Titre : Anticorps anti-cytoplasme des polynucléaires neutrophiles

Anticorps anti-cytoplasme des polynucléaires neutrophiles : Questions médicales fréquentes

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?\nQuel rôle joue l'historique médical dans le diagnostic ?\nLes ANCA peuvent-ils être détectés chez des personnes saines ?", "url": "https://questionsmedicales.fr/mesh/D019268?page=4#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Anticorps anti-cytoplasme des polynucléaires neutrophiles", "description": "Quels sont les symptômes associés aux ANCA ?\nLes ANCA provoquent-ils des symptômes respiratoires ?\nY a-t-il des symptômes cutanés liés aux ANCA ?\nLes ANCA affectent-ils les reins ?\nLes symptômes des ANCA sont-ils similaires à d'autres maladies ?", "url": "https://questionsmedicales.fr/mesh/D019268?page=4#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Anticorps anti-cytoplasme des polynucléaires neutrophiles", "description": "Peut-on prévenir les maladies liées aux ANCA ?\nLes vaccinations sont-elles recommandées pour les patients ANCA ?\nComment réduire le risque de complications ?\nL'évitement de certains médicaments est-il conseillé ?\nLe stress influence-t-il les maladies ANCA ?", "url": "https://questionsmedicales.fr/mesh/D019268?page=4#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Anticorps anti-cytoplasme des polynucléaires neutrophiles", "description": "Quels traitements sont utilisés pour les ANCA ?\nLes traitements sont-ils personnalisés pour chaque patient ?\nLes ANCA nécessitent-ils un suivi régulier ?\nY a-t-il des effets secondaires aux traitements ?\nLes traitements peuvent-ils guérir les ANCA ?", "url": "https://questionsmedicales.fr/mesh/D019268?page=4#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Anticorps anti-cytoplasme des polynucléaires neutrophiles", "description": "Quelles sont les complications possibles des ANCA ?\nLes ANCA peuvent-ils entraîner des infections ?\nY a-t-il un risque de cancer associé aux ANCA ?\nLes complications sont-elles réversibles ?\nComment surveiller les complications des ANCA ?", "url": "https://questionsmedicales.fr/mesh/D019268?page=4#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Anticorps anti-cytoplasme des polynucléaires neutrophiles", "description": "Quels sont les facteurs de risque des ANCA ?\nLe sexe influence-t-il le risque d'ANCA ?\nL'âge joue-t-il un rôle dans le développement des ANCA ?\nCertaines professions augmentent-elles le risque d'ANCA ?\nLes infections antérieures sont-elles un facteur de risque ?", "url": "https://questionsmedicales.fr/mesh/D019268?page=4#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer la présence d'ANCA ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un test sanguin spécifique détecte les ANCA dans le sérum du patient." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour les ANCA ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests ELISA et indirect immunofluorescence sont couramment utilisés." } }, { "@type": "Question", "name": "Les ANCA sont-ils toujours présents dans les maladies ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Non, leur présence varie selon la maladie et le stade de l'inflammation." } }, { "@type": "Question", "name": "Quel rôle joue l'historique médical dans le diagnostic ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "L'historique aide à identifier les symptômes et les antécédents de maladies auto-immunes." } }, { "@type": "Question", "name": "Les ANCA peuvent-ils être détectés chez des personnes saines ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des ANCA peuvent être présents à faible niveau chez des individus sains." } }, { "@type": "Question", "name": "Quels sont les symptômes associés aux ANCA ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, fièvre, perte de poids et douleurs articulaires." } }, { "@type": "Question", "name": "Les ANCA provoquent-ils des symptômes respiratoires ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent causer des symptômes respiratoires comme la toux et l'essoufflement." } }, { "@type": "Question", "name": "Y a-t-il des symptômes cutanés liés aux ANCA ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des éruptions cutanées et des lésions peuvent apparaître chez certains patients." } }, { "@type": "Question", "name": "Les ANCA affectent-ils les reins ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent entraîner des atteintes rénales, comme la glomérulonéphrite." } }, { "@type": "Question", "name": "Les symptômes des ANCA sont-ils similaires à d'autres maladies ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent être confondus avec d'autres maladies auto-immunes ou inflammatoires." } }, { "@type": "Question", "name": "Peut-on prévenir les maladies liées aux ANCA ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de méthode de prévention spécifique, mais un mode de vie sain aide." } }, { "@type": "Question", "name": "Les vaccinations sont-elles recommandées pour les patients ANCA ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les vaccinations peuvent être recommandées pour prévenir les infections." } }, { "@type": "Question", "name": "Comment réduire le risque de complications ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi médical régulier et une gestion proactive des symptômes sont essentiels." } }, { "@type": "Question", "name": "L'évitement de certains médicaments est-il conseillé ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments peuvent aggraver les symptômes et doivent être évités." } }, { "@type": "Question", "name": "Le stress influence-t-il les maladies ANCA ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress peut aggraver les symptômes et doit être géré efficacement." } }, { "@type": "Question", "name": "Quels traitements sont utilisés pour les ANCA ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les corticostéroïdes et les immunosuppresseurs sont souvent prescrits." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés pour chaque patient ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le traitement est adapté en fonction de la gravité et des symptômes du patient." } }, { "@type": "Question", "name": "Les ANCA nécessitent-ils un suivi régulier ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi régulier est essentiel pour ajuster le traitement et surveiller l'évolution." } }, { "@type": "Question", "name": "Y a-t-il des effets secondaires aux traitements ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent avoir des effets secondaires comme l'infection ou l'ostéoporose." } }, { "@type": "Question", "name": "Les traitements peuvent-ils guérir les ANCA ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de cure, mais les traitements peuvent contrôler les symptômes et la progression." } }, { "@type": "Question", "name": "Quelles sont les complications possibles des ANCA ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des atteintes rénales, pulmonaires et cardiovasculaires." } }, { "@type": "Question", "name": "Les ANCA peuvent-ils entraîner des infections ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements immunosuppresseurs augmentent le risque d'infections." } }, { "@type": "Question", "name": "Y a-t-il un risque de cancer associé aux ANCA ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Certaines études suggèrent un risque accru de certains cancers chez les patients ANCA." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié." } }, { "@type": "Question", "name": "Comment surveiller les complications des ANCA ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Des examens réguliers et des tests sanguins aident à surveiller les complications." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque des ANCA ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents familiaux, le tabagisme et certaines infections." } }, { "@type": "Question", "name": "Le sexe influence-t-il le risque d'ANCA ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les femmes sont plus souvent touchées par les maladies associées aux ANCA." } }, { "@type": "Question", "name": "L'âge joue-t-il un rôle dans le développement des ANCA ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les ANCA apparaissent généralement chez les adultes jeunes à moyens d'âge." } }, { "@type": "Question", "name": "Certaines professions augmentent-elles le risque d'ANCA ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les professions exposant à des produits chimiques peuvent augmenter le risque." } }, { "@type": "Question", "name": "Les infections antérieures sont-elles un facteur de risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines infections peuvent déclencher la production d'ANCA chez des individus prédisposés." } } ] } ] }

