questionsmedicales.fr
Composés hétérocycliques
Composés hétéromonocycliques
Pyridines
Composés de pyridinium
1-Méthyl-4-phényl-pyridinium
1-Méthyl-4-phényl-pyridinium : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Maladie de Parkinson
Neurotoxicité
Imagerie par résonance magnétique
Électromyographie
Analyse sanguine
Toxicologie
Évaluation neurologique
Réflexes
Symptômes
5
Tremblements
Troubles de la marche
Troubles cognitifs
Démence
Système nerveux
Neurones dopaminergiques
Douleurs musculaires
Douleurs articulaires
Prévention
5
Prévention
Équipements de protection
Vaccins
Prévention des maladies
Mode de vie sain
Maladies neurodégénératives
Éducation à la santé
Sensibilisation
Contrôles médicaux
Détection précoce
Traitements
5
Médicaments dopaminergiques
Thérapie physique
Réhabilitation
Qualité de vie
Antioxydants
Stress oxydatif
Acupuncture
Thérapies complémentaires
Traitement précoce
Progression des symptômes
Complications
5
Complications
Troubles moteurs
Chutes
Troubles de la marche
Qualité de vie
Symptômes parkinsoniens
Complications cardiovasculaires
Santé cardiovasculaire
Facteurs de risque
5
Facteurs de risque
Pesticides
Antécédents familiaux
Maladies neurodégénératives
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "1-Méthyl-4-phényl-pyridinium : Questions médicales les plus fréquentes",
"headline": "1-Méthyl-4-phényl-pyridinium : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les 1-Méthyl-4-phényl-pyridinium : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-06-14",
"dateModified": "2025-03-11",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "1-Méthyl-4-phényl-pyridinium"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Composés de pyridinium",
"url": "https://questionsmedicales.fr/mesh/D011726",
"about": {
"@type": "MedicalCondition",
"name": "Composés de pyridinium",
"code": {
"@type": "MedicalCode",
"code": "D011726",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D03.383.725.762"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "1-Méthyl-4-phényl-pyridinium",
"alternateName": "1-Methyl-4-phenylpyridinium",
"code": {
"@type": "MedicalCode",
"code": "D015655",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Hemmige S Yathirajan",
"url": "https://questionsmedicales.fr/author/Hemmige%20S%20Yathirajan",
"affiliation": {
"@type": "Organization",
"name": "Department of Studies in Chemistry University of Mysore, Manasagangotri, Mysore-570 006, India."
}
},
{
"@type": "Person",
"name": "Yuka Yamamoto",
"url": "https://questionsmedicales.fr/author/Yuka%20Yamamoto",
"affiliation": {
"@type": "Organization",
"name": "Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. yuka@kms.ac.jp."
}
},
{
"@type": "Person",
"name": "Katsuya Mitamura",
"url": "https://questionsmedicales.fr/author/Katsuya%20Mitamura",
"affiliation": {
"@type": "Organization",
"name": "Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan."
}
},
{
"@type": "Person",
"name": "Jun Toyohara",
"url": "https://questionsmedicales.fr/author/Jun%20Toyohara",
"affiliation": {
"@type": "Organization",
"name": "Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan."
