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"description": "Comment diagnostiquer une dysfonction des protéines G rac ?\nQuels tests sont utilisés pour évaluer les protéines G rac ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec les protéines G rac ?\nPeut-on utiliser l'imagerie pour diagnostiquer des anomalies ?",
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"description": "Quels traitements sont disponibles pour les dysfonctionnements des protéines G rac ?\nLes traitements sont-ils personnalisés selon le patient ?\nLes thérapies ciblées sont-elles efficaces ?\nY a-t-il des effets secondaires aux traitements ?\nLes interventions chirurgicales sont-elles nécessaires ?",
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des protéines G rac ?",
"position": 1,
"acceptedAnswer": {
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"text": "Le diagnostic repose sur des tests génétiques et des analyses biochimiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les protéines G rac ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de liaison au GTP et des analyses de signalisation cellulaire sont utilisés."
}
},
{
"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les biopsies ne sont généralement pas nécessaires, sauf pour des études spécifiques."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les protéines G rac ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes variés comme des troubles neurologiques ou métaboliques peuvent apparaître."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser l'imagerie pour diagnostiquer des anomalies ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'imagerie peut aider à évaluer des effets secondaires, mais pas directement les protéines G."
}
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{
"@type": "Question",
"name": "Quels sont les symptômes d'une mutation des protéines G rac ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les mutations peuvent entraîner des troubles neurologiques, métaboliques ou endocriniens."
}
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{
"@type": "Question",
"name": "Les symptômes sont-ils toujours présents avec des anomalies des protéines G ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certaines anomalies peuvent être asymptomatiques ou présenter des symptômes légers."
}
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{
"@type": "Question",
"name": "Comment les symptômes varient-ils selon le type de protéine G rac affectée ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes varient selon la voie de signalisation affectée et le tissu impliqué."
}
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{
"@type": "Question",
"name": "Les symptômes peuvent-ils s'aggraver avec le temps ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains symptômes peuvent s'aggraver si la dysfonction des protéines G n'est pas traitée."
}
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{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques aux troubles métaboliques ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme l'obésité ou le diabète peuvent être liés à des anomalies des protéines G."
}
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{
"@type": "Question",
"name": "Peut-on prévenir les dysfonctionnements des protéines G rac ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais un mode de vie sain peut réduire certains risques."
}
},
{
"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les personnes à risque et permettre une surveillance."
}
},
{
"@type": "Question",
"name": "Y a-t-il des recommandations diététiques pour prévenir les troubles ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et riche en nutriments peut soutenir la santé cellulaire."
}
},
{
"@type": "Question",
"name": "Les activités physiques aident-elles à prévenir les troubles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé métabolique et réduire les risques."
}
},
{
"@type": "Question",
"name": "Les vaccinations ont-elles un rôle dans la prévention ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccinations ne ciblent pas directement les protéines G, mais protègent contre certaines infections."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les dysfonctionnements des protéines G rac ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des thérapies géniques, des médicaments ciblés et des interventions symptomatiques."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés selon le patient ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques et des symptômes."
}
},
{
"@type": "Question",
"name": "Les thérapies ciblées sont-elles efficaces ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les thérapies ciblées montrent des résultats prometteurs, mais leur efficacité varie selon les cas."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires aux traitements ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, comme tout traitement, il peut y avoir des effets secondaires, nécessitant un suivi."
}
},
{
"@type": "Question",
"name": "Les interventions chirurgicales sont-elles nécessaires ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas, des interventions chirurgicales peuvent être nécessaires pour corriger des anomalies."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies des protéines G rac ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des troubles neurologiques, des cancers et des maladies métaboliques."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent gravement affecter la qualité de vie, nécessitant un suivi médical."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de cancer associés aux protéines G rac ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies des protéines G sont liées à un risque accru de cancers spécifiques."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles survenir à tout âge ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent survenir à tout âge, selon le type de mutation et l'environnement."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque pour les troubles des protéines G rac ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques, des habitudes de vie et des expositions environnementales."
}
},
{
"@type": "Question",
"name": "L'hérédité joue-t-elle un rôle dans les troubles des protéines G ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines mutations des protéines G rac sont héréditaires et peuvent être transmises."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils les troubles ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines ou à des agents pathogènes peut augmenter le risque."
