Titre : Inhibiteur tissulaire de métalloprotéinase-1

Inhibiteur tissulaire de métalloprotéinase-1 : Questions médicales fréquentes

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tissulaire de métalloprotéinase-1 - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Inhibiteur tissulaire de métalloprotéinase-1", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-01", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Inhibiteur tissulaire de métalloprotéinase-1", "description": "Comment diagnostiquer une anomalie de TIMP-1 ?\nQuels symptômes indiquent un déséquilibre de TIMP-1 ?\nY a-t-il des biomarqueurs associés à TIMP-1 ?\nQuel rôle joue TIMP-1 dans le cancer ?\nComment TIMP-1 est-il mesuré en clinique ?", "url": "https://questionsmedicales.fr/mesh/D019715?page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Inhibiteur tissulaire de métalloprotéinase-1", "description": "Quels symptômes sont liés à une surproduction de TIMP-1 ?\nTIMP-1 affecte-t-il la cicatrisation des plaies ?\nQuels signes indiquent une carence en TIMP-1 ?\nY a-t-il des symptômes associés à des maladies inflammatoires ?\nComment TIMP-1 influence-t-il l'inflammation ?", "url": "https://questionsmedicales.fr/mesh/D019715?page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Inhibiteur tissulaire de métalloprotéinase-1", "description": "Peut-on prévenir les déséquilibres de TIMP-1 ?\nQuels facteurs de mode de vie influencent TIMP-1 ?\nY a-t-il des recommandations pour maintenir TIMP-1 ?\nLes suppléments peuvent-ils aider TIMP-1 ?\nComment le suivi médical aide-t-il TIMP-1 ?", "url": "https://questionsmedicales.fr/mesh/D019715?page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Inhibiteur tissulaire de métalloprotéinase-1", "description": "Quels traitements ciblent TIMP-1 ?\nTIMP-1 peut-il être utilisé comme cible thérapeutique ?\nQuels médicaments influencent TIMP-1 ?\nY a-t-il des essais cliniques sur TIMP-1 ?\nComment les traitements affectent-ils TIMP-1 ?", "url": "https://questionsmedicales.fr/mesh/D019715?page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Inhibiteur tissulaire de métalloprotéinase-1", "description": "Quelles complications peuvent survenir avec un excès de TIMP-1 ?\nTIMP-1 est-il lié à des maladies chroniques ?\nComment TIMP-1 affecte-t-il la santé cardiovasculaire ?\nY a-t-il des risques de cancer liés à TIMP-1 ?\nQuels effets secondaires peuvent résulter d'un traitement de TIMP-1 ?", "url": "https://questionsmedicales.fr/mesh/D019715?page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Inhibiteur tissulaire de métalloprotéinase-1", "description": "Quels facteurs augmentent le risque de déséquilibre de TIMP-1 ?\nLes maladies auto-immunes influencent-elles TIMP-1 ?\nLe stress a-t-il un impact sur TIMP-1 ?\nL'alimentation joue-t-elle un rôle dans TIMP-1 ?\nY a-t-il un lien entre TIMP-1 et l'inactivité physique ?", "url": "https://questionsmedicales.fr/mesh/D019715?page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une anomalie de TIMP-1 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests sanguins mesurant les niveaux de TIMP-1 peuvent être effectués." } }, { "@type": "Question", "name": "Quels symptômes indiquent un déséquilibre de TIMP-1 ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme l'inflammation ou des troubles de cicatrisation peuvent survenir." } }, { "@type": "Question", "name": "Y a-t-il des biomarqueurs associés à TIMP-1 ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des biomarqueurs comme le collagène et les métalloprotéinases sont souvent étudiés." } }, { "@type": "Question", "name": "Quel rôle joue TIMP-1 dans le cancer ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "TIMP-1 peut inhiber la progression tumorale en régulant la dégradation de la matrice." } }, { "@type": "Question", "name": "Comment TIMP-1 est-il mesuré en clinique ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Il est mesuré par des tests immunologiques spécifiques dans des échantillons de sang." } }, { "@type": "Question", "name": "Quels symptômes sont liés à une surproduction de TIMP-1 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Une surproduction peut entraîner des douleurs articulaires et une fibrose tissulaire." } }, { "@type": "Question", "name": "TIMP-1 affecte-t-il la cicatrisation des plaies ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un excès de TIMP-1 peut ralentir la cicatrisation des plaies." } }, { "@type": "Question", "name": "Quels signes indiquent une carence en TIMP-1 ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Une carence peut se manifester par une dégradation excessive de la matrice