}
},
{
"@type": "Person",
"name": "Takashi Norikane",
"url": "https://questionsmedicales.fr/author/Takashi%20Norikane",
"affiliation": {
"@type": "Organization",
"name": "Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Narrative review of brivaracetam for genetic generalized epilepsies.",
"datePublished": "2022-10-21",
"url": "https://questionsmedicales.fr/article/36332461",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.seizure.2022.10.009"
}
},
{
"@type": "ScholarlyArticle",
"name": "Deep Brain Stimulation for Children with Generalized Epilepsy.",
"datePublished": "2023-09-27",
"url": "https://questionsmedicales.fr/article/38000839",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.nec.2023.09.002"
}
},
{
"@type": "ScholarlyArticle",
"name": "Surgical Treatment of Drug-Resistant Generalized Epilepsy.",
"datePublished": "2022-06-17",
"url": "https://questionsmedicales.fr/article/35713776",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s11910-022-01210-w"
}
},
{
"@type": "ScholarlyArticle",
"name": "[Idiopathic generalized epilepsies: Analysis of 101 patients].",
"datePublished": "2022-08-25",
"url": "https://questionsmedicales.fr/article/36030098",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.medcli.2022.06.019"
}
},
{
"@type": "ScholarlyArticle",
"name": "Outpatient visit behavior in patients with epilepsy: Generalized Epilepsy is more frequently non-attendance than Focal Epilepsy.",
"datePublished": "2023-07-11",
"url": "https://questionsmedicales.fr/article/37441983",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.yebeh.2023.109345"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Composés hétérocycliques",
"item": "https://questionsmedicales.fr/mesh/D006571"
},
{
"@type": "ListItem",
"position": 3,
"name": "Composés hétéromonocycliques",
"item": "https://questionsmedicales.fr/mesh/D006573"
},
{
"@type": "ListItem",
"position": 4,
"name": "Pyridines",
"item": "https://questionsmedicales.fr/mesh/D011725"
},
{
"@type": "ListItem",
"position": 5,
"name": "Composés de pyridinium",
"item": "https://questionsmedicales.fr/mesh/D011726"
},
{
"@type": "ListItem",
"position": 6,
"name": "1-Méthyl-4-phényl-pyridinium",
"item": "https://questionsmedicales.fr/mesh/D015655"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : 1-Méthyl-4-phényl-pyridinium - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur 1-Méthyl-4-phényl-pyridinium",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-17",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur 1-Méthyl-4-phényl-pyridinium",
"description": "Comment diagnostiquer l'exposition au MPP+ ?\nQuels examens sont recommandés pour le MPP+ ?\nQuels symptômes indiquent une intoxication au MPP+ ?\nLe MPP+ peut-il être détecté dans le sang ?\nQuels tests neurologiques sont utiles pour le MPP+ ?",
"url": "https://questionsmedicales.fr/mesh/D015655?mesh_terms=Epilepsy,+Generalized#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur 1-Méthyl-4-phényl-pyridinium",
"description": "Quels sont les symptômes principaux du MPP+ ?\nLe MPP+ cause-t-il des troubles cognitifs ?\nY a-t-il des symptômes non moteurs liés au MPP+ ?\nComment le MPP+ affecte-t-il le système nerveux ?\nLe MPP+ provoque-t-il des douleurs ?",
"url": "https://questionsmedicales.fr/mesh/D015655?mesh_terms=Epilepsy,+Generalized#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur 1-Méthyl-4-phényl-pyridinium",
"description": "Comment prévenir l'exposition au MPP+ ?\nY a-t-il des vaccins contre le MPP+ ?\nLes changements de mode de vie aident-ils à prévenir le MPP+ ?\nL'éducation sur le MPP+ est-elle importante ?\nLes contrôles réguliers sont-ils recommandés ?",
"url": "https://questionsmedicales.fr/mesh/D015655?mesh_terms=Epilepsy,+Generalized#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur 1-Méthyl-4-phényl-pyridinium",
"description": "Quels traitements sont efficaces contre le MPP+ ?\nLa réhabilitation est-elle utile pour les patients exposés au MPP+ ?\nPeut-on utiliser des antioxydants pour traiter le MPP+ ?\nLes thérapies complémentaires sont-elles bénéfiques ?\nLe traitement précoce du MPP+ est-il crucial ?",
"url": "https://questionsmedicales.fr/mesh/D015655?mesh_terms=Epilepsy,+Generalized#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur 1-Méthyl-4-phényl-pyridinium",
"description": "Quelles complications peuvent survenir avec le MPP+ ?\nLe MPP+ peut-il entraîner des chutes ?\nY a-t-il un risque accru de dépression avec le MPP+ ?\nLe MPP+ peut-il affecter la qualité de vie ?\nDes complications cardiovasculaires sont-elles possibles ?",
"url": "https://questionsmedicales.fr/mesh/D015655?mesh_terms=Epilepsy,+Generalized#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur 1-Méthyl-4-phényl-pyridinium",
"description": "Quels sont les principaux facteurs de risque du MPP+ ?\nL'âge est-il un facteur de risque pour le MPP+ ?\nLes antécédents familiaux influencent-ils le risque ?\nLe sexe joue-t-il un rôle dans le risque de MPP+ ?\nLe mode de vie influence-t-il le risque de MPP+ ?",
"url": "https://questionsmedicales.fr/mesh/D015655?mesh_terms=Epilepsy,+Generalized#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer l'exposition au MPP+ ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests biologiques et des évaluations neurologiques sont utilisés pour diagnostiquer l'exposition."
