questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines membranaires
Protéines de transport membranaire
Canaux ioniques
Canaux potassiques
Canaux potassiques voltage-dépendants
Canaux potassiques rectifiants retardés
Canaux potassiques KNCQ
Canal potassique KCNQ1
Canal potassique KCNQ1 : Questions médicales fréquentes
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Canal potassique KCNQ1 : Questions médicales les plus fréquentes",
"headline": "Canal potassique KCNQ1 : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Canal potassique KCNQ1 : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-06-11",
"dateModified": "2025-03-08",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Canal potassique KCNQ1"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Canaux potassiques KNCQ",
"url": "https://questionsmedicales.fr/mesh/D051656",
"about": {
"@type": "MedicalCondition",
"name": "Canaux potassiques KNCQ",
"code": {
"@type": "MedicalCode",
"code": "D051656",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.543.585.400.750.900.124.249"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Canal potassique KCNQ1",
"alternateName": "KCNQ1 Potassium Channel",
"code": {
"@type": "MedicalCode",
"code": "D051657",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Jodene Eldstrom",
"url": "https://questionsmedicales.fr/author/Jodene%20Eldstrom",
"affiliation": {
"@type": "Organization",
"name": "Department of Anesthesiology, Pharmacology & Therapeutics, The University of British Columbia, Vancouver, BC, Canada."
}
},
{
"@type": "Person",
"name": "David Fedida",
"url": "https://questionsmedicales.fr/author/David%20Fedida",
"affiliation": {
"@type": "Organization",
"name": "Department of Anesthesiology, Pharmacology & Therapeutics, The University of British Columbia, Vancouver, BC, Canada."
}
},
{
"@type": "Person",
"name": "Adam Szewczyk",
"url": "https://questionsmedicales.fr/author/Adam%20Szewczyk",
"affiliation": {
"@type": "Organization",
"name": "Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland."
}
},
{
"@type": "Person",
"name": "Georg Kuenze",
"url": "https://questionsmedicales.fr/author/Georg%20Kuenze",
"affiliation": {
"@type": "Organization",
"name": "Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America."
}
},
{
"@type": "Person",
"name": "Alfred L George",
"url": "https://questionsmedicales.fr/author/Alfred%20L%20George",
"affiliation": {
"@type": "Organization",
"name": "Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs.",
"datePublished": "2023-08-01",
"url": "https://questionsmedicales.fr/article/37526928",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1085/jgp.202313339"
}
},
{
"@type": "ScholarlyArticle",
"name": "Long QT syndrome-associated calmodulin variants disrupt the activity of the slowly activating delayed rectifier potassium channel.",
"datePublished": "2023-07-10",
"url": "https://questionsmedicales.fr/article/37428651",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1113/JP284994"
}
},
{
"@type": "ScholarlyArticle",
"name": "Computational Study on Effect of KCNQ1 P535T Mutation in a Cardiac Ventricular Tissue.",
"datePublished": "2023-05-11",
"url": "https://questionsmedicales.fr/article/37166559",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s00232-023-00287-9"
}
},
{
"@type": "ScholarlyArticle",
"name": "A novel stop-gain pathogenic variant in the KCNQ1 gene causing long QT syndrome 1.",
"datePublished": "2023-01-12",
"url": "https://questionsmedicales.fr/article/36635780",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s40001-023-00984-0"
}
},
{
"@type": "ScholarlyArticle",
"name": "Novel combinations of variations in KCNQ1 were associated with patients with long QT syndrome or Jervell and Lange-Nielsen syndrome.",
"datePublished": "2023-08-12",
"url": "https://questionsmedicales.fr/article/37568094",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12872-023-03417-2"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides aminés, peptides et protéines",
"item": "https://questionsmedicales.fr/mesh/D000602"
},
{
"@type": "ListItem",
"position": 3,
"name": "Protéines",
"item": "https://questionsmedicales.fr/mesh/D011506"
},
{
"@type": "ListItem",
"position": 4,
"name": "Protéines membranaires",
