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"name": "Diagnostic",
"headline": "Diagnostic sur Steroid 16-alpha-hydroxylase",
"description": "Comment diagnostiquer une déficience en 16-alpha-hydroxylase ?\nQuels tests génétiques sont utilisés pour cette enzyme ?\nQuels symptômes peuvent indiquer un problème avec cette enzyme ?\nQuel rôle joue l'imagerie dans le diagnostic ?\nLes tests de fonction hépatique sont-ils pertinents ?",
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"headline": "Symptômes sur Steroid 16-alpha-hydroxylase",
"description": "Quels sont les symptômes d'une surproduction d'androgènes ?\nComment se manifeste une insuffisance en stéroïdes ?\nLes symptômes varient-ils selon le sexe ?\nY a-t-il des symptômes associés à des troubles métaboliques ?\nLes symptômes peuvent-ils apparaître à l'adolescence ?",
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"description": "Peut-on prévenir les troubles liés à cette enzyme ?\nY a-t-il des tests de dépistage recommandés ?\nComment l'éducation peut-elle aider à la prévention ?\nLes habitudes alimentaires influencent-elles la santé hormonale ?\nLe stress a-t-il un impact sur cette enzyme ?",
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"headline": "Traitements sur Steroid 16-alpha-hydroxylase",
"description": "Quels traitements sont disponibles pour les déséquilibres hormonaux ?\nLes médicaments peuvent-ils aider à réguler cette enzyme ?\nY a-t-il des traitements non médicamenteux ?\nComment la chirurgie peut-elle être impliquée ?\nLes traitements sont-ils différents pour les hommes et les femmes ?",
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"headline": "Complications sur Steroid 16-alpha-hydroxylase",
"description": "Quelles complications peuvent survenir avec un déséquilibre hormonal ?\nLes troubles psychologiques sont-ils liés à cette enzyme ?\nY a-t-il des risques de cancer associés ?\nComment les maladies métaboliques sont-elles liées ?\nLes complications sont-elles réversibles ?",
"url": "https://questionsmedicales.fr/mesh/D039181?mesh_terms=Interrupted+Time+Series+Analysis&page=2#section-complications"
},
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"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Steroid 16-alpha-hydroxylase",
"description": "Quels facteurs de risque sont associés à des troubles hormonaux ?\nL'âge influence-t-il le risque de déséquilibre hormonal ?\nLes médicaments peuvent-ils affecter cette enzyme ?\nLe mode de vie joue-t-il un rôle dans le risque ?\nLes facteurs environnementaux influencent-ils le risque ?",
"url": "https://questionsmedicales.fr/mesh/D039181?mesh_terms=Interrupted+Time+Series+Analysis&page=2#section-facteurs de risque"
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"@type": "Question",
"name": "Comment diagnostiquer une déficience en 16-alpha-hydroxylase ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins pour mesurer les niveaux d'hormones stéroïdiennes sont effectués."
}
},
{
"@type": "Question",
"name": "Quels tests génétiques sont utilisés pour cette enzyme ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des analyses génétiques ciblent les mutations dans le gène CYP3A4."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec cette enzyme ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme l'hyperandrogénie ou des irrégularités menstruelles peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'imagerie dans le diagnostic ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'imagerie peut aider à évaluer les glandes endocrines, mais n'est pas spécifique."
}
},
{
"@type": "Question",
"name": "Les tests de fonction hépatique sont-ils pertinents ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, car le foie est crucial pour le métabolisme des stéroïdes et peut indiquer des anomalies."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une surproduction d'androgènes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Acné, hirsutisme, irrégularités menstruelles et infertilité peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Comment se manifeste une insuffisance en stéroïdes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, perte de poids, hypotension et dépression peuvent être des signes d'insuffisance."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le sexe ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les hommes et les femmes peuvent présenter des symptômes différents en raison des hormones."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes associés à des troubles métaboliques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme le diabète peuvent être liés à des anomalies hormonales."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils apparaître à l'adolescence ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des changements hormonaux peuvent se manifester durant la puberté."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les troubles liés à cette enzyme ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surveillance régulière et un mode de vie sain peuvent aider à prévenir certains troubles."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests hormonaux réguliers peuvent être recommandés pour les personnes à risque."