}
},
{
"@type": "Question",
"name": "Quels examens sont recommandés pour le MPP+ ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IRM et l'électromyographie peuvent aider à évaluer les dommages neurologiques."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une intoxication au MPP+ ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tremblements, rigidité et bradykinésie peuvent indiquer une intoxication au MPP+."
}
},
{
"@type": "Question",
"name": "Le MPP+ peut-il être détecté dans le sang ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des analyses sanguines peuvent détecter la présence de MPP+."
}
},
{
"@type": "Question",
"name": "Quels tests neurologiques sont utiles pour le MPP+ ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de coordination et de réflexes peuvent évaluer l'impact neurologique du MPP+."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes principaux du MPP+ ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent tremblements, rigidité musculaire et troubles de la marche."
}
},
{
"@type": "Question",
"name": "Le MPP+ cause-t-il des troubles cognitifs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition au MPP+ peut entraîner des troubles cognitifs et de la mémoire."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes non moteurs liés au MPP+ ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme la dépression et l'anxiété peuvent survenir."
}
},
{
"@type": "Question",
"name": "Comment le MPP+ affecte-t-il le système nerveux ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le MPP+ endommage les neurones dopaminergiques, entraînant des symptômes parkinsoniens."
}
},
{
"@type": "Question",
"name": "Le MPP+ provoque-t-il des douleurs ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des douleurs musculaires et articulaires peuvent être présentes chez les patients."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'exposition au MPP+ ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les environnements contaminés et utiliser des équipements de protection."
}
},
{
"@type": "Question",
"name": "Y a-t-il des vaccins contre le MPP+ ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de vaccin spécifique contre le MPP+."
}
},
{
"@type": "Question",
"name": "Les changements de mode de vie aident-ils à prévenir le MPP+ ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sain peut réduire le risque de maladies neurodégénératives."
}
},
{
"@type": "Question",
"name": "L'éducation sur le MPP+ est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'éducation sur les risques et les symptômes est essentielle pour la prévention."
}
},
{
"@type": "Question",
"name": "Les contrôles réguliers sont-ils recommandés ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des contrôles réguliers peuvent aider à détecter précocement les symptômes."
}
},
{
"@type": "Question",
"name": "Quels traitements sont efficaces contre le MPP+ ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments dopaminergiques et des thérapies physiques."
}
},
{
"@type": "Question",
"name": "La réhabilitation est-elle utile pour les patients exposés au MPP+ ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la réhabilitation aide à améliorer la mobilité et la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des antioxydants pour traiter le MPP+ ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antioxydants peuvent être envisagés pour réduire le stress oxydatif lié au MPP+."
}
},
{
"@type": "Question",
"name": "Les thérapies complémentaires sont-elles bénéfiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines thérapies complémentaires, comme l'acupuncture, peuvent soulager les symptômes."
}
},
{
"@type": "Question",
"name": "Le traitement précoce du MPP+ est-il crucial ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un traitement précoce peut ralentir la progression des symptômes parkinsoniens."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le MPP+ ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des troubles moteurs sévères et des problèmes cognitifs."
}
},
{
"@type": "Question",
"name": "Le MPP+ peut-il entraîner des chutes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les troubles de la marche augmentent le risque de chutes chez les patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de dépression avec le MPP+ ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients exposés au MPP+ présentent un risque accru de dépression."
}
},
{
"@type": "Question",
"name": "Le MPP+ peut-il affecter la qualité de vie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes parkinsoniens peuvent significativement réduire la qualité de vie."
}
},
{
"@type": "Question",
"name": "Des complications cardiovasculaires sont-elles possibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études suggèrent un lien entre MPP+ et complications cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque du MPP+ ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition à des pesticides et à des produits chimiques industriels augmente le risque."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le MPP+ ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque d'effets néfastes du MPP+ augmente avec l'âge."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies neurodégénératives augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque de MPP+ ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études montrent que les hommes sont plus à risque que les femmes."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque de MPP+ ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 11/03/2025
Contenu vérifié selon les dernières recommandations médicales
5 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry University of Mysore, Manasagangotri, Mysore-570 006, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
3-Methyl-5-(4-methyl-phen-oxy)-1-phenyl-1
IUCrData
2022-09-27
Crystal structure studies of 4-ethyl-piperazin-1-ium 3,5-di-nitro-benzoate, 4-methyl-piperazin-1-ium 3,5-di-nitro-benzoate and 4-methyl-piperazin-1-ium 4-iodo-benzoate.
