Titre : Dégénerescence striatonigrique

Dégénerescence striatonigrique : Questions médicales fréquentes

Termes MeSH sélectionnés :

Intervertebral Disc Displacement
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prévention ?", "url": "https://questionsmedicales.fr/mesh/D020955?mesh_terms=Intervertebral+Disc+Displacement&page=477#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Dégénerescence striatonigrique", "description": "Quels traitements sont disponibles pour cette maladie ?\nLes médicaments antiparkinsoniens sont-ils efficaces ?\nLa physiothérapie est-elle recommandée ?\nY a-t-il des traitements expérimentaux en cours ?\nLes thérapies complémentaires sont-elles utiles ?", "url": "https://questionsmedicales.fr/mesh/D020955?mesh_terms=Intervertebral+Disc+Displacement&page=477#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Dégénerescence striatonigrique", "description": "Quelles complications peuvent survenir ?\nLa dépression est-elle une complication fréquente ?\nLes complications affectent-elles la qualité de vie ?\nLes troubles de la déglutition sont-ils préoccupants ?\nLes complications peuvent-elles être gérées ?", "url": "https://questionsmedicales.fr/mesh/D020955?mesh_terms=Intervertebral+Disc+Displacement&page=477#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Dégénerescence striatonigrique", "description": "Quels sont les facteurs de risque connus ?\nLe sexe influence-t-il le risque de maladie ?\nLes antécédents de traumatismes crâniens sont-ils un facteur ?\nY a-t-il un lien avec d'autres maladies neurodégénératives ?\nL'exposition à des toxines peut-elle jouer un rôle ?", "url": "https://questionsmedicales.fr/mesh/D020955?mesh_terms=Intervertebral+Disc+Displacement&page=477#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer la dégénérescence striatonigrique ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur l'évaluation clinique, l'imagerie cérébrale et des tests neurologiques." } }, { "@type": "Question", "name": "Quels examens sont utilisés pour le diagnostic ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "L'IRM et la TEP sont couramment utilisés pour visualiser les anomalies cérébrales." } }, { "@type": "Question", "name": "Quels symptômes initiaux sont observés ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes initiaux incluent des troubles de la marche et des mouvements involontaires." } }, { "@type": "Question", "name": "Le diagnostic peut-il être confirmé par une biopsie ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Non, le diagnostic est principalement clinique et par imagerie, la biopsie n'est pas courante." } }, { "@type": "Question", "name": "Y a-t-il des tests génétiques pour cette maladie ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de tests génétiques spécifiques pour la dégénérescence striatonigrique." } }, { "@type": "Question", "name": "Quels sont les symptômes principaux de cette maladie ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent rigidité, tremblements, troubles de l'équilibre et dysarthrie." } }, { "@type": "Question", "name": "Les troubles cognitifs sont-ils fréquents ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles cognitifs comme la démence peuvent survenir au cours de la maladie." } }, { "@type": "Question", "name": "Comment évoluent les symptômes au fil du temps ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes s'aggravent progressivement, affectant la qualité de vie et l'autonomie." } }, { "@type": "Question", "name": "Y a-t-il des symptômes non moteurs associés ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes non moteurs comme la dépression et l'anxiété peuvent apparaître." } }, { "@type": "Question", "name": "Les symptômes varient-ils d'un patient à l'autre ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'intensité et la combinaison des symptômes peuvent varier considérablement entre les patients." } }, { "@type": "Question", "name": "Peut-on prévenir la dégénérescence striatonigrique ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de méthodes prouvées pour prévenir cette maladie neurodégénérative." } }, { "@type": "Question", "name": "Y