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Régulation négative
Régulation négative : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"name": "Diagnostic",
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"description": "Comment diagnostiquer une régulation négative ?\nQuels tests sont utilisés pour évaluer la régulation négative ?\nQuels biomarqueurs indiquent une régulation négative ?\nLa régulation négative est-elle visible sur des imageries ?\nPeut-on mesurer la régulation négative in vivo ?",
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"description": "Quels traitements ciblent la régulation négative ?\nLes inhibiteurs peuvent-ils aider ?\nY a-t-il des traitements naturels ?\nComment la nutrition influence-t-elle la régulation ?\nLes thérapies comportementales sont-elles efficaces ?",
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"description": "Quelles complications peuvent survenir ?\nLa régulation négative peut-elle causer des cancers ?\nY a-t-il des risques cardiovasculaires ?\nDes troubles endocriniens peuvent-ils apparaître ?\nLa régulation négative affecte-t-elle la fertilité ?",
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"name": "Facteurs de risque",
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"description": "Quels sont les facteurs de risque principaux ?\nLe tabagisme est-il un facteur de risque ?\nL'alimentation influence-t-elle la régulation ?\nLe manque de sommeil est-il un risque ?\nLe vieillissement est-il un facteur de risque ?",
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"@type": "Question",
"name": "Comment diagnostiquer une régulation négative ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses d'expression génique peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer la régulation négative ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests PCR et les microarrays sont couramment utilisés pour évaluer l'expression."
}
},
{
"@type": "Question",
"name": "Quels biomarqueurs indiquent une régulation négative ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux réduits de certaines protéines ou ARN peuvent indiquer une régulation négative."
}
},
{
"@type": "Question",
"name": "La régulation négative est-elle visible sur des imageries ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle nécessite des analyses moléculaires pour être détectée."
}
},
{
"@type": "Question",
"name": "Peut-on mesurer la régulation négative in vivo ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques comme l'imagerie par résonance magnétique fonctionnelle peuvent aider."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à la régulation négative ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes varient selon le contexte, mais peuvent inclure fatigue ou dysfonctionnement cellulaire."
}
},
{
"@type": "Question",
"name": "La régulation négative provoque-t-elle des douleurs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, si elle affecte des processus biologiques liés à la douleur."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes neurologiques ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles neurologiques peuvent survenir si des gènes régulés affectent le système nerveux."
}
},
{
"@type": "Question",
"name": "La régulation négative affecte-t-elle l'humeur ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut influencer l'humeur si elle impacte des neurotransmetteurs ou hormones."
}
},
{
"@type": "Question",
"name": "Des symptômes métaboliques peuvent-ils apparaître ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la régulation négative peut perturber le métabolisme, entraînant divers symptômes."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la régulation négative ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Prévenir les facteurs de risque et maintenir un mode de vie sain peut aider."
}
},
{
"@type": "Question",
"name": "L'exercice physique joue-t-il un rôle ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut influencer positivement l'expression génique."
}
},
{
"@type": "Question",
"name": "Le stress impacte-t-il la régulation négative ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut exacerber la régulation négative de certains gènes."
}
},
{
"@type": "Question",
"name": "Une bonne hygiène de vie est-elle suffisante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut réduire les risques, mais d'autres facteurs génétiques et environnementaux jouent aussi."
}
},
{
"@type": "Question",
"name": "Les vaccinations influencent-elles la régulation ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent moduler l'expression immunitaire, mais pas directement la régulation négative."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent la régulation négative ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies géniques et des médicaments peuvent être utilisés pour moduler l'expression."
}
},
{
"@type": "Question",
"name": "Les inhibiteurs peuvent-ils aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les inhibiteurs de certaines voies de signalisation peuvent réduire la régulation négative."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements naturels ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines plantes médicinales peuvent influencer l'expression génique, mais des études sont nécessaires."
}
},
{
"@type": "Question",
"name": "Comment la nutrition influence-t-elle la régulation ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut moduler l'expression des gènes et réduire la régulation négative."
}
},
{
"@type": "Question",
"name": "Les thérapies comportementales sont-elles efficaces ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent aider à gérer les symptômes associés, mais ne ciblent pas directement la régulation."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies chroniques ou des troubles métaboliques peuvent résulter d'une régulation négative prolongée."
}
},
{
"@type": "Question",
"name": "La régulation négative peut-elle causer des cancers ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une régulation négative de gènes suppresseurs de tumeurs peut augmenter le risque de cancer."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques cardiovasculaires ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres dans l'expression génique peuvent contribuer à des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Des troubles endocriniens peuvent-ils apparaître ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la régulation négative peut affecter les hormones et entraîner des troubles endocriniens."
}
},
{
"@type": "Question",
"name": "La régulation négative affecte-t-elle la fertilité ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut perturber l'équilibre hormonal et affecter la fertilité chez les individus."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque principaux ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs génétiques, environnementaux et le mode de vie peuvent influencer la régulation négative."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut induire une régulation négative de gènes liés à la santé pulmonaire."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle la régulation ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation déséquilibrée peut affecter l'expression génique et la régulation."
