Comment diagnostiquer une anomalie d'eIF-4G ?

Des tests génétiques et des analyses protéomiques peuvent identifier des anomalies.

Quels tests sont utilisés pour évaluer eIF-4G ?

Les tests incluent l'électrophorèse et la PCR pour détecter des mutations.

Les biopsies peuvent-elles aider au diagnostic ?

Oui, les biopsies tissulaires peuvent révéler des niveaux anormaux d'eIF-4G.

Quels marqueurs biologiques sont associés à eIF-4G ?

Des niveaux de protéines spécifiques et des ARNm peuvent servir de marqueurs.

L'imagerie est-elle utile pour diagnostiquer des troubles liés à eIF-4G ?

L'imagerie peut aider à évaluer des complications, mais pas directement eIF-4G.

Quels symptômes sont liés à une dysfonction d'eIF-4G ?

Les symptômes peuvent inclure des troubles de croissance et des anomalies métaboliques.

Y a-t-il des symptômes neurologiques associés ?

Oui, des troubles neurologiques peuvent survenir en raison d'une mauvaise traduction.

Les symptômes varient-ils selon l'âge ?

Oui, les symptômes peuvent se manifester différemment selon l'âge du patient.

Des symptômes immunitaires peuvent-ils apparaître ?

Oui, une dysfonction d'eIF-4G peut affecter le système immunitaire.

Les symptômes sont-ils réversibles ?

Cela dépend de la cause sous-jacente et de la rapidité du traitement.

Peut-on prévenir les troubles liés à eIF-4G ?

La prévention est difficile, mais un dépistage génétique peut aider.

Y a-t-il des mesures préventives recommandées ?

Des conseils sur la nutrition et le mode de vie peuvent être bénéfiques.

Le suivi médical est-il important ?

Oui, un suivi régulier peut aider à détecter des problèmes précocement.

Les vaccinations peuvent-elles aider ?

Les vaccinations ne préviennent pas directement les troubles d'eIF-4G.

L'éducation génétique est-elle utile ?

Oui, l'éducation sur les risques génétiques peut aider à la prise de décision.

Quels traitements sont disponibles pour les troubles d'eIF-4G ?

Les traitements peuvent inclure des thérapies géniques et des médicaments ciblés.

La nutrition joue-t-elle un rôle dans le traitement ?

Oui, une nutrition adéquate peut soutenir la fonction cellulaire et la traduction.

Des thérapies expérimentales existent-elles ?

Oui, des essais cliniques explorent de nouvelles approches thérapeutiques.

Les traitements sont-ils personnalisés ?

Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques.

Les traitements sont-ils efficaces à long terme ?

L'efficacité dépend de la nature de la dysfonction et de la réponse au traitement.

Quelles complications peuvent survenir avec eIF-4G ?

Des complications incluent des troubles métaboliques et des problèmes de croissance.

Les complications sont-elles graves ?

Certaines complications peuvent être graves et nécessiter une intervention médicale.

Y a-t-il des complications à long terme ?

Oui, des complications chroniques peuvent affecter la qualité de vie.

Les complications peuvent-elles être évitées ?

Certaines complications peuvent être évitées par un traitement précoce.

Comment gérer les complications liées à eIF-4G ?

La gestion implique un suivi médical régulier et des traitements adaptés.

Quels sont les facteurs de risque pour eIF-4G ?

Les facteurs incluent des mutations génétiques et des antécédents familiaux.

L'environnement influence-t-il eIF-4G ?

Oui, certains facteurs environnementaux peuvent affecter l'expression d'eIF-4G.

L'alimentation peut-elle être un facteur de risque ?

Une alimentation déséquilibrée peut influencer la fonction d'eIF-4G.

Les infections jouent-elles un rôle ?

Certaines infections peuvent perturber la fonction d'eIF-4G et provoquer des troubles.

Le stress a-t-il un impact sur eIF-4G ?

Oui, le stress peut affecter la régulation de l'expression d'eIF-4G.

Facteur-4G d'initiation eucaryote - Informations médicales vérifiées

The SIB Swiss Institute of Bioinformatics Semantic Web of data.

25 Oct 2023

DOI: 10.1093/nar/gkad902 PMID: 37878411

The SIB Swiss Institute of Bioinformatics (https://www.sib.swiss/) is a federation of bioinformatics research and service groups. The international life science community in academia and industry has ...

Investigating the potential of the semantic web for education: Exploring Wikidata as a learning platform.

13 Mar 2023

DOI: 10.1007/s10639-023-11664-1 PMID: 37361737

Wikidata is a free, multilingual, open knowledge-base that stores structured, linked data. It has grown rapidly and as of December 2022 contains over 100 million items and millions of statements, maki...

CAENet: Contrast adaptively enhanced network for medical image segmentation based on a differentiable pooling function.

Dec 2023

DOI: 10.1016/j.compbiomed.2023.107578 PMID: 37918260

Pixel differences between classes with low contrast in medical image semantic segmentation tasks often lead to confusion in category classification, posing a typical challenge for recognition of small...

Semantic Web Semantics Image Processing, Computer-Assisted

Automatic transparency evaluation for open knowledge extraction systems.

31 08 2023

DOI: 10.1186/s13326-023-00293-9 PMID: 37653549

This paper proposes Cyrus, a new transparency evaluation framework, for Open Knowledge Extraction (OKE) systems. Cyrus is based on the state-of-the-art transparency models and linked data quality asse... In Cyrus, data transparency includes ten dimensions which are grouped in two categories. In this paper, six of these dimensions, i.e., provenance, interpretability, understandability, licensing, avail... This is the first research to study the transparency of OKE systems that provides a comprehensive set of transparency dimensions spanning ethics, trustworthy AI, and data quality approaches to transpa...