a-t-il des facteurs de mode de vie à considérer ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Un mode de vie sain, incluant exercice et alimentation équilibrée, peut être bénéfique." } }, { "@type": "Question", "name": "Les activités mentales peuvent-elles aider ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, maintenir une activité mentale peut contribuer à la santé cognitive générale." } }, { "@type": "Question", "name": "Les dépistages réguliers sont-ils recommandés ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Il n'y a pas de dépistage spécifique recommandé pour cette maladie, mais un suivi neurologique est conseillé." } }, { "@type": "Question", "name": "Les antécédents familiaux influencent-ils la prévention ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux peuvent augmenter le risque, mais la prévention reste difficile." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour cette maladie ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des médicaments pour gérer les symptômes, mais il n'existe pas de cure." } }, { "@type": "Question", "name": "Les médicaments antiparkinsoniens sont-ils efficaces ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Les médicaments antiparkinsoniens peuvent aider, mais leur efficacité varie selon les patients." } }, { "@type": "Question", "name": "La physiothérapie est-elle recommandée ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la physiothérapie peut aider à améliorer la mobilité et la qualité de vie des patients." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux en cours ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des recherches sont en cours sur des traitements expérimentaux, mais rien n'est encore validé." } }, { "@type": "Question", "name": "Les thérapies complémentaires sont-elles utiles ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Certaines thérapies complémentaires peuvent apporter un soulagement, mais leur efficacité n'est pas prouvée." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des chutes, des infections et des problèmes de déglutition." } }, { "@type": "Question", "name": "La dépression est-elle une complication fréquente ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la dépression est courante chez les patients atteints de dégénérescence striatonigrique." } }, { "@type": "Question", "name": "Les complications affectent-elles la qualité de vie ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications peuvent gravement affecter la qualité de vie et l'autonomie des patients." } }, { "@type": "Question", "name": "Les troubles de la déglutition sont-ils préoccupants ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les troubles de la déglutition peuvent entraîner des risques d'aspiration et de malnutrition." } }, { "@type": "Question", "name": "Les complications peuvent-elles être gérées ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées par des soins médicaux et des thérapies adaptées." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque connus ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs de risque incluent l'âge avancé, des antécédents familiaux et des troubles neurologiques." } }, { "@type": "Question", "name": "Le sexe influence-t-il le risque de maladie ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les hommes semblent être plus à risque de développer cette maladie que les femmes." } }, { "@type": "Question", "name": "Les antécédents de traumatismes crâniens sont-ils un facteur ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des traumatismes crâniens peuvent augmenter le risque de dégénérescence striatonigrique." } }, { "@type": "Question", "name": "Y a-t-il un lien avec d'autres maladies neurodégénératives ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des liens existent avec d'autres maladies neurodégénératives comme la maladie de Parkinson." } }, { "@type": "Question", "name": "L'exposition à des toxines peut-elle jouer un rôle ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Certaines études suggèrent que l'exposition à des toxines environnementales pourrait être un facteur de risque." } } ] } ] }

