Titre : Complement C3-C5 Convertases

Complement C3-C5 Convertases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Complement System Proteins
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Complement C3-C5 Convertases : Questions médicales les plus fréquentes", "headline": "Complement C3-C5 Convertases : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Complement C3-C5 Convertases : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-03-14", "dateModified": "2025-03-09", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Complement C3-C5 Convertases" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Enzymes activatrices du complément", "url": "https://questionsmedicales.fr/mesh/D003166", "about": { "@type": "MedicalCondition", "name": "Enzymes activatrices du complément", "code": { "@type": "MedicalCode", "code": "D003166", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Alternative pathway C3-C5 Convertases", "alternateName": "Complement C3-C5 Convertases, Alternative Pathway", "url": "https://questionsmedicales.fr/mesh/D050578", "about": { "@type": "MedicalCondition", "name": "Alternative pathway C3-C5 Convertases", "code": { "@type": "MedicalCode", "code": "D050578", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045.387.500" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Alternative pathway complement C3 convertase", "alternateName": "Complement C3 Convertase, Alternative Pathway", "url": "https://questionsmedicales.fr/mesh/D051561", "about": { "@type": "MedicalCondition", "name": "Alternative pathway complement C3 convertase", "code": { "@type": "MedicalCode", "code": "D051561", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045.387.500.374" } } }, { "@type": "MedicalWebPage", "name": "Alternative pathway C5 convertase", "alternateName": "Complement C5 Convertase, Alternative Pathway", "url": "https://questionsmedicales.fr/mesh/D051566", "about": { "@type": "MedicalCondition", "name": "Alternative pathway C5 convertase", "code": { "@type": "MedicalCode", "code": "D051566", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045.387.500.750" } } } ] }, { "@type": "MedicalWebPage", "name": "Classical pathway C3-C5 Convertases", "alternateName": "Complement C3-C5 Convertases, Classical Pathway", "url": "https://questionsmedicales.fr/mesh/D050579", "about": { "@type": "MedicalCondition", "name": "Classical pathway C3-C5 Convertases", "code": { "@type": "MedicalCode", "code": "D050579", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045.387.750" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Classical pathway complement C3 convertase", "alternateName": "Complement C3 Convertase, Classical Pathway", "url": "https://questionsmedicales.fr/mesh/D051574", "about": { "@type": "MedicalCondition", "name": "Classical pathway complement C3 convertase", "code": { "@type": "MedicalCode", "code": "D051574", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045.387.750.500" } } }, { "@type": "MedicalWebPage", "name": "Classical pathway C5 convertase", "alternateName": "Complement C5 Convertase, Classical Pathway", "url": "https://questionsmedicales.fr/mesh/D051577", "about": { "@type": "MedicalCondition", "name": "Classical pathway C5 convertase", "code": { "@type": "MedicalCode", "code": "D051577", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045.387.750.750" } } } ] }, { "@type": "MedicalWebPage", "name": "Mannose-Binding Protein-Associated Serine Proteases", "alternateName": "Mannose-Binding Protein-Associated Serine Proteases", "url": "https://questionsmedicales.fr/mesh/D050606", "about": { "@type": "MedicalCondition", "name": "Mannose-Binding Protein-Associated Serine Proteases", "code": { "@type": "MedicalCode", "code": "D050606", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.124.486.274.045.387.875" } } } ], "about": { "@type": "MedicalCondition", "name": "Complement C3-C5 Convertases", "alternateName": "Complement C3-C5 Convertases", "code": { "@type": "MedicalCode", "code": "D050577", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "John D Lambris", "url": "https://questionsmedicales.fr/author/John%20D%20Lambris", "affiliation": { "@type": "Organization", "name": "Department of Laboratory Medicine and Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA." } }, { "@type": "Person", "name": "Tom Eirik Mollnes", "url": "https://questionsmedicales.fr/author/Tom%20Eirik%20Mollnes", "affiliation": { "@type": "Organization", "name": "Research Laboratory, Nordland Hospital, 8092 Bodø, Norway." } }, { "@type": "Person", "name": "Dimitrios C Mastellos", "url": "https://questionsmedicales.fr/author/Dimitrios%20C%20Mastellos", "affiliation": { "@type": "Organization", "name": "National Center for Scientific Research 'Demokritos', Athens, Greece." } }, { "@type": "Person", "name": "Giuseppe Remuzzi", "url": "https://questionsmedicales.fr/author/Giuseppe%20Remuzzi", "affiliation": { "@type": "Organization", "name": "Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy." } }, { "@type": "Person", "name": "Markus Huber-Lang", "url": "https://questionsmedicales.fr/author/Markus%20Huber-Lang", "affiliation": { "@type": "Organization", "name": "Institute of Clinical and Experimental Trauma Immunology, University Hospital of Ulm, Ulm, Germany." