Les antécédents familiaux et certaines infections augmentent le risque de troubles des cellules B.
Antécédents familiauxInfections
#2
L'âge est-il un facteur de risque ?
Oui, le risque de troubles des cellules B augmente avec l'âge.
ÂgeRisque
#3
Le mode de vie influence-t-il le risque ?
Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.
Mode de vieAlimentation
#4
Les expositions environnementales sont-elles un risque ?
Oui, certaines expositions chimiques peuvent augmenter le risque de troubles des cellules B.
Expositions environnementalesChimie
#5
Le stress psychologique est-il un facteur de risque ?
Oui, le stress chronique peut affaiblir le système immunitaire et augmenter le risque.
Stress psychologiqueSystème immunitaire
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"name": "Comment diagnostiquer une anomalie de l'antigène B ?",
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"text": "Des tests sanguins et des analyses de cellules B peuvent être effectués."
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"@type": "Question",
"name": "Quels marqueurs sont utilisés pour le diagnostic ?",
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"@type": "Question",
"name": "Quelle est l'importance des biopsies dans le diagnostic ?",
"position": 3,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les tests génétiques sont-ils utiles ?",
"position": 4,
"acceptedAnswer": {
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"@type": "Question",
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"name": "Quels symptômes sont associés à une dysfonction des cellules B ?",
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"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 7,
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"position": 8,
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"position": 9,
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"@type": "Question",
"name": "Les douleurs articulaires sont-elles un symptôme ?",
"position": 10,
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"@type": "Question",
"name": "Comment prévenir les infections liées aux troubles des cellules B ?",
"position": 11,
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"name": "Y a-t-il des mesures préventives spécifiques ?",
"position": 12,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les examens réguliers sont-ils recommandés ?",
"position": 13,
"acceptedAnswer": {
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"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle préventif ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
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{
"@type": "Question",
"name": "Le stress peut-il affecter les cellules B ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
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"@type": "Question",
"name": "Quels traitements sont disponibles pour les troubles des cellules B ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des immunothérapies et des médicaments ciblés."
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{
"@type": "Question",
"name": "La chimiothérapie est-elle efficace ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut être utilisée pour traiter certains cancers des cellules B."
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"@type": "Question",
"name": "Quels sont les effets secondaires des traitements ?",
"position": 18,
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"@type": "Answer",
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"@type": "Question",
"name": "Les transfusions sanguines sont-elles nécessaires ?",
"position": 19,
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"@type": "Answer",
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"@type": "Question",
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"position": 20,
"acceptedAnswer": {
"@type": "Answer",
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec des troubles des cellules B ?",
"position": 21,
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"@type": "Answer",
"text": "Les complications incluent des infections récurrentes et des cancers des cellules B."
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"@type": "Question",
"name": "Les troubles auto-immuns sont-ils une complication ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une dysfonction des cellules B peut entraîner des troubles auto-immuns."
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"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent réduire la qualité de vie en augmentant la fatigue et les infections."
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"@type": "Question",
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"position": 24,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les complications cardiovasculaires sont-elles possibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles immunitaires peuvent augmenter le risque de complications cardiovasculaires."
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"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
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}
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Institute for Myeloma & Bone Cancer Research, West Hollywood, CA, United States; Oncotherapeutics Inc., West Hollywood, CA, United States. Electronic address: jberenson@imbcr.org.
Publications dans "Antigène de maturation des cellules B" :
Currently used stratification models in myeloma precursor disease as well as staging systems and response criteria in myeloma have limitations including failure to identify functionally high-risk myel...
B cell maturation antigen (BCMA) targeted immunotherapies have demonstrated remarkable clinical efficacy in multiple myeloma (MM). Here, we evaluated the BCMA expression in MM and other plasma cell dy...
From January 2018 to August 2021, 377 patients with PCDs were enrolled in this study, including 334 MM, 21 systemic light chain amyloidosis (AL), 5 POEMS syndrome, 14 monoclonal gammopathy of undeterm...
The patients with MM had a median BCMA positive rate of 88.55% (range, 0.2% - 99.9%) and median BCMA MFI of 1281 (range, 109 - 48586). While the median BCMA positive rate in other PCDs was 55.8% (6.2%...
In conclusion, BCMA has the potential to be a therapeutic target for other PCDs besides MM....
B-cell maturation antigen (BCMA) is a clinically validated target for multiple myeloma. T-cell engineered with chimeric antigen receptors (CARs) directed against BCMA have demonstrated robust therapeu...
The BAFF-APRIL system is crucial for the pathogenesis of systemic lupus erythematosus (SLE) by promoting B cell survival, differentiation and the maintenance of humoral autoimmunity. Here, we investig...
The considerable efficacy of B-cell maturation antigen-targeted chimeric antigen receptor (CAR)-T-cell therapy has been extensively demonstrated in the treatment of relapsed or refractory multiple mye...
This retrospective study reviewed 99 patients with relapsed or refractory multiple myeloma who underwent B-cell maturation antigen CAR-T-cell therapy at our institution between April 2018 and Septembe...
Among 93 evaluable patients, the incidence of prolonged hematologic toxicities was high after CAR-T-cell infusion, including 38.71% (36/93) of patients with prolonged neutropenia, 22.58% (21/93) with ...
Our findings improve the understanding of the impact of cytokines on hematopoietic functions, which could contribute to the mechanism investigation and exploration of potential intervention strategies...
B-Cell maturation antigen (BCMA) is a cell membrane receptor expressed on mature B lymphocytes, with elevated serum levels found among patients with B-cell malignancies, including chronic lymphocytic ...
Chimeric Antigen Receptor (CAR) T-cell is a breakthrough in cancer immunotherapy. The primary step of successful CAR T cell therapy is designing a specific single-chain fragment variable (scFv). This ...
Following the second generation of anti-BCMA CAR designing, the protein structure, function prediction, physicochemical complementarity at the ligand-receptor interface, and biding sites analysis of a...
In-silico results approved the suitable protein folding, perfect orientation, and correct locating of functional domains at the receptor-ligand binding site. The in-vitro results confirmed high expres...
In-silico studies before experimental assessments are crucial for state-of-art CAR designing. Highly activation and cytotoxicity of anti-BCMA CAR T-cell revealed that our CAR construct methodology wou...
Chimeric antigen receptor (CAR) T cell therapy targeting B cell maturation antigen (BCMA) has been approved for treating multiple myeloma (MM). Some clinical studies reported suboptimal outcomes, incl...
The aim of this study was to investigate serum levels of soluble B-cell maturation antigen (sBCMA) in childhood-onset systemic lupus erythematous (cSLE) patients with renal involvement, and to elucida...
116 cases of cSLE patients with renal involvement (84 females and 32 males; median age 11.6 (10.1, 12.9) years) hospitalized in Department of Pediatric Nephrology and Rheumatology, the First Affiliate...
Serum sBCMA levels were significantly increased in primary cSLE when compared with treated cSLE patients and HCs, whereas there was no significant difference between treated cSLE patients and HCs. Pat...
In cSLE patients with renal involvement, serum sBCMA levels correlated significantly with disease activity, immunological, and hematological parameters, but not with renal parameters. Our results sugg...
Infections are common in plasma cell cancer multiple myeloma (MM) due to disease-related immune deficiencies and cancer treatment. Myeloma cells express Toll-like receptors (TLRs), and TLR activation ...