questionsmedicales.fr
Procédures de chirurgie opératoire
Procédures orthopédiques
Allongement osseux
Technique d'Ilizarov
Technique d'Ilizarov : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Déformations osseuses
Imagerie par résonance magnétique
Longueur osseuse
Radiographie
Chirurgie orthopédique
Douleur
Symptômes
5
Infection osseuse
Chirurgie
Distraction osseuse
Douleur
Effets secondaires
Infection
Prévention
5
Prévention des fractures
Sport
Complications
Chirurgie orthopédique
Déformations osseuses
Croissance
Traitements
5
Technique d'Ilizarov
Régénération osseuse
Fractures
Déformations osseuses
Distraction osseuse
Allongement osseux
Soins post-opératoires
Réhabilitation
Durée du traitement
Technique d'Ilizarov
Complications
5
Douleur chronique
Réhabilitation
Non-consolidation
Circulation sanguine
Facteurs de risque
5
Médicaments
Cicatrisation
Antécédents médicaux
Complications
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Technique d'Ilizarov : Questions médicales les plus fréquentes",
"headline": "Technique d'Ilizarov : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Technique d'Ilizarov : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-01-16",
"dateModified": "2025-04-10",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Technique d'Ilizarov"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Allongement osseux",
"url": "https://questionsmedicales.fr/mesh/D001852",
"about": {
"@type": "MedicalCondition",
"name": "Allongement osseux",
"code": {
"@type": "MedicalCode",
"code": "D001852",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "E04.555.120"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Technique d'Ilizarov",
"alternateName": "Ilizarov Technique",
"code": {
"@type": "MedicalCode",
"code": "D018889",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Aihemaitijiang Yusufu",
"url": "https://questionsmedicales.fr/author/Aihemaitijiang%20Yusufu",
"affiliation": {
"@type": "Organization",
"name": "Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China. ahmatjang@163.com."
}
},
{
"@type": "Person",
"name": "Piotr Morasiewicz",
"url": "https://questionsmedicales.fr/author/Piotr%20Morasiewicz",
"affiliation": {
"@type": "Organization",
"name": "Department and Clinic of Orthopaedic and Traumatologic Surgery, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland."
}
},
{
"@type": "Person",
"name": "Maimaiaili Yushan",
"url": "https://questionsmedicales.fr/author/Maimaiaili%20Yushan",
"affiliation": {
"@type": "Organization",
"name": "Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Xinjiang Medical University, Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Ürümqi, Xinjiang, People's Republic of China. 424257832@qq.com."
}
},
{
"@type": "Person",
"name": "Sihe Qin",
"url": "https://questionsmedicales.fr/author/Sihe%20Qin",
"affiliation": {
"@type": "Organization",
"name": "Department of Orthopedics, Rehabilitation Hospital, National Research Center for Rehabilitation, Beijing, China."
}
},
{
"@type": "Person",
"name": "Yanshi Liu",
"url": "https://questionsmedicales.fr/author/Yanshi%20Liu",
"affiliation": {
"@type": "Organization",
"name": "Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Establishing the Link between X-Chromosome Aberrations and",
"datePublished": "2023-09-11",
"url": "https://questionsmedicales.fr/article/37759468",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/cells12182245"
}
},
{
"@type": "ScholarlyArticle",
"name": "Geometrical Properties of the Nucleus and Chromosome Intermingling Are Possible Major Parameters of Chromosome Aberration Formation.",
"datePublished": "2022-08-03",
"url": "https://questionsmedicales.fr/article/35955776",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/ijms23158638"
}
},
{
"@type": "ScholarlyArticle",
"name": "Prenatal diagnosis of chromosomal aberrations by chromosomal microarray analysis and pregnancy outcomes of fetuses with polyhydramnios.",
"datePublished": "2024-05-06",
"url": "https://questionsmedicales.fr/article/38710614",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1080/14767058.2024.2344089"
}
},
{
"@type": "ScholarlyArticle",
"name": "Wheat doubled haploids have a marked prevalence of chromosomal aberrations.",
"datePublished": "2023-05-01",
"url": "https://questionsmedicales.fr/article/37128182",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/tpg2.20309"
}
},
{
"@type": "ScholarlyArticle",
"name": "Optical genome mapping for detection of chromosomal aberrations in prenatal diagnosis.",
"datePublished": "2023-06-27",
"url": "https://questionsmedicales.fr/article/37366235",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/aogs.14613"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Procédures de chirurgie opératoire",
"item": "https://questionsmedicales.fr/mesh/D013514"
},
{
"@type": "ListItem",
"position": 3,
"name": "Procédures orthopédiques",
"item": "https://questionsmedicales.fr/mesh/D019637"
},
{
"@type": "ListItem",
"position": 4,
"name": "Allongement osseux",
"item": "https://questionsmedicales.fr/mesh/D001852"
},
{
"@type": "ListItem",
"position": 5,
"name": "Technique d'Ilizarov",
"item": "https://questionsmedicales.fr/mesh/D018889"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Technique d'Ilizarov - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Technique d'Ilizarov",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-06",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Technique d'Ilizarov",