}
},
{
"@type": "Question",
"name": "Le mode de vie peut-il affecter le risque de troubles ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie malsain, comme le tabagisme, peut augmenter le risque de dysfonction."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales peuvent déclencher des anomalies dans les protéines G rac."
}
}
]
}
]
}
To determine the risk factors for local of adult patients treated for desmoid tumors by cryoablation....
Eighty-four patients treated for nonabdominopelvic desmoid tumors by cryoablation from July 2012 to July 2020 were included in a retrospective study. The population was composed of 64 women (76.19%) a...
Local relapse was found in 19 (22.62%) of 84 patients. The 12-, 24-, and 36-month progression-free survival rates were 89% (95% confidence interval [CI], 79-94), 74% (95% CI, 60-83), and 68% (95% CI, ...
The local recurrence of desmoid tumors after cryoablation depends on a number of prognostic factors, in particular, a non-abdominal wall location of the tumor and previous local treatment such as surg...
In Japan, 8000 women were newly diagnosed with cervical cancer in 2018. The healthcare insurance policy in Japan allows physicians to utilize vaginal volt cytology tests and serum biomarker measuremen...
From January 2009 to December 2015, the medical records of patients with recurrence who were initially diagnosed with International Federation of Gynecology and Obstetrics stage I-III cervical cancer ...
In the study period, 84 of the 981 patients experienced recurrence, and 88.1% had an asymptomatic recurrence. The disease-free interval was not related to the recurrence site. In univariate analysis, ...
In this retrospective study, routine imaging analysis and serum biomarker measurement did not contribute to patient prognosis after recurrence. In contrast, vaginal vault cytology can improve survival...
Total mesorectal excision is the standard surgical procedure for rectal cancer treatment. Several studies have shown a close correlation between the prognosis of patients with rectal cancer and the co...
To assess the correlation between macroscopic assessment of mesorectal excision and long-term oncological outcomes....
Retrospective analysis of an Institutional Review Board-approved database....
Tertiary referral center....
Patients with rectal cancer who were operated on between March 2016 and October 2019 were classified into 3 groups based on the mesorectal specimen quality: complete, near complete, and incomplete. On...
Relationship between total mesorectal excision and local and distant recurrence rates in patients with rectal cancer....
A total of 124 patients (35.5% females) were included in the analysis, with a mean age of 58.1 (SD 12) years and a mean BMI of 26.4 (SD 4.59) kg/m². Neoadjuvant chemoradiation was administered to 71% ...
Retrospective, single-center study with relatively short follow-up....
In the era of a multidisciplinary approach and extensive use of neoadjuvant therapy, macroscopic completeness of total mesorectal excision may not be as valuable a prognosticator as in the past. Large...
ANTECEDENTES:La escisión total desl mesorrecto es el estándar de oro para el tratamiento del cáncer de recto. Varios estudios han demostrado una estrecha correlación entre el pronóstico de los pacient...
The prognosis for local recurrence after rectal cancer treatment is poor. A minority of patients are eligible for surgery with curative intent, which could possibly be improved by earlier detection. T...
In a population-based retrospective cohort (cohort A), all patients who had undergone resection surgery for rectal cancer in the region of Västra Götaland, Sweden, diagnosed 2010-2014, were identified...
Cohort A consisted of 1208 patients, out of whom 78 (6%) were diagnosed with local recurrence. Forty-six patients were diagnosed between scheduled follow-up visits. Fifty-eight patients were symptomat...
A majority of patients with local recurrence were diagnosed outside of the scheduled follow-up. Most of the patients were symptomatic at diagnosis. Symptoms were common in patients after rectal cancer...
Anastomotic recurrence is thought to be caused by implantation of tumor cells to the anastomotic line; however, its risk factors and prognostic significance remain unclear....
This study aimed to clarify the risk factors for anastomotic recurrence in colorectal cancer and assess the prognosis in comparison to nonanastomotic local recurrence....
A single-center retrospective observational study....
The medical records of the study participants were retrospectively collected from the Department of Surgical Oncology at the University of Tokyo Hospital database....
