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"description": "Comment diagnostiquer la dégénérescence striatonigrique ?\nQuels examens sont utilisés pour le diagnostic ?\nQuels symptômes initiaux sont observés ?\nLe diagnostic peut-il être confirmé par une biopsie ?\nY a-t-il des tests génétiques pour cette maladie ?",
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"@type": "Question",
"name": "Comment diagnostiquer la dégénérescence striatonigrique ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'évaluation clinique, l'imagerie cérébrale et des tests neurologiques."
}
},
{
"@type": "Question",
"name": "Quels examens sont utilisés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IRM et la TEP sont couramment utilisés pour visualiser les anomalies cérébrales."
}
},
{
"@type": "Question",
"name": "Quels symptômes initiaux sont observés ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes initiaux incluent des troubles de la marche et des mouvements involontaires."
}
},
{
"@type": "Question",
"name": "Le diagnostic peut-il être confirmé par une biopsie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, le diagnostic est principalement clinique et par imagerie, la biopsie n'est pas courante."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests génétiques pour cette maladie ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de tests génétiques spécifiques pour la dégénérescence striatonigrique."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes principaux de cette maladie ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent rigidité, tremblements, troubles de l'équilibre et dysarthrie."
}
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{
"@type": "Question",
"name": "Les troubles cognitifs sont-ils fréquents ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles cognitifs comme la démence peuvent survenir au cours de la maladie."
}
},
{
"@type": "Question",
"name": "Comment évoluent les symptômes au fil du temps ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes s'aggravent progressivement, affectant la qualité de vie et l'autonomie."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes non moteurs associés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes non moteurs comme la dépression et l'anxiété peuvent apparaître."
}
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{
"@type": "Question",
"name": "Les symptômes varient-ils d'un patient à l'autre ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'intensité et la combinaison des symptômes peuvent varier considérablement entre les patients."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la dégénérescence striatonigrique ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de méthodes prouvées pour prévenir cette maladie neurodégénérative."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs de mode de vie à considérer ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant exercice et alimentation équilibrée, peut être bénéfique."
}
},
{
"@type": "Question",
"name": "Les activités mentales peuvent-elles aider ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, maintenir une activité mentale peut contribuer à la santé cognitive générale."
}
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{
"@type": "Question",
"name": "Les dépistages réguliers sont-ils recommandés ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'y a pas de dépistage spécifique recommandé pour cette maladie, mais un suivi neurologique est conseillé."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils la prévention ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents familiaux peuvent augmenter le risque, mais la prévention reste difficile."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour cette maladie ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments pour gérer les symptômes, mais il n'existe pas de cure."
}
},
{
"@type": "Question",
"name": "Les médicaments antiparkinsoniens sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les médicaments antiparkinsoniens peuvent aider, mais leur efficacité varie selon les patients."
}
},
{
"@type": "Question",
"name": "La physiothérapie est-elle recommandée ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la physiothérapie peut aider à améliorer la mobilité et la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux en cours ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches sont en cours sur des traitements expérimentaux, mais rien n'est encore validé."
}
},
{
"@type": "Question",
"name": "Les thérapies complémentaires sont-elles utiles ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines thérapies complémentaires peuvent apporter un soulagement, mais leur efficacité n'est pas prouvée."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des chutes, des infections et des problèmes de déglutition."
}
},
{
"@type": "Question",
"name": "La dépression est-elle une complication fréquente ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la dépression est courante chez les patients atteints de dégénérescence striatonigrique."
}
},
{
"@type": "Question",
"name": "Les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent gravement affecter la qualité de vie et l'autonomie des patients."
}
},
{
"@type": "Question",
"name": "Les troubles de la déglutition sont-ils préoccupants ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les troubles de la déglutition peuvent entraîner des risques d'aspiration et de malnutrition."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être gérées ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées par des soins médicaux et des thérapies adaptées."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque connus ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs de risque incluent l'âge avancé, des antécédents familiaux et des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Le sexe influence-t-il le risque de maladie ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les hommes semblent être plus à risque de développer cette maladie que les femmes."
}
},
{
"@type": "Question",
"name": "Les antécédents de traumatismes crâniens sont-ils un facteur ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des traumatismes crâniens peuvent augmenter le risque de dégénérescence striatonigrique."
}
},
{
"@type": "Question",
"name": "Y a-t-il un lien avec d'autres maladies neurodégénératives ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des liens existent avec d'autres maladies neurodégénératives comme la maladie de Parkinson."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines peut-elle jouer un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent que l'exposition à des toxines environnementales pourrait être un facteur de risque."
}
}
]
}
]
}
Prostate cancer (PCa) is the second most frequent cancer among men in the Western population. Infections, such as the one caused by the human papillomavirus (HPV), have been shown to promote inflammat...