Sources (4772 au total)

Total Hip Arthroplasty Leads to Better Results After Low-Energy Displaced Femoral Neck Fracture in Patients Aged 55 to 70 Years: A Randomized Controlled Multicenter Trial Comparing Internal Fixation and Total Hip Arthroplasty.

The optimal treatment of displaced femoral neck fractures in patients 55 to 70 years old remains controversial. The aim of the present study was to assess the effect of closed reduction and internal f... This multicenter randomized controlled trial included all patients 55 to 70 years old who presented with a low-energy displaced femoral neck fracture between December 2013 and December 2018. Patients ... A total of 102 patients with a mean (± standard deviation) age of 63.7 ± 4.2 years were allocated to IF (n = 51) or THA (n = 51). The mean difference in the primary outcome, the HHS at 12 months posto... In this randomized controlled trial, we showed that patients between 55 and 70 years old who underwent THA for a low-energy displaced femoral neck fracture experienced better outcomes than those who u... Therapeutic Level I . See Instructions for Authors for a complete description of levels of evidence....

A novel adaptive cubic quasi-Newton optimizer for deep learning based medical image analysis tasks, validated on detection of COVID-19 and segmentation for COVID-19 lung infection, liver tumor, and optic disc/cup.

Most of existing deep learning research in medical image analysis is focused on networks with stronger performance. These networks have achieved success, while their architectures are complex and even... Our purpose is to design an adaptive cubic quasi-Newton optimizer, which could help to escape from suboptimal solution and improve the performance of deep neural networks on four medical image analysi... In this work, we introduce a novel adaptive cubic quasi-Newton optimizer with high-order moment (termed ACQN-H) for medical image analysis. The optimizer dynamically captures the curvature of the loss... Experiments on four tasks show that ACQN-H achieves improvements over other stochastic optimizers: (1) comparing with AdaBound, ACQN-H achieves 0.49%, 0.11%, and 0.70% higher accuracy on the COVID-che... The proposed optimizer ACQN-H has been validated on four medical image analysis tasks including: detection of COVID-19 using COVID-Net on COVID-chestxray, COVID-19 lung infection segmentation using In...

Impact of Interfractional Bladder and Trigone Displacement and Deformation on Radiation Exposure and Subsequent Acute Genitourinary Toxicity: A Post Hoc Analysis of Patients Treated with Magnetic Resonance Imaging-Guided Prostate Stereotactic Body Radiation Therapy in a Phase 3 Randomized Trial.

Emerging data suggest that trigone dosimetry may be more associated with poststereotactic body radiation therapy (SBRT) urinary toxicity than whole bladder dosimetry. We quantify the dosimetric effect... Seventy-seven patients treated with MRI-guided prostate SBRT (40 Gy/5 fractions) on the MRI arm of a phase 3 single-center randomized trial were included. Bladder and trigone structures were contoured... The average treatment bladder volume was about 30% smaller than the simulation bladder volume; however, the trigone volume remained fairly consistent despite being positively correlated with total bla... The trigone exhibits little volume change, but considerable interfractional displacement/deformation. As a result, the relative volume of the trigone receiving high doses during prostate SBRT varies s...

Post-operative L5 radiculopathy after L5-S1 hyperlordotic anterior lumbar interbody fusion (HL-ALIF) is related to a greater increase of lordosis and smaller post-operative posterior disc height: results from a cohort study.

A single-centre retrospective study.... This study aims to investigate the rate of L5 radiculopathy, to identify imaging features associated with the complication and to evaluate the clinical outcomes in adult spine deformity patients under... Design: retrospective cohort study. A single-centre prospective database was queried to analyse patients undergoing hyperlordotic (HL) ALIF with posterior fusion to correct spinal deformity. Clinical ... Thirty-nine patients with a mean age of 63.2 ± 8.6 years underwent HL-ALIF from January 2016 to December 2019. Seven of them developed post-operative root pain (5) or weakness (2) (Group A), while thi... Post-operative root problems were observed in 17.9% of patients undergoing HL-ALIF for adult spine deformity. L5 radiculopathy was associated with larger sagittal angular corrections and smaller post-... Diagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding....

Prospective, multicenter clinical trial comparing the M6-C compressible cervical disc with anterior cervical discectomy and fusion for the treatment of single-level degenerative cervical radiculopathy: 5-year results of an FDA investigational device exemption study.

Various total disc replacement (TDR) designs have been compared to anterior cervical discectomy and fusion (ACDF) with favorable short and long-term outcomes in FDA-approved investigational device exe... To evaluate the long-term safety and effectiveness of the M6-C compressible artificial cervical disc and compare to ACDF at 5 years.... Prospective, multicenter, concurrently and historically controlled, FDA-approved IDE clinical trial.... Subjects with one-level symptomatic degenerative cervical radiculopathy were enrolled and received M6-C (n=160) or ACDF (n=189) treatment as part of the IDE study. Safety outcomes were evaluated at 5 ... The primary endpoint of this analysis was composite clinical success (CCS) at 60 months. Secondary endpoints were function and pain (neck disability index, VAS), physical quality of life (SF-36, SF-12... Propensity score subclassification was used to control for selection bias and match baseline covariates of the control group to the M6-C subjects. Sixty-month CCS rates were estimated for each treatme... At 5 years postoperatively, the M6-C treatment resulted in 82.3% CCS while the ACDF group showed 67.0% CCS (superiority p=.013). Secondary endpoints indicated that significantly more M6-C subjects ach... Subjects treated with the M6-C artificial disc demonstrated superior 5-year achievement of clinical success when compared to ACDF controls. In addition, significantly more subjects in the M6-C group s...

