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"description": "Comment diagnostiquer une déficience en facteur XIa ?\nQuels tests sanguins sont utilisés pour évaluer le facteur XIa ?\nQuels symptômes indiquent un problème avec le facteur XIa ?\nLe facteur XIa peut-il être mesuré directement ?\nQuel rôle joue le facteur XIa dans les tests de coagulation ?",
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"@type": "Question",
"name": "Comment diagnostiquer une déficience en facteur XIa ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de coagulation comme le temps de céphaline activé (TCA) sont utilisés."
}
},
{
"@type": "Question",
"name": "Quels tests sanguins sont utilisés pour évaluer le facteur XIa ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le dosage du facteur XI et le TCA sont couramment utilisés pour l'évaluation."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent un problème avec le facteur XIa ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des saignements excessifs ou des ecchymoses fréquentes peuvent indiquer un problème."
}
},
{
"@type": "Question",
"name": "Le facteur XIa peut-il être mesuré directement ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il est généralement évalué indirectement par des tests de coagulation."
}
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{
"@type": "Question",
"name": "Quel rôle joue le facteur XIa dans les tests de coagulation ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il influence le temps de coagulation, notamment le TCA, en activant d'autres facteurs."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en facteur XIa ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des saignements prolongés, des hématomes et des saignements de nez."
}
},
{
"@type": "Question",
"name": "Les saignements sont-ils toujours visibles avec un déficit en facteur XIa ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Pas toujours, certains saignements internes peuvent ne pas être visibles immédiatement."
}
},
{
"@type": "Question",
"name": "Comment se manifestent les saignements liés au facteur XIa ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent se manifester par des saignements après une chirurgie ou des traumatismes mineurs."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge pour le facteur XIa ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les jeunes peuvent avoir des symptômes plus prononcés que les personnes âgées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes associés à des complications du facteur XIa ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des complications peuvent inclure des hémorragies internes graves ou des thromboses."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications liées au facteur XIa ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les activités à risque et suivre un traitement médical régulier peut aider."
}
},
{
"@type": "Question",
"name": "Les personnes avec un déficit en facteur XIa doivent-elles éviter certains médicaments ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments anticoagulants doivent être évités pour prévenir les saignements."
}
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{
"@type": "Question",
"name": "Y a-t-il des recommandations diététiques pour le facteur XIa ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et riche en vitamine K peut soutenir la coagulation sanguine."
}
},
{
"@type": "Question",
"name": "Les vaccinations sont-elles sûres pour les personnes avec un déficit en facteur XIa ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccinations sont généralement sûres, mais consultez un médecin au préalable."
}
},
{
"@type": "Question",
"name": "Comment le suivi médical aide-t-il à prévenir les problèmes liés au facteur XIa ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un suivi régulier permet d'ajuster les traitements et de surveiller les symptômes."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour une déficience en facteur XIa ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des transfusions de plasma et des médicaments anticoagulants."
}
},
{
"@type": "Question",
"name": "Les anticoagulants affectent-ils le facteur XIa ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains anticoagulants ciblent spécifiquement le facteur XIa pour réduire les caillots."
}
},
{
"@type": "Question",
"name": "Le facteur XIa peut-il être remplacé par des médicaments ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de traitement de remplacement spécifique pour le facteur XIa."
}
},
{
"@type": "Question",
"name": "Comment la thérapie génique pourrait-elle aider le facteur XIa ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique pourrait potentiellement corriger les déficiences en facteur XIa à l'avenir."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils différents pour les enfants et les adultes ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements peuvent varier en fonction de l'âge et de la gravité des symptômes."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles d'une déficience en facteur XIa ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des hémorragies internes, des saignements prolongés et des thromboses."
}
},
{
"@type": "Question",
"name": "Les thromboses sont-elles une complication du facteur XIa ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un déséquilibre dans la coagulation peut entraîner des thromboses malgré une déficience."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées au facteur XIa ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut un traitement médical approprié et une surveillance régulière des symptômes."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles plus fréquentes chez certains groupes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées et celles avec des antécédents familiaux peuvent être plus à risque."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être évitées ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être évitées par un suivi médical et un traitement préventif."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour une déficience en facteur XIa ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents familiaux, certaines maladies génétiques et l'âge avancé sont des facteurs de risque."