Sources (10000 au total)

Serum antineutrophil cytoplasmic antibody positivity at the time of renal biopsy is associated with disease activity of lupus nephritis.

To investigate the correlations between serum antineutrophil cytoplasmic antibody (ANCA) and clinicopathological features, induction treatment response, and prognosis of lupus nephritis (LN) patients.... In this retrospective study, biopsy-proven LN patients from October 2010 to September 2020 were tested for serum ANCA by indirect immunofluorescence and ELISA and were divided into ANCA-positive group... Thirty-five of 115 patients (30.43%) were seropositive for ANCA. ANCA-positive patients had significantly higher systemic lupus erythematosus activity index and activity index scores, higher 24-h urin... LN patients with ANCA seropositivity at renal biopsy have a significantly higher disease activity, and their pathological manifestations are predominantly proliferative LN. These patients require a mo...

Influence of smoking on disease activity and prognosis of antineutrophil cytoplasmic antibody-associated vasculitis: a retrospective cohort study.

Antineutrophil cytoplasmic antibody-associated vasculitides (AAV) are a group of autoimmune diseases characterized by inflammation of small blood vessels. Smoking is a potential trigger for such disea... The aim of this study was to analyze the link between AAV and smoking based on clinical characteristics, disease activity, and mortality.... This retrospective study included 223 AAV patients. Their smoking status was assessed at diagnosis and they were classified as ever smokers (ESs), including current or past smokers, and never smokers ... The ESs had similar organ involvement to the NSs, except for significantly greater frequency of renal replacement therapy (31% vs 14%; P = 0.003). Median (interquartile range [IQR]) time from symptom ... Ever smoking is associated with increased AAV activity and more frequent renal replacement therapy and immunosuppressive treatment, resulting in a poorer survival prognosis in AAV patients. Future mul...

Autoreactive Plasmablasts After B Cell Depletion With Rituximab and Relapses in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Autoreactive B cells are responsible for antineutrophil cytoplasmic antibody (ANCA) production in ANCA-associated vasculitis (AAV). Rituximab (RTX) depletes circulating B cells, including autoreactive... Sequential flow cytometry was performed on 148 samples of peripheral blood mononuclear cells from 23 patients with proteinase 3 (PR3)-ANCA-positive AAV who were treated with RTX for remission inductio... At B cell recurrence, PR3+ B cell frequency among B cells was higher than baseline (P < 0.01). Within both PR3+ and total B cells, frequencies of transitional and naive subsets were higher at B cell r... The composition of the autoreactive B cell pool varies significantly following RTX treatment in AAV, and early plasmablast enrichment within the autoreactive pool is associated with future relapses....