This study included 1584 patients with colorectal cancer who underwent surgical resection between January 2005 and December 2017. We focused on 15 patients who had an anastomotic recurrence....
The main outcome measures were the risk factors of anastomotic recurrence at the primary resection and prognosis data in comparison to that of nonanastomotic local recurrence....
There were 15 patients (0.95%) with anastomotic recurrence and 35 (2.21%) with nonanastomotic local recurrence. Univariate analysis revealed that lymph node metastasis and advanced T stage are the ris...
The small number of patients with anastomotic recurrence is a major limitation of this study. Additionally, the retrospective study design may have increased the risk of selection bias....
Lymph node metastasis and advanced T stage were associated with anastomotic recurrence. The prognosis of patients with anastomotic recurrence was similar to that with resected nonanastomotic local rec...
ANTECEDENTES:Se cree que la recurrencia anastomótica es causada por la implantación de células tumorales en la línea anastomótica; sin embargo, los factores de riesgo asociados y el significado en cua...
Accurate preoperative localization of tumor-bearing lesions is crucial for the successful surgical management of suspected recurrent parathyroid carcinoma. The purpose of this study was to evaluate th...
Twenty-nine patients with suspected recurrent parathyroid carcinoma were included in this retrospective cohort study. Patients underwent preoperative 99m Tc-MIBI SPECT/CT and cervical ultrasound. The ...
Of the 29 patients, histopathological results revealed 48 metastases/recurrent lesions in 26 patients. The diagnostic value of 99m Tc-MIBI SPECT/CT, cervical ultrasound, and the two modalities in comb...
The combined use of 99m Tc-MIBI SPECT/CT and cervical ultrasound is the most efficient strategy in the diagnosis of parathyroid carcinoma relapse, whereas 99m Tc-MIBI SPECT/CT is the preferred method ...
To investigate the local recurrence rates of men treated with Mohs microsurgery (MMS) for penile carcinoma. The secondary outcome was surgical complications from the MMS procedure or the subsequent re...
All patients from 2010 to 2020 with penile carcinoma at our institution were seen in a multidisciplinary setting. Patients with Ta, Tis, T1, and T2 disease were considered candidates for MMS. Clinical...
A total of 43 patients met inclusion criteria. The median age at diagnosis was 64 years. Stage distribution was Ta in 4.7%, Tis in 58.1%, T1a in 14.0%, T1b in 7.0%, and T2 in 16.3%. No patients had a ...
MMS provides effective local control for Ta, Tis, and T1 penile cancer with an overall local recurrence rate of 2% and an acceptable complication rate. A multi-disciplinary team involving urologic onc...
Phyllodes tumours of the breast are rare fibroepithelial neoplasms with a propensity for recurrence. While surgical excision remains the standard of care, the optimal margin width is an area of active...
We conducted a retrospective, cohort study of patients with phyllodes tumours treated at our institution between 2003 and 2021. Demographic, histopathological, and recurrence data were captured; malig...
Of 187 patients with phyllodes tumours, 82.9% (n = 155) were classified as benign while 17.1% (n = 32) were borderline. Initial surgical margins were positive in 26.2% (n = 49), < 2 mm in 50.8% (n = 9...
In this large cohort of benign and borderline phyllodes tumours, positive resection margins and not margin width at the initial surgery were associated with a increased recurrence. Individualization o...
Patients with locally recurrent rectal cancer (LRRC) generally have poor prognosis, especially those who have (a history of) distant metastases. The aim of this study was to investigate the impact of ...
Consecutive patients with surgically treated LRRC between 2005 and 2019 in two tertiary referral hospitals were retrospectively analysed. Oncological survival of patients without distant metastases we...
A total of 535 LRRC patients were analysed, of whom 398 (74%) had no (history of) metastases, 22 (4%) had synchronous metastases with the primary tumour, 44 (8%) had metachronous metastases, and 71 (1...
LRRC patients with synchronous distant metastases undergoing curative surgery have relatively poor prognosis. However, LRRC patients with a history of distant metastases diagnosed nearby the primary t...
The influence of various morphological, anatomical, genetic and other factors on the local recurrence-free survival of patients who have undergone different renal cell cancer (RCC) treatment is still ...