Titre : Polyangéite microscopique

Polyangéite microscopique : Questions médicales fréquentes

Termes MeSH sélectionnés :

Complement C4
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Polyangéite microscopique : Questions médicales les plus fréquentes", "headline": "Polyangéite microscopique : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Polyangéite microscopique : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-07-03", "dateModified": "2025-03-30", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Polyangéite microscopique" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Vascularites associées aux anticorps anti-cytoplasme des neutrophiles", "url": "https://questionsmedicales.fr/mesh/D056648", "about": { "@type": "MedicalCondition", "name": "Vascularites associées aux anticorps anti-cytoplasme des neutrophiles", "code": { "@type": "MedicalCode", "code": "D056648", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "C20.111.193" } } }, "about": { "@type": "MedicalCondition", "name": "Polyangéite microscopique", "alternateName": "Microscopic Polyangiitis", "code": { "@type": "MedicalCode", "code": "D055953", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Jason Jungsik Song", "url": "https://questionsmedicales.fr/author/Jason%20Jungsik%20Song", "affiliation": { "@type": "Organization", "name": "Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea." } }, { "@type": "Person", "name": "Sang-Won Lee", "url": "https://questionsmedicales.fr/author/Sang-Won%20Lee", "affiliation": { "@type": "Organization", "name": "Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea. sangwonlee@yuhs.ac." } }, { "@type": "Person", "name": "Sung Soo Ahn", "url": "https://questionsmedicales.fr/author/Sung%20Soo%20Ahn", "affiliation": { "@type": "Organization", "name": "Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea." } }, { "@type": "Person", "name": "Yong-Beom Park", "url": "https://questionsmedicales.fr/author/Yong-Beom%20Park", "affiliation": { "@type": "Organization", "name": "Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea." } }, { "@type": "Person", "name": "Taejun Yoon", "url": "https://questionsmedicales.fr/author/Taejun%20Yoon", "affiliation": { "@type": "Organization", "name": "Department of Medical Science, College of Medicine, BK21 Plus Project, Yonsei University, Seoul, Republic of Korea." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.", "datePublished": "2022-07-11", "url": "https://questionsmedicales.fr/article/35898513", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3389/fimmu.2022.853891" } }, { "@type": "ScholarlyArticle", "name": "Variations of C3 and C4 Before and During Pregnancy in Systemic Lupus Erythematosus: Association With Disease Flares and Obstetric Outcomes.", "datePublished": "2023-05-01", "url": "https://questionsmedicales.fr/article/37127323", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3899/jrheum.2022-1135" } }, { "@type": "ScholarlyArticle", "name": "HMGB1 cleavage by complement C1s and its potent anti-inflammatory product.", "datePublished": "2023-04-26", "url": "https://questionsmedicales.fr/article/37180096", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3389/fimmu.2023.1151731" } }, { "@type": "ScholarlyArticle", "name": "A complement C4-derived glycopeptide is a biomarker for PMM2-CDG.", "datePublished": "2024-04-08", "url": "https://questionsmedicales.fr/article/38587076", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1172/jci.insight.172509" } }, { "@type": "ScholarlyArticle", "name": "Analysis of the complement component C4 gene with schizophrenia subphenotypes.", "datePublished": "2024-07-30", "url": "https://questionsmedicales.fr/article/39084106", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.schres.2024.07.039" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Maladies du système immunitaire", "item": "https://questionsmedicales.fr/mesh/D007154" }, { "@type": "ListItem", "position": 3, "name": "Maladies auto-immunes", "item": "https://questionsmedicales.fr/mesh/D001327" }, { "@type": "ListItem", "position": 4, "name": "Vascularites associées aux anticorps anti-cytoplasme des neutrophiles", "item": "https://questionsmedicales.fr/mesh/D056648" }, { "@type": "ListItem", "position": 5, "name": "Polyangéite microscopique", "item": "https://questionsmedicales.fr/mesh/D055953" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Polyangéite microscopique - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Polyangéite microscopique", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-18", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Polyangéite microscopique", "description": "Comment diagnostiquer la polyangéite microscopique ?\nQuels tests sanguins sont utilisés ?\nQuels symptômes orientent vers ce diagnostic ?\nLa biopsie est-elle toujours nécessaire ?\nQuels examens d'imagerie sont recommandés ?", "url": "https://questionsmedicales.fr/mesh/D055953?mesh_terms=Complement+C4&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Polyangéite microscopique", "description": "Quels sont les symptômes courants ?