Superior functional outcome following reverse shoulder arthroplasty compared to hemiarthroplasty for displaced three and four-part fractures in patients 65 and older: Results from a prospective multicentre randomised controlled trial - The Shoulder Hemiarthroplasty or Reverse Polarity Arthoplasty (SHeRPA) trial.

Acute unreconstructible 3- or 4-part proximal humerus fractures can be treated with hemiarthroplasty or reverse polarity shoulder arthroplasty. Randomized trials using implants from multiple different... This study aims to determine whether cemented reverse polarity arthroplasty produces a superior outcome compared to cemented hemiarthroplasty using one implant system in patients aged 65 years and ove... A prospective patient and assessor blinded multicenter randomized controlled trial was conducted of shoulder hemiarthroplasty or reverse polarity arthroplasty in patients aged 65 years and older with ... 18 patients were randomized to hemiarthroplasty and 18 to reverse polarity arthroplasty across 4 sites. The primary outcome as measured by the Constant score at 12 months was better in the reverse pol... Treatment of unreconstructible 3- or 4-part proximal humerus fractures with reverse polarity shoulder arthroplasty results in a superior outcome compared to shoulder hemiarthroplasty at 12 months meas...

Palmitic acid and trans-4-hydroxy-3-methoxycinnamate, the active ingredients of Yaobishu formula, reduce inflammation and pain by regulating gut microbiota and metabolic changes after lumbar disc herniation to activate autophagy and the Wnt/β-catenin pathway.

The imbalance in gut microbiota triggers an inflammatory response that spreads from the gut to the discs and is associated with lumbar disc herniation (LDH). In this study, we investigated the mechani...

The use of a modified posterior approach (SPAIRE) may be associated with an increase in return to pre-injury level of mobility compared to a standard lateral approach in hemiarthroplasty for displaced intracapsular hip fractures: a single-centre study of the first 285 cases over a period of 3.5 years.

A tendon-sparing modification of the posterior approach to the hip joint was introduced in the specialist hip unit at our institution in 2016. The SPAIRE technique-acronym for "Saving Piriformis And I... The review included all hemiarthroplasty patients. Pre-fracture mobility and place of residence, surgical approach, grade of senior surgeon in theatre, stem modularity, acute and overall length of sta... The odds of returning to pre-injury level of mobility were higher in the SPAIRE technique group than in the standard lateral group; adjusted odds ratio (95% confidence interval (CI)) 1.7 (1.1 to 2.7, ... When used in hip hemiarthroplasty, the SPAIRE technique appears safe and may confer benefit in maintaining the pre-injury level of mobility over the standard lateral approach....

Cervical Total Disc Replacement and Anterior Cervical Discectomy and Fusion: Comparison of 30-Day Population Comorbidities and Perioperative Complications Using 6 Years of American College of Surgeons National Surgical Quality Improvement Program Participant Use File Data.

American College of Surgeons National Surgical Quality Improvement Program Participant Use File data from 2014 through 2019 were used to compare 1- and 2-level anterior cervical discectomy and fusion ... One- and 2-level ACDF and cTDR patients were identified by current procedural terminology codes. Demographics, comorbidities, and adverse events were summarized. Unmatched cohorts were compared using ... American College of Surgeons National Surgical Quality Improvement Program 2014 through 2019 Participant Use File datasets represent 4,862,497 unique patients, identifying 13,347 1-level, 6933 2-level... Adjusting for demographics and comorbidities; ACDF has a higher average risk of adverse event. When ACDF and cTDR are equipoise, consideration for cTDR may be indicated in populations with higher rate...