"description": "Comment diagnostiquer une fracture complexe ?\nQuels tests sont utilisés pour évaluer les déformations osseuses ?\nQuels signes indiquent une nécrose osseuse ?\nComment évaluer la longueur des os ?\nQuels symptômes nécessitent une intervention chirurgicale ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Chromosome+Aberrations#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Technique d'Ilizarov",
"description": "Quels sont les symptômes d'une fracture ?\nComment reconnaître une infection osseuse ?\nQuels signes indiquent une mauvaise cicatrisation ?\nQuels symptômes peuvent survenir après la distraction osseuse ?\nQuels sont les effets secondaires possibles de la technique ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Chromosome+Aberrations#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Technique d'Ilizarov",
"description": "Comment prévenir les fractures chez les sportifs ?\nQuelles mesures prendre pour éviter les infections post-chirurgicales ?\nComment éviter les complications après une chirurgie osseuse ?\nQuels conseils pour une bonne cicatrisation osseuse ?\nComment prévenir les déformations osseuses chez les enfants ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Chromosome+Aberrations#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Technique d'Ilizarov",
"description": "Comment fonctionne la technique d'Ilizarov ?\nQuels types de fractures sont traités par cette technique ?\nQuel est le rôle de la distraction osseuse ?\nQuels soins post-opératoires sont nécessaires ?\nCombien de temps dure le traitement avec la technique d'Ilizarov ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Chromosome+Aberrations#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Technique d'Ilizarov",
"description": "Quelles sont les complications possibles de la technique d'Ilizarov ?\nComment gérer une infection après la chirurgie ?\nQuels signes indiquent une complication grave ?\nComment prévenir les douleurs chroniques après la chirurgie ?\nQuels sont les risques de non-consolidation osseuse ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Chromosome+Aberrations#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Technique d'Ilizarov",
"description": "Quels facteurs augmentent le risque de fractures ?\nComment le tabagisme influence-t-il la cicatrisation osseuse ?\nQuels médicaments peuvent affecter la guérison osseuse ?\nComment l'alimentation influence-t-elle la santé osseuse ?\nQuels antécédents médicaux augmentent les risques de complications ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Chromosome+Aberrations#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une fracture complexe ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un examen clinique et des imageries comme les radiographies sont nécessaires."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les déformations osseuses ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des radiographies et des IRM peuvent être utilisés pour évaluer les déformations."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une nécrose osseuse ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur persistante, gonflement et incapacité à utiliser le membre affecté."
}
},
{
"@type": "Question",
"name": "Comment évaluer la longueur des os ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des mesures radiographiques précises sont effectuées pour évaluer la longueur."
}
},
{
"@type": "Question",
"name": "Quels symptômes nécessitent une intervention chirurgicale ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur intense, déformation sévère ou incapacité fonctionnelle persistante."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une fracture ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur aiguë, gonflement, déformation et incapacité à bouger le membre."
}
},
{
"@type": "Question",
"name": "Comment reconnaître une infection osseuse ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Rougeur, chaleur, douleur et écoulement au site de la fracture ou de la chirurgie."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une mauvaise cicatrisation ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur persistante, mobilité limitée et déformation visible de l'os."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent survenir après la distraction osseuse ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur, gonflement et parfois des picotements au niveau du site de distraction."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires possibles de la technique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Inconfort, infection, et parfois des problèmes de croissance osseuse."
}
},
{
"@type": "Question",
"name": "Comment prévenir les fractures chez les sportifs ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Renforcement musculaire, échauffement adéquat et utilisation d'équipements de protection."
}
},
{
"@type": "Question",
"name": "Quelles mesures prendre pour éviter les infections post-chirurgicales ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir une bonne hygiène, suivre les instructions médicales et surveiller les signes d'infection."
}
},
{
"@type": "Question",
"name": "Comment éviter les complications après une chirurgie osseuse ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Suivre les recommandations médicales, éviter les activités à risque et faire des contrôles réguliers."