}
},
{
"@type": "Question",
"name": "Comment l'éducation peut-elle aider à la prévention ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'éducation sur les symptômes et les risques peut aider à une détection précoce."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles la santé hormonale ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut soutenir la santé hormonale et prévenir des déséquilibres."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur cette enzyme ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut affecter la production hormonale et aggraver les symptômes."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les déséquilibres hormonaux ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies hormonales substitutives peuvent être prescrites pour rétablir l'équilibre."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider à réguler cette enzyme ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains inhibiteurs enzymatiques peuvent être utilisés pour moduler l'activité."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements non médicamenteux ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des changements de mode de vie, comme l'alimentation et l'exercice, peuvent aider."
}
},
{
"@type": "Question",
"name": "Comment la chirurgie peut-elle être impliquée ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas, une intervention chirurgicale peut être nécessaire pour corriger des anomalies."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils différents pour les hommes et les femmes ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des besoins hormonaux spécifiques."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec un déséquilibre hormonal ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme l'infertilité, le diabète et des maladies cardiovasculaires peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les troubles psychologiques sont-ils liés à cette enzyme ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme l'anxiété et la dépression peuvent être exacerbés par des déséquilibres."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de cancer associés ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent un lien entre les déséquilibres hormonaux et le cancer hormonal."
}
},
{
"@type": "Question",
"name": "Comment les maladies métaboliques sont-elles liées ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les déséquilibres hormonaux peuvent contribuer à des maladies métaboliques comme le diabète."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié et précoce."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés à des troubles hormonaux ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antécédents familiaux, l'obésité et le stress sont des facteurs de risque connus."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de déséquilibre hormonal ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente avec l'âge, surtout pendant la ménopause chez les femmes."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils affecter cette enzyme ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent interférer avec l'activité de la stéroïde 16-alpha-hydroxylase."
}
},
{
"@type": "Question",
"name": "Le mode de vie joue-t-il un rôle dans le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains produits chimiques peut affecter la fonction hormonale."
}
}
]
}
]
}
This study used California's unique Workplace Violent Incident Reporting System (WVIRS) to describe changes in workplace violence (WV) exposure for hospital-based healthcare workers during the pandemi...
Interrupted time series analysis....
We compared the linear trends in weekly WV incidents reported during the period before the COVID-19 pandemic (7/1/2017-3/20/2020) to the period following California's shutdown (3/21/2020-6/30/2021). W...
A total of 418 hospitals reported 37,561 incidents during the study period. For EDs, the number of reported incidents remained essentially constant, despite a 26% drop in outpatient visits between the...
WV persists steadily in California's hospitals. Despite major reductions in patient volume due to COVID-19, weekly reported ED incidents remained essentially unchanged....
Surveys and media reported that WV increased during the pandemic, but it has been difficult to measure these changes using a large-scale database. The absolute number of WV incidents did not increase ...
There was no public contribution to this study. The goal of this analysis was to summarize findings from administrative data. The findings presented can inform future discussion of public policy and a...
Natural disasters are associated with increased mental health disorders and suicidal ideation; however, associations with suicide deaths are not well understood. We explored how Hurricane Florence, wh...
We used publicly available NC death records data to estimate associations between Hurricane Florence and monthly suicide death rates using a controlled, interrupted time series analysis. Hurricane exp...
8363 suicide deaths occurred between January 2014 and December 2019. The overall suicide death rate in NC between 2014 and 2019 was 15.53 per 100 000 person-years (95% CI 15.20 to 15.87). Post-Hurrica...
Although results did not indicate a strong post-Hurricane Florence impact on suicide rates, subgroup analysis suggests differential impacts of Hurricane Florence on several groups, warranting future f...
This analysis investigates the relationship between drought and antiretroviral treatment (ART) adherence and retention in HIV care in the Hlabisa sub-district, KwaZulu-Natal, South Africa. Data on dro...