}
},
{
"@type": "Question",
"name": "Le sexe influence-t-il le risque de déficience en facteur XIa ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études montrent que les hommes peuvent être plus à risque que les femmes dans certains cas."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes augmentent-elles le risque de problèmes avec le facteur XIa ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines maladies auto-immunes peuvent affecter la coagulation et le facteur XIa."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le facteur XIa ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de complications augmente avec l'âge en raison de la dégradation des mécanismes de coagulation."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux influencent-ils le risque de déficience en facteur XIa ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de troubles de la coagulation augmentent le risque de déficience en facteur XIa."
}
}
]
}
]
}
Network meta-analysis has been an essential methodology of systematic reviews for comparative effectiveness research. The restricted maximum likelihood (REML) method is one of the current standard inf...
With recent advancements in bronchoscopic procedures, data on the best modality to sample peripheral pulmonary lesions (PPLs) is lacking, especially comparing bronchoscopy with computed tomography-gui...
We performed a meta-analysis, pairwise meta-analysis and network meta-analysis on studies reporting diagnostic yield and complications with the use of CT-TBNA, radial endobronchial ultrasound (rEBUS),...
We included 363 studies. The overall pooled diagnostic yield was 78.1%, the highest with CT-TBNA (88.9%), followed by RAB (84.8%) and the least with rEBUS (72%). In the pairwise meta-analysis, only rE...
Although CT-TBNA is the most effective approach to sample PPLs, RAB has a comparable diagnostic yield with a lesser complication rate. Further prospective studies are needed comparing CT-TBNA and RAB....
Eczema (atopic dermatitis) is the most burdensome skin condition worldwide and cannot currently be prevented or cured. Topical anti-inflammatory treatments are used to control eczema symptoms, but the...
To compare and rank the efficacy and safety of topical anti-inflammatory treatments for people with eczema using a network meta-analysis....
We searched the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase and trial registries on 29 June 2023, and checked the reference lists of included studies....
We included within-participant or between-participant randomised controlled trials (RCTs) in people of any age with eczema of any severity, but excluded trials in clinically infected eczema, seborrhoe...
We used standard Cochrane methods. Primary outcomes were patient-reported eczema symptoms, clinician-reported eczema signs and investigator global assessment. Secondary outcomes were health-related qu...
We included 291 studies involving 45,846 participants with the full spectrum of eczema severity, mainly conducted in high-income countries in secondary care settings. Most studies included adults, wit...
Potent TCS, JAK inhibitors and tacrolimus 0.1% were consistently ranked as amongst the most effective topical anti-inflammatory treatments for eczema and PDE-4 inhibitors as amongst the least effectiv...
Despite considerable improvement in outcomes for preterm infants, rates of bronchopulmonary dysplasia (BPD) remain high, affecting an estimated 33% of very low birthweight infants, with corresponding ...
To determine whether differences in efficacy and safety exist between high-dose dexamethasone, moderate-dose dexamethasone, low-dose dexamethasone, hydrocortisone, and placebo in the prevention of BPD...
We searched the Cochrane Library for all systematic reviews of systemic corticosteroids for the prevention of BPD and searched for completed and ongoing studies in the following databases in January 2...
We included randomized controlled trials (RCTs) in preterm infants (< 37 weeks' gestation) at risk for BPD that evaluated systemic corticosteroids (high-dose [≥ 4 mg/kg cumulative dose] dexamethasone,...
Our main information sources were the systematic reviews, with reference to the original manuscript only for data not included in these reviews. Teams of two paired review authors independently perfor...
We included 59 studies, involving 6441 infants, in our analyses. Only six of the included studies provided direct comparisons between any of the treatment (dexamethasone or hydrocortisone) groups, for...
Low-dose dexamethasone increased the risk for cerebral palsy (RR 1.92, 95% CI 1.12 to 3.28; moderate-certainty evidence) compared with control. Hydrocortisone may decrease the risk of major neurosenso...
