Comment diagnostiquer une anomalie des protéines de transport ?

Des tests génétiques et des analyses biochimiques peuvent être utilisés.

Quels tests sont utilisés pour évaluer le transport vésiculaire ?

L'imagerie par résonance magnétique et les tests enzymatiques sont courants.

Les biopsies sont-elles utiles pour le diagnostic ?

Oui, les biopsies peuvent révéler des anomalies dans les protéines de transport.

Quels symptômes peuvent indiquer un problème de transport vésiculaire ?

Des troubles neurologiques ou métaboliques peuvent signaler un dysfonctionnement.

Peut-on utiliser des marqueurs biologiques pour le diagnostic ?

Oui, certains marqueurs peuvent indiquer des anomalies dans le transport vésiculaire.

Quels sont les symptômes d'une déficience en protéines de transport ?

Les symptômes incluent fatigue, troubles cognitifs et problèmes métaboliques.

Les troubles du mouvement sont-ils liés aux protéines de transport ?

Oui, des anomalies peuvent entraîner des troubles du mouvement et de la coordination.

Y a-t-il des symptômes digestifs associés ?

Des problèmes digestifs comme des nausées peuvent survenir en cas de dysfonction.

Les troubles de la vision peuvent-ils être un symptôme ?

Oui, certaines anomalies peuvent affecter la vision et entraîner des troubles visuels.

Des symptômes psychologiques peuvent-ils apparaître ?

Oui, des troubles de l'humeur et de l'anxiété peuvent être liés à ces anomalies.

Peut-on prévenir les anomalies des protéines de transport ?

Certaines anomalies génétiques ne peuvent pas être prévenues, mais un dépistage peut aider.

Le dépistage prénatal est-il utile ?

Oui, il peut identifier des risques génétiques avant la naissance.

L'éducation génétique peut-elle aider ?

Oui, elle informe les familles sur les risques et les options de gestion.

Des habitudes de vie saines peuvent-elles réduire les risques ?

Oui, une alimentation équilibrée et l'exercice peuvent améliorer la santé cellulaire.

Les vaccinations ont-elles un rôle dans la prévention ?

Certaines vaccinations peuvent prévenir des infections qui aggravent les symptômes.

Quels traitements sont disponibles pour les anomalies de transport ?

Les traitements peuvent inclure des thérapies géniques et des médicaments spécifiques.

La nutrition joue-t-elle un rôle dans le traitement ?

Oui, une alimentation adaptée peut aider à gérer certains symptômes métaboliques.

Les thérapies physiques sont-elles bénéfiques ?

Oui, elles peuvent améliorer la mobilité et la qualité de vie des patients.

Des médicaments peuvent-ils corriger les déficiences ?

Certains médicaments peuvent aider à compenser les déficiences fonctionnelles.

Y a-t-il des traitements expérimentaux en cours ?

Oui, des essais cliniques explorent de nouvelles approches thérapeutiques.

Quelles complications peuvent survenir avec ces anomalies ?

Des complications neurologiques, métaboliques et immunitaires peuvent se développer.

Les complications peuvent-elles affecter la qualité de vie ?

Oui, elles peuvent gravement altérer la qualité de vie et nécessiter des soins continus.

Y a-t-il des risques de maladies associées ?

Oui, des maladies comme le diabète ou des troubles neurologiques peuvent survenir.

Les complications peuvent-elles être réversibles ?

Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.

Comment surveiller les complications potentielles ?

Des suivis réguliers et des examens médicaux sont essentiels pour détecter les complications.

Quels sont les facteurs de risque génétiques ?

Des mutations génétiques spécifiques peuvent augmenter le risque d'anomalies.

L'environnement joue-t-il un rôle dans ces anomalies ?

Oui, l'exposition à des toxines peut influencer le développement de ces anomalies.

L'âge parental est-il un facteur de risque ?

Oui, l'âge avancé des parents peut augmenter le risque de certaines anomalies génétiques.

Des antécédents familiaux augmentent-ils le risque ?

Oui, des antécédents familiaux de maladies génétiques peuvent accroître le risque.

Le mode de vie influence-t-il le risque d'anomalies ?

Oui, des habitudes de vie malsaines peuvent contribuer à des anomalies métaboliques.

Protéines du transport vésiculaire - Informations médicales vérifiées

Psychological status and physical performance are independently associated with autonomic function.

05 May 2022

DOI: 10.1186/s12938-022-00996-7 PMID: 35513815

Falls among older adults have become a global concern. While previous studies have established associations between autonomic function indicator; heart rate variability (HRV) and blood pressure variab... In this cross-sectional survey, adults aged ≥ 60 years were recruited. Continuous non-invasive BP was monitored over 5 min of supine and 3 min of standing. Psychological status was assessed in terms o... A total of 62 participants were recruited consisting of 37 fallers and 25 non-fallers. Multivariate analysis revealed that Lawton IADL was independently associated with systolic blood pressure variabi... Our findings suggest that fallers had poorer ANS, greater dependence in IADLs, and were more anxious. IADL dependency and anxiety were the most predictive of autonomic dysfunction, and can be used in ...

