to be predicted by emotion recognition for the DLD group, by social competence and emotional well-being for the LL group, and by social compete...
This study concludes that transition interventions must be differentiated according to language ability; support for DLD adolescents should focus on emotion recognition skill, provision for LL adolesc...
What is already known on the subject There is limited research exploring the transition from primary school to secondary for adolescents with DLD or LL ability. Research on TD has highlighted vulnerab...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restrictive interests and/or repetitive behaviors and deficits in social interaction and communication. ASD is a multif...
The spatiotemporal index (STI) is a standard metric for quantifying the stability and patterning of speech movements. The STI has often been applied to individual speech articulators, but an STI deriv...
A total of 85 children with DLD and with typical language development (or typically developing [TD] children), aged 4-8 years, were studied. In this methodological article, two experiments were conduc...
In sentence production, most group differences aligned across kinematic and acoustic STI measures. The acoustic, but not the kinematic, STI showed higher variability in children with DLD compared with...
The kinematic and acoustic STIs assess different components of speech movement patterning. However, the relationship between acoustic and kinematic spatiotemporal stability is strong in two tasks of v...
Developmental language disorder (DLD) is a common (with up to 7% prevalence) yet underdiagnosed childhood disorder whose underlying biological profile and comorbidities are not fully understood, espec...
To identify clinically relevant conditions that co-occur with DLD at the population level....
This case-control study used an electronic health record (EHR)-based population-level approach to compare the prevalence of comorbid health phenotypes between DLD cases and matched controls. These cas...
Common and rare comorbidities of DLD at the population level were identified using EHRs and a phecode-based enrichment analysis....
Comorbidity analysis was conducted for 5273 DLD cases (mean [SD] age, 16.8 [7.2] years; 3748 males [71.1%]) and 26 353 matched controls (mean [SD] age, 14.6 [5.5] years; 18 729 males [71.1%]). Relevan...
This study found both rare and common comorbidities of DLD. Comorbidity profiles may be leveraged to identify risk of additional health challenges, beyond language impairment, among children with DLD....