"item": "https://questionsmedicales.fr/mesh/D008565"
},
{
"@type": "ListItem",
"position": 5,
"name": "Protéines de transport membranaire",
"item": "https://questionsmedicales.fr/mesh/D026901"
},
{
"@type": "ListItem",
"position": 6,
"name": "Canaux ioniques",
"item": "https://questionsmedicales.fr/mesh/D007473"
},
{
"@type": "ListItem",
"position": 7,
"name": "Canaux potassiques",
"item": "https://questionsmedicales.fr/mesh/D015221"
},
{
"@type": "ListItem",
"position": 8,
"name": "Canaux potassiques voltage-dépendants",
"item": "https://questionsmedicales.fr/mesh/D024642"
},
{
"@type": "ListItem",
"position": 9,
"name": "Canaux potassiques rectifiants retardés",
"item": "https://questionsmedicales.fr/mesh/D051668"
},
{
"@type": "ListItem",
"position": 10,
"name": "Canaux potassiques KNCQ",
"item": "https://questionsmedicales.fr/mesh/D051656"
},
{
"@type": "ListItem",
"position": 11,
"name": "Canal potassique KCNQ1",
"item": "https://questionsmedicales.fr/mesh/D051657"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Canal potassique KCNQ1 - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Canal potassique KCNQ1",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-03",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Canal potassique KCNQ1",
"description": "Comment diagnostiquer une dysfonction du canal KCNQ1 ?\nQuels tests sont utilisés pour évaluer KCNQ1 ?\nQuels symptômes indiquent un problème avec KCNQ1 ?\nLe diagnostic de KCNQ1 est-il basé sur des antécédents familiaux ?\nQuels spécialistes peuvent diagnostiquer des troubles KCNQ1 ?",
"url": "https://questionsmedicales.fr/mesh/D051657?page=2#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Canal potassique KCNQ1",
"description": "Quels sont les symptômes d'une mutation KCNQ1 ?\nLes symptômes de KCNQ1 varient selon l'âge ?\nComment les symptômes de KCNQ1 affectent-ils la vie quotidienne ?\nLes symptômes de KCNQ1 sont-ils toujours présents ?\nLes symptômes de KCNQ1 peuvent-ils s'aggraver avec le temps ?",
"url": "https://questionsmedicales.fr/mesh/D051657?page=2#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Canal potassique KCNQ1",
"description": "Comment prévenir les complications liées à KCNQ1 ?\nLes tests génétiques aident-ils à la prévention de KCNQ1 ?\nL'éducation des patients est-elle importante pour KCNQ1 ?\nLes activités physiques sont-elles sûres pour les patients KCNQ1 ?\nLes conseils diététiques peuvent-ils prévenir KCNQ1 ?",
"url": "https://questionsmedicales.fr/mesh/D051657?page=2#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Canal potassique KCNQ1",
"description": "Quels traitements sont disponibles pour les troubles KCNQ1 ?\nLa chirurgie est-elle une option pour KCNQ1 ?\nLes changements de mode de vie aident-ils avec KCNQ1 ?\nLes bêta-bloquants sont-ils efficaces pour KCNQ1 ?\nLes traitements sont-ils personnalisés pour KCNQ1 ?",
"url": "https://questionsmedicales.fr/mesh/D051657?page=2#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Canal potassique KCNQ1",
"description": "Quelles sont les complications possibles de KCNQ1 ?\nKCNQ1 peut-il entraîner des AVC ?\nLes complications de KCNQ1 sont-elles réversibles ?\nComment les complications de KCNQ1 sont-elles surveillées ?\nLes complications de KCNQ1 varient-elles selon les individus ?",
"url": "https://questionsmedicales.fr/mesh/D051657?page=2#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Canal potassique KCNQ1",
"description": "Quels sont les facteurs de risque pour KCNQ1 ?\nL'âge est-il un facteur de risque pour KCNQ1 ?\nLe stress peut-il aggraver KCNQ1 ?\nLes médicaments peuvent-ils influencer KCNQ1 ?\nLes habitudes de vie affectent-elles KCNQ1 ?",
"url": "https://questionsmedicales.fr/mesh/D051657?page=2#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une dysfonction du canal KCNQ1 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic peut inclure des tests génétiques et des électrocardiogrammes."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer KCNQ1 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent l'électrophysiologie et l'analyse génétique."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent un problème avec KCNQ1 ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme des palpitations ou des syncopes peuvent indiquer un problème."
