Titre : ATP-dependent proteases

ATP-dependent proteases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Off-Label Use
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"Diagnostic", "headline": "Diagnostic sur ATP-dependent proteases", "description": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?\nQuels tests sanguins sont utiles pour évaluer ces protéases ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec ces enzymes ?\nPeut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Off-Label+Use&page=5#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur ATP-dependent proteases", "description": "Quels sont les symptômes d'une déficience en protéases ATP-dépendantes ?\nLes troubles neurologiques sont-ils liés à ces protéases ?\nComment la dégradation des protéines affecte-t-elle la santé ?\nY a-t-il des signes cutanés associés à ces troubles ?\nLes douleurs musculaires peuvent-elles être un symptôme ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Off-Label+Use&page=5#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur ATP-dependent proteases", "description": "Comment prévenir les troubles liés aux protéases ?\nL'exercice physique joue-t-il un rôle préventif ?\nLes contrôles médicaux réguliers sont-ils importants ?\nY a-t-il des vaccins pour prévenir ces troubles ?\nLe stress peut-il affecter la fonction des protéases ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Off-Label+Use&page=5#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur ATP-dependent proteases", "description": "Quels traitements existent pour les troubles liés aux protéases ?\nLes suppléments alimentaires peuvent-ils aider ?\nLa thérapie génique est-elle une option ?\nLes médicaments anti-inflammatoires sont-ils utiles ?\nComment la physiothérapie peut-elle aider ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Off-Label+Use&page=5#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur ATP-dependent proteases", "description": "Quelles complications peuvent survenir avec des troubles protéolytiques ?\nLes complications cardiovasculaires sont-elles possibles ?\nComment les troubles protéolytiques affectent-ils le système immunitaire ?\nY a-t-il un risque accru de cancer ?\nLes troubles neurologiques peuvent-ils s'aggraver ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Off-Label+Use&page=5#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur ATP-dependent proteases", "description": "Quels sont les facteurs de risque pour les troubles protéolytiques ?\nLe mode de vie influence-t-il ces risques ?\nLes maladies auto-immunes sont-elles un facteur de risque ?\nLe stress chronique est-il un facteur de risque ?\nL'exposition à des toxines peut-elle augmenter le risque ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Off-Label+Use&page=5#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests enzymatiques et des analyses protéomiques peuvent être utilisés." } }, { "@type": "Question", "name": "Quels tests sanguins sont utiles pour évaluer ces protéases ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des dosages d'enzymes spécifiques et des marqueurs de dégradation protéique sont recommandés." } }, { "@type": "Question", "name": "Les biopsies sont-elles nécessaires pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des biopsies peuvent aider à évaluer l'activité des protéases dans les tissus." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème avec ces enzymes ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme la fatigue, la perte de poids et des troubles métaboliques peuvent survenir." } }, { "@type": "Question", "name": "Peut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'imagerie peut aider à visualiser des anomalies tissulaires, mais pas directement les protéases." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une déficience en protéases ATP-dépendantes ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, troubles digestifs, et accumulation de protéines mal repliées peuvent se manifester." } }, { "@type": "Question", "name": "Les troubles neurologiques sont-ils liés à ces protéases ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dysfonctionnements peuvent entraîner des troubles neurologiques et cognitifs." } }, { "@type": "Question", "name": "Comment la dégradation des protéines affecte-t-elle la santé ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Une dégradation inappropriée peut mener à des maladies dégénératives et à l'inflammation." } }, { "@type": "Question", "name": "Y a-t-il des signes cutanés associés à ces troubles ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des éruptions cutanées et des problèmes de cicatrisation peuvent être observés." } }, { "@type": "Question", "name": "Les douleurs musculaires peuvent-elles être un symptôme ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des douleurs musculaires peuvent survenir en raison d'une dégradation protéique anormale." } }, { "@type": "Question", "name": "Comment prévenir les troubles liés aux protéases ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir leur fonction." } }, { "@type": "Question", "name": "L'exercice physique joue-t-il un rôle préventif ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la santé musculaire et enzymatique." } }, { "@type": "Question", "name": "Les contrôles médicaux réguliers sont-ils importants ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des bilans réguliers peuvent détecter précocement des anomalies protéolytiques." } }, { "@type": "Question", "name": "Y a-t-il des vaccins pour prévenir ces troubles ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de vaccins spécifiques pour ces troubles enzymatiques." } }, { "@type": "Question", "name": "Le stress peut-il affecter la fonction des protéases ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut perturber l'équilibre enzymatique et la santé cellulaire." } }, { "@type": "Question", "name": "Quels traitements existent pour les troubles liés aux protéases ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies enzymatiques et des médicaments ciblant les voies protéolytiques sont utilisés." } }, { "@type": "Question", "name": "Les suppléments alimentaires peuvent-ils aider ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains suppléments peuvent soutenir la fonction protéolytique et la santé cellulaire." } }, { "@type": "Question", "name": "La thérapie génique est-elle une option ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La thérapie génique est explorée pour corriger des déficiences enzymatiques spécifiques." } }, { "@type": "Question", "name": "Les médicaments anti-inflammatoires sont-ils utiles ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent réduire l'inflammation causée par une dégradation protéique anormale." } }, { "@type": "Question", "name": "Comment la physiothérapie peut-elle aider ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "La physiothérapie peut améliorer la fonction musculaire et réduire la douleur associée." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec des troubles protéolytiques ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des maladies dégénératives, des troubles métaboliques et des infections peuvent survenir." } }, { "@type": "Question", "name": "Les complications cardiovasculaires sont-elles possibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des déséquilibres protéolytiques peuvent contribuer à des maladies cardiovasculaires." } }, { "@type": "Question", "name": "Comment les troubles protéolytiques affectent-ils le système immunitaire ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent affaiblir le système immunitaire, rendant l'organisme plus vulnérable aux infections." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans la dégradation des protéines peuvent être liées à certains cancers." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils s'aggraver ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles protéolytiques non traités peuvent aggraver les symptômes neurologiques." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les troubles protéolytiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'âge avancé, des antécédents familiaux et des maladies métaboliques augmentent le risque." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il ces risques ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques." } }, { "@type": "Question", "name": "Les maladies auto-immunes sont-elles un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent perturber la fonction des protéases et entraîner des complications." } }, { "@type": "Question", "name": "Le stress chronique est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter la régulation des protéases et la santé globale." } }, { "@type": "Question", "name": "L'exposition à des toxines peut-elle augmenter le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines toxines peuvent altérer la fonction des protéases et causer des dommages cellulaires." } } ] } ] }

