Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany; Faculty of Fisheries, İzmir Katip Çelebi University, Çiğli, 35620 İzmir, Turkey.
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany. Electronic address: zhenfeizi0@sina.com.
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany. Electronic address: proksch@uni-duesseldorf.de.
GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. Electronic address: mj.reis@campus.fct.unl.pt.
MARE-IPLeiria, Marine and Environmental Sciences Centre, School of Tourism and Marine Technology, Polytechnic of Leiria, 2520-630 Peniche, Portugal. Electronic address: marta.neves@ipleiria.pt.
Coimbra Chemistry Center - Institute of Molecular Sciences (CQC-IMS), Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: pjfc7@ci.uc.pt.
GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal; MARE-IPLeiria, Marine and Environmental Sciences Centre, School of Tourism and Marine Technology, Polytechnic of Leiria, 2520-630 Peniche, Portugal. Electronic address: c.brito@campus.fct.unl.pt.
CiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic of Leiria, 2411-901 Leiria, Portugal. Electronic address: ana.o.rodrigues@ipleiria.pt.
iBB - Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal; Associate Laboratory i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. Electronic address: ccarvalho@tecnico.ulisboa.pt.
School of Life Sciences, University of Lincoln, Lincoln LN6 7DL, UK; Quadram Institute, Norwich Research Park, Norwich NR4 7UQ, UK. Electronic address: megmort@msn.com.
Coimbra Chemistry Center - Institute of Molecular Sciences (CQC-IMS), Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: mmoreno@ci.uc.pt.
Coimbra Chemistry Center - Institute of Molecular Sciences (CQC-IMS), Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: rbrito@ci.uc.pt.
An in-vitro study was performed to investigate the molecular basis of the wound healing and skin protective features of Helichrysum italicum (HI), a medicinal plant from the Mediterranean basin....
A dermal fibroblast cell line culture was treated with HI hydro-alcoholic extract to detect the gene expression levels of three selected primers: FGF-2, HAS-2 and MMP-9. Cell proliferation assay was p...
HI extract caused statistically significant upregulation of FGF-2 (P=0.0473) and HAS-2 (P=0.0335) gene expressions compared to the untreated control cells. The treatment ended with 1.74 and 3.10 fold ...
In general, it may be considered that HI has certain anabolic effects on the extracellular matrix of the skin because of the significant increases it causes in FGF-2 and HAS-2. Therefore, it may have ...
The phytochemical analysis of a methanolic extract from Helichrysum petiolare Hilliard & B. L. (Asteraceae) confirmed the content of phenylpropanoids and flavonoids. Five secondary metabolites were is...
Helichrysum plicatum species are used in Turkish folk medicine as lithagogue, diuretic, and nephritic. Research on the methanol (MeOH) extract of flowers of H. plicatum DC. subsp. plicatum resulted in...
In the present work the composition of biogenic volatile organic compounds (BVOCs) and the essential oil (EO) of Helichrysum araxinum Takht. ex Kirp. aerial parts, together with the antimicrobial acti...
Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A prop...
The aim of this study is to investigate how climate change influences the distribution of economically and environmentally important species of P. abyssinica and H. citrispinum in Ethiopia. The specie...
The MaxEnt model predicted habitat suitability for H. citrispinum species with an Area Under Curve (AUC) value of 0.961 ± 0.027, and 0.809 ± 0.045 for P. abyssinica, indicating excellent discriminator...
Topographic position index (TPI) is the most impactful predictor variable on the distribution of the two species. Consequently, potentially habitable areas (with diverse aspects and slopes) are increa...
Corsican Helichrysum italicum essential oil (HIEO) is characterized by high concentrations of neryl acetate, and we previously demonstrated that Corsican HIEO increases the expression of genes that ar...
Helichrysum italicum (H. italicum) is a halophyte shrub with bright yellow flowers with a strong curry-like aroma. The essential oils of H. italicum have been used in the production of cosmetics and p...
Helichrysum italicum (HI) is a Mediterranean plant with well-reported use in traditional medicine for a wide range of applications, including digestive and liver disorders, intestinal parasitic infect...
The aim of this study was to explain the mechanism behind the previously demonstrated effects of HI and to justify its use in traditional medicine....
A microarray-based transcriptome analysis was used to discover the global transcriptional alterations in primary colon fibroblasts after exposure to HI infusion for 6 h and 24 h. In addition, quantita...
Altogether we identified 217 differentially expressed genes compared to non-treated cells, and only 8 were common to both treatments. Gene ontology analysis revealed that 24 h treatment with HI infusi...
With the careful evaluation of the role of individual genes, especially SERPING1, ARHGAP1, IL33 and CDKN1A, represented in the enriched pathways and processes, we propose the main mode of HI action, w...
Natural products have many healing effects on the skin with minimal or no adverse effects. In this study, we analyzed the regenerative properties of a waste product (hydrolate) derived from...