}
},
{
"@type": "Question",
"name": "Quels conseils pour une bonne cicatrisation osseuse ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée, repos suffisant et éviter le tabac favorisent la cicatrisation."
}
},
{
"@type": "Question",
"name": "Comment prévenir les déformations osseuses chez les enfants ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller la croissance, encourager l'activité physique et consulter un médecin si nécessaire."
}
},
{
"@type": "Question",
"name": "Comment fonctionne la technique d'Ilizarov ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle utilise un cadre externe pour stabiliser l'os et favoriser la régénération."
}
},
{
"@type": "Question",
"name": "Quels types de fractures sont traités par cette technique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fractures complexes, fractures non consolidées et déformations osseuses."
}
},
{
"@type": "Question",
"name": "Quel est le rôle de la distraction osseuse ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet d'allonger l'os progressivement en créant un nouvel os entre les segments."
}
},
{
"@type": "Question",
"name": "Quels soins post-opératoires sont nécessaires ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveillance des signes d'infection, gestion de la douleur et rééducation."
}
},
{
"@type": "Question",
"name": "Combien de temps dure le traitement avec la technique d'Ilizarov ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut durer de plusieurs semaines à plusieurs mois selon le cas."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles de la technique d'Ilizarov ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections, douleurs chroniques, et problèmes de consolidation osseuse."
}
},
{
"@type": "Question",
"name": "Comment gérer une infection après la chirurgie ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antibiotiques et soins locaux sont nécessaires pour traiter l'infection efficacement."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une complication grave ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre élevée, douleur intense et écoulement purulent au site opératoire."
}
},
{
"@type": "Question",
"name": "Comment prévenir les douleurs chroniques après la chirurgie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une rééducation précoce et une gestion adéquate de la douleur sont essentielles."
}
},
{
"@type": "Question",
"name": "Quels sont les risques de non-consolidation osseuse ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Mauvaise circulation sanguine, infection ou mauvaise technique chirurgicale peuvent causer cela."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de fractures ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, l'ostéoporose et les activités sportives à risque augmentent ce risque."
}
},
{
"@type": "Question",
"name": "Comment le tabagisme influence-t-il la cicatrisation osseuse ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme retarde la cicatrisation et augmente le risque d'infections post-opératoires."
}
},
{
"@type": "Question",
"name": "Quels médicaments peuvent affecter la guérison osseuse ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les corticostéroïdes et certains anti-inflammatoires peuvent retarder la guérison."
}
},
{
"@type": "Question",
"name": "Comment l'alimentation influence-t-elle la santé osseuse ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en calcium et vitamine D est essentielle pour la santé osseuse."
}
},
{
"@type": "Question",
"name": "Quels antécédents médicaux augmentent les risques de complications ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antécédents de maladies osseuses, diabète ou troubles circulatoires augmentent les risques."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 10/04/2025
Contenu vérifié selon les dernières recommandations médicales
6 publications dans cette catégorie
Affiliations :
Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China. ahmatjang@163.com.
6 publications dans cette catégorie
Affiliations :
Department and Clinic of Orthopaedic and Traumatologic Surgery, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
Department of Orthopaedic and Trauma Surgery, University Hospital in Opole, Institute of Medical Sciences, University of Opole, Witosa 26, 41-405, Opole, Poland.
5 publications dans cette catégorie
Affiliations :
Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Xinjiang Medical University, Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Ürümqi, Xinjiang, People's Republic of China. 424257832@qq.com.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Orthopedics, Rehabilitation Hospital, National Research Center for Rehabilitation, Beijing, China.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Orthopedics and Musculoskeletal Traumatology, Medical University of Warsaw, Lindleya 4, 02-005, Warsaw, Poland. L.szelerski@gmail.com.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Orthopedics and Musculoskeletal Traumatology, Medical University of Warsaw, Lindleya 4, 02-005, Warsaw, Poland.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Physiotherapy in Motor Disorders and Dysfunctions, University School of Physical Education in Wroclaw, 51-612 Wroclaw, Poland.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Orthopaedic Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. hanpei_cn@163.com.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopedics and Musculoskeletal Traumatology, Medical University of Warsaw, Lindleya 4, 02-005, Warsaw, Poland.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Microrepair and Reconstruction, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. 8212682@qq.com.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Massage and Physical Therapy, Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wrocław, Poland.