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "The complement system testing in clinical laboratory.", "datePublished": "2023-02-04", "url": "https://questionsmedicales.fr/article/36746263", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.cca.2023.117238" } }, { "@type": "ScholarlyArticle", "name": "Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.", "datePublished": "2023-07-21", "url": "https://questionsmedicales.fr/article/37480051", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s12974-023-02850-6" } }, { "@type": "ScholarlyArticle", "name": "The Complement System in Metabolic-Associated Kidney Diseases.", "datePublished": "2022-07-18", "url": "https://questionsmedicales.fr/article/35924242", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3389/fimmu.2022.902063" } }, { "@type": "ScholarlyArticle", "name": "The complement system in pediatric acute kidney injury.", "datePublished": "2022-10-06", "url": "https://questionsmedicales.fr/article/36203104", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1007/s00467-022-05755-3" } }, { "@type": "ScholarlyArticle", "name": "Balancing selection on the complement system of a wild rodent.", "datePublished": "2023-05-25", "url": "https://questionsmedicales.fr/article/37231383", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s12862-023-02122-0" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Acides aminés, peptides et protéines", "item": "https://questionsmedicales.fr/mesh/D000602" }, { "@type": "ListItem", "position": 3, "name": "Protéines", "item": "https://questionsmedicales.fr/mesh/D011506" }, { "@type": "ListItem", "position": 4, "name": "Protéines du sang", "item": "https://questionsmedicales.fr/mesh/D001798" }, { "@type": "ListItem", "position": 5, "name": "Immunoprotéines", "item": "https://questionsmedicales.fr/mesh/D007162" }, { "@type": "ListItem", "position": 6, "name": "Protéines du système du complément", "item": "https://questionsmedicales.fr/mesh/D003165" }, { "@type": "ListItem", "position": 7, "name": "Enzymes activatrices du complément", "item": "https://questionsmedicales.fr/mesh/D003166" }, { "@type": "ListItem", "position": 8, "name": "Complement C3-C5 Convertases", "item": "https://questionsmedicales.fr/mesh/D050577" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Complement C3-C5 Convertases - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Complement C3-C5 Convertases", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-06", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Complement C3-C5 Convertases", "description": "Comment diagnostiquer une déficience en convertases C3-C5 ?\nQuels tests sont utilisés pour évaluer l'activité du complément ?\nQuels signes cliniques suggèrent une activation du complément ?\nPeut-on mesurer l'activité des convertases dans le sang ?\nQuels marqueurs biologiques sont associés aux convertases ?", "url": "https://questionsmedicales.fr/mesh/D050577?mesh_terms=Complement+System+Proteins&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Complement C3-C5 Convertases", "description": "Quels symptômes indiquent une activation excessive du complément ?\nComment se manifestent les troubles liés aux convertases ?\nLes troubles du complément causent-ils des symptômes neurologiques ?\nQuels signes indiquent une déficience en C3 ?\nLes symptômes varient-ils selon le type de déficience ?", "url": "https://questionsmedicales.fr/mesh/D050577?mesh_terms=Complement+System+Proteins&page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Complement C3-C5 Convertases", "description": "Peut-on prévenir les déficiences en complément ?\nQuelles mesures préventives peuvent réduire les infections ?\nLes patients doivent-ils éviter certains aliments ?\nComment le suivi médical aide-t-il à prévenir les complications ?\nLes conseils génétiques sont-ils utiles pour les familles ?", "url": "https://questionsmedicales.fr/mesh/D050577?mesh_terms=Complement+System+Proteins&page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Complement C3-C5 Convertases", "description": "Quels traitements sont disponibles pour les déficiences en complément ?\nComment traiter une activation excessive du complément ?\nLes transfusions sanguines aident-elles en cas de déficience ?\nY a-t-il des thérapies géniques pour les déficiences en complément ?\nLes traitements sont-ils personnalisés selon le patient ?", "url": "https://questionsmedicales.fr/mesh/D050577?mesh_terms=Complement+System+Proteins&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Complement C3-C5 Convertases", "description": "Quelles complications peuvent survenir avec une déficience en C3 ?\nLes complications sont-elles réversibles ?\nComment les complications affectent-elles la qualité de vie ?\nLes complications neurologiques sont-elles fréquentes ?\nQuelles sont les complications liées à l'activation excessive du complément ?", "url": "https://questionsmedicales.fr/mesh/D050577?mesh_terms=Complement+System+Proteins&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Complement C3-C5 Convertases", "description": "Quels facteurs augmentent le risque de déficience en complément ?\nL'âge influence-t-il le risque de troubles du complément ?\nLes infections fréquentes sont-elles un facteur de risque ?\nLe sexe joue-t-il un rôle dans les troubles du complément ?\nLes maladies génétiques augmentent-elles le risque ?", "url": "https://questionsmedicales.fr/mesh/D050577?mesh_terms=Complement+System+Proteins&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une déficience en convertases C3-C5 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests sanguins mesurant les niveaux de C3 et C5 peuvent indiquer une déficience." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer l'activité du complément ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests d'hémolyse et les dosages de protéines du complément sont courants." } }, { "@type": "Question", "name": "Quels signes cliniques suggèrent une activation du complément ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme des infections récurrentes ou des maladies auto-immunes peuvent indiquer une activation." } }, { "@type": "Question", "name": "Peut-on mesurer l'activité des convertases dans le sang ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests spécifiques peuvent évaluer l'activité des convertases dans le sérum." } }, { "@type": "Question", "name": "Quels marqueurs biologiques sont associés aux convertases ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Les niveaux de C3a et C5a, produits de clivage, sont des marqueurs importants." } }, { "@type": "Question", "name": "Quels symptômes indiquent une activation excessive du complément ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme des éruptions cutanées, des douleurs articulaires et de la fièvre peuvent survenir." } }, { "@type": "Question", "name": "Comment se manifestent les troubles liés aux convertases ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent se manifester par des infections fréquentes et des réactions inflammatoires." } }, { "@type": "Question", "name": "Les troubles du complément causent-ils des symptômes neurologiques ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles neurologiques peuvent survenir en raison d'une inflammation cérébrale." } }, { "@type": "Question", "name": "Quels signes indiquent une déficience en C3 ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des infections bactériennes récurrentes et des maladies auto-immunes peuvent être des signes." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon le type de déficience ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent varier selon que la déficience concerne C3 ou C5." } }, { "@type": "Question", "name": "Peut-on prévenir les déficiences en complément ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention est difficile, mais un diagnostic précoce peut aider à gérer les symptômes." } }, { "@type": "Question", "name": "Quelles mesures préventives peuvent réduire les infections ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des vaccinations et une bonne hygiène peuvent aider à réduire le risque d'infections." } }, { "@type": "Question", "name": "Les patients doivent-ils éviter certains aliments ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Il n'y a pas de restrictions alimentaires spécifiques, mais une alimentation équilibrée est conseillée." } }, { "@type": "Question", "name": "Comment le suivi médical aide-t-il à prévenir les complications ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi régulier permet d'identifier et de traiter rapidement les complications potentielles." } }, { "@type": "Question", "name": "Les conseils génétiques sont-ils utiles pour les familles ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les conseils génétiques peuvent aider à comprendre les risques de transmission." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les déficiences en complément ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des immunoglobulines intraveineuses et des antibiotiques prophylactiques." } }, { "@type": "Question", "name": "Comment traiter une activation excessive du complément ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments anti-inflammatoires et des inhibiteurs du complément peuvent être utilisés." } }, { "@type": "Question", "name": "Les transfusions sanguines aident-elles en cas de déficience ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les transfusions peuvent aider à restaurer les niveaux de protéines du complément." } }, { "@type": "Question", "name": "Y a-t-il des thérapies géniques pour les déficiences en complément ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des recherches sont en cours sur les thérapies géniques pour traiter ces déficiences." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés selon le patient ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements sont souvent adaptés en fonction des besoins individuels du patient." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec une déficience en C3 ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des infections graves, des maladies auto-immunes et des complications rénales peuvent survenir." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes." } }, { "@type": "Question", "name": "Comment les complications affectent-elles la qualité de vie ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Elles peuvent réduire la qualité de vie en entraînant des douleurs chroniques et des limitations fonctionnelles." } }, { "@type": "Question", "name": "Les complications neurologiques sont-elles fréquentes ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des complications neurologiques peuvent survenir, notamment des troubles cognitifs." } }, { "@type": "Question", "name": "Quelles sont les complications liées à l'activation excessive du complément ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme des lésions tissulaires et des réactions inflammatoires peuvent se produire." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque de déficience en complément ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des antécédents familiaux et certaines maladies auto-immunes augmentent le risque." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de troubles du complément ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque peut augmenter avec l'âge en raison de la dégradation du système immunitaire." } }, { "@type": "Question", "name": "Les infections fréquentes sont-elles un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des infections fréquentes peuvent indiquer une déficience sous-jacente du complément." } }, { "@type": "Question", "name": "Le sexe joue-t-il un rôle dans les troubles du complément ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines déficiences sont plus fréquentes chez les femmes en raison de facteurs hormonaux." } }, { "@type": "Question", "name": "Les maladies génétiques augmentent-elles le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines maladies génétiques peuvent prédisposer à des déficiences du complément." } } ] } ] }