Acta crystallographica. Section E, Crystallographic communications
2021-10-21
Crystal-structure studies of 4-phenyl-piperazin-1-ium 4-eth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-meth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-methyl-benzoate monohydrate and 4-phenyl-piperazin-1-ium tri-fluoro-acetate 0.12-hydrate.
Acta crystallographica. Section E, Crystallographic communications
2022-06-10
5-(4-Fluoro-phen-yl)-1-[4-(4-methyl-phen-yl)thia-zol-2-yl]-3-[4-(prop-2-yn-yloxy)phen-yl]-4,5-di-hydro-1
IUCrData
2022-10-25
Syntheses and crystal structures of 4-(4-meth-oxy-phen-yl)piperazin-1-ium 4-methyl-benzoate monohydrate and bis-[4-(4-meth-oxy-phen-yl)piperazin-1-ium] benzene-1,2-di-carboxyl-ate.
Acta crystallographica. Section E, Crystallographic communications
2022-08-26
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. yuka@kms.ac.jp.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Howard University, 525 College Street NW, Washington DC 20059, USA.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
3 publications dans cette catégorie
Affiliations :
Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Türkiye.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
Crystal structures and Hirshfeld surface analyses of methyl 4-{2,2-di-chloro-1-[(
Acta crystallographica. Section E, Crystallographic communications
2024-01-26
Crystal-structure studies of 4-phenyl-piperazin-1-ium 4-eth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-meth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-methyl-benzoate monohydrate and 4-phenyl-piperazin-1-ium tri-fluoro-acetate 0.12-hydrate.
Acta crystallographica. Section E, Crystallographic communications
2022-06-10
Crystal structures of 1-(4-chloro-phen-yl)-4-(4-methyl-phen-yl)-2,5-dioxo-1,2,5,6,7,8-hexa-hydro-quinoline-3-carb-oxy-lic acid and 4-(4-meth-oxy-phen-yl)-1-(4-methyl-phen-yl)-2,5-dioxo-1,2,5,6,7,8-hexa-hydro-quinoline-3-carbo-nitrile.
Acta crystallographica. Section E, Crystallographic communications
2021-03-05
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Neuroprotective Drug Discovery Center, Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Division of Clinical Pharmacy, Department of Pharmacy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Neuroprotective Drug Discovery Center, Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry University of Mysore, Manasagangotri, Mysore-570 006, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry Mangalore University Mangalagangotri, Mangalore-574 199, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry Mangalore University Mangalagangotri, Mangalore-574 199, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Thomas Jefferson High School for Science and Technology, 6560 Braddock Rd Alexandria VA 22312, USA.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, School of Basic Sciences and Research, Sharda University, Greater Noida 201306, India.
Department of Chemistry, Pondicherry University, Puducherry 605 014, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Pondicherry University, Puducherry 605 014, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201306, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
The licensed treatment options for genetic generalized epilepsies are limited although many patients with these conditions require chronic pharmacological management with antiseizure medications and t...
In order to carry out a narrative review on the efficacy and safety of brivaracetam in genetic generalized epilepsies, a literature research was performed in Pubmed, EMBASE, Cochrane and Clinical Tria...
Promising results were found with doses ranging from 50 to 200 mg/day in terms of efficacy (with > 50% responder rates between 36 and 84%), tolerability, and short and long-term safety (24-57% drug-as...
According to our review, brivaracetam is a valid treatment alternative in patients with genetic generalized epilepsies capable of improving patients' quality of life by reducing seizure frequency with...
Intracranial neuromodulation is an evolving therapy for patients with drug-resistant epilepsy (DRE). Deep brain stimulation (DBS) is now available as a therapy for patients with DRE and focal-onset se...
To summarize current evidence and recent developments in the surgical treatment of drug-resistant generalized epilepsy....