extracellulaire." } }, { "@type": "Question", "name": "Y a-t-il des symptômes associés à des maladies inflammatoires ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme l'arthrite peuvent être liées à des niveaux anormaux de TIMP-1." } }, { "@type": "Question", "name": "Comment TIMP-1 influence-t-il l'inflammation ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "TIMP-1 peut moduler l'inflammation en régulant les métalloprotéinases impliquées." } }, { "@type": "Question", "name": "Peut-on prévenir les déséquilibres de TIMP-1 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir l'équilibre." } }, { "@type": "Question", "name": "Quels facteurs de mode de vie influencent TIMP-1 ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Le tabagisme et l'obésité peuvent affecter les niveaux de TIMP-1." } }, { "@type": "Question", "name": "Y a-t-il des recommandations pour maintenir TIMP-1 ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Pratiquer une activité physique régulière et gérer le stress sont recommandés." } }, { "@type": "Question", "name": "Les suppléments peuvent-ils aider TIMP-1 ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Certains suppléments antioxydants peuvent soutenir la régulation de TIMP-1." } }, { "@type": "Question", "name": "Comment le suivi médical aide-t-il TIMP-1 ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi régulier permet de détecter et de corriger les déséquilibres de TIMP-1." } }, { "@type": "Question", "name": "Quels traitements ciblent TIMP-1 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies géniques et des inhibiteurs spécifiques sont en cours d'étude." } }, { "@type": "Question", "name": "TIMP-1 peut-il être utilisé comme cible thérapeutique ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en régulant TIMP-1, on peut potentiellement traiter certaines pathologies." } }, { "@type": "Question", "name": "Quels médicaments influencent TIMP-1 ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Certains anti-inflammatoires peuvent moduler l'expression de TIMP-1." } }, { "@type": "Question", "name": "Y a-t-il des essais cliniques sur TIMP-1 ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, plusieurs essais cliniques explorent son rôle dans diverses maladies." } }, { "@type": "Question", "name": "Comment les traitements affectent-ils TIMP-1 ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements peuvent soit augmenter, soit diminuer les niveaux de TIMP-1 selon le contexte." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec un excès de TIMP-1 ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Un excès peut entraîner des maladies fibrosantes et des troubles cardiovasculaires." } }, { "@type": "Question", "name": "TIMP-1 est-il lié à des maladies chroniques ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des niveaux anormaux de TIMP-1 sont associés à des maladies chroniques comme le diabète." } }, { "@type": "Question", "name": "Comment TIMP-1 affecte-t-il la santé cardiovasculaire ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Des niveaux élevés de TIMP-1 peuvent contribuer à l'athérosclérose." } }, { "@type": "Question", "name": "Y a-t-il des risques de cancer liés à TIMP-1 ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Des niveaux élevés de TIMP-1 peuvent être associés à une progression tumorale." } }, { "@type": "Question", "name": "Quels effets secondaires peuvent résulter d'un traitement de TIMP-1 ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements peuvent entraîner des effets secondaires comme des réactions allergiques." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque de déséquilibre de TIMP-1 ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'âge avancé, le tabagisme et l'obésité sont des facteurs de risque connus." } }, { "@type": "Question", "name": "Les maladies auto-immunes influencent-elles TIMP-1 ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les maladies auto-immunes peuvent perturber l'équilibre de TIMP-1." } }, { "@type": "Question", "name": "Le stress a-t-il un impact sur TIMP-1 ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter les niveaux de TIMP-1 dans l'organisme." } }, { "@type": "Question", "name": "L'alimentation joue-t-elle un rôle dans TIMP-1 ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation riche en graisses saturées peut perturber les niveaux de TIMP-1." } }, { "@type": "Question", "name": "Y a-t-il un lien entre TIMP-1 et l'inactivité physique ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'inactivité physique peut contribuer à des déséquilibres de TIMP-1." } } ] } ] }

Sources (10000 au total)

Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy.