Aged Blood Pressure Blood Pressure Monitoring, Ambulatory Cross-Sectional Studies Hand Strength +2 autres

Physical function across the lifespan in adults with multiple sclerosis: An application of the Short Physical Performance Battery.

May 2023

DOI: 10.1016/j.msard.2023.104624 PMID: 37004273

Multiple sclerosis (MS) typically has its onset in early and middle adulthood, but the population is steadily becoming more dominated by older adults. One of the primary consequences of both MS and ag... The study involved secondary analysis of cross-sectional data from multiple studies. Ambulatory adults with MS who were relapse-free for the last 30 days were recruited, and controls were recruited ba... The two-way ANOVA indicated a main effect of MS status (F(5,500)=34.74, p<.01, η... Overall, MS status and aging have additive effects on physical function, and the summary SPPB score may be driven by a specific component within each age group. SPPB scores may be driven more by mobil...

Humans Aged Adult Longevity Cross-Sectional Studies +3 autres

Physical performance tasks were linked to the PROMIS physical function metric in patients undergoing hemodialysis.

07 2023

DOI: 10.1016/j.jclinepi.2023.04.007 PMID: 37105321

To investigate whether a multi-item performance outcome measure, the physical performance test (PPT), can be calibrated to a common scale with patient-reported outcome measures, using the Patient-Repo... We analyzed baseline data (N = 1,113) from the CONVINCE study, an international trial in end-stage kidney disease patients comparing high-dose hemodiafiltration with high-flux hemodialysis. Assumption... Although some evidence for multidimensionality was found, classical test statistics (Cronbach's Alpha = 0.93), Mokken (Loevinger's H = 0.50), and bifactor analysis (explained common variance = 0.65) i... We found preliminary evidence that the PPT can be linked to the PROMIS PF metric in hemodialysis patients, enabling group comparisons across patient-reported outcome and performance outcome measures. ...

Humans Surveys and Questionnaires Physical Functional Performance Renal Dialysis Patient Reported Outcome Measures +1 autres

Association between physical activity and physical and functional performance in non-institutionalized Mexican older adults: a cohort study.

03 05 2022

DOI: 10.1186/s12877-022-03083-7 PMID: 35505279

Aging is an independent risk factor for deterioration in functional capacity. Some studies have reported that physical activity (PA) improves functional capacity and physical performance among older a... A longitudinal analysis using data from the Frailty, Dynapenia and Sarcopenia in Mexican adults (FRADYSMEX, by its Spanish acronym) cohort study was conducted. PA was assessed through the Community He... Older people who performed moderate to vigorous-intensity PA had a lower risk of dependence in IADL (OR = 0.17; 95%CI: 0.10, 0.80) and lower risk of low PP (OR = 0.18; 95%CI: 0.11, 0.58) compared to t... Older adults living in the community who perform PA of moderate to vigorous intensity have a lower risk of dependence in BADL and IADL and have a lower risk of low PP....

Aged Cohort Studies Exercise Frailty Humans +2 autres

Gait parameters, functional performance and physical activity in active and inactive Juvenile Idiopathic Arthritis.

10 2022

DOI: 10.1016/j.gaitpost.2022.09.080 PMID: 36191581

Children with Juvenile Idiopathic Arthritis (JIA) may adopt different movement patterns and participate in physical activity during different states of disease.... Which specific features of gait and physical function performance differ among children with active or inactive JIA compared to healthy children?... Forty-three children participated (14.5 ± 4.2 yrs; 60 % female). 3D-motion analysis methods were coupled with force measures from an instrumented treadmill captured gait mechanical measures. The 30-se... Compared to healthy controls children with active and inactive JIA had worse outcomes (12-21 % slower self-selected and fast walking speeds, 28-34 % slower stair navigation times, 28 % fewer chair ris... Gait speed, specific load-bearing functional tasks and leg stiffness features of gait may be informative 'functional biomarkers' for assessing JIA burden and tracking treatment efficacy. Additional pr...

Child Humans Female Male Arthritis, Juvenile +7 autres

A Data Analytics Approach to Assess the Functional and Physical Performance of Female Soccer Players: A Cohort Design.

22 07 2022

DOI: 10.3390/ijerph19158941 PMID: 35897308

The aim of this study was twofold: (i) to observe the individual results of fitness status [countermovement jump (CMJ)], hop test, linear sprinting time, stride frequency, stride distance, force-power... The study followed a cohort design. Sixteen female soccer players competing in the second division of the Spanish league were monitored during the first days of the pre-season. These players were eval...

