Titre : Sclérodermie diffuse

Sclérodermie diffuse : Questions médicales fréquentes

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observés ?\nLa radiographie est-elle utile dans le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D045743?page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Sclérodermie diffuse", "description": "Quels sont les symptômes principaux ?\nLa fatigue est-elle un symptôme courant ?\nY a-t-il des symptômes respiratoires ?\nComment se manifeste l'atteinte digestive ?\nLes troubles vasculaires sont-ils fréquents ?", "url": "https://questionsmedicales.fr/mesh/D045743?page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Sclérodermie diffuse", "description": "Peut-on prévenir la sclérodermie diffuse ?\nQuels facteurs de risque sont identifiés ?\nLe tabagisme influence-t-il la maladie ?\nL'exposition au froid est-elle un risque ?\nLes infections peuvent-elles aggraver la maladie ?", "url": "https://questionsmedicales.fr/mesh/D045743?page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Sclérodermie diffuse", "description": "Quels traitements sont disponibles ?\nLes corticostéroïdes sont-ils efficaces ?\nQuelles thérapies physiques sont recommandées ?\nY a-t-il des traitements expérimentaux ?\nComment gérer les symptômes cutanés ?", "url": "https://questionsmedicales.fr/mesh/D045743?page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Sclérodermie diffuse", "description": "Quelles sont les complications possibles ?\nLa sclérodermie peut-elle affecter le cœur ?\nY a-t-il un risque d'infections ?\nComment la sclérodermie affecte-t-elle les reins ?\nLes complications digestives sont-elles fréquentes ?", "url": "https://questionsmedicales.fr/mesh/D045743?page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Sclérodermie diffuse", "description": "Quels sont les principaux facteurs de risque ?\nL'âge joue-t-il un rôle ?\nLes facteurs environnementaux sont-ils significatifs ?\nY a-t-il un lien avec d'autres maladies auto-immunes ?\nLe stress peut-il aggraver la maladie ?", "url": "https://questionsmedicales.fr/mesh/D045743?page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer la sclérodermie diffuse ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur l'examen clinique, les antécédents médicaux et des tests sanguins." } }, { "@type": "Question", "name": "Quels tests sanguins sont utilisés ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests incluent la recherche d'anticorps spécifiques comme les anticorps anti-Scl-70." } }, { "@type": "Question", "name": "Les biopsies cutanées sont-elles nécessaires ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Elles peuvent être réalisées pour évaluer l'atteinte tissulaire et confirmer le diagnostic." } }, { "@type": "Question", "name": "Quels signes cliniques sont observés ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Les signes incluent un durcissement de la peau, des œdèmes et des troubles vasculaires." } }, { "@type": "Question", "name": "La radiographie est-elle utile dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut aider à évaluer les atteintes pulmonaires ou digestives associées." } }, { "@type": "Question", "name": "Quels sont les symptômes principaux ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent un durcissement de la peau, des douleurs articulaires et des troubles digestifs." } }, { "@type": "Question", "name": "La fatigue est-elle un symptôme courant ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la fatigue est fréquente et peut être liée à l'inflammation et à l'atteinte organique." } }, { "@type": "Question", "name": "Y a-t-il des symptômes respiratoires ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des difficultés respiratoires peuvent survenir en raison de l'atteinte pulmonaire." } }, { "@type": "Question", "name": "Comment se manifeste l'atteinte digestive ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut se traduire par des reflux, des troubles de la déglutition et des douleurs abdominales." } }, { "@type": "Question", "name": "Les troubles vasculaires sont-ils fréquents ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des phénomènes de Raynaud et des ulcères digitaux peuvent se produire." } }, { "@type": "Question", "name": "Peut-on prévenir la sclérodermie diffuse ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de méthode de prévention connue, mais éviter les facteurs de risque peut aider." } }, { "@type": "Question", "name": "Quels facteurs de risque sont identifiés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents familiaux, des expositions environnementales et le sexe féminin." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il la maladie ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut aggraver les symptômes et augmenter le risque de complications." } }, { "@type": "Question", "name": "L'exposition au froid est-elle un risque ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition au froid peut déclencher des symptômes vasculaires comme le phénomène de Raynaud." } }, { "@type": "Question", "name": "Les infections peuvent-elles aggraver la maladie ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections peuvent exacerber les symptômes et compliquer la gestion de la maladie." } }, { "@type": "Question", "name": "Quels traitements sont disponibles ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des immunosuppresseurs, des anti-inflammatoires et des thérapies symptomatiques." } }, { "@type": "Question", "name": "Les corticostéroïdes sont-ils efficaces ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent réduire l'inflammation, mais leur utilisation doit être prudente en raison des effets secondaires." } }, { "@type": "Question", "name": "Quelles thérapies physiques sont recommandées ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La kinésithérapie peut aider à maintenir la mobilité et à réduire la douleur articulaire." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements comme les inhibiteurs de la tyrosine kinase sont en cours d'évaluation." } }, { "@type": "Question", "name": "Comment gérer les symptômes cutanés ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des crèmes hydratantes et des traitements topiques peuvent aider à soulager les symptômes cutanés." } }, { "@type": "Question", "name": "Quelles sont les complications possibles ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des atteintes pulmonaires, cardiaques et rénales, ainsi que des troubles digestifs." } }, { "@type": "Question", "name": "La sclérodermie peut-elle affecter le cœur ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des arythmies, une hypertension pulmonaire et une insuffisance cardiaque." } }, { "@type": "Question", "name": "Y a-t-il un risque d'infections ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les patients peuvent être plus susceptibles aux infections en raison d'une immunité altérée." } }, { "@type": "Question", "name": "Comment la sclérodermie affecte-t-elle les reins ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut provoquer une hypertension rénale et une insuffisance rénale, nécessitant une surveillance." } }, { "@type": "Question", "name": "Les complications digestives sont-elles fréquentes ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles incluent des reflux, des troubles de la motilité et des malabsorption." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux, le sexe féminin et certaines expositions environnementales sont des facteurs de risque." } }, { "@type": "Question", "name": "L'âge joue-t-il un rôle ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la sclérodermie diffuse survient généralement entre 30 et 50 ans, mais peut toucher d'autres âges." } }, { "@type": "Question", "name": "Les facteurs environnementaux sont-ils significatifs ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des solvants organiques et à la silice peut augmenter le risque." } }, { "@type": "Question", "name": "Y a-t-il un lien avec d'autres maladies auto-immunes ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes ayant d'autres maladies auto-immunes peuvent avoir un risque accru." } }, { "@type": "Question", "name": "Le stress peut-il aggraver la maladie ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Le stress peut exacerber les symptômes, bien que son rôle exact dans la sclérodermie ne soit pas clair." } } ] } ] }