To evaluate the potential of cerebrospinal fluid (CSF) levels of matrix metalloproteinases and tissue-type inhibitors (MMP; TIMP), and ratios of MMPs to TIMPs, to function as biomarkers for sporadic o... CSF concentrations of the matrix metalloproteinases MMP-2, MMP-9 and MMP-14, as well as the tissue inhibitors of metalloproteinases TIMP-1, TIMP-2 and TIMP-3, were determined using immunoassays. These... In the sCAA/control cohorts, inconsistent differences were found for individual MMPs and TIMPs, but MMP-2/TIMP-2 (discovery/validation: p = 0.004; p = 0.02) and MMP-14/TIMP-2 ratios (discovery/validat... CSF MMP-2/TIMP-2 and MMP-14/TIMP-2 were consistently decreased in sCAA, compared to controls. Additionally, MMP-14/TIMP-2 levels were also decreased in symptomatic D-CAA, compared to both pre-symptoma...

Ex Vivo Analysis of an Association of Mechanical Strength of Dilated Ascending Aorta with Tissue Matrix Metalloproteinases and Cytokines.

We analyzed the associations of the mechanical strength of dilated ascending aorta wall (intraoperative samples from 30 patients with non-syndromic aneurysms) with tissue MMPs and the cytokine system....

Effects of Surgery Combined with Different Chemotherapy on Matrix Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinase-1 in Children with Neuroblastoma.

Neuroblastoma (NB) is a common extracranial malignancy in children and accounts for 15% of all cancer-related deaths in children, with the 5-year survival of patients in an advanced stage being lower ... To analyze the efficacy of surgery plus different chemotherapy on children with NB and to investigate the correlation of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-1... From April 2005 to May 2017, a total of 92 cases of NB treated in our hospital were assessed for eligibility and recruited. They were assigned at a ratio of 1: 1 to receive either CAV (cyclophosphamid... The two groups had similar efficacy (84.00% vs. 95.24%) and surgical resection rates (60.00% vs. 61.90%) after the initial chemotherapy (... Surgery plus chemotherapy for children with NB yields a promising clinical efficacy and a favorable surgical resection outcome. MMP-9 and TIMP-1 may be the potential biological indicators for chemothe...

Tissue Inhibitor of Metalloproteinase-1 Enhances Eosinophilic Airway Inflammation in Severe Asthma.

Severe asthma (SA) is characterized by persistent airway inflammation and remodeling, followed by lung function decline. The present study aimed to evaluate the role of tissue inhibitor of metalloprot... We enrolled 250 adult asthmatics (54 with SA and 196 with non-SA) and 140 healthy controls (HCs). Serum TIMP-1 levels were determined by enzyme-linked immunosorbent assay. The release of TIMP-1 from a... Significantly higher levels of serum TIMP-1 were noted in asthmatics than in HCs, in the SA group than in non-SA group, and in the type 2 SA group than in non-type 2 SA group (... These findings suggest that TIMP-1 enhances eosinophilic airway inflammation and that serum TIMP-1 may be a potential biomarker and/or therapeutic target for type 2 SA....

Circulating tissue inhibitor of metalloproteinases 1 (TIMP-1) at COVID-19 onset predicts severity status.

Systemic biomarkers for severity of SARS-CoV-2 infection are of great interest. In this study, we evaluated a set of collagen metabolites and extracellular matrix remodeling biomarkers including proco... Ninety COVID-19 patients with the absence of chronic liver diseases were enrolled. Serum PIIINP, TIMP-1, and HA were measured and correlated with inflammatory indices and clinical variables. Patients ... Serum TIMP-1, but not PIIINP and HA was significantly higher in patients with WHO score ≥5 compared to patients with WHO score <5 [PIIINP: 7.2 (5.4-9.5) vs. 7.1 (4.5-9.9),... In patients with COVID-19, circulating TIMP-1 was associated with disease severity and with systemic inflammatory index, suggesting that TIMP-1 could represent a promising non-invasive prognostic biom...