Oui, les corticostéroïdes sont souvent prescrits pour réduire l'inflammation lors des poussées.
CorticostéroïdesInflammation
#3
Y a-t-il des traitements non médicamenteux ?
Oui, la rééducation physique et les thérapies complémentaires peuvent aider à gérer les symptômes.
Rééducation physiqueThérapies complémentaires
#4
Les traitements peuvent-ils arrêter la progression de la maladie ?
Certains traitements peuvent ralentir la progression, mais aucun ne guérit la maladie.
Progression de la maladieTraitements
#5
Comment les patients gèrent-ils les symptômes ?
Les patients utilisent souvent des stratégies de gestion du stress et des exercices adaptés.
Gestion du stressExercices adaptés
Complications
5
#1
Quelles sont les complications possibles de la maladie ?
Les complications incluent des infections, des problèmes de mobilité et des troubles psychologiques.
InfectionsTroubles psychologiques
#2
La sclérose en plaques peut-elle entraîner des handicaps ?
Oui, elle peut entraîner des handicaps physiques et cognitifs, affectant la vie quotidienne.
Handicaps physiquesVie quotidienne
#3
Les troubles urinaires sont-ils fréquents ?
Oui, de nombreux patients souffrent de troubles urinaires, affectant leur qualité de vie.
Troubles urinairesQualité de vie
#4
Comment la maladie affecte-t-elle la santé mentale ?
Elle peut entraîner des dépressions et de l'anxiété, nécessitant un suivi psychologique.
DépressionAnxiété
#5
Les complications peuvent-elles être gérées ?
Oui, un suivi médical régulier et des thérapies adaptées peuvent aider à gérer les complications.
Suivi médicalThérapies adaptées
Facteurs de risque
5
#1
Quels sont les principaux facteurs de risque ?
Les facteurs incluent l'âge, le sexe féminin, des antécédents familiaux et le tabagisme.
ÂgeAntécédents familiaux
#2
Le climat influence-t-il le risque de sclérose en plaques ?
Oui, les régions éloignées de l'équateur présentent un risque plus élevé de la maladie.
ClimatRisque
#3
Les infections virales sont-elles un facteur de risque ?
Certaines infections virales, comme le virus Epstein-Barr, sont associées à un risque accru.
Infections viralesVirus Epstein-Barr
#4
Le sexe joue-t-il un rôle dans le risque ?
Oui, les femmes sont plus susceptibles de développer la maladie que les hommes.
Sexe fémininRisque
#5
L'origine ethnique influence-t-elle le risque ?
Oui, certaines origines ethniques, comme les Caucasiens, présentent un risque plus élevé.
Origine ethniqueRisque
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"text": "Le diagnostic repose sur l'examen neurologique, l'IRM et les tests de liquide céphalorachidien."
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
"name": "Quels sont les symptômes courants de la sclérose en plaques ?",
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"@type": "Question",
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"position": 8,
"acceptedAnswer": {
"@type": "Answer",
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"@type": "Question",
"name": "Les symptômes varient-ils d'une personne à l'autre ?",
"position": 9,
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"@type": "Answer",
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"name": "Le tabagisme influence-t-il le risque ?",
"position": 12,
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"@type": "Answer",
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"@type": "Question",
"name": "L'exposition au soleil a-t-elle un impact ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
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"@type": "Question",
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"position": 26,
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"name": "Le climat influence-t-il le risque de sclérose en plaques ?",
"position": 27,
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"@type": "Answer",
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}
},
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"@type": "Question",
"name": "Les infections virales sont-elles un facteur de risque ?",
"position": 28,
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"@type": "Answer",
"text": "Certaines infections virales, comme le virus Epstein-Barr, sont associées à un risque accru."
}
},
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"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque ?",
"position": 29,
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"@type": "Answer",
"text": "Oui, les femmes sont plus susceptibles de développer la maladie que les hommes."
}
},
{
"@type": "Question",
"name": "L'origine ethnique influence-t-elle le risque ?",
"position": 30,
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"@type": "Answer",
"text": "Oui, certaines origines ethniques, comme les Caucasiens, présentent un risque plus élevé."