Current surgical treatments of drug-resistant generalized epilepsy include vagus nerve stimulation (VNS), deep brain stimulation (DBS) and corpus callosotomy (CC). Neurostimulation with VNS and/or DBS...
Idiopathic generalized epilepsies (IGI) are an electroclinical syndrome that includes four subsyndromes according to the ILAE 2017 classification. The long-term prognosis of these syndromes is uncerta...
Observational and retrospective study of a serie of patients diagnosed with EGI. Epidemiological variables, pharmacological treatment, freedom of seizures and recurrence after withdrawal of treatment ...
We included 101 patients, the majority women (56.4%), with a median evolution of epilepsy of 17 years (interquartile range: 7-31). The most frequent syndrome was juvenile myoclonic epilepsy (46.5%), f...
Juvenile myoclonic epilepsy was the most frequent subtype of IGE. We observed significant differences in terms of polytherapy in the different syndromes, although not in the rates of remission of seiz...
Patients with epilepsy (PWE), especially those with Idiopathic Epilepsy (GE), are at a high risk of disadvantage caused by non-adherence. It has been suggested that medical visit behavior may be a sur...
This was a retrospective study of PWE who visited the Department of Psychiatry and Neurology at Hokkaido University Hospital between January 2017 and December 2019. Demographic and clinical informatio...
Of the 9151 total appointments, 413 were non-attendances, with an overall non-attendance rate of 4.5%. IGE was a more frequent non-attendance than Focal Epilepsy (FE) (odds ratio (OR) 1.94; 95% confid...
GE was more frequent in the non-attendance group than in the FE group. Among patients with GE, females were found to have non-attendance less frequently; however, there was no clear difference in the ...
There are three neurostimulation devices available to treat generalized epilepsy: vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS). However, the choic...
Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic review of PubMed, Embase, and Web of Science was performed for studies reporting seizure ...
Sufficient data for meta-analysis were available from seven studies for VNS (n = 510) and nine studies for DBS (n = 87). Data from RNS (five studies, n = 18) were insufficient for meta-analysis. The m...
Our meta-analysis indicates that the use of DBS may lead to greater seizure reduction than VNS in generalized epilepsy. Results from RNS use are promising, but further research is required....
Studies that evaluated vestibular function with epilepsy are fewer than auditory studies. We assessed vestibular function in children with epilepsy in inter-ictal period....
This cross-sectional study included 35 children with generalized epilepsy (boys=15; girls=20; age=11.20±1.21 years; epilepsy duration=3.54±1.80 years) and treated with valproate (VPA) and 24 healthy c...
Dizziness was the vestibular symptom in 22.86% of cases. Vestibular dysfunctions (VDs) were found in 65.71%. Manifestations of peripheral VD (65.71%) included unilateral caloric weakness and reduced c...
VDs are common in children with epilepsy. Bilateral peripheral VD was more common than central VD, suggesting an adverse effect of VPA. However, epilepsy cannot be excluded as a cause of central VD....
Current applications of neurostimulation for generalized epilepsy use a one-target-fits-all approach that is agnostic to the specific epilepsy syndrome and seizure type being treated. The authors desc...
Alterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimagin...
IGE patients and healthy participants underwent resting-state fMRI and arterial spin labeling imaging to calculate degree centrality (DC) and cerebral blood flow (CBF), respectively. Across-voxel CBF-...
The study included 26 children with IGE and 35 sex- and age-matched healthy controls (HCs). Compared with the HCs, the IGE group presented lower across-voxel CBF-DC correlations, higher CBF/DC ratio i...
Children with IGE present altered neurovascular coupling, associated with lower performance intelligence quotient scores. The study shed a new insight into the pathophysiology of epilepsy and provided...
Sleep impairment is one of the most common comorbidities affecting people with epilepsy (PWE). The bidirectional relation between epilepsy and sleep has been widely established. Several studies invest...
This observational study included adult patients newly diagnosed with epilepsy and drug-naive as well as a control group of healthy subjects. All PWE and controls underwent a dynamic 24-h EEG with sig...
Twenty-four PWE were included and distributed in two groups based on epilepsy type. Eleven patients were included in the generalized epilepsy group (63.6% male; 34.91 ± 9.80 years) and 13 patients in ...
This study highlighted the alteration of sleep quality, continuity, and stability in both patients with focal or generalized epilepsy compared with controls, also in the absence of ictal events. This ...