Titre : Stabilité de l'ARN

Stabilité de l'ARN : Questions médicales fréquentes

Nom anglais: RNA Stability

Descriptor UI: D020871

Tree Number: G02.111.780

Termes MeSH sélectionnés :

Interprofessional Relations
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Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Stabilité de l'ARN", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-02", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Stabilité de l'ARN", "description": "Comment évaluer la stabilité de l'ARN ?\nQuels marqueurs indiquent une instabilité de l'ARN ?\nQuels tests sont utilisés pour mesurer l'ARN ?\nPeut-on détecter des anomalies d'ARN ?\nQuel rôle joue l'ARNm dans le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D020871?mesh_terms=Interprofessional+Relations&page=1000#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Stabilité de l'ARN", "description": "Quels symptômes sont liés à l'instabilité de l'ARN ?\nL'instabilité de l'ARN peut-elle causer des maladies ?\nQuels signes cliniques sont observés ?\nY a-t-il des symptômes spécifiques aux maladies liées à l'ARN ?\nComment l'instabilité de l'ARN affecte-t-elle la santé ?", "url": "https://questionsmedicales.fr/mesh/D020871?mesh_terms=Interprofessional+Relations&page=1000#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Stabilité de l'ARN", "description": "Comment prévenir l'instabilité de l'ARN ?\nY a-t-il des facteurs environnementaux à éviter ?\nL'exercice physique influence-t-il l'ARN ?\nDes suppléments peuvent-ils aider ?\nComment le stress affecte-t-il l'ARN ?", "url": "https://questionsmedicales.fr/mesh/D020871?mesh_terms=Interprofessional+Relations&page=1000#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Stabilité de l'ARN", "description": "Quels traitements ciblent l'instabilité de l'ARN ?\nPeut-on utiliser des inhibiteurs pour stabiliser l'ARN ?\nQuels médicaments sont efficaces contre l'instabilité de l'ARN ?\nComment la thérapie génique aide-t-elle ?\nY a-t-il des traitements expérimentaux ?", "url": "https://questionsmedicales.fr/mesh/D020871?mesh_terms=Interprofessional+Relations&page=1000#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Stabilité de l'ARN", "description": "Quelles complications peuvent survenir ?\nL'instabilité de l'ARN peut-elle entraîner des cancers ?\nQuels troubles métaboliques sont liés à l'ARN ?\nY a-t-il des risques neurologiques ?\nComment l'instabilité de l'ARN affecte-t-elle le système immunitaire ?", "url": "https://questionsmedicales.fr/mesh/D020871?mesh_terms=Interprofessional+Relations&page=1000#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Stabilité de l'ARN", "description": "Quels facteurs génétiques influencent l'ARN ?\nL'âge est-il un facteur de risque ?\nLes infections virales impactent-elles l'ARN ?\nLe tabagisme influence-t-il l'ARN ?\nY a-t-il des facteurs nutritionnels à considérer ?", "url": "https://questionsmedicales.fr/mesh/D020871?mesh_terms=Interprofessional+Relations&page=1000#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment évaluer la stabilité de l'ARN ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "On utilise des techniques comme le Northern blot et la PCR en temps réel." } }, { "@type": "Question", "name": "Quels marqueurs indiquent une instabilité de l'ARN ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des niveaux élevés de dégradation et des variations dans l'expression génique peuvent indiquer une instabilité." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour mesurer l'ARN ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Les tests incluent l'électrophorèse et les analyses de séquençage." } }, { "@type": "Question", "name": "Peut-on détecter des anomalies d'ARN ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des techniques comme le séquençage de nouvelle génération peuvent détecter des anomalies." } }, { "@type": "Question", "name": "Quel rôle joue l'ARNm dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'ARNm est crucial pour évaluer l'expression des gènes associés à des maladies." } }, { "@type": "Question", "name": "Quels symptômes sont liés à l'instabilité de l'ARN ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes variés peuvent apparaître, selon la maladie sous-jacente, comme la fatigue." } }, { "@type": "Question", "name": "L'instabilité de l'ARN peut-elle causer des maladies ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle est liée à des maladies comme certains cancers et des troubles neurodégénératifs." } }, { "@type": "Question", "name": "Quels signes cliniques sont observés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Les signes peuvent inclure des anomalies de croissance ou des troubles métaboliques." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux maladies liées à l'ARN ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes spécifiques peuvent inclure des troubles neurologiques ou immunitaires." } }, { "@type": "Question", "name": "Comment l'instabilité de l'ARN affecte-t-elle la santé ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut perturber l'expression génique, entraînant des dysfonctionnements cellulaires." } }, { "@type": "Question", "name": "Comment prévenir l'instabilité de l'ARN ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir la stabilité de l'ARN." } }, { "@type": "Question", "name": "Y a-t-il des facteurs environnementaux à éviter ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des toxines et à des radiations peut affecter la stabilité de l'ARN." } }, { "@type": "Question", "name": "L'exercice physique influence-t-il l'ARN ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la stabilité de l'ARN." } }, { "@type": "Question", "name": "Des suppléments peuvent-ils aider ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Certains suppléments, comme les antioxydants, peuvent soutenir la stabilité de l'ARN." } }, { "@type": "Question", "name": "Comment le stress affecte-t-il l'ARN ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Le stress chronique peut altérer la stabilité de l'ARN et affecter l'expression génique." } }, { "@type": "Question", "name": "Quels traitements ciblent l'instabilité de l'ARN ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies géniques et des médicaments stabilisateurs d'ARN sont en développement." } }, { "@type": "Question", "name": "Peut-on utiliser des inhibiteurs pour stabiliser l'ARN ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains inhibiteurs peuvent réduire la dégradation de l'ARN dans les cellules." } }, { "@type": "Question", "name": "Quels médicaments sont efficaces contre l'instabilité de l'ARN ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments comme les antisens oligonucleotides sont utilisés pour cibler l'ARN." } }, { "@type": "Question", "name": "Comment la thérapie génique aide-t-elle ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut corriger les défauts d'ARN, améliorant ainsi l'expression génique." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des essais cliniques testent de nouvelles approches pour stabiliser l'ARN." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent des maladies génétiques, des cancers et des troubles métaboliques." } }, { "@type": "Question", "name": "L'instabilité de l'ARN peut-elle entraîner des cancers ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'instabilité de l'ARN est souvent associée à des mécanismes tumoraux." } }, { "@type": "Question", "name": "Quels troubles métaboliques sont liés à l'ARN ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Des troubles comme le diabète et l'obésité peuvent être influencés par l'instabilité de l'ARN." } }, { "@type": "Question", "name": "Y a-t-il des risques neurologiques ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies neurodégénératives peuvent être exacerbées par l'instabilité de l'ARN." } }, { "@type": "Question", "name": "Comment l'instabilité de l'ARN affecte-t-elle le système immunitaire ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut altérer la réponse immunitaire, rendant l'organisme plus vulnérable aux infections." } }, { "@type": "Question", "name": "Quels facteurs génétiques influencent l'ARN ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des mutations dans des gènes régulateurs peuvent affecter la stabilité de l'ARN." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement peut affecter la stabilité de l'ARN et l'expression génique." } }, { "@type": "Question", "name": "Les infections virales impactent-elles l'ARN ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections virales peuvent perturber la stabilité de l'ARN dans les cellules hôtes." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il l'ARN ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut induire des modifications qui affectent la stabilité de l'ARN." } }, { "@type": "Question", "name": "Y a-t-il des facteurs nutritionnels à considérer ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une carence en nutriments essentiels peut compromettre la stabilité de l'ARN." } } ] } ] }