}
},
{
"@type": "Question",
"name": "Le diagnostic de KCNQ1 est-il basé sur des antécédents familiaux ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les antécédents familiaux de troubles cardiaques sont importants."
}
},
{
"@type": "Question",
"name": "Quels spécialistes peuvent diagnostiquer des troubles KCNQ1 ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les cardiologues et les généticiens sont souvent impliqués dans le diagnostic."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une mutation KCNQ1 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des arythmies, des évanouissements et des douleurs thoraciques."
}
},
{
"@type": "Question",
"name": "Les symptômes de KCNQ1 varient selon l'âge ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier, étant plus fréquents chez les jeunes adultes."
}
},
{
"@type": "Question",
"name": "Comment les symptômes de KCNQ1 affectent-ils la vie quotidienne ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent limiter l'activité physique et nécessiter une surveillance médicale."
}
},
{
"@type": "Question",
"name": "Les symptômes de KCNQ1 sont-ils toujours présents ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certains patients peuvent être asymptomatiques malgré une mutation."
}
},
{
"@type": "Question",
"name": "Les symptômes de KCNQ1 peuvent-ils s'aggraver avec le temps ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, sans traitement, les symptômes peuvent s'aggraver avec l'âge."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications liées à KCNQ1 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La surveillance régulière et le traitement précoce sont essentiels."
}
},
{
"@type": "Question",
"name": "Les tests génétiques aident-ils à la prévention de KCNQ1 ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les personnes à risque."
}
},
{
"@type": "Question",
"name": "L'éducation des patients est-elle importante pour KCNQ1 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, comprendre la maladie aide les patients à gérer leurs symptômes."
}
},
{
"@type": "Question",
"name": "Les activités physiques sont-elles sûres pour les patients KCNQ1 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cela dépend de la gravité des symptômes; une évaluation médicale est nécessaire."
}
},
{
"@type": "Question",
"name": "Les conseils diététiques peuvent-ils prévenir KCNQ1 ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut contribuer à la santé cardiaque générale."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les troubles KCNQ1 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments antiarythmiques et des dispositifs implantables."
}
},
{
"@type": "Question",
"name": "La chirurgie est-elle une option pour KCNQ1 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la chirurgie peut être envisagée dans les cas graves d'arythmies."
}
},
{
"@type": "Question",
"name": "Les changements de mode de vie aident-ils avec KCNQ1 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, éviter le stress et adopter une alimentation saine peuvent aider."
}
},
{
"@type": "Question",
"name": "Les bêta-bloquants sont-ils efficaces pour KCNQ1 ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les bêta-bloquants peuvent aider à contrôler les arythmies."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour KCNQ1 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements sont souvent adaptés en fonction des symptômes et des antécédents."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles de KCNQ1 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des arythmies graves et un risque accru de mort subite."
}
},
{
"@type": "Question",
"name": "KCNQ1 peut-il entraîner des AVC ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des arythmies peuvent augmenter le risque d'accidents vasculaires cérébraux."
}
},
{
"@type": "Question",
"name": "Les complications de KCNQ1 sont-elles réversibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
}
},
{
"@type": "Question",
"name": "Comment les complications de KCNQ1 sont-elles surveillées ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles sont surveillées par des examens réguliers et des tests de fonction cardiaque."