}
}
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}
]
}
Departments of Medicine, Biomedicine, and Clinical Research, Neurologic Clinic and Policlinic, University Hospital and University of Basel, Basel, Switzerland.
Publications dans "Sclérose en plaques récurrente-rémittente" :
Neuroimmunology Group, Department of Medicine, University of Lleida-IRBLleida, Lleida, Spain Department of Neurology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
Publications dans "Sclérose en plaques récurrente-rémittente" :
Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurology, The University Hospital Brno, Czech Republic. Electronic address: jan.kolcava1@gmail.com.
Publications dans "Sclérose en plaques récurrente-rémittente" :
Clinical relapses are the defining feature of relapsing forms of multiple sclerosis (MS), but relatively little is known about the time course of relapse recovery....
The aim of this study was to investigate the time course of and patient factors associated with the speed and success of relapse recovery in people with relapsing-remitting MS (RRMS)....
Using data from CombiRx, a large RRMS trial (clinicaltrials.gov identifier NCT00211887), we measured the time to recovery from the first on-trial relapse. We used Kaplan-Meier survival analyses and Co...
CombiRx included 1008 participants. We investigated 240 relapses. Median time to relapse recovery was 111 days. Most recovery events took place within 1 year of relapse onset: 202 of 240 (84%) individ...
Recovery from relapses takes place up to approximately 1 year after the event. Relapse severity, but no other patient factors, was associated with the speed of relapse recovery. Our findings inform cl...
Cognitive impairment (CI) frequently occurs in multiple sclerosis (MS) and is assumed to increase over time. However, recent studies have suggested that the evolution of cognitive status in patients w...
To explore the evolutionary patterns of cognitive status in a cohort of RRMS patients initiating a new disease modifying treatment (DMT), and to determine whether PROMs may have a predictive value for...
The present prospective study is a 12-month follow-up of a cohort of 59 RRMS patients who underwent yearly a comprehensive, multiparametric assessment combining clinical (with EDSS assessment), neurop...
A total of 33 patients (56%) were defined as cognitively impaired at baseline, and 20 (38%) were defined as impaired at follow-up after 12 months. The mean raw scores and Z-scores of all the cognitive...
These findings provide additional evidence that evolution of CI in MS may be a dynamic phenomenon and will not usually follow an inevitable, declining trajectory, and do not support the utility of PRO...
Different therapeutic strategies are available for the treatment of people with relapsing-remitting multiple sclerosis (RRMS), including immunomodulators, immunosuppressants and biological agents. Alt...
To compare the efficacy and safety, through network meta-analysis, of interferon beta-1b, interferon beta-1a, glatiramer acetate, natalizumab, mitoxantrone, fingolimod, teriflunomide, dimethyl fumarat...
CENTRAL, MEDLINE, Embase, and two trials registers were searched on 21 September 2021 together with reference checking, citation searching and contact with study authors to identify additional studies...
Randomised controlled trials (RCTs) that studied one or more of the available immunomodulators and immunosuppressants as monotherapy in comparison to placebo or to another active agent, in adults with...
Two authors independently selected studies and extracted data. We considered both direct and indirect evidence and performed data synthesis by pairwise and network meta-analysis. Certainty of the evid...
We included 50 studies involving 36,541 participants (68.6% female and 31.4% male). Median treatment duration was 24 months, and 25 (50%) studies were placebo-controlled. Considering the risk of bias,...
We are highly confident that, compared to placebo, two-year treatment with natalizumab, cladribine, or alemtuzumab decreases relapses more than with other DMTs. We are moderately confident that a two-...
In relapsing-remitting multiple sclerosis (RRMS), analyses from observational studies comparing dimethyl fumarate (DMF) and teriflunomide showed conflicting results. We aimed to compare the effectiven...
We included all patients who initiated DMF or teriflunomide between 2013 and 2022, listed in the Swiss National Treatment Registry. Coarsened exact matching was applied using age, gender, disease dura...