In 2021, the ten provinces in Canada enacted COVID-19 vaccine mandates that restricted access to non-essential businesses and services to those that could provide proof of full vaccination to decrease...
Aggregated data from the Canadian COVID-19 Vaccination Coverage Surveillance System (CCVCSS) were used to measure vaccine uptake (defined as the weekly proportion of individuals who received at least ...
The times series models demonstrated significant increases in vaccine uptake following mandate announcement in BC, AB, SK, MB, NS, and NL. No trends in the effect of mandate announcements were observe...
Vaccine mandate announcements could have increased vaccine uptake. However, it is difficult to interpret this effect within the larger epidemiological context. Effectiveness of the mandates can be aff...
To evaluate the influence of febuxostat on adverse events and mortality in gout....
We retrospectively enrolled patients with newly diagnosed gout and prescribed urate-lowering therapy between 2006 and 2017 from the Taiwan National Health Insurance Database. These patients were divid...
The proportion of febuxostat use gradually increased from 0% in 2012 to 30% in those with comorbidities and 10% in those without comorbidities in 2017. Allopurinol use decreased from 30% in 2012 to 10...
Febuxostat may reduce SJS and TEN in all gout patients but increase AMI, PCI, and all-cause mortality in gout patients with comorbidities....
To determine death occurrences of Puerto Ricans on the mainland USA following the arrival of Hurricane Maria in Puerto Rico in September 2017....
Cross-sectional study....
Persons of Puerto Rican origin on the mainland USA....
Hurricane Maria....
We use an interrupted time series design to analyse all-cause mortality of Puerto Ricans in the USA following the hurricane. Hispanic origin data from the National Vital Statistics System and from the...
We found an increase in mortality for persons of Puerto Rican origin during the 6-month period following the hurricane (October 2017 through March 2018), suggesting that deaths among these persons wer...
Our findings suggest an undercounting of previous deaths as a result of the hurricane due to the systematic effects on the displaced and resident populations in the mainland USA. Displaced populations...
The growth of parkrun between 2004 and 2019 has been heralded as a success story for public health as a result of its physical activity and wellbeing benefits for participants. However, parkrun was no...
The study combines aggregated parkrun weekly finisher data from 32,470 Lower Layer Super Output Areas (LSOA) in England from January 2015 to February 2023 with Office of National Statistics (ONS) data...
Visualisation and interrupted time series analysis showed a significant and long-term decrease in parkrun participation following the reopening of parkrun events. This was consistent across all IMD qu...
The reduction in parkrun participation during the pandemic and following the reopening of events is likely to have negatively impacted wellbeing in would-be participants. Going forwards, policymakers ...
To analyze epidemiological characteristics of mumps in different periods and explore the impact of different immunization strategies of mumps containing vaccine (MuCV) on the incidence of mumps in Quz...
Beverage and food taxes have become a popular 'best buy' public health intervention in the global battle to tackle noncommunicable diseases. Though many countries have introduced taxes, mainly targeti...
We used weekly electronic point-of-sale data from a major food retailer in Bermuda. We assessed historical weekly sales and price data using an interrupted time series design on 2,703 unique products ...
By January 2020, the average price per ounce of SSBs increased by 26.0%, while the price of untaxed beverages (including waters and non-added sugar drinks) remained constant. The increasing price of S...
The tax was largely passed through to consumers. However, several factors mitigated the impact of the tax on the prices paid for SSBs by consumers, including the specific design of the tax, price prom...
A male is less adaptable to biological stressors than a female fetus with consequent higher morbidity and mortality. Adverse birth outcomes increase and male livebirths decrease after environmental di...
Interrupted time series analysis was used to analyze Queensland administrative birth records from July 2007 to June 2018 for significant changes in the sex ratio at birth, measured as the proportion o...
Contrary to our hypothesis, increases in the proportion of male livebirths were observed following early-pregnancy exposure to cyclone Yasi and mid-pregnancy exposure to Marcia, although the latter wa...
This study found a significant association between severe TCs and sex ratio at birth. The stage of pregnancy at which maternal stressors were experienced modified this association. Among people expose...