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Acides aminés, peptides et protéines
Protéines
Protéines de transport
Protéines AAA
ATPases associated with diverse cellular activities
ATP-dependent proteases
ATP-dependent proteases : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"description": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?\nQuels tests sanguins sont utiles pour évaluer ces protéases ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec ces enzymes ?\nPeut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?",
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests enzymatiques et des analyses protéomiques peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels tests sanguins sont utiles pour évaluer ces protéases ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des dosages d'enzymes spécifiques et des marqueurs de dégradation protéique sont recommandés."
}
},
{
"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des biopsies peuvent aider à évaluer l'activité des protéases dans les tissus."
}
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{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec ces enzymes ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme la fatigue, la perte de poids et des troubles métaboliques peuvent survenir."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'imagerie peut aider à visualiser des anomalies tissulaires, mais pas directement les protéases."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en protéases ATP-dépendantes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, troubles digestifs, et accumulation de protéines mal repliées peuvent se manifester."
}
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{
"@type": "Question",
"name": "Les troubles neurologiques sont-ils liés à ces protéases ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des dysfonctionnements peuvent entraîner des troubles neurologiques et cognitifs."
}
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{
"@type": "Question",
"name": "Comment la dégradation des protéines affecte-t-elle la santé ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une dégradation inappropriée peut mener à des maladies dégénératives et à l'inflammation."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes cutanés associés à ces troubles ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des éruptions cutanées et des problèmes de cicatrisation peuvent être observés."
}
},
{
"@type": "Question",
"name": "Les douleurs musculaires peuvent-elles être un symptôme ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des douleurs musculaires peuvent survenir en raison d'une dégradation protéique anormale."
}
},
{
"@type": "Question",
"name": "Comment prévenir les troubles liés aux protéases ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir leur fonction."
}
},
{
"@type": "Question",
"name": "L'exercice physique joue-t-il un rôle préventif ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé musculaire et enzymatique."
}
},
{
"@type": "Question",
"name": "Les contrôles médicaux réguliers sont-ils importants ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des bilans réguliers peuvent détecter précocement des anomalies protéolytiques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des vaccins pour prévenir ces troubles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de vaccins spécifiques pour ces troubles enzymatiques."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter la fonction des protéases ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut perturber l'équilibre enzymatique et la santé cellulaire."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour les troubles liés aux protéases ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies enzymatiques et des médicaments ciblant les voies protéolytiques sont utilisés."
}
},
{
"@type": "Question",
"name": "Les suppléments alimentaires peuvent-ils aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains suppléments peuvent soutenir la fonction protéolytique et la santé cellulaire."
}
},
{
"@type": "Question",
"name": "La thérapie génique est-elle une option ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est explorée pour corriger des déficiences enzymatiques spécifiques."
}
},
{
"@type": "Question",
"name": "Les médicaments anti-inflammatoires sont-ils utiles ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent réduire l'inflammation causée par une dégradation protéique anormale."
}
},
{
"@type": "Question",
"name": "Comment la physiothérapie peut-elle aider ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "La physiothérapie peut améliorer la fonction musculaire et réduire la douleur associée."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des troubles protéolytiques ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies dégénératives, des troubles métaboliques et des infections peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les complications cardiovasculaires sont-elles possibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres protéolytiques peuvent contribuer à des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Comment les troubles protéolytiques affectent-ils le système immunitaire ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent affaiblir le système immunitaire, rendant l'organisme plus vulnérable aux infections."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de cancer ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies dans la dégradation des protéines peuvent être liées à certains cancers."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques peuvent-ils s'aggraver ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles protéolytiques non traités peuvent aggraver les symptômes neurologiques."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les troubles protéolytiques ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, des antécédents familiaux et des maladies métaboliques augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il ces risques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent perturber la fonction des protéases et entraîner des complications."
}
},
{
"@type": "Question",
"name": "Le stress chronique est-il un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter la régulation des protéases et la santé globale."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines peut-elle augmenter le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines toxines peuvent altérer la fonction des protéases et causer des dommages cellulaires."