Sources (10000 au total)

The effect of hand fine motor skills on peritoneal dialysis-related peritonitis.

06 Nov 2023
DOI: 10.1111/1744-9987.14079 PMID: 37932586

We aimed to evaluate the relationship between the hand fine motor skills of peritoneal dialysis (PD) practitioners and PD-related peritonitis.... This multicenter prospective observational study was conducted with 120 incident PD patients. Patients were divided into two groups who had PD-related peritonitis within the first year as Group 1, and... Initial NHPT (28.5 ± 6.0 s vs. 25.8 ± 5.0 s, p = 0.011) and NST (82.3 (61.5-102.8) s versus 65.3 (52.3-88.5) s p = 0.023) scores were significantly higher in Group 1 than Group 2. In multivariate logi... Decreased hand fine motor skills of PD patients is a risk factor for peritonitis....

Development of lymph node metastasis-related prognostic markers in breast cancer.

16 Jan 2024
DOI: 10.1016/j.jprot.2023.105045 PMID: 37939914

Lymph node metastasis (LNM) from Breast cancer (BC) is commonly seen in BC progression. Currently, the identification of genes linked with LNM in BC remains in mystery.... Genes related to BC LNM were screened, and a risk model was constructed based on LASSO-Cox analysis. Combined with the Kaplan-Meier curve, the ability of riskscore to distinguish different baseline ch... A higher survival rate and longer survival time in low-risk BC patients. The 1, 3 and 5 year AUC values of the training set were 0.79, 0.74, and 0.73, respectively. Results for the validation set was ... We built a prognostic model of BC based on LNM-related genes, proffering evaluation for prognosis and precise cure of BC.... At present, the genes related to lymph node metastasis in BC are still largely unknown and need to be further explored. Searching for potential lymph node metastasis-related genes of BC will provide m...

Humans Female Breast Neoplasms Lymphatic Metastasis Prognosis +2 autres

Interventions to reduce electronic health record-related burnout: a systematic review.

03 Nov 2023
DOI: 10.1055/a-2203-3787 PMID: 37923381

Electronic health records are a significant contributing factor in clinician burnout, which negatively impacts patient care.... To identify and appraise published solutions that aim to reduce EHR-related burnout in clinicians.... A literature search strategy was developed following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Six databases were searched for articles publish... We identified 44 articles describing interventions to reduce EHR-related burnout. These interventions included the use of scribes, EHR training, and EHR modifications. These interventions were general... The findings of this review underscore the potential benefits of interventions to reduce EHR-related burnout, as well as the need for further research with more robust study designs involving randomiz...

Presentation and Outcomes of Adults With Overdose-Related Out-of-Hospital Cardiac Arrest.

01 Nov 2023
DOI: 10.1001/jamanetworkopen.2023.41921 PMID: 37934498

Drug overdose (OD) is a public health challenge and an important cause of out-of-hospital cardiac arrest (OHCA). Existing studies evaluating OD-related OHCA (OD-OHCA) either aggregate all drugs or foc... To evaluate the temporal pattern, clinical presentation, care, and outcomes of adult patients with OHCA overall and according to the drug-specific profile.... This cohort study of adults with OHCA in King County Washington was conducted between January 1, 2015, and December 31, 2021. Etiology of OHCA was determined using emergency medical service, hospital,... Out-of-hospital cardiac arrest.... The primary outcome was survival to hospital discharge. The secondary outcome was survival with favorable functional status defined by Cerebral Performance Category 1 or 2 based on review of the hospi... In this cohort study, there were 6790 adult patients with emergency medical services-treated OHCA from a US metropolitan system. During the 7-year study period, there were 702 patients with OD-OHCA (m... In a population-based cohort study, the incidence of OD-OHCA increased significantly from 2015 to 2021, with the greatest increase observed among patients with a combined stimulant-opioid OHCA. Presen...

Adult Humans Female Male Aged +5 autres

Maternal liver-related symptoms during pregnancy in primary sclerosing cholangitis.

Jan 2024
DOI: 10.1016/j.jhepr.2023.100951 PMID: 38089547

Although worsening liver-related symptoms during pregnancy can occur in primary sclerosing cholangitis (PSC), there are insufficient data to effectively counsel patients on their pre-conception risk a... We conducted a multicentre retrospective observational study of females with PSC and known pregnancy with live birth, via the International PSC Study Group. We included 450 patients from 12 European c... There were 266 pregnancies in 178 patients following PSC diagnosis. Worsening liver-related symptoms were reported in 66/228 (28.9%) pregnancies; they had a reduced transplant-free survival (... Liver-related symptoms are frequently encountered during pregnancies before the diagnosis of PSC, and pregnancy may expose the pre-clinical phase of PSC in some patients. Worsening liver-related sympt... Patients with PSC can develop worsening of their liver-related symptoms during pregnancy; however, risk factors for this and the long-term implications are not known. We identified that there is a sig...

Work-related asthma and its impact on quality of life and work productivity.

31 Oct 2023
DOI: 10.1016/j.jaip.2023.10.044 PMID: 37918649

The impact of Work-related asthma (WRA) on quality of life (QoL) and work productivity remains largely neglected/uncertain despite its high prevalence.... We aimed to investigate the association of WRA with QoL and work productivity as compared to subjects with asthma unrelated to work and those without asthma and rhinitis.... A cross-sectional survey was carried out among workers during their periodic occupational health visit in Belgium. The mini Asthma QoL Questionnaire (mAQLQ), Medical Outcome Study Short Form-8 (SF-8),... WRA and having poor asthma control were significantly associated with lower global mAQLQ scores compared to non-WRA. Asthmatic subjects had significantly lower physical and mental health components of... Comprehensive management of WRA should be done to reduce the worsening of QoL and work productivity of those affected....