\nLa polyangéite microscopique cause-t-elle des problèmes rénaux ?\nY a-t-il des symptômes respiratoires associés ?\nLes symptômes varient-ils d'un patient à l'autre ?\nPeut-on avoir des symptômes neurologiques ?", "url": "https://questionsmedicales.fr/mesh/D055953?mesh_terms=Complement+C4&page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Polyangéite microscopique", "description": "Peut-on prévenir la polyangéite microscopique ?\nQuels conseils de mode de vie peuvent aider ?\nLes vaccinations sont-elles recommandées ?\nFaut-il éviter certains médicaments ?\nLe suivi médical est-il important ?", "url": "https://questionsmedicales.fr/mesh/D055953?mesh_terms=Complement+C4&page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Polyangéite microscopique", "description": "Quels traitements sont utilisés pour cette maladie ?\nLes corticostéroïdes sont-ils efficaces ?\nCombien de temps dure le traitement ?\nY a-t-il des effets secondaires aux traitements ?\nDes traitements biologiques sont-ils disponibles ?", "url": "https://questionsmedicales.fr/mesh/D055953?mesh_terms=Complement+C4&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Polyangéite microscopique", "description": "Quelles sont les complications possibles ?\nLa polyangéite microscopique peut-elle être mortelle ?\nComment prévenir les complications ?\nLes complications affectent-elles la qualité de vie ?\nY a-t-il des complications à long terme ?", "url": "https://questionsmedicales.fr/mesh/D055953?mesh_terms=Complement+C4&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Polyangéite microscopique", "description": "Quels sont les facteurs de risque connus ?\nL'âge influence-t-il le risque ?\nLes infections peuvent-elles déclencher la maladie ?\nLe sexe joue-t-il un rôle dans le risque ?\nDes facteurs environnementaux sont-ils impliqués ?", "url": "https://questionsmedicales.fr/mesh/D055953?mesh_terms=Complement+C4&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer la polyangéite microscopique ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur des analyses sanguines, des biopsies et des examens d'imagerie." } }, { "@type": "Question", "name": "Quels tests sanguins sont utilisés ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests incluent la recherche d'anticorps anti-MPO et des marqueurs d'inflammation." } }, { "@type": "Question", "name": "Quels symptômes orientent vers ce diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Symptômes comme la fatigue, la fièvre, et des douleurs articulaires peuvent indiquer la maladie." } }, { "@type": "Question", "name": "La biopsie est-elle toujours nécessaire ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Non, la biopsie n'est pas toujours nécessaire, mais elle peut confirmer le diagnostic." } }, { "@type": "Question", "name": "Quels examens d'imagerie sont recommandés ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Les IRM et les scanners peuvent aider à visualiser les atteintes organiques." } }, { "@type": "Question", "name": "Quels sont les symptômes courants ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, fièvre, éruptions cutanées et douleurs musculaires." } }, { "@type": "Question", "name": "La polyangéite microscopique cause-t-elle des problèmes rénaux ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner une insuffisance rénale aiguë due à l'inflammation des vaisseaux rénaux." } }, { "@type": "Question", "name": "Y a-t-il des symptômes respiratoires associés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme la toux et des douleurs thoraciques peuvent survenir." } }, { "@type": "Question", "name": "Les symptômes varient-ils d'un patient à l'autre ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'intensité et la combinaison des symptômes peuvent varier considérablement." } }, { "@type": "Question", "name": "Peut-on avoir des symptômes neurologiques ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme des maux de tête ou des troubles de la vision peuvent apparaître." } }, { "@type": "Question", "name": "Peut-on prévenir la polyangéite microscopique ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de méthode de prévention spécifique, mais un suivi médical régulier est conseillé." } }, { "@type": "Question", "name": "Quels conseils de mode de vie peuvent aider ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Adopter un mode de vie sain, éviter le tabac et gérer le stress peuvent être bénéfiques." } }, { "@type": "Question", "name": "Les vaccinations sont-elles recommandées ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les vaccinations peuvent aider à prévenir certaines infections, surtout sous traitement immunosuppresseur." } }, { "@type": "Question", "name": "Faut-il éviter certains médicaments ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments peuvent aggraver la maladie, il est donc important de consulter un médecin." } }