No effect was observed for the outcomes of major neurosensory disability or cerebral palsy. The evidence for the primary outcomes was of overall low certainty, with notable deductions for imprecision ...
While early treatment with moderate-dose dexamethasone or late treatment with high-dose dexamethasone may lead to the best effects for survival without BPD, the certainty of the evidence is low. There...
Severely calcified coronary stenoses are difficult to treat with percutaneous coronary interventions. The presence of severe calcifications complicates lesion preparation, advancement of stents and ac...
We will conduct a systematic review of randomised trials enrolling patients with calcified coronary artery disease undergoing percutaneous coronary intervention. We will investigate any percutaneous t...
No ethics approval is required for this study. The results will be published in a peer-reviewed journal in this field....
CRD42021226034....
Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects mainly young adults (two to three times more frequently in women than in men) and causes significant disability ...
To compare adverse effects of immunotherapies for people with MS or clinically isolated syndrome (CIS), and to rank these treatments according to their relative risks of adverse effects through networ...
We searched CENTRAL, PubMed, Embase, two other databases and trials registers up to March 2022, together with reference checking and citation searching to identify additional studies....
We included participants 18 years of age or older with a diagnosis of MS or CIS, according to any accepted diagnostic criteria, who were included in randomized controlled trials (RCTs) that examined o...
We used standard Cochrane methods for data extraction and pairwise meta-analyses. For NMAs, we used the netmeta suite of commands in R to fit random-effects NMAs assuming a common between-study varian...
This NMA included 123 trials with 57,682 participants...
We found mostly low and very low-certainty evidence that drugs used to treat MS may not increase SAEs, but may increase withdrawals compared with placebo. The results suggest that there is no importan...
A comprehensive network meta-analysis comparing the effects of individual sodium-glucose cotransporter 2 (SGLT2) inhibitors on patients with and without comorbidities including diabetes mellitus (DM),...
We searched PubMed, Embase, Cochrane, and ClinicalTrials.gov for randomized controlled trials up to March 28, 2023. Network meta-analysis using a random-effects model was conducted to calculate risk r...
A total of fourteen trials with 75,334 patients were analyzed. Among these, 40,956 had taken SGLT2 inhibitors and 34,378 had not. One of the main results with particular findings was empagliflozin use...
Our network meta-analysis revealed that empagliflozin users with diabetes experienced a lower risk of dying from any cause than those using dapagliflozin. Additionally, canagliflozin users demonstrate...
PROSPERO [CRD42022361906]....
Multiple randomized controlled trials, each comparing a subset of competing interventions, can be synthesized by means of a network meta-analysis to estimate relative treatment effects between all int...
Surgical treatment of complete rectal prolapse can be undertaken via an abdominal or a perineal approach. The present network meta-analysis aimed to compare the outcomes of different abdominal and per...
A PRISMA-compliant systematic review of PubMed, Scopus, and Web of Science was conducted. Randomized clinical trials comparing two or more procedures for the treatment of complete rectal prolapse were...
Nine randomized controlled trials with 728 patients were included. The follow-up ranged between 12 and 47 months. Posterior mesh rectopexy had significantly lower odds of recurrence than did the Altem...
Posterior mesh rectopexy ranked best with the lowest recurrence while perineal procedures ranked worst with the highest recurrence rates....
Several vaccines showed a good safety profile and significant efficacy against COVID-19. Moreover, in the absence of direct head to head comparison between COVID-19 vaccines, a network meta-analysis t...
Databases PubMed, CENTRAL, medRxiv, and clinicaltrials.gov were searched. Studies were included if they were placebo-controlled clinical trials and reported the safety profile and/or effectiveness of ...
Forty-nine clinical trials that included 421,173 participants and assessed 28 vaccines were included in this network meta-analysis. The network meta-analysis showed that Pfizer is the most effective i...
We found that almost all of the vaccines included in this study crossed the threshold of 50% efficacy. However, some of them did not reach the previously mentioned threshold against the B.1.351 varian...
