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"description": "Comment diagnostiquer une infection par le VIH ?\nQuels tests pour l'hépatite B ?\nQuels symptômes indiquent une infection par le VIH ?\nComment évaluer la charge virale du VIH ?\nQuels marqueurs pour l'hépatite B chronique ?",
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"description": "Quels sont les facteurs de risque du VIH ?\nQui est à risque d'hépatite B ?\nQuel rôle des antécédents médicaux ?\nComment le statut socio-économique influence-t-il le risque ?\nQuels comportements augmentent le risque d'hépatite B ?",
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"name": "Comment diagnostiquer une infection par le VIH ?",
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"text": "Un test sanguin pour détecter les anticorps anti-VIH ou l'ARN du VIH."
}
},
{
"@type": "Question",
"name": "Quels tests pour l'hépatite B ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Tests sanguins pour détecter les antigènes et anticorps de l'hépatite B."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une infection par le VIH ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Symptômes comme fièvre, fatigue, éruptions cutanées, et ganglions enflés."
}
},
{
"@type": "Question",
"name": "Comment évaluer la charge virale du VIH ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par un test sanguin mesurant la quantité d'ARN viral dans le sang."
}
},
{
"@type": "Question",
"name": "Quels marqueurs pour l'hépatite B chronique ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antigène HBs et ADN du virus de l'hépatite B dans le sang."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes de l'hépatite B ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, jaunisse, douleurs abdominales, et perte d'appétit."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires de la lamivudine ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Nausées, fatigue, maux de tête, et douleurs musculaires."
}
},
{
"@type": "Question",
"name": "Comment se manifeste une infection par le VIH ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infection aiguë avec symptômes grippaux, suivie d'une phase asymptomatique."
}
},
{
"@type": "Question",
"name": "Quels signes d'une résistance à la lamivudine ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Échec du traitement, augmentation de la charge virale malgré la prise de médicaments."
}
},
{
"@type": "Question",
"name": "Quels symptômes d'une hépatite B aiguë ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Symptômes similaires à ceux de la grippe, suivis de jaunisse et douleurs abdominales."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'infection par le VIH ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Utilisation de préservatifs, dépistage régulier et traitement préventif."
}
},
{
"@type": "Question",
"name": "Quelles mesures pour éviter l'hépatite B ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Vaccination, éviter le partage d'aiguilles et pratiques sexuelles protégées."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque de résistance à la lamivudine ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Prendre le médicament régulièrement et suivre les recommandations médicales."
}
},
{
"@type": "Question",
"name": "Quel rôle du dépistage dans la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le dépistage précoce permet de traiter rapidement et de réduire la transmission."
}
},
{
"@type": "Question",
"name": "Comment sensibiliser à l'hépatite B ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éducation sur les modes de transmission et l'importance de la vaccination."
}
},
{
"@type": "Question",
"name": "Comment la lamivudine est-elle administrée ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par voie orale sous forme de comprimés, généralement une fois par jour."
}
},
{
"@type": "Question",
"name": "Quels autres médicaments avec la lamivudine ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Souvent combinée avec d'autres antirétroviraux pour le VIH."
}
},
{
"@type": "Question",
"name": "Quelle est la posologie de la lamivudine ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La dose standard est de 150 mg deux fois par jour ou 300 mg une fois par jour."
}
},
{
"@type": "Question",
"name": "Comment surveiller l'efficacité du traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par des tests réguliers de la charge virale et des tests de fonction hépatique."
}
},
{
"@type": "Question",
"name": "Quels traitements pour l'hépatite B ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antiviraux comme la lamivudine, l'entécavir ou l'interféron."
}
},
{
"@type": "Question",
"name": "Quelles complications de l'hépatite B chronique ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cirrhose, cancer du foie et insuffisance hépatique."
}
},
{
"@type": "Question",
"name": "Quels risques d'une résistance à la lamivudine ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Échec du traitement et progression de l'infection par le VIH ou l'hépatite B."
}
},
{
"@type": "Question",
"name": "Comment la lamivudine affecte-t-elle le foie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Peut entraîner des anomalies des tests hépatiques, nécessitant une surveillance."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications du VIH avancé ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections opportunistes, cancers et défaillance multi-organes."
}
},
{
"@type": "Question",
"name": "Quels effets à long terme de la lamivudine ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Peut entraîner des effets secondaires chroniques, comme des problèmes hépatiques."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque du VIH ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Relations sexuelles non protégées, partage de seringues et antécédents d'infections."
}
},
{
"@type": "Question",
"name": "Qui est à risque d'hépatite B ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Personnes non vaccinées, utilisateurs de drogues injectables et partenaires sexuels multiples."
}
},
{
"@type": "Question",
"name": "Quel rôle des antécédents médicaux ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antécédents d'infections ou de traitements peuvent augmenter le risque d'infection."
}
},
{
"@type": "Question",
"name": "Comment le statut socio-économique influence-t-il le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un statut socio-économique faible peut limiter l'accès aux soins et à la prévention."
}
},
{
"@type": "Question",
"name": "Quels comportements augmentent le risque d'hépatite B ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Partage d'aiguilles, relations sexuelles non protégées et manque de vaccination."
}
}
]
}
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The use of DTG-containing two-drug regimens is one of the most promising solutions to the need to ease the management of HIV treatment without harming its efficacy and safety. We report long- term res...
This is a prospective, clinical, uncontrolled cohort enrolling ART-experienced people living with HIV (PLWH) with HIV-RNA < 50 copies/ml for 6 months or longer, negative hepatitis B virus surface anti...
