Titre : Cyclic GMP-Dependent Protein Kinases

Cyclic GMP-Dependent Protein Kinases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Sensitivity and Specificity
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sont-ils liés aux kinases cGMP ?\nComment les kinases cGMP affectent-elles la fonction cardiaque ?\nY a-t-il des symptômes spécifiques aux maladies liées aux kinases cGMP ?\nLes troubles de l'humeur peuvent-ils être liés aux kinases cGMP ?", "url": "https://questionsmedicales.fr/mesh/D017869?mesh_terms=Sensitivity+and+Specificity&page=5#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Cyclic GMP-Dependent Protein Kinases", "description": "Comment prévenir les troubles liés aux kinases cGMP ?\nL'alimentation influence-t-elle les kinases cGMP ?\nLe stress a-t-il un impact sur les kinases cGMP ?\nLes examens réguliers sont-ils importants ?\nL'exercice physique aide-t-il à la prévention ?", "url": "https://questionsmedicales.fr/mesh/D017869?mesh_terms=Sensitivity+and+Specificity&page=5#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Cyclic GMP-Dependent Protein Kinases", 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"https://questionsmedicales.fr/mesh/D017869?mesh_terms=Sensitivity+and+Specificity&page=5#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Cyclic GMP-Dependent Protein Kinases", "description": "Quels sont les facteurs de risque pour les dysfonctionnements cGMP ?\nL'âge influence-t-il la fonction des kinases cGMP ?\nLe mode de vie sédentaire est-il un facteur de risque ?\nLe stress chronique est-il un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?", "url": "https://questionsmedicales.fr/mesh/D017869?mesh_terms=Sensitivity+and+Specificity&page=5#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des kinases cGMP ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests biochimiques et des analyses génétiques peuvent être utilisés pour évaluer la fonction des kinases cGMP." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour mesurer le cGMP ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des dosages immunologiques et des tests enzymatiques peuvent mesurer les niveaux de cGMP dans les tissus." } }, { "@type": "Question", "name": "Quels symptômes indiquent un problème avec les kinases cGMP ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes variés comme des troubles cardiovasculaires ou neurologiques peuvent indiquer un dysfonctionnement." } }, { "@type": "Question", "name": "Les tests génétiques sont-ils utiles pour les kinases cGMP ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les tests génétiques peuvent identifier des mutations affectant les kinases cGMP." } }, { "@type": "Question", "name": "Comment évaluer l'activité des kinases cGMP ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'activité peut être évaluée par des essais enzymatiques spécifiques in vitro." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une déficience en kinases cGMP ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent inclure des troubles de la circulation sanguine et des problèmes de vision." } }, { "@type": "Question", "name": "Les troubles neurologiques sont-ils liés aux kinases cGMP ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans les kinases cGMP peuvent contribuer à des troubles neurologiques." } }, { "@type": "Question", "name": "Comment les kinases cGMP affectent-elles la fonction cardiaque ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Elles régulent la relaxation et la contraction cardiaque, influençant la pression artérielle." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux maladies liées aux kinases cGMP ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes spécifiques peuvent inclure des douleurs thoraciques et des palpitations." } }, { "@type": "Question", "name": "Les troubles de l'humeur peuvent-ils être liés aux kinases cGMP ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des études suggèrent un lien entre les kinases cGMP et la régulation de l'humeur." } }, { "@type": "Question", "name": "Comment prévenir les troubles liés aux kinases cGMP ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Maintenir un mode de vie sain et surveiller les facteurs de risque cardiovasculaires aide à prévenir." } }, { "@type": "Question", "name": "L'alimentation influence-t-elle les kinases cGMP ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation riche en antioxydants peut soutenir la fonction des kinases cGMP." } }, { "@type": "Question", "name": "Le stress a-t-il un impact sur les kinases cGMP ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter la signalisation cGMP et la santé cardiovasculaire." } }, { "@type": "Question", "name": "Les examens réguliers sont-ils importants ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des examens réguliers peuvent aider à détecter précocement des dysfonctionnements cGMP." } }, { "@type": "Question", "name": "L'exercice physique aide-t-il à la prévention ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la signalisation cGMP et la santé globale." } }, { "@type": "Question", "name": "Quels traitements ciblent les kinases cGMP ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des inhibiteurs spécifiques et des modulateurs de cGMP sont utilisés pour traiter certaines conditions." } }, { "@type": "Question", "name": "Les médicaments augmentant le cGMP sont-ils efficaces ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des médicaments comme les nitrates et les inhibiteurs de la phosphodiestérase peuvent être efficaces." } }, { "@type": "Question", "name": "Comment les thérapies géniques peuvent-elles aider ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Les thérapies géniques peuvent corriger des mutations dans les gènes des kinases cGMP." } }, { "@type": "Question", "name": "Y a-t-il des traitements naturels pour les dysfonctionnements cGMP ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Certaines plantes médicinales peuvent avoir des effets bénéfiques sur la signalisation cGMP." } }, { "@type": "Question", "name": "Les changements de mode de vie peuvent-ils aider ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation saine et l'exercice peuvent améliorer la fonction des kinases cGMP." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec des dysfonctionnements cGMP ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications peuvent inclure des maladies cardiovasculaires et des troubles neurologiques." } }, { "@type": "Question", "name": "Les troubles de la coagulation sont-ils liés aux kinases cGMP ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans les kinases cGMP peuvent affecter la coagulation sanguine." } }, { "@type": "Question", "name": "Y a-t-il des risques de cancer associés aux kinases cGMP ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Certaines études suggèrent un lien entre les dysfonctionnements cGMP et le développement du cancer." } }, { "@type": "Question", "name": "Les maladies rénales peuvent-elles être influencées par cGMP ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les kinases cGMP jouent un rôle dans la régulation de la fonction rénale." } }, { "@type": "Question", "name": "Les troubles respiratoires sont-ils liés aux kinases cGMP ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans la signalisation cGMP peuvent contribuer à des troubles respiratoires." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les dysfonctionnements cGMP ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent l'hypertension, le diabète et le tabagisme." } }, { "@type": "Question", "name": "L'âge influence-t-il la fonction des kinases cGMP ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement peut affecter la signalisation cGMP et la santé cardiovasculaire." } }, { "@type": "Question", "name": "Le mode de vie sédentaire est-il un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire peut augmenter le risque de dysfonctionnement des kinases cGMP." } }, { "@type": "Question", "name": "Le stress chronique est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut perturber la signalisation cGMP et augmenter les risques de maladies." } }, { "@type": "Question", "name": "Les antécédents familiaux jouent-ils un rôle ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de maladies cardiovasculaires peuvent augmenter le risque." } } ] } ] }