}
},
{
"@type": "Question",
"name": "Les complications de KCNQ1 varient-elles selon les individus ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la gravité et le type de complications peuvent varier d'une personne à l'autre."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour KCNQ1 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, des maladies cardiaques et des médicaments."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour KCNQ1 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente souvent avec l'âge, surtout chez les hommes."
}
},
{
"@type": "Question",
"name": "Le stress peut-il aggraver KCNQ1 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut déclencher ou aggraver les symptômes d'arythmie."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils influencer KCNQ1 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent interférer avec la fonction du canal KCNQ1."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie affectent-elles KCNQ1 ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes de vie saines peuvent réduire le risque de complications."
}
}
]
}
]
}
The KCNQ1 channel is important for the repolarization phase of the cardiac action potential. Loss of function mutations in KCNQ1 can cause long QT syndrome (LQTS), which can lead to cardiac arrythmia ...
Calmodulin (CaM) is a highly conserved mediator of calcium (Ca...
Heart diseases such as arrhythmia are the main causes of sudden death. Arrhythmias are typically caused by mutations in specific genes, damage in the cardiac tissue, or due to some chemical exposure. ...
Inherited primary arrhythmias, such as long QT (LQT) syndromes, are electrical abnormalities of the heart mainly due to variants in 3 genes. We herein describe a novel stop-gain pathogenic variant in ...
The patient and his family underwent clinical evaluation, electrocardiographic Holter monitoring, and whole-exome sequencing. Sanger sequencing and segregation analysis were used to confirm the varian...
The proband suffered from bradycardia and had experienced syncope without stress. The corrected QT interval was 470 ms (the Schwartz score ≥ 3.5), and the Holter monitoring showed sinus rhythm, infreq...
The KCNQ1 gene is the main cause of LQT syndromes in our population. The common genes of LQT syndromes should be studied in our country's different ethnicities to determine the exact role of these gen...
Long QT syndrome (LQTS) is one of the primary causes of sudden cardiac death (SCD) in youth. Studies have identified mutations in ion channel genes as key players in the pathogenesis of LQTS. However,...
Three unrelated Chinese pedigrees diagnosed with LQTS or Jervell and Lange-Nielsen syndrome (JLNS) were recruited clinically. Whole exome sequencing (WES) was performed and further validated by multip...
All of the probands in our study experienced syncope episodes and featured typically prolonged QTc-intervals. Two probands also presented with congenital hearing loss and iron-deficiency anemia and th...
Our study expanded the LQTS genetic spectrum, thus favoring disease screening and diagnosis, personalized treatment, and genetic consultation....
Beckwith-Wiedemann syndrome (BWS) is an imprinting disorder with characteristic features, such as overgrowth, macroglossia, and exomphalos. Hypomethylation of the KCNQ1OT1:TSS-differentially methylate...
The voltage-gated potassium channel KvLQT1 encoded by KCNQ1 plays an important role in the repolarization of myocardial action potentials. KCNQ1 mutations can cause Long QT syndrome type 1 (LQT1), whi...
Ever since they were first observed in Purkinje fibers of the heart, funny channels have had close connections to potassium channels. Indeed, funny channels were initially thought to produce a potassi...
Congenital long QT syndrome is a type of inherited cardiovascular disorder characterized by prolonged QT interval. Patient often suffer from syncopal episodes, electrocardiographic abnormalities and l...
The association between particulate matter and fasting blood glucose (FBG) has shown conflicting results. Genome-wide association studies have shown that KCNQ1 rs2237892 polymorphism is associated wit...
Data collected from a family-based cohort study in Northern China, were used to perform the analysis. A generalized additive Gaussian model was used to examine the short-term effects of air pollutants...
A total of 4418 participants were included in the study. In the single pollutant model, the FBG level increased 0.0031 mmol/L with per 10 μg/m...
Short-term exposures to PM...