The suggested algorithm consists of three blocks: "Generator", "Modeling", "Analysis". The first block creates a three-dimensional model of the leaflet apparatus using the specified parameters (height...
The verification of the algorithm has demonstrated the following deviations in the lumen area in the open state: 2.85% for 19 mm, 14.81% for 21 mm, and 23.17% for 23 mm models. This difference is due ...
The developed algorithm makes it possible to automatically generate three-dimensional models of the leaflet apparatus, numerically simulate the opening process using the finite element method, statist...
The purpose of this study is to develop a new model for the dynamic characteristics of left ventricular assist devices (LVADs) interacting with the cardiovascular system under constant-speed modes....
A new hysteresis model is established on the basis of the hysteresis effect and turbomachinery principles. The simulation results from the hysteresis model were compared with the inertia model. The in...
Compared with the inertia model, at the partial support mode, the relative estimation error of the time to the maximum and minimum pump flow (Q) in the hysteresis model decreased at least 16.3% cardia...
The hysteresis model provides a general calculation method for simulating the dynamic characteristics of constant-speed LVADs under interaction with the cardiovascular system. It is more accurate than...
The hysteresis model is helpful for the rapid estimation of unsteady dynamic characteristics in absence of a physical pump prototype at the preliminary design stage....
Ascending aorta simulations provide insight into patient-specific hemodynamic conditions. Numerous studies have assessed fluid biomarkers which show a potential to aid clinicians in the diagnosis proc...
To define a reference chart comparing pressure drop vs. flow generated by a set of arterial cannulae currently utilized in cardiopulmonary bypass conditions in pediatric surgery....
Cannulae from two manufacturers were selected considering their design and outer and inner diameters. Cannula performance was evaluated in terms of pressure drop vs. flow during simulated cardiopulmon...
Utilizing a pressure drop limit of 100 mmHg, our results suggest a recommended flow limit of 500, 900, 1400, 2600, and 3100 mL/min for Braile arterial cannulae sizes 8, 10, 12, 14, and 16 Fr, respecti...
This study reinforces discrepancies in pressure drop between cannulae of the same diameter supplied by different manufacturers and the importance of independent translational research to evaluate comp...
Biomechanics plays a critical role in coronary artery disease development. FSI simulation is commonly used to understand the hemodynamics and mechanical environment associated with atherosclerosis pat...
Three-dimensional (3D) cardiovascular fluid dynamics simulations typically require hours to days of computing time on a high-performance computing cluster. One-dimensional (1D) and lumped-parameter ze...
The combination of medical imaging and computational hemodynamics is a promising technology to diagnose/prognose coronary artery disease (CAD). However, the clinical translation of in silico hemodynam...
The geometry of the right coronary artery (RCA) of 144 hemodynamically stable patients with different stenosis degree were reconstructed from angiography. On them, unsteady-state CFD simulations were ...
The comparison between paired N vs. shear-thinning non-N simulations revealed remarkably similar profiles of WSS-based and helicity-based quantities, independent of the adopted blood rheology model an...
This study, performed on 288 angio-based CFD simulations on 144 RCA models presenting with different degrees of stenosis, suggests that the assumptions on blood rheology have negligible impact both on...
Eulerian and Lagrangian power-law formulations are both widely used for computational fluid dynamics (CFD) to predict flow-induced hemolysis in blood-contacting medical devices. Both are based on the ...
In this study, we demonstrate the inaccuracy of Eulerian hemolysis power-law model predictions due to the erroneous treatment of exposure time by systematically considering four benchmark test cases w...
Compared with Lagrangian predictions, we show that, as flow acceleration becomes more pronounced, the resultant inaccuracy in the Eulerian predictions increases. For the inclined Couette flow case, th...
The inaccuracy of hemolysis predictions due to the erroneous treatment of exposure time in the Eulerian power-law model can be significant when there is streamwise velocity variation in the flow field...
This study investigates the application of a Predictive Surrogate Model (PSM) for the prediction of the fluid and solid variables in the abdominal aorta by integrating Proper Orthogonal Decomposition ...
The Fluid-Structure Interaction (FSI) solver, which serves as the Full-Order Model (FOM), can capture the blood hemodynamics and structural mechanics precisely for a variety of physiological states, n...
Detailed analyses have been conducted on velocity components, pressure, Wall Shear Stress (WSS), and Oscillatory Shear Index (OSI) variables. Firstly, the reconstruction error has been derived based o...
The PSM is evaluated against rest and exercise conditions, exhibiting promising results despite the inherent complexities of the physiological conditions. Despite the inherent complexities of phenomen...
The choice of appropriate boundary conditions is a crucial step in the development of cardiovascular models for blood flow simulations. The three-element Windkessel model is usually employed as a lump...
The proposed technique is based on Time-Domain Vector Fitting, a modeling algorithm that, given samples of the input and output of a system, such as pressure and flow waveforms, can derive a different...
The capabilities of the proposed method are tested on a 1D circulation model consisting of the 55 largest human systemic arteries, to demonstrate its accuracy and its usefulness to estimate boundary c...
Results suggest that the proposed method is able to accurately estimate boundary conditions of arbitrary order. Higher order boundary conditions can improve the accuracy of cardiovascular simulations,...