}
},
{
"@type": "Question",
"name": "Le manque de sommeil est-il un risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le manque de sommeil peut perturber la régulation des gènes liés au stress et à la santé."
}
},
{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la régulation négative des gènes, augmentant les risques de maladies."
}
}
]
}
]
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We aimed to determine the incidence of growth failure in infants with necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP) and whether initial laparotomy versus peritoneal drain...
Infants with surgical NEC and SIP have high mortality, and most have neurodevelopmental impairment and poor growth. Existing literature on growth outcomes for these infants is limited....
This is a preplanned secondary study of the Necrotizing Enterocolitis Surgery Trial dataset. The primary outcome was growth failure (Z-score for weight <-2.0) at 18 to 22 months. We used logistic regr...
Among 217 survivors, 207 infants (95%) had primary outcome data. Growth failure at 18 to 22 months occurred in 24/50 (48%) of NEC infants versus 65/157 (42%) SIP (P=0.4). The mean weight-for-age Z-sco...
This first ever prospective study of growth outcomes in infants with surgical NEC or SIP demonstrates that growth failure is very common, especially in infants with NEC, and persists at 18-22 months....
Clostridium ramosum is one of the obligate anaerobes that constitute the intestinal microbiota, and one of the rare Clostridia. With Clostridium ramosum, very few data have been reported to investigat...
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal emergency in preterm neonates. Research on early predictive biomarkers is fundamental. This is a systematic review of studies a...
Prophylactic mesh placement (PMP) is increasingly being used to reduce the incidence of incisional hernia after routine and emergency midline laparotomy (EML). However, such studies are not available ...
We herein report a case of enterocutaneous fistula in a patient with autosomal dominant polycystic kidney disease (ADPKD). A 37-year-old Japanese man was admitted to our hospital. Three months prior t...
Septic shock, largely caused by intestinal perforation, is a common critical disease in intensive care unit (ICU). For hospitals and health systems, a performance improvement program for sepsis was st...
To compare the clinical outcomes in preterm infants following surgical necrotizing enterocolitis (sNEC) and spontaneous intestinal perforation (SIP)....
Retro-spective comparison of clinical information in preterm infants with sNEC and SIP admitted between January, 2013 and December 31, 2018. The clinical outcomes were compared in two groups, includin...
114 infants had sNEC, and 37 had SIP. Infants with SIP had lower median gestational age [25.1 weeks (23.5, 27.1) vs 26.6 (24.4, 31.0), P=0.03], an earlier mean (SD) age of disease onset [10.1 (11.3) d...
In our cohort, preterm infants with SIP and sNEC did not show significant differences in postoperative morbidity and brain MRI abnormalities at term equivalent age. sNEC had lower discharge weight z s...
Metastatic melanoma of the small intestine is relatively common, and among affected patients, the proportion with involvement of the small intestine ranges from 35% to 70%. Small intestinal perforatio...
A 59-year-old woman with a history of a laparoscopic Roux-en-Y gastric bypass and toe amputation due to malignant melanoma (stadium IIIC) presented with an acute abdomen. The abdominal computed tomogr...
We report the first case of a perforation at the jejunojejunostomy after Roux-en-Y gastric bypass caused by metastatic melanoma. This exceptional case illustrates that a history of malignant melanoma ...
Review of age of onset of necrotising enterocolitis (NEC) and focal intestinal perforation (FIP) in very preterm (≤32 weeks) and/or very low birthweight (VLBW, ≤1500 g) infants....
Preregistered review undertaken according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses in July 2021 and updated October 2021....
MEDLINE/ PubMed, Embase, CINAHL and Cochrane Central Register of Controlled Trials....
Eligible studies reported age of onset of NEC and/or FIP in randomised controlled trials of >200 or observational studies of >500 infants....
Titles/abstracts were screened; eligible articles underwent data extraction. Age of onset as day of life (DOL) and/or corrected gestational age (CGA) were extracted alongside study information, such a...
Of the 747 screened studies 188 were eligible. Removal of duplicates, studies without onset data and ineligible populations left 10 RCTs and 14 observational studies contributing 51 NEC cohorts; 49 re...
Average onset of NEC in exclusively very preterm/very low birthweight infants is in the third week of life and unlike in cohorts including more mature or heavier infants is not impacted by birth gesta...
Intestinal resection and a proximal stoma is the preferred surgical approach in patients with severe secondary peritonitis due to perforation of the small intestine. However, proximal stomas may resul...
Between January 2005 and June 2018, we performed a retrospective chart review of 20 patients (> 18 years) with diffuse faecal peritonitis caused by small intestinal perforation and treated with primar...
The median age was 65 years (range: 23-90 years). Twelve patients were female (60%). Simple suturing of the small intestinal perforation was performed in three cases and intestinal resection with prim...
Primary suturing or resection with anastomosis and open abdomen with VAC in small intestinal perforation with severe faecal peritonitis is associated with a high rate of leakage and enteroatmospheric ...
The study was approved by the Danish Patient Safety Authority (case number 3-3013-1555/1) and the Danish Data Protection Agency (file number 18/28,404). No funding was received....