Sources (10000 au total)

The sensitivity and specificity of COVID-19 rapid anti-gene test in comparison to RT-PCR test as a gold standard test.

Coronavirus disease 2019 (COVID-19) is a modern infectious disease, first identified in December 2019 in Wuhan, China. The etiology is via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),... This is a cohort hospital-based study done during the period of July to September 2020. Both rapid anti-gene test kit (SARS-CoV-2) and RT-qPCR were used for the detection of COVID-19 in suspected case... A total of 148 cases were tested using both the RT-qPCR and rapid test. Twenty-nine (19.6%) of these cases had positive results for RT-qPCR and 119 (80.4%) were negative, whereas 52 (35.1%) patients w... We cannot consider rapid anti-gene test alone as a diagnostic method for COVID-19. We should also conduct RT-PCR test and other investigations like imaging CT scan of chest to confirm the diagnosis. T...

Sensitivity and specificity of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised to detect dysarthria in individuals with amyotrophic lateral sclerosis.

Given the widespread use of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) to measure disease progression in ALS and recent reports demonstrating its poor sensitivity, we... Paired ALSFRS-R and validated Speech Intelligibility Test (SIT) data from individuals with ALS were analyzed. Trained raters completed duplicate, independent, and blinded ratings of audio recordings t... A total of 250 paired SIT and ALSFRS-R data points were analyzed. Dysarthria was confirmed in 72.4% (n = 181). Dysarthric speakers demonstrated lower ALSFRS-R bulbar subscale (8.9 vs. 11.2) and speech... The ALSFRS-R bulbar and speech item subscale scores may be useful, inexpensive, and quick tools for monitoring dysarthria status in ALS....