Humans Artificial Intelligence COVID-19 Semantic Web

Hospital admission after primary care consultation for community-onset lower urinary tract infection: a cohort study of risks and predictors using linked data.

09 2023

DOI: 10.3399/BJGP.2022.0592 PMID: 37487642

Urinary tract infections (UTIs) are a common indication for antibiotic prescriptions, reductions in which would reduce antimicrobial resistance (AMR). Risk stratification of patients allows reductions... To identify risk factors for hospital admission following UTI, to inform targeted antibiotic stewardship.... Retrospective cohort study of East London primary care patients.... Hospital admission outcomes following primary care consultation for UTI were analysed using linked data from primary care, secondary care, and microbiology, from 1 April 2012 to 31 March 2017. The out... Of the 169 524 episodes of UTI, UHA occurred in 1336 cases (0.8%, 95% confidence interval [CI] = 0.7 to 0.8) and AHA in 6516 cases (3.8%, 95% CI = 3.8 to 3.9). On multivariable analysis, increased odd... Urinary infection-related hospital admission after primary care consultation for community-onset lower UTI was rare; however, increased odds for UHA were observed for some patient groups. Efforts to r...

Adult Humans Cohort Studies Retrospective Studies Semantic Web +6 autres

Appropriateness of end-of-life care for children with genetic and congenital conditions: a cohort study using routinely collected linked data.

Sep 2023

DOI: 10.1007/s00431-023-05030-z PMID: 37328636

This study aims to evaluate the appropriateness of end-of-life care for children with genetic and congenital conditions. This is a decedent cohort study. We used 6 linked, Belgian, routinely collected...

Child Humans Cohort Studies Semantic Web Terminal Care +2 autres

Mortality and cause of death during inpatient psychiatric care in New South Wales, Australia: A retrospective linked data study.

08 2023

DOI: 10.1016/j.jpsychires.2023.05.043 PMID: 37315354

Premature mortality in people with mental illness is well-documented, yet deaths during inpatient psychiatric care have received little research attention. This study investigates mortality rates and ... A retrospective cohort study using linked administrative datasets with complete capture of psychiatric admissions in NSW from 2002 to 2012 (n = 421,580) was conducted. Univariate and multivariate rand... The mortality rate during inpatient psychiatric care was 1.12 deaths per 1000 episodes of care and appeared to decline over the study period. Suicide accounted for 17% of inpatient deaths, while physi... The mortality rate and number of avoidable deaths during inpatient psychiatric care were substantial and warrant further systemic investigation. This was driven by a dual burden of physical health con...

Humans Male New South Wales Retrospective Studies Cause of Death +3 autres

Did the UK's public health shielding policy protect the clinically extremely vulnerable during the COVID-19 pandemic in Wales? Results of EVITE Immunity, a linked data retrospective study.

May 2023

DOI: 10.1016/j.puhe.2023.02.008 PMID: 36933354

The UK shielding policy intended to protect people at the highest risk of harm from COVID-19 infection. We aimed to describe intervention effects in Wales at 1 year.... Retrospective comparison of linked demographic and clinical data for cohorts comprising people identified for shielding from 23 March to 21 May 2020; and the rest of the population. Health records wer... The shielded cohort included 117,415 people, with 3,086,385 in the comparator cohort. The largest clinical categories in the shielded cohort were severe respiratory condition (35.5%), immunosuppressiv... Deaths and healthcare utilisation were higher amongst shielded people than the general population, as would be expected in the sicker population. Differences in testing rates, deprivation and pre-exis...

Humans Female Male COVID-19 Retrospective Studies +5 autres

Relative rates of cancers and deaths in Australian communities with PFAS environmental contamination associated with firefighting foams: A cohort study using linked data.

02 2023

DOI: 10.1016/j.canep.2022.102296 PMID: 36508965

Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants that are potentially harmful to health. We examined if rates of selected cancers and causes of deaths were elevated in three A... All residents identified in the Medicare Enrolment File (1983-2019)-a consumer directory for Australia's universal healthcare-who ever lived in an exposure area (Katherine, Oakey and Williamtown), and... We observed higher rates of prostate cancer (SIR=1·76, 95 % confidence interval (CI) 1·36-2·24) in Katherine; laryngeal cancer (SIR=2·71, 95 % CI 1·30-4·98), kidney cancer (SIR=1·82, 95 % CI 1·04-2·96... There was limited evidence to support an association between living in a PFAS exposure area and risks of cancers or cause-specific deaths....

Male Humans Aged Cohort Studies Australia +7 autres

Diagnostic accuracy of linked administrative data for dementia diagnosis in community-dwelling older men in Australia.

15 11 2022

DOI: 10.1186/s12877-022-03579-2 PMID: 36380274

Routinely collected health administrative data can be used to estimate the prevalence or incidence of dementia at a population level but can be inaccurate. This study aimed to examine the accuracy of ... We performed a retrospective analysis of the Concord Health and Ageing in Men Project (CHAMP) in Sydney, Australia. Of the 1705 men aged ≥70 years in the CHAMP study, 1400 had available linked adminis... Administrative data identified 28 participants as having dementia, compared to 88 identified through clinical assessment. Administrative data had a sensitivity of 20% (95% CI: 13-30%, 18/88), specific... Administrative hospital and death data has limited accuracy for dementia diagnosis with poor sensitivity and PPV. The prevalence of dementia is likely underestimated using hospital and deaths data....

Male Humans Aged Independent Living Dementia +3 autres

Facteur-4G d'initiation eucaryote : Questions médicales fréquentes

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