Sources (8833 au total)

Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis.

Patients with diffuse cutaneous systemic sclerosis (dcSSc) frequently show spontaneous improvement of skin fibrosis. Our aim was to examine whether an improvement in skin fibrosis predicts lower likel... Patients from the European Scleroderma Trials and Research (EUSTAR) cohort with dcSSc, baseline modified Rodnan skin score (mRSS) ≥7, and valid mRSS at 12±3 months follow up were included. Regression/... Of 1257 included patients, 883 (70.2%) were stable, 282 (22.4%) regressive, and 92 (7.3%) progressive. Regressive patients, adjusted for baseline mRSS, baseline immunosuppression, baseline FVC, and di... We found that regression of skin fibrosis is associated with a lower probability of lung progression and better survival at follow up. The link between the disease course of skin and lung fibrosis in ...

Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis.

This phase 3 study was undertaken to investigate the efficacy and safety of lenabasum, a cannabinoid type 2 receptor agonist, in patients with diffuse cutaneous systemic sclerosis (dcSSc).... A multinational double-blind study was conducted in 365 dcSSc patients who were randomized and dosed 1:1:1 with lenabasum 20 mg, lenabasum 5 mg, or placebo, each twice daily and added to background tr... The primary end point, the American College of Rheumatology combined response index in dcSSc (CRISS) at week 52 for lenabasum 20 mg twice a day versus placebo, was not met, with CRISS score of 0.888 v... A benefit of lenabasum in dcSSc was not demonstrated. Most patients were treated with background IST, and treatment with mycophenolate mofetil in particular was associated with better outcomes. These ...

A 24-Week, Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis.

We undertook this study to explore the efficacy, safety, and tolerability of ziritaxestat, a selective autotaxin inhibitor, in patients with early diffuse cutaneous systemic sclerosis (dcSSc).... NOVESA was a 24-week, multicenter, phase IIa, double-blind, placebo-controlled study. Adults with dcSSc were randomized to oral ziritaxestat 600 mg once daily or matching placebo. The primary efficacy... Patients were randomized to ziritaxestat (n = 21) or placebo (n = 12). Reduction in MRSS was significantly greater in the ziritaxestat group versus the placebo group (-8.9 versus -6.0 units, respectiv... Ziritaxestat resulted in significantly greater reduction in MRSS at week 24 than placebo; no new safety signals emerged. Biomarker analysis suggests ziritaxestat may reduce fibrosis. Modulation of the...

Diffuse Gastrointestinal Motor Compromise in Patients with Scleroderma: Utility of Minimally Invasive Techniques.

Scleroderma is a systemic inflammatory disorder that can compromise the gastrointestinal tract in up to 90% of patients.... The purpose of this work is to characterize esophageal, gastric, and intestinal compromise in patients with scleroderma by means of minimally invasive methods and its association with symptoms and sev... Patients with systemic sclerosis were recruited according to the criteria of the American College of Rheumatology. The study of digestive involvement was carried out on four consecutive days: esophage... A total of 30 patients were included, with an average age of 52.7 years and 93% women. Average disease evolution duration was 6.5 years, 70% with limited variety. Rodnan averaged 12 points, being high... Gastrointestinal involvement in patients with scleroderma is frequent and is observed regardless of the symptoms and clinical characteristics of the latter, except for skin involvement....