Clinical impact of antineutrophil cytoplasmic antibody positivity on the occurrence of interstitial lung disease in patients with polymyositis/dermatomyositis.

This study investigated the clinical impact of antineutrophil cytoplasmic antibody (ANCA) positivity on the occurrence of interstitial lung disease (ILD) in patients with probable and definite polymyo... The medical records of 75 PM/DM patients were retrospectively reviewed. ANCA and anti-Jo 1 positivity at diagnosis were obtained, and pulmonary function test and chest high-resolution computed tomogra... The median age was 50.0 years and 21.3% were male. ANCA and anti-Jo 1 were detected in 12 (16.0%) and 26 patients (34.7%), respectively. ILD occurred in 32 patients, 24 of whom had ILD at the time of ... ANCA positivity at the time of PM/DM diagnosis might be an important risk factor for ILD in PM/DM patients....

Acute exacerbation in antineutrophil cytoplasmic antibody-associated interstitial lung disease: Clinical features and risk factors.

Acute exacerbation (AE) is a life-threatening clinical event that occurs during the clinical course of idiopathic pulmonary fibrosis (IPF). Several studies have reported that AE also occurs in interst... We retrospectively reviewed the data of 54 ANCA-ILD patients and 304 IPF patients. We investigated the frequency of AE, post-AE prognoses, risk factors for AE, and major causes of death in ANCA-ILD pa... Fourteen (25.9%) ANCA-ILD patients and 84 (27.6%) IPF patients developed AE. The median survival times (MSTs) after AE in ANCA-ILD and IPF patients were 35.5 and 60 days, respectively (p = 0.588, log-... ANCA-ILD patients could develop AE, and the frequency of AE in ANCA-ILD is similar to that in IPF. AE is the most frequent cause of death in ANCA-ILD patients. A low %FVC and a high serum CRP level we...

Bronchiectasis in patients with antineutrophil cytoplasmic antibody-associated vasculitis: a case control study on clinical features and prognosis.

Bronchiectasis was reported in 2%-40% of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), but there were no studies on the prevalence, risk factors and impact of AAV-asso... AAV patients were retrospectively enrolled. The clinical, laboratory and imaging features and the prognosis were analyzed and compared between those with and without bronchiectasis.... Bronchiectasis was present in 48/212 (22.6%) of our AAV patients, among whom 41 were confirmed in 210 patients (19.5%) who received chest HRCT at the initial diagnosis of AAV. There were more women an... Nearly 20% of patients showed bronchiectasis on chest HRCT at the initial diagnosis of AAV, and positivity of anti-MPO was associated with bronchiectasis in a Chinese cohort of AAV patients....

Pulmonary and Intestinal Involvement in a Patient with Myeloperoxidase-specific Antineutrophil Cytoplasmic Antibody-positive Hermansky-Pudlak Syndrome.

A 26-year-old Japanese woman was admitted with a 1-month history of diarrhea, a high fever for a few days, and exacerbation of dyspnea. She was treated with an antifibrotic drug and long-term oxygen t...

Clinicopathologic features in childhood-onset lupus nephritis with antineutrophil cytoplasmic antibody positivity--a multi-center retrospective study.

Positive antineutrophil cytoplasmic antibody (ANCA) serology in adult-onset lupus nephritis (LN) is associated with more active disease and distinct renal pathology, but data with respect to childhood... Clinical and histopathologic data of 61 ANCA-positive and 330 ANCA-negative LN children (1<age≤18 years) retrospectively enrolled from three pediatric nephrology centers were analyzed. Among them, 217... Among 61 ANCA-positive LN children, 86.9% of them had antimyeloperoxidase antibodies. Both ANCA-positive and ANCA-negative children had high disease activities with median SLEDAI-2K of 16 (13, 20). He... Positive ANCA serology in LN children was associated with different clinical and histopathologic features compared to those with negative ANCA serology. Further studies are needed to clarify the patho...

Predicting the depressive status using empirical dietary inflammatory index in patients with antineutrophil cytoplasmic antibody-associated vasculitis.

This study investigated whether the empirical dietary inflammatory index (eDII) score is associated with the inflammatory burden as well as the depressive status in patients with antineutrophil cytopl... Eighty-four patients with AAV participated in this study. Birmingham vasculitis activity score (BVAS) and short-form 36-item Health Survey mental component summary (SF-36 MCS) were considered as indic... The median age was 64.5 years (36 men). The eDII scores inversely correlated with SF-36 MCS (r = -0.298, p = 0.006) but not with BVAS. SF-36 MCS significantly differ between the lower and higher eDII ... We demonstrated for the first time that the eDII could predict the depressive status by estimating SF-36 MCS without utilising K-CESD-R ≥ 16 in patients with AAV....