Sensitivity and specificity of monocyte distribution width (MDW) in detecting patients with infection and sepsis in patients on sepsis pathway in the emergency department.

Monocyte distribution width (MDW) is a biomarker for the early identification of sepsis. We assessed its accuracy in patients presenting with suspected sepsis in the emergency department (ED).... This was a single gate, single centre study in consecutive adults (≥ 18 years) admitted to the ED with suspected sepsis and clinical history compatible with infection, between 01 January and 31 Decemb... The overall median MDW was 22.0 (IQR 19.3, 25.6). Using Sepsis-3 (qSOFA) to define sepsis, the Area Under Curve (AUC) for a receiver operator characteristic (ROC) relationship was 0.59 (95% CI 0.56, 0... In this population of ED admissions with a strong clinical suspicion of sepsis, MDW had a performance to identify sepsis comparable to that of other commonly used biomarkers. In this setting, MDW coul...

Large-scale pathogenicity prediction analysis of cancer-associated kinase mutations reveals variability in sensitivity and specificity of computational methods.

Mutations in kinases are the most frequent genetic alterations in cancer; however, experimental evidence establishing their cancerous nature is available only for a small fraction of these mutants.... Predicition analysis of kinome mutations is the primary aim of this study. Further objective is to compare the performance of various softwares in pathogenicity prediction of kinase mutations.... We employed a set of computational tools to predict the pathogenicity of over forty-two thousand mutations and deposited the kinase-wise data in Mendeley database (Estimated Pathogenicity of Kinase Mu... Mutations are more likely to be drivers when being present in the kinase domain (vs. non-kinase domain) and belonging to hotspot residues (vs. non-hotspot residues). We identified that, while predicti... The study provides a large dataset of kinase mutations along with their predicted pathogenicity that can be used as a training set for future studies. Furthermore, a comparative sensitivity and select... Primary-structure-based in silico tools identified more cancerous/deleterious mutations in the kinase domains and at the hot spot residues while having higher sensitivity than specificity in detecting...

A sensitive and specific nano-vehicle based on self-amplified dual-input synthetic gene circuit for intracellular imaging and treatment.

Synthetic genetic circuits (SGCs) that sense multiple biomarkers and respond intelligently provide a powerful tool for intracellular biosensing. The SGC is usually loaded into the nanoscale liposomes ...

FEN1-aided recombinase polymerase amplification (FARPA) for one-pot and multiplex detection of nucleic acids with an ultra-high specificity and sensitivity.

Recombinase polymerase amplification (RPA) running at 37-42 °C is fast, efficient and less-implemented; however, the existing technologies of nucleic acid testing based on RPA have some limitations in...

A Novel Scoring System for MYB RNA In Situ Hybridization Displays High Sensitivity and Specificity for Adenoid Cystic Carcinoma in a Clinical Setting.

MYB RNA in situ hybridization (ISH) has emerged as a reliable and accessible marker to support adenoid cystic carcinoma (ACC) diagnosis, though still not well studied. Here, we report our results in a... 79 cases (23 retrospective and 56 prospective) underwent MYB RNA ISH testing (44 ACC and 35 non-ACC). MYB RNA ISH results were initially interpreted based on previously established (original) scoring ... An abluminal pattern was characteristic and exclusive to ACC. All i-scores, % LS, and percent positive were significantly higher in ACC. Original scoring criteria yielded a 95.5% sensitivity (Sn), 68.... MYB RNA ISH has a higher Sn than MYB::NFIB FISH while retaining high Sp. Our model provides improvements to specificity compared to original scoring criteria and highlight the importance of abluminal ...

Estimating sensitivity and specificity of diagnostic tests using latent class models that account for conditional dependence between tests: a simulation study.

Latent class models are increasingly used to estimate the sensitivity and specificity of diagnostic tests in the absence of a gold standard, and are commonly fitted using Bayesian methods. These model... A simulation study and a reanalysis of a published case study are used to highlight the impact of the conditional dependence structure chosen on estimates of sensitivity and specificity. We describe a... The findings highlight that assuming conditional independence between tests within a latent class, where conditional dependence exists, results in biased estimates of sensitivity and specificity and p... We have illustrated that misspecification of the conditional dependence structure leads to biased estimates of sensitivity and specificity when there is a correlation between tests. Due to the minimal...