Sources (10000 au total)

On and off-label uses of interleukin-17 inhibitors for patients with plaque-type psoriasis in Thailand: a real-world study.

Off-label uses of biologics in the treatment of psoriasis are usually implemented in limited-resource settings and studies regarding their response profiles are limited.... This was a retrospective study performed in moderate-to-severe plaque-type psoriasis patients who had been treated with either secukinumab, ixekizumab or brodalumab at a university hospital in Thailan... A total of 142 patients were included in the data analysis consisting of three groups of 48 patients, 86 patients, and 8 patients treated by secukinumab, ixekizumab, and brodalumab, respectively. Pati... Off-label, patient-oriented regimens could be a promising choice of IL-17 inhibitors for administration in special settings. Off-label regimens are not inferior in terms of skin clearance to an on-lab...

Anti-Inflammatory and Immunomodulatory Effect of High-Dose Immunoglobulins in Children: From Approved Indications to Off-Label Use.

The large-scale utilization of immunoglobulins in patients with inborn errors of immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as immunomodulatory and anti-inflamma... To provide pragmatic indications for a need-based application of high-dose immunoglobulins in the pediatric context.... A literature search was performed using PubMed, from inception until 1st August 2023, including the following keywords: anti-inflammatory; children; high dose gammaglobulin; high dose immunoglobulin; ... In the light of the current imbalance between gammaglobulins' demand and availability, this review advocates the urgency of a more conscious utilization of this medical product, giving indications abo...

Off-label use versus formal recommendations of conventional and novel antibiotics for the treatment of infections caused by multidrug-resistant bacteria.

The infections caused by multidrug- and extensively drug-resistant (MDR, XDR) bacteria, including Gram-positive cocci (GPC, including methicillin-resistant Staphylococcus aureus, MDR-Streptococcus pne...

Safety Profile and Complication Rates in Emergency Off-label Use of Tirofiban in Interventional Neuroradiology : An Observational Dual Center Study.

Tirofiban has been approved for the treatment of acute coronary syndrome. Meanwhile, tirofiban is frequently applied in emergency situations in interventional neuroradiology (INR). The objective of th... Data of 86 patients, who underwent neurointerventional therapy and were treated with tirofiban at 2 neuroendovascular centers between January 2016 and July 2017 were retrospectively analyzed. Despite ... Median patient age was 62 years (range 26-88 years). Patients received tirofiban for extracranial (n = 35) or intracranial stenting (n = 35), coiling of ruptured cerebral aneurysms (n = 6), continuous... Whereas the safety profile of tirofiban when applied off-label in INR is acceptable, the highest risk for relevant tirofiban-associated complications is observed in older patients treated by emergency...

Optimizing therapeutic decision-making for off-label medicines use: A scoping review and consensus recommendations for improving practice and research

Off-label medicines use is a common and sometimes necessary practice in many populations, with important clinical, ethical and financial consequences, including potential unintended harm or lack of ef... We conducted a scoping review to summarize the literature on available off-label use guidance, including types, extent and scientific rigor of evidence incorporated. Findings informed the development ... We found 31 published guidance documents on therapeutic decision-making for off-label use. Of 20 guidances with general recommendations, only 35% detailed the types and quality of evidence needed and ... We provide comprehensive consensus recommendations to optimize therapeutic decision-making for off-label medicines use and concurrently drive clinically relevant research. Successful implementation re...

Safety profile of methotrexate used off-label in ectopic pregnancy: an active monitoring study based on a Chinese hospital pharmacovigilance system.

Methotrexate (MTX) is characterized as first-line therapy although its indication of ectopic pregnancy is off-label use. We aimed to conduct a retrospective cohort study to investigate the incidence, ... Basing on China Hospital Pharmacovigilance System (CHPS), a retrospective analysis was performed to evaluate the safety of MTX (... The total incidence of ADRs was 54.0%. Anaemia (37.6%) was the most frequent ADR, followed by hepatic function abnormal (11.3%), hyperuricemia (6.1%), neutropenia (4.6%), leukopenia (4.0%), and dyslip... MTX is quite safe in ectopic pregnancy, despite its mild to moderate hematotoxicity, hepatotoxicity and nephrotoxicity. Taking CHPS can present the accurate denominator of the incidence of adverse dru...