In total, 2028 patients were included in this study, of whom 1498 were matched (DMF: n = 1090, 69.6% female, mean age 45.1 years, median EDSS score 2.0; teriflunomide: n = 408, 68.9% female, mean age ...
Analysis of real-world data showed that DMF treatment was associated with more favorable outcomes than teriflunomide treatment....
Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to neurodegeneration, resulting in progressive disability. Repeated magnetic resonance imaging (MRI) of the brain provid...
Recent studies supported coagulation involvement in multiple sclerosis, an inflammatory-demyelinating and degenerative disease of the central nervous system. The main objectives of this observational ...
We compared i) serum/plasma levels of complement(C)/coagulation/vascular factors, viral/microbiological assays, fat-soluble vitamins and lymphocyte count among people with multiple sclerosis sampled i...
Compared to controls, multiple sclerosis patients had a higher Body-Mass-Index, Protein-C and activated-C9; and a lower activated-C4. Levels of Tissue-Factor, Tie-2 and P-Selectin/CD62P were lower in ...
Tissue-factor was one of the top-5 variables in the models discriminating either multiple sclerosis from controls or multiple sclerosis relapse from remission and correlated with mean-transit-time of ...
ClinicalTrials.gov, identifier NCT04380220....
Fingolimod is indicated for the treatment of relapsing-remitting multiple sclerosis (RRMS) and also targets cardiovascular system due to receptors on cardiomyocytes. Results of previous studies are co...
A total of 86 patients with RRMS treated with fingolimod were included in the study. All patients underwent a standard 12-lead surface electrocardiogram at initiation of treatment and 6 h after treatm...
Heart rate was significantly lower after fingolimod treatment (p< 0.001). While the post-treatment values of RR and QT intervals were significantly longer (p< 0.001) and post-treatment iCEB was higher...
In this study, it was found that fingolimod did not statistically significantly change any of the heart rate-corrected ventricular repolarization parameters, including iCEBc, and it is safe in terms o...
Multiple Sclerosis (MS) associated cognitive impairment is believed to be mostly connected with damage to gray matter. The contribution of white matter is still poorly understood. We aim to examine th...
Thirty RRMS patients were selected undergo the (3-seconds-interstimulus-interval paced auditory serial addition test) PASAT-3, the (symbol digit modalities test (SDMT) and full-brain MRI scans on a SI...
The mean scores on the PASAT-3 and SDMT were 31.5 ± 12.8 and 46.9 ± 16.7 respectively. Better cognitive performance was correlated to higher FA values, while lower cognitive function was correlated to...
White matter tracts, particularly the superior cerebellar peduncle, contribute to the cognitive impairment in RRMS. Larger sample sizes for longitudinal research are necessary....
Multiple sclerosis is an inflammatory demyelination process in the central nervous system (CNS) causing neurological disability and poor quality of life. Currently, Thai Food and Drug Administration (...
This study aimed to evaluate the cost-utility and budget impact of rituximab for multiple sclerosis treatment compared with best supportive care, the standard practice in Thailand to treat the disease...
A rituximab biosimilar demonstrated higher effectiveness and lower associated costs, compared to best supportive care, with the highest probability of being cost-effective (96%). The probability of re...
In Thailand, a rituximab biosimilar would reduce the overall costs of multiple sclerosis treatment and should, therefore, be included in the National List of Essential Medicines....
Disease-modifying therapies (DMTs) in multiple sclerosis (MS) can be classified according to the efficacy in which they prevent inflammatory activity. To date, there are limited data regarding the use...
A retrospective cohort study was done using the Argentina MS patient registry, RelevarEM. Patients diagnosed with relapsing-remitting MS (RRMS) according to validated diagnostic criteria and under tre...
Out of 2450 RRMS patients under a DMT, 462 (19%) were on HETs. One third of those patients (35%) received HETs as the first treatment. The most frequent reason for switching to HETs was treatment fail...
The demographic and clinical characteristics of patients under HET in Argentina were identified. Based on a real-world setting, we found a significant trend towards and a rapid increase in the use of ...