218 individuals switched their regimen since 2015. The mean estimated follow-up was of 64.3 months (95% CI 61.3-67.3) for approximately 1000 patient/years. After 5 years of follow-up, 77.1% were still...
These long-term results over 5 years reinforce the durability and good tolerability of DTG-3TC. Our results continue to support the recommended switch use of this 2DR as a well-accepted treatment opti...
With longer life expectancy in people living with HIV (PLWH) on antiretroviral therapy, cardiovascular disease (CVD) has become a common cause of mortality among them. Abacavir has been associated wit...
Randomised, controlled, superiority trial of virologically suppressed PLWH on dolutegravir, abacavir and lamivudine (DTG/ABC/3TC) for ≥6 months. In total, 70 PLWH will be randomised 1:2 to either cont...
Result from this study will lead to a better understanding of the association between antiretroviral therapy and the impact on weight and risk of CVD. Findings will be useful for both clinicians and P...
Pre-results registration at ClinicalTrials.gov Identifier: NCT04904406, registered 27 May 2021....
Protocol version 9.0, 4 April 2023, approved 10-05-2023 by Ethics Committee of the Capital Region, Denmark (H-20011433). Danish Medicines Agency (EudraCT no. 2019-004999-19). Regional Data Protection ...
In Argentina, transgender women (TGW) have a high HIV prevalence (34%). However, this population shows lower levels of adherence, retention in HIV care and viral suppression than cisgender patients. T...
Since 2019, for the first time, a two-drug regimen with dolutegravir/lamivudine (DTG/3TC) has been recommended for HIV treatment as initial and subsequent therapy in the international guidelines. Howe...
Post-marketing surveillance was conducted to evaluate the real-world safety and effectiveness of DTG/3TC in Japanese PLHIV. One hundred ninety-seven patients who received oral DTG 50 mg/3TC 300 mg as ...
This is a 2-year (from 2020 to 2022) report of approximately 6 years of survey, and 187 patients were registered from 21 Japanese sites. The number of antiretroviral therapy (ART)-experienced patients...
No new clinical concerns of safety and effectiveness were identified in Japanese ART-experienced PLHIV treated with DTG/3TC. We could not discuss the safety and effectiveness in ART-naïve patients bec...
Dolutegravir plus lamivudine (2-DR) is suggested as an initial and switch option in HIV-1 treatment. The aim of this study was to analyze the effectiveness, durability, and safety of 2-DR compared to ...
This was an observational, ambispective study that included all treatment-naïve (TN) and treatment-experienced (TE) people living with HIV/AIDS (PLWH), who started 2-DR or 3-DR between 01 July 2018, a...
292 PLWH were included (39 TN and 253 TE). In TN PLWH, non-inferiority was not achieved at 24 weeks (17; 95% CI -17 to 51 p = 0.348). By week 48, all PLWH on 3-DR maintained VL<50 copies/mL compared t...
Our results did not show non-inferiority in terms of virological effectiveness. Additionally, durability and safety of 2-DR were confirmed to be similar to 3-DR....
The World Health Organization (WHO) recommends that HIV treatment scale-up is accompanied by a robust assessment of drug resistance emergence and transmission. The WHO HIV Drug Resistance (HIVDR) moni...
We carried out a cross-sectional study between March 2017 and December 2019. Adults (older than 15 years) living with HIV (PLHIV) initiating ART or receiving first-line ART for between 9-15 months at ...
Of 828 participants -enrolled, viral load (VL) testing was performed on 408 initiators and 409 ART experienced. Unsuppressed VL was found in 68.1% 419 initiators and 18.8% (77/409) of the ART experien...
High rates of PDR and ADR for NNRTI and ADR for NRTI were observed in our study. These findings support the replacement of NNRTIs with dolutegravir (DTG) but high levels of NRTI resistance in highly t...
HIV post- exposure prophylaxis (PEP) is a prevention tool for individuals with a recent potential exposure to HIV. Doravirine has been available since 2019 in combination with tenofovir disoproxil fum...
It is not clear if there is a difference between three-drug regimens (3DR) and two-drug regimens (2DR) in terms of suppression of chronic inflammation. We compared C-reactive protein (CRP), CD4...
Dolutegravir (DTG) +lamivudine (3TC) combination has been found to be as effective as triple therapies, and has been extensively prescribed in clinical practice as a maintenance therapy. We aimed to i...
The analysis included data of people living with HIV (PLWH) with HIV-RNA ≤50 copies/mL enrolled in an Italian retrospective multicohort study who were switching to DTG+3TC. Primary endpoint was viral ...
A total of 966 PLWH were included; 20.1% had a history of previous VF. VR was detected in 23 PLWH. The one-year probability was 1.2% (95% confidence interval [CI], 0.2%-2.2%) in PLWH without previous ...
Despite the low absolute one-year risk in both groups, real-world data confirmed that PLWH with a previous failure have an increased risk of viral rebound....
Fixed-dose combination of dolutegravir (DTG) with tenofovir disoproxil fumarate (TDF) and lamivudine (3TC) likely improves adherence and has a favorable resistance profile. We evaluated predicted effi...
Drug resistance mutations were analyzed in a retrospective dataset of individuals <19 years of age, failing ABC (n = 293) AZT (n = 288) or TDF (n = 69) based treatment. Pol sequences were submitted to...
Genotypes were assessed for 650 individuals with a median age of 14 years (IQR 10-17 years). More individuals failed a protease inhibitor (PI)-based (78.3%) than a non-nucleoside reverse transcriptase...
Cross-resistance to TDF was limited, further reducing concerns about use of transition to TLD in children and adolescents. The NADIA trial has subsequently shown that patients failing a TDF/3TC/EFV re...