Titre : ATP-dependent proteases

ATP-dependent proteases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Fuchs' Endothelial Dystrophy
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "ATP-dependent proteases : Questions médicales les plus fréquentes", "headline": "ATP-dependent proteases : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les ATP-dependent proteases : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-05-23", "dateModified": "2025-02-17", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "ATP-dependent proteases" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "ATPases associated with diverse cellular activities", "url": "https://questionsmedicales.fr/mesh/D000074183", "about": { "@type": "MedicalCondition", "name": "ATPases associated with diverse cellular activities", "code": { "@type": "MedicalCode", "code": "D000074183", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.157.025.750" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "ATP-dependent endopeptidases", "alternateName": "ATP-Dependent Endopeptidases", "url": "https://questionsmedicales.fr/mesh/D057065", "about": { "@type": "MedicalCondition", "name": "ATP-dependent endopeptidases", "code": { "@type": "MedicalCode", "code": "D057065", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.157.025.750.032.099" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Protease La", "alternateName": "Protease La", "url": "https://questionsmedicales.fr/mesh/D049070", "about": { "@type": "MedicalCondition", "name": "Protease La", "code": { "@type": "MedicalCode", "code": "D049070", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.157.025.750.032.099.750" } } } ] } ], "about": { "@type": "MedicalCondition", "name": "ATP-dependent proteases", "alternateName": "ATP-Dependent Proteases", "code": { "@type": "MedicalCode", "code": "D049069", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Zhou Sha", "url": "https://questionsmedicales.fr/author/Zhou%20Sha", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, 44106, USA." } }, { "@type": "Person", "name": "Jennifer Fishovitz", "url": "https://questionsmedicales.fr/author/Jennifer%20Fishovitz", "affiliation": { "@type": "Organization", "name": "Department of Chemistry and Physics, Saint Mary's College, Notre Dame, Indiana, 46556, USA." } }, { "@type": "Person", "name": "Sujatha Chilakala", "url": "https://questionsmedicales.fr/author/Sujatha%20Chilakala", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Cleveland State University, Cleveland, Ohio, 44115, USA." } }, { "@type": "Person", "name": "Yan Xu", "url": "https://questionsmedicales.fr/author/Yan%20Xu", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Cleveland State University, Cleveland, Ohio, 44115, USA." } }, { "@type": "Person", "name": "Irene Lee", "url": "https://questionsmedicales.fr/author/Irene%20Lee", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, 44106, USA." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Integrative analysis of gene expression datasets in corneal endothelium samples of Fuchs endothelial corneal dystrophy.", "datePublished": "2023-11-02", "url": "https://questionsmedicales.fr/article/37918501", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.exer.2023.109712" } }, { "@type": "ScholarlyArticle", "name": "Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy.", "datePublished": "2023-06-13", "url": "https://questionsmedicales.fr/article/37318135", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1097/ICO.0000000000003292" } }, { "@type": "ScholarlyArticle", "name": "Cataract surgery in patients with Fuchs' dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty.", "datePublished": "2022-05-19", "url": "https://questionsmedicales.fr/article/35589882", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1038/s41598-022-12434-8" } }, { "@type": "ScholarlyArticle", "name": "RNA-Seq-based transcriptome analysis of corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy.", "datePublished": "2023-05-27", "url": "https://questionsmedicales.fr/article/37244951", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1038/s41598-023-35468-y" } }, { "@type": "ScholarlyArticle", "name": "Descemet Stripping Automated Endothelial Keratoplasty versus Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy: A National Registry-Based Comparison.", "datePublished": "2023-07-28", "url": "https://questionsmedicales.fr/article/37517576", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.ophtha.2023.07.024" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Acides aminés, peptides et protéines", "item": "https://questionsmedicales.fr/mesh/D000602" }, { "@type": "ListItem", "position": 3, "name": "Protéines", "item": "https://questionsmedicales.fr/mesh/D011506" }, { "@type": "ListItem", "position": 