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Régulation négative
Régulation négative : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"name": "Diagnostic",
"headline": "Diagnostic sur Régulation négative",
"description": "Comment diagnostiquer une régulation négative ?\nQuels tests sont utilisés pour évaluer la régulation négative ?\nQuels biomarqueurs indiquent une régulation négative ?\nLa régulation négative est-elle visible sur des imageries ?\nPeut-on mesurer la régulation négative in vivo ?",
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"description": "Quels symptômes sont associés à la régulation négative ?\nLa régulation négative provoque-t-elle des douleurs ?\nY a-t-il des symptômes neurologiques ?\nLa régulation négative affecte-t-elle l'humeur ?\nDes symptômes métaboliques peuvent-ils apparaître ?",
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"description": "Peut-on prévenir la régulation négative ?\nL'exercice physique joue-t-il un rôle ?\nLe stress impacte-t-il la régulation négative ?\nUne bonne hygiène de vie est-elle suffisante ?\nLes vaccinations influencent-elles la régulation ?",
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"description": "Quels traitements ciblent la régulation négative ?\nLes inhibiteurs peuvent-ils aider ?\nY a-t-il des traitements naturels ?\nComment la nutrition influence-t-elle la régulation ?\nLes thérapies comportementales sont-elles efficaces ?",
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"headline": "Complications sur Régulation négative",
"description": "Quelles complications peuvent survenir ?\nLa régulation négative peut-elle causer des cancers ?\nY a-t-il des risques cardiovasculaires ?\nDes troubles endocriniens peuvent-ils apparaître ?\nLa régulation négative affecte-t-elle la fertilité ?",
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"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Régulation négative",
"description": "Quels sont les facteurs de risque principaux ?\nLe tabagisme est-il un facteur de risque ?\nL'alimentation influence-t-elle la régulation ?\nLe manque de sommeil est-il un risque ?\nLe vieillissement est-il un facteur de risque ?",
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"@type": "Question",
"name": "Comment diagnostiquer une régulation négative ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses d'expression génique peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer la régulation négative ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests PCR et les microarrays sont couramment utilisés pour évaluer l'expression."
}
},
{
"@type": "Question",
"name": "Quels biomarqueurs indiquent une régulation négative ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux réduits de certaines protéines ou ARN peuvent indiquer une régulation négative."
}
},
{
"@type": "Question",
"name": "La régulation négative est-elle visible sur des imageries ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle nécessite des analyses moléculaires pour être détectée."
}
},
{
"@type": "Question",
"name": "Peut-on mesurer la régulation négative in vivo ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques comme l'imagerie par résonance magnétique fonctionnelle peuvent aider."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à la régulation négative ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes varient selon le contexte, mais peuvent inclure fatigue ou dysfonctionnement cellulaire."
}
},
{
"@type": "Question",
"name": "La régulation négative provoque-t-elle des douleurs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, si elle affecte des processus biologiques liés à la douleur."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes neurologiques ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles neurologiques peuvent survenir si des gènes régulés affectent le système nerveux."
}
},
{
"@type": "Question",
"name": "La régulation négative affecte-t-elle l'humeur ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut influencer l'humeur si elle impacte des neurotransmetteurs ou hormones."
}
},
{
"@type": "Question",
"name": "Des symptômes métaboliques peuvent-ils apparaître ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la régulation négative peut perturber le métabolisme, entraînant divers symptômes."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la régulation négative ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Prévenir les facteurs de risque et maintenir un mode de vie sain peut aider."
}
},
{
"@type": "Question",
"name": "L'exercice physique joue-t-il un rôle ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut influencer positivement l'expression génique."
}
},
{
"@type": "Question",
"name": "Le stress impacte-t-il la régulation négative ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut exacerber la régulation négative de certains gènes."
}
},
{
"@type": "Question",
"name": "Une bonne hygiène de vie est-elle suffisante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut réduire les risques, mais d'autres facteurs génétiques et environnementaux jouent aussi."
}
},
{
"@type": "Question",
"name": "Les vaccinations influencent-elles la régulation ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent moduler l'expression immunitaire, mais pas directement la régulation négative."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent la régulation négative ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies géniques et des médicaments peuvent être utilisés pour moduler l'expression."
}
},
{
"@type": "Question",
"name": "Les inhibiteurs peuvent-ils aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les inhibiteurs de certaines voies de signalisation peuvent réduire la régulation négative."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements naturels ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines plantes médicinales peuvent influencer l'expression génique, mais des études sont nécessaires."
}
},
{
"@type": "Question",
"name": "Comment la nutrition influence-t-elle la régulation ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut moduler l'expression des gènes et réduire la régulation négative."
}
},
{
"@type": "Question",
"name": "Les thérapies comportementales sont-elles efficaces ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent aider à gérer les symptômes associés, mais ne ciblent pas directement la régulation."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies chroniques ou des troubles métaboliques peuvent résulter d'une régulation négative prolongée."
}
},
{
"@type": "Question",
"name": "La régulation négative peut-elle causer des cancers ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une régulation négative de gènes suppresseurs de tumeurs peut augmenter le risque de cancer."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques cardiovasculaires ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres dans l'expression génique peuvent contribuer à des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Des troubles endocriniens peuvent-ils apparaître ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la régulation négative peut affecter les hormones et entraîner des troubles endocriniens."