Sources (10000 au total)

Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.

Alzheimer's disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CL... To address whether changes in plasma complement protein levels in AD relate to AD-associated complement gene variants we first measured relevant plasma complement proteins (clusterin, C1q, C1s, CR1, f... Complement dysregulation is evident in AD and may contribute to pathology. AD-associated SNPs in CR1, C1S and CFH impact plasma levels of the encoded proteins, suggesting a mechanism for impact on dis...

Balancing selection on the complement system of a wild rodent.

Selection pressure exerted by pathogens can influence patterns of genetic diversity in the host. In the immune system especially, numerous genes encode proteins involved in antagonistic interactions w... Using a population sample of whole-genome resequencing data from wild bank voles (n = 31), we estimated the extent of genetic diversity and tested for signatures of balancing selection in multiple com... The present study adds to the growing evidence that balancing selection may be an important evolutionary force on components of the innate immune system. The identified target in the complement system...

Significance of urine complement proteins in monitoring lupus activity.

Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported. The ... First, we used bioinformatics and functional enrichment to screen and identify the urine protein profile of SLE patients. Then, analyzed and verified the proteins related to the complement pathway by ... A total of 14 complement pathway-related proteins were screened for differences in expression between the active group and the stable group, eight of these DEPs were up-regulated and six were down-reg... Complement-related DEPs in urine have a certain correlation with SLE disease activity. Urine C9, C8A, C4B and C8G present promising non-invasive biomarkers for monitoring lupus activity....

Full characterization of the three pathways of the complement system in patients with systemic lupus erythematosus.

To date a complete characterization of the components of the complement (C) pathways (CLassical, LEctin and ALternative) in patients with systemic lupus erythematosus (SLE) has not been performed. We ... New generation functional assays of the three pathways of the C system were assessed in 284 patients with SLE. Linear regression analysis was performed to study the relationship between the activity, ... Lower values of the functional tests AL and LE were more frequent than those of the CL pathway. Clinical activity was not related to inferior values of C routes functional assays. The presence of incr... Not only the CL route, but also the AL and LE are related to SLE features. C expression patterns are linked to disease profiles. While accrual damage was associated with higher functional tests of C p...