Publications dans "Technique d'Ilizarov" :
Ubiquitous to normal female human somatic cells, X-chromosome inactivation (XCI) tightly regulates the transcriptional silencing of a single X chromosome from each pair. Some genes escape XCI, includi...
Ionizing radiation causes chromosome aberrations, which are possible biomarkers to assess space radiation cancer risks. Using the Monte Carlo codes Relativistic Ion Tracks (RITRACKS) and Radiation-Ind...
To explore the prenatal clinical utility of chromosome microarray analysis (CMA) for polyhydramnios and evaluate the short and long-term prognosis of fetuses with polyhydramnios....
A total of 600 singleton pregnancies with persistent polyhydramnios from 2014 to 2020 were retrospectively enrolled in this study. All cases received amniocentesis and were subjected to CMA results. A...
The detection rates of either aneuploidy or pathogenic copy number variants in fetuses with non-isolated polyhydramnios were significantly higher than those with isolated polyhydramnios (5.0...
For low-risk pregnancies, invasive prenatal diagnosis of isolated polyhydramnios might be unnecessary. CMA should be considered for fetuses with structural anomalies. In CMA-negative cases, the progno...
Double haploid (DH) population development is widely used in many crops, including wheat (Triticum aestivum L.), to rapidly produce fixed germplasm for breeding and genetic studies. The genome shock t...
Chromosomal aberrations are the most important etiological factors for birth defects. Optical genome mapping is a novel cytogenetic tool for detecting a broad range of chromosomal aberrations in a sin...
We retrospectively performed optical genome mapping analysis of amniotic fluid samples from 34 fetuses with various clinical indications and chromosomal aberrations detected through standard-of-care t...
In total, we analyzed 46 chromosomal aberrations from 34 amniotic fluid samples, including 5 aneuploidies, 10 large copy number variations, 27 microdeletions/microduplications, 2 translocations, 1 iso...
Our study highlights that optical genome mapping can provide comprehensive and accurate information on chromosomal aberrations in a single test, suggesting that optical genome mapping has the potentia...
The phenotype of the chromosomal aberration 47, XXY exhibits considerable heterogenicity. In addition, epilepsy is extremely uncommon in individuals with this chromosomal disorder. As a result, the cl...
Clinical data and the evolution of epilepsy in a boy diagnosed with chromosomal aberration 47, XXY were collected and analyzed. Furthermore, a systematic literature review was conducted to examine the...
We identified a novel phenotype associated with the chromosomal anomaly 47, XXY in a 2-year-2-month-old boy who presented with self-limited epilepsy with autonomic seizures at onset, followed by devel...
The epilepsy types and syndromes associated with the chromosomal anomaly 47, XXY demonstrated considerable heterogeneity. Among the observed phenotypes, IESS and focal epilepsy, which displayed partia...
Deletions and partial losses of chromosome 7 (chr7) are frequent in acute myeloid leukemia (AML) and are linked to dismal outcome. However, the genomic landscape and prognostic impact of concomitant g...
To discover genetic lesions in adult AML patients with aberrations of chromosome 7 [abn(7)], 60 paired diagnostic/remission samples were investigated by whole-exome sequencing in the exploration cohor...
In the exploration cohort, the most frequently mutated gene was TP53 (33%), followed by epigenetic regulators (DNMT3A, KMT2C, IDH2) and signaling genes (NRAS, PTPN11). Thirty percent of 519 patients h...
This work unraveled formerly underestimated genetic lesions and provides a comprehensive overview of the spectrum of recurrent gene mutations and their clinical relevance in AML with abn(7). KMT2C mut...
Kazakhstan is known as a country with a complex radioecological situation resulting from different sources such as a natural radiation background, extensive activities of the industrial system of the ...
Secondary acute myeloid leukemia (S-AML) patients generally have a poor prognosis, but the chromosomal aberrations of S-AML have been rarely reported. We aimed to explore the chromosomal aberrations a...
The clinical characteristics and karyotypes of 26 patients with S-AML were retrospectively analyzed. The overall survival (OS) was measured from the time of the patients' transition to AML (...
The study included 26 S-AML patients (13 males and 13 females), with a median age of 63 years (range, 20-77 years). They transformed from various hematologic malignancies or solid tumors; most of them...
S-AML patients with abnormal karyotype have higher LDH levels and shorter OS than normal karyotype patients, and the OS of hypodiploidy was much shorter than hyperdiploid....
Merkel cell carcinoma is a rare, aggressive skin tumor initiated by polyomavirus integration or UV light DNA damage. In New Zealand, there is a propensity toward the UV-driven form (31 of 107, 29% vir...