}
},
{
"@type": "Question",
"name": "La régulation négative affecte-t-elle la fertilité ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut perturber l'équilibre hormonal et affecter la fertilité chez les individus."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque principaux ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs génétiques, environnementaux et le mode de vie peuvent influencer la régulation négative."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut induire une régulation négative de gènes liés à la santé pulmonaire."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle la régulation ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation déséquilibrée peut affecter l'expression génique et la régulation."
}
},
{
"@type": "Question",
"name": "Le manque de sommeil est-il un risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le manque de sommeil peut perturber la régulation des gènes liés au stress et à la santé."
}
},
{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la régulation négative des gènes, augmentant les risques de maladies."
}
}
]
}
]
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Since the discovery of the Proprotein Convertase Subtilisin/Kexin Type 9(PCSK9) gene has been involved in regulating low-density lipoprotein metabolism and cardiovascular disease (CVD), many therapeut...
The S127R is a PCSK9 gain of function mutation. Firstly, We used the data of the gene expression Omnibus(GEO) database to identify the differentially expressed genes between S127R mutation carriers an...
88 DEGs were identified, including 45 up-regulated and 43 down-regulated DEGs. Furthermore, we identified the six genes (MMP9, CASP3, EGR1, NGFR, LEFTY1 and NODAL) as significantly different genes bet...
PCSK9 might play an essential role in angiogenesis, unlike its typical role in lipid metabolism, and MMP9, Caspase3, LEFTY1, NODAL, and EGR1 may be involved in the regulation of angiogenesis as critic...
Acute ischemic stroke (AIS) represents an important cause of disability and death. Since only a minor percentage of patients with AIS are eligible for acute therapy, the management of risk factors is ...
Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) regulates the cell-surface localization of LDL receptors in hepatocytes and is associated with LDL and lipoprotein(a) [Lp(a)] uptake, reducing blo...
The complement system serves as a crucial defense mechanism against invading pathogens; however, dysregulation of this system can result in harmful consequences. Central to the complement cascade are ...
In this study, we propose a novel assay for the functional evaluation of these complexes. Our approach leverages a widely available human lymphoma cell line, which when sensitized with antibodies, tri...
The assay detects recombinant gain-of-function (GoF) components of both convertase types within human serum or plasma. Furthermore, we demonstrate the assay's practical utility in analyzing nephrologi...
We provided a proof-of-concept of a new assay that detects convertase overactivity in individuals carrying variants of both pathogenic character or those of unknown significance in ubiquitous compleme...
Defective insulin processing is associated with obesity and diabetes. Prohormone convertase 1/3 (PC1/3) is an endopeptidase required for the processing of neurotransmitters and hormones. PC1/3 deficie...
Islet prohormone-processing enzymes convert peptide hormone precursors to mature hormones. Defective beta cell prohormone processing and the release of incompletely processed peptide hormones are obse...
Immunostaining and high-dimensional image analysis were performed on pancreatic sections from a cross-sectional cohort of 54 donors obtained from the Network for Pancreatic Organ Donors with Diabetes ...
Alpha and beta cell morphology were altered in donors with type 1 diabetes, including decreased alpha and beta cell size. As expected, the insulin-positive and PC1/3-positive areas in the islets were ...
Our high-resolution histomorphological analysis of human pancreatic islets from donors with and without diabetes has uncovered details of the cellular origin of islet prohormone peptide processing def...
This study is aimed at screening the potential ideal lead compounds from natural drug library (ZINC database), which had potential inhibition effects against proprotein converse subtilisin/kexin type ...
A series of computer-aided virtual screening techniques were used to identify potential inhibitors of PCSK9. Structure-based virtual screening by LibDock was carried out to calculate the LibDock score...
Two novel natural compounds ZINC000004099069 and ZINC000014952116 from the ZINC database were found to bind with PCSK9 with a higher binging affinity together with more favorable interaction energy. A...
This study elucidated that ZINC000004099069 and ZINC000014952116 were finally screened as safe and potential drug candidates, which may have great significance in the development of PCSK9 inhibitor de...
It is well known that elevated cholesterol is associated with enhanced platelet aggregation and patients suffering from familial hypercholesterolemia (FH) have a high risk of thrombotic cardiovascular...
This study enrolled all 15 patients treated in the University Hospital Hradec Králové for FH. PCSK9ab have been administered in 12 of 15 patients while 8 patients were also undergoing lipid apheresis....
Although apheresis decreased the reactivity of platelets in general, platelet responses were not different between non-apheresis patients treated with PCSK9ab and apheresis patients (post-apheresis va...
This study showed for the first time the suitability of PCSK9ab treatment for reduction of platelet reactivity in FH patients....
Fam3a has been demonstrated to regulate pancreatic β-cell function and glucose homeostasis. However, the role and mechanism of Fam3a in regulating α-cell function remains unexplored....
Glucagon and glucagon-like peptide-1 (GLP-1) levels in pancreas and plasma were measured in global Fam3a knockout (Fam3a...
Compared with wild-type mice, pancreatic and plasma active GLP-1 levels were increased in Fam3a...
Fam3a deficiency in α-cells enhances pancreatic GLP-1 production to improve β-cell function via paracrine signaling in an Nr4a2-Foxa2-PC1/3-dependent manner. Our study unveils a novel strategy for rep...
Background and Aims Protein convertase subtilisin/Kexin type 9 monoclonal antibodies (PCSK9mab) are a novel addition to the therapeutic options for managing hyperlipidemia. Various guidelines have adv...