}
}
]
}
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To describe the characteristics and the survival of patients with cancer with intended off-label use (OLU) cancer treatment and reimbursement request....
Cohort study using medical record data....
Three major cancer centres in Switzerland....
519 patients with cancer and a reimbursement request for OLU between January 2015 and July 2018....
Characteristics of patients with cancer with and without access to intended OLU. Characteristics included the Glasgow prognostic score (GPS) which includes C reactive protein and albumin and discrimin...
OLU was intended for 519 (17%) of 3046 patients with cancer, as first-line treatment in 51% (n=264) and second-line in 31% (n=162). Of the 519 patients, 63% (n=328) were male, 63% (n=329) had solid ca...
Contrary to the common assumption, OLU in oncology is typically not primarily intended for patients with exhausted treatment options. Patient characteristics largely differ between patients with and w...
JAK inhibitors target specific inflammatory cytokines involved in various inflammatory diseases. Four molecules have been approved for dermatological use: upadacitinib, baricitinib, abrocitinib and to...
A 70-year-old man presented with a left pilon fracture after a 10-foot fall from a ladder. The severe amount of comminution, joint destruction, and impaction from this injury eventually resulted in a ...
We do not endorse the off-label use of a tensioned proximal humerus plate for all tibiotalar fusions; however, we do believe that this is a useful technique in certain situations with large zones of d...
JAK inhibitors target specific inflammatory cytokines involved in various inflammatory diseases. Four molecules have been approved for dermatological use: upadacitinib, baricitinib, abrocitinib and to...
FreeStyle Libre 1 (FGM) has been approved by the FDA for children older than 4 years. It enables noninvasive glucose monitoring without the need for finger pricking. Parents of very young children oft...
This was an ambi-directional cohort study. We recruited parents of very young children with type 1 diabetes mellitus (T1DM) who were less than 5 years old when they started using FGM at the King Saud ...
We included 31 children with mean age of the children when they started using FGM was 3.88 ± 1.10 years (range, 1.46-5.4 years), and the mean sensor use was 2.3 ± 1.3 years. During the use of the devi...
The safety profile of FGM used for very young children with T1DM is the same for older children, which leads to improved metabolic control and sleep quality of both the parent and the child....
As an adjuvant drug, alprostadil lipid microsphere injection (Lipo-PGE...
To examine the current prevalence and cost of paediatric off-label drug prescriptions in Gansu, China, and the potential influencing factors....
The prevalence of off-label prescriptions in paediatrics was evaluated according to the National Medical Products Administration drug instructions in the China Pharmaceutical Reference (China Pharmace...
A multicentre cross-sectional study of outpatient paediatric prescriptions in 196 secondary and tertiary hospitals in Gansu Province, China, in March and September 2020....
We retrieved 104 029 paediatric prescriptions, of which 39 480 (38.0%) contained off-label use. The most common diseases treated by off-label drugs were respiratory system diseases (n=15 831, 40.1%). ...
Off-label drug use is widespread in paediatric practice in China. Three-quarters of the prescriptions may potentially include inappropriate medication use, resulting in a daily economic burden of abou...
Until recently, few therapeutic options, other than symptomatic treatment, were available for patients with primary progressive multiple sclerosis (PPMS). Ocrelizumab is the only approved treatment in...
To evaluate published data concerning the efficacy of these five treatments frequently used as off-label disease-modifying therapies....
We reviewed and summarized the studies published in Pubmed since the inception of the database....
Evidence from randomized controlled trials is lacking to support the use of these treatments as disease-modifying therapies in PPMS....
The literature lacks dedicated studies to support the off-label use of these disease-modifying therapies in PPMS. However, some limited data are available in the literature suggesting that the use of ...
Using commercially available automated insulin delivery (AID) systems for treating type 1 diabetes during pregnancy remains controversial. This retrospective study assessed six pregnant women with typ...
Off-label use is frequently practiced in hip revision arthroplasty, as there may be indications for the application of implants for purposes outside the one the manufacturers intended (i.e. large bone...