4, "name": "Protéines de transport", "item": "https://questionsmedicales.fr/mesh/D002352" }, { "@type": "ListItem", "position": 5, "name": "Protéines AAA", "item": "https://questionsmedicales.fr/mesh/D000074582" }, { "@type": "ListItem", "position": 6, "name": "ATPases associated with diverse cellular activities", "item": "https://questionsmedicales.fr/mesh/D000074183" }, { "@type": "ListItem", "position": 7, "name": "ATP-dependent proteases", "item": "https://questionsmedicales.fr/mesh/D049069" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : ATP-dependent proteases - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur ATP-dependent proteases", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-05", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur ATP-dependent proteases", "description": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?\nQuels tests sanguins sont utiles pour évaluer ces protéases ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec ces enzymes ?\nPeut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Fuchs'+Endothelial+Dystrophy&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur ATP-dependent proteases", "description": "Quels sont les symptômes d'une déficience en protéases ATP-dépendantes ?\nLes troubles neurologiques sont-ils liés à ces protéases ?\nComment la dégradation des protéines affecte-t-elle la santé ?\nY a-t-il des signes cutanés associés à ces troubles ?\nLes douleurs musculaires peuvent-elles être un symptôme ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Fuchs'+Endothelial+Dystrophy&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur ATP-dependent proteases", "description": "Comment prévenir les troubles liés aux protéases ?\nL'exercice physique joue-t-il un rôle préventif ?\nLes contrôles médicaux réguliers sont-ils importants ?\nY a-t-il des vaccins pour prévenir ces troubles ?\nLe stress peut-il affecter la fonction des protéases ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Fuchs'+Endothelial+Dystrophy&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur ATP-dependent proteases", "description": "Quels traitements existent pour les troubles liés aux protéases ?\nLes suppléments alimentaires peuvent-ils aider ?\nLa thérapie génique est-elle une option ?\nLes médicaments anti-inflammatoires sont-ils utiles ?\nComment la physiothérapie peut-elle aider ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Fuchs'+Endothelial+Dystrophy&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur ATP-dependent proteases", "description": "Quelles complications peuvent survenir avec des troubles protéolytiques ?\nLes complications cardiovasculaires sont-elles possibles ?\nComment les troubles protéolytiques affectent-ils le système immunitaire ?\nY a-t-il un risque accru de cancer ?\nLes troubles neurologiques peuvent-ils s'aggraver ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Fuchs'+Endothelial+Dystrophy&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur ATP-dependent proteases", "description": "Quels sont les facteurs de risque pour les troubles protéolytiques ?\nLe mode de vie influence-t-il ces risques ?\nLes maladies auto-immunes sont-elles un facteur de risque ?\nLe stress chronique est-il un facteur de risque ?\nL'exposition à des toxines peut-elle augmenter le risque ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Fuchs'+Endothelial+Dystrophy&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests enzymatiques et des analyses protéomiques peuvent être utilisés." } }, { "@type": "Question", "name": "Quels tests sanguins sont utiles pour évaluer ces protéases ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des dosages d'enzymes spécifiques et des marqueurs de dégradation protéique sont recommandés." } }, { "@type": "Question", "name": "Les biopsies sont-elles nécessaires pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des biopsies peuvent aider à évaluer l'activité des protéases dans les tissus." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème avec ces enzymes ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme la fatigue, la perte de poids et des troubles métaboliques peuvent survenir." } }, { "@type": "Question", "name": "Peut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'imagerie peut aider à visualiser des anomalies tissulaires, mais pas directement les protéases." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une déficience en protéases ATP-dépendantes ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, troubles digestifs, et accumulation de protéines mal repliées peuvent se manifester." } }, { "@type": "Question", "name": "Les troubles neurologiques sont-ils liés à ces protéases ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dysfonctionnements peuvent entraîner des troubles neurologiques et cognitifs." } }, { "@type": "Question", "name": "Comment la dégradation des protéines affecte-t-elle la santé ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Une dégradation inappropriée peut mener à des maladies dégénératives et à l'inflammation." } }, { "@type": "Question", "name": "Y a-t-il des signes cutanés associés à ces troubles ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des éruptions cutanées et des problèmes de cicatrisation peuvent être observés." } }, { "@type": "Question", "name": "Les douleurs musculaires peuvent-elles être un symptôme ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des douleurs musculaires peuvent survenir en raison d'une dégradation protéique anormale." } }, { "@type": "Question", "name": "Comment prévenir les troubles liés aux protéases ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir leur fonction." } }, { "@type": "Question", "name": "L'exercice physique joue-t-il un rôle préventif ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la santé musculaire et enzymatique." } }, { "@type": "Question", "name": "Les contrôles médicaux réguliers sont-ils importants ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des bilans réguliers peuvent détecter précocement des anomalies protéolytiques." } }, { "@type": "Question", "name": "Y a-t-il des vaccins pour prévenir ces troubles ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de vaccins spécifiques pour ces troubles enzymatiques." } }, { "@type": "Question", "name": "Le stress peut-il affecter la fonction des protéases ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut perturber l'équilibre enzymatique et la santé cellulaire." } }, { "@type": "Question", "name": "Quels traitements existent pour les troubles liés aux protéases ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies enzymatiques et des médicaments ciblant les voies protéolytiques sont utilisés." } }, { "@type": "Question", "name": "Les suppléments alimentaires peuvent-ils aider ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains suppléments peuvent soutenir la fonction protéolytique et la santé cellulaire." } }, { "@type": "Question", "name": "La thérapie génique est-elle une option ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La thérapie génique est explorée pour corriger des déficiences enzymatiques spécifiques." } }, { "@type": "Question", "name": "Les médicaments anti-inflammatoires sont-ils utiles ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent réduire l'inflammation causée par une dégradation protéique anormale." } }, { "@type": "Question", "name": "Comment la physiothérapie peut-elle aider ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "La physiothérapie peut améliorer la fonction musculaire et réduire la douleur associée." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec des troubles protéolytiques ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des maladies dégénératives, des troubles métaboliques et des infections peuvent survenir." } }, { "@type": "Question", "name": "Les complications cardiovasculaires sont-elles possibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des déséquilibres protéolytiques peuvent contribuer à des maladies cardiovasculaires." } }, { "@type": "Question", "name": "Comment les troubles protéolytiques affectent-ils le système immunitaire ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent affaiblir le système immunitaire, rendant l'organisme plus vulnérable aux infections." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans la dégradation des protéines peuvent être liées à certains cancers." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils s'aggraver ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles protéolytiques non traités peuvent aggraver les symptômes neurologiques." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les troubles protéolytiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'âge avancé, des antécédents familiaux et des maladies métaboliques augmentent le risque." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il ces risques ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques." } }, { "@type": "Question", "name": "Les maladies auto-immunes sont-elles un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent perturber la fonction des protéases et entraîner des complications." } }, { "@type": "Question", "name": "Le stress chronique est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter la régulation des protéases et la santé globale." } }, { "@type": "Question", "name": "L'exposition à des toxines peut-elle augmenter le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines toxines peuvent altérer la fonction des protéases et causer des dommages cellulaires." } } ] } ] }

Sources (7590 au total)

Cataract surgery in patients with Fuchs' dystrophy and corneal decompensation indicated for Descemet's membrane endothelial keratoplasty.

The availability of corneal donor tissue is limited in most developing countries. This study evaluated whether patients with coexisting cataract and Fuchs' dystrophy with corneal decompensation awaiti...

Descemet Stripping Automated Endothelial Keratoplasty versus Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy: A National Registry-Based Comparison.

To compare the outcome between posterior lamellar corneal transplant procedures for Fuchs endothelial corneal dystrophy, taking preoperative patient characteristics in consideration. Surgical methods ... Registry-based study with propensity score matching.... One thousand six hundred seventy-seven patients from all Swedish corneal transplantation units treated from 2012 through 2019.... All patients undergoing endothelial keratoplasty performed from 2012 through 2019 with completed 2-year follow-up data reported to The Swedish Corneal Transplant Register were included, totaling 1677 ... Best-corrected visual acuity (BCVA) at the 2-year follow-up, frequency of graft dislocation, graft rejection episodes, and graft failure within 2 years including primary graft failure.... The preoperative corneal status was affected more severely in the DSAEK group before matching. In the matched groups, the median BCVA 2 years after surgery was 0.1 logarithm of the minimum angle of re... Visual acuity improved in most patients (90%) with all 3 surgical methods. However, DMEK and phacoemulsification plus DSAEK reached higher levels of visual acuity 2 years after surgery, and phacoemuls... The author(s) have no proprietary or commercial interest in any materials discussed in this article....

Detecting Subclinical Corneal Edema Using Corneal Thickness Mapping in Patients Presenting Fuchs Endothelial Corneal Dystrophy.

To determine whether local corneal thickness changes observed with optical coherence tomography (OCT) can detect subclinical corneal edema in Fuchs endothelial corneal dystrophy (FECD).... Retrospective cohort study.... A series of patients presenting FECD who underwent cataract surgery alone (45 eyes) or with concomitant Descemet membrane endothelial keratoplasty (triple procedure; 117 eyes). The study reviewed medi... The median difference between 5- and 2-mm corneal thickness in the supra-nasal quadrant (∆5-2mmSN) was 38 µm (interquartile range 34-46) in the cataract group and 17 µm (2-38) in the triple procedure ... Local changes in corneal thickness may be useful in detecting preclinical corneal edema, especially in patients with FECD undergoing cataract surgery....

Intergenic variants, rs1200114 and rs1200108 are genetically associated along with a decreased ATP1B1 expression in Fuchs Endothelial Corneal Dystrophy.

Fuchs endothelial corneal dystrophy (FECD) is an age-related, bilateral corneal condition, characterized by apoptosis of the terminally differentiated endothelial cells. A genome-wide association stud...

DNA methylation changes and increased mRNA expression of coagulation proteins, factor V and thrombomodulin in Fuchs endothelial corneal dystrophy.

Late-onset Fuchs endothelial corneal dystrophy (FECD) is a disease affecting the corneal endothelium (CE), associated with a cytosine-thymine-guanine repeat expansion at the CTG18.1 locus in the trans...

Clinical Outcomes of Preloaded Descemet Membrane Endothelial Keratoplasty With Endothelium Inward: A 24-Month Comparative Analysis Between Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy.

The aim of this study was to compare long-term clinical outcomes of preloaded Descemet membrane endothelial keratoplasty (DMEK) between Fuchs endothelial corneal dystrophy (FECD) and bullous keratopat... In this single-center retrospective clinical case series, 71 eyes of 64 patients indicated with FECD (62%) or BK (38%) (with or without cataract) were treated with preloaded DMEK grafts between March ... The mean intraoperative graft unfolding time in FECD did not differ from the BK group ( P = 0.6061). Cystoid macular edema did not differ in either group ( P = 0.6866). The rebubbling rate was found t... Preloaded DMEK with "endothelium-in" offers acceptable intraoperative time, rebubbling rate, and clinical outcomes in both FECD and BK groups. Patients with FECD show better postoperative clinical out...

Fuchs endothelial corneal dystrophy: an updated review.

The present review will summarize FECD-associated genes and pathophysiology, diagnosis, current therapeutic approaches, and future treatment perspectives.... Literature review.... Fuchs' endothelial corneal dystrophy (FECD) is the most common bilateral corneal dystrophy and accounts for one-third of all corneal transplants performed in the US. FECD is caused by a combination of... With the characterization and understanding of FECD-related genes and ongoing research into regenerative therapies for corneal endothelium, we can hope to see more significant improvements in the futu...