Prostate tissue fragments were collected by prostate biopsy and subjected to polymerase chain reaction with primers for the HPV L1 gene to identify the presence of the virus....
Among 162 patients, 10 (6.2%) had HPV and in 152 (93.8%) HPV was not identified in prostate biopsies. HPV was detected in 7/95 (7.4%) of patients with PCa, in 2/55 (3.6%) of patients without PCa, and ...
There were no significant levels of HPV L1 protein in prostate tissue. The findings suggest the absence of HPV oncogenic activity in the prostate tissue of patients with PCa....
In this study, it was aimed to investigate the reliability of total prostate-specific antigen (t-PSA) in prostate cancer screening in hyperglycemic (≥126 mg/dL) individuals....
This research was planned as a cross-sectional retrospective study. Three hundred eleven cases which underwent biopsy with the suspicion of prostate cancer in the hospital were included in the study. ...
It was determined that the t-PSA measurement was higher in the patient group with cancer (P < .001). It was determined that the median t-PSA levels of the intermediate and high cancer groups were high...
As a contribution to literature, we found that the t-PSA test lost its sensitivity in cases with plasma glucose levels above normal. Loss of sensitivity may result in underdiagnosis in prostate cancer...
In recent observational studies, a potential link between prostatitis and prostate cancer (PCa) has been hinted at, yet the causality remains ambiguous. In our endeavor to scrutinize the conceivable c...
With emerging evidence to improve prostate cancer (PCa) screening, multiparametric magnetic prostate imaging is becoming an essential noninvasive component of the diagnostic routine. Computer-aided di...
We collected 1647 fine-grained biopsy-confirmed findings, including Gleason scores and prostatitis, to form a training dataset. In our experimental framework for lesion detection, all models utilized ...
An optimal model configuration with fine class granularity (prostatitis included) and OHE has scored the lesion-wise partial Free-Response Receiver Operating Characteristic (FROC) area under the curve...
This paper examines several configurations for model training in the biparametric MRI setup and proposes optimal value ranges. It also shows that the fine-grained class configuration, including prosta...
To assess the efficacy of 2-core prostate biopsy in advanced prostate cancer patients. This included a retrospective analysis of 12-core prostate biopsies and a prospective validation that a reduced n...
The first phase analyzed retrospective data from 12-core prostate biopsies between January 2013 and 2018. In the second phase, from January 2018 to January 2022, in a prospective setting, patients wit...
In the retrospective analysis, the number of positive cores in metastatic disease was 12 in 93 (73.8%), 11 in 14 (11.1%), and 10 in 7 (5.6%) patients. Using probability analysis, 94% of patients with ...
A 2-core biopsy is adequate in almost all patients with metastatic prostate cancer with PSA > 75, and this avoids excess complications and morbidity associated with a systematic 12-core prostate biops...
Financial toxicity (FT) is a growing concern among cancer survivors that adversely affects the quality of life and survival. Individuals diagnosed with aggressive cancers are often at a greater risk o...
PCa patients enrolled in the North Carolina-Louisiana Prostate Cancer Project (PCaP) were recontacted for long-term follow-up. The prevalence of FT in the PCaP cohort was estimated. FT was estimated u...
More than one-third of PCa patients reported experiencing FT. PCa aggressiveness was significantly independently associated with high FT; high aggressive PCa at diagnosis had more than twice the risk ...
Aggressive PCa was associated with high FT. Future studies should collect more information about the characteristics of men with high FT and identify additional risk factors of FT....
Prostate-specific membrane antigen (PSMA) hybrid imaging is a promising new technique gaining importance in the field of prostate cancer (PCa) diagnosis and treatment planning. By combining PSMA radio...
Cribriform (CBFM) pattern on prostate biopsy has been implicated as a predictor for high-risk features, potentially leading to adverse outcomes after definitive treatment. This study aims to investiga...
Patients who underwent multiparametric magnetic resonance imaging (mpMRI), combined 12-core transrectal ultrasound (TRUS) guided systematic (SB) and MRI/US fusion-guided biopsy were retrospectively qu...
Between 2015 and 2022, a total of 131 consecutive patients with CBFM pattern on prostate biopsy and pre-biopsy mpMRI were included. Clinical feature analysis included 1572 systematic biopsy cores (114...
The extent of disease for CBFM-containing tumors is difficult to capture on mpMRI. When comparing MRI lesions of similar dimensions and PIRADS scores, CBFM-containing tumors appear to have larger canc...
Purpose: Determine the time-dependent magnitude of intrafraction prostate displacement and a cutoff for the tracking decision. Methods: Nine patients with localized prostate cancer were treated with u...
Apart from other risk factors, chronic inflammation is also associated with the onset of Prostate Cancer (PCa), wherein pathogen infection and tissue microbiome dysbiosis are known to play a major rol...