Athletic Performance Data Science Exercise Test Female Humans +3 autres

Velocity walking test: Selective influences on physical functional performance for better tracking of older women.

06 2023

DOI: 10.1016/j.archger.2023.104962 PMID: 36804697

To examine the selective influences of changes in walking test capability on physical functional performance (COD speed, COD deficit, linear sprint speed, chair stand test, handgrip strength, and unlo... The performances of eighty women ((age, 64.7 ± 3.38 y; body mass, 66.3 ± 11.15 kg; height, 153.5 ± 5.71 cm, BMI, 28.08 ± 4.00 kg/m... Strength and conditioning coaches and professionals involved with older women should consider the COD deficit (i.e., linear velocity minus change of direction velocity), as a complementary measure to ...

Aged Female Humans Exercise Test Hand Strength +7 autres

Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity.

05 2023

DOI: 10.1007/s00467-022-05758-0 PMID: 36315277

History of chronic kidney disease and kidney transplantation is known to influence physical performance capacity. The aim of this study was to compare the physical performance of pediatric kidney tran... Twenty-four pediatric kidney transplant recipients (62.5% boys) were tested at a median age of 10.8 years. Physical performance capacity was tested with a test set including six different components a... The physical performance capacity in pediatric kidney transplant recipients was lower compared to healthy controls. Surprisingly, no statistically significant correlation was found between graft funct... The physical performance of pediatric kidney transplant recipients is reduced, especially in those with congenital nephrotic syndrome. Clinical parameters, including graft function, did not predict ph...

Male Humans Child Female Kidney Transplantation +5 autres

Assessing individual-level measurement precision of the Short Physical Performance Battery using the test information function.

01 03 2023

DOI: 10.1097/MRR.0000000000000557 PMID: 36591991

The Short Physical Performance Battery (SPPB) is a commonly used tool to assess lower extremity function, composed of three assessments (standing balance, gait speed, and chair stand). While its valid...

Aged Humans Walking Speed Lower Extremity Psychometrics +1 autres

Investigation of the correlation between knee joint position sense and physical functional performance in individuals with transtibial amputation.

01 Oct 2023

DOI: 10.1097/PXR.0000000000000206 PMID: 36723386

In individuals with transtibial amputation, the distal part of the lower extremity is lost. Therefore, the knee joint is of greater importance to be able to provide physical performance. The aim of th... The study included 21 subjects with transtibial amputation. A digital inclinometer was used to evaluate the joint position sense of the amputated side knee joint. The timed up and go test, the 4-squar... The mean age of the participants was 52.52 ± 15.68 years. The mean of the error in knee joint position sense was 5.33 degree (standard deviation = 3.08 degree). The error in knee joint position sense ... The knee joint position sense on the amputated side was found to be associated with physical functional performance in individuals with transtibial amputation. Residual limb knee joint position sense ...

Humans Adult Middle Aged Aged Postural Balance +6 autres

Protéines du transport vésiculaire : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Antigène CD63

Auxilines

Cavéolines

Protéines adaptatrices du transport vésiculaire

Phosphatidylinositol 3-kinases de classe III

Clathrine

Complexe I de protéines de revêtement

Dynamines

Complexes de tri endosomique requis pour le transport

Protéines Munc18

Protéines SNARE

Protéines SNAP

Synaptotagmines

Cavéoline-3

Complexe protéique adaptateur 1

Complexe protéique adaptateur 2

Complexe protéique adaptateur 3

Complexe protéique adaptateur 4

Sous-unités du complexe de la protéine adaptatrice

Protéines d'assemblage monomériques de la clathrine

Nexines de tri

Protéine de tri vacuolaire VPS15

Chaines lourdes de la clathrine

Chaines légères de la clathrine

Facteur-1 d'ADP-ribosylation

Protéine du coatomère

Dynamine-I

Dynamine-II

Dynamine-III

Ubiquitine protéine ligases NEDD4

Protéines Q-SNARE

Protéines R-SNARE

Synaptotagmine I

Synaptotagmine II

Complexe protéique adaptateur, sous-unités alpha

Complexe protéique adaptateur, sous-unités bêta

Complexe protéique adaptateur, sous-unités delta

Sous-unités gamma du complexe protéique adaptateur

Complexe protéique adaptateur, sous-unités mu

Complexe protéique adaptateur, sous-unités sigma

Protéines Qa-SNARE

Protéines Qb-SNARE

Protéines Qc-SNARE

Synaptobrévine-1

Synaptobrévine-2

Synaptobrévine-3

Syntaxine-1

Syntaxine-16

Protéine SNAP-25

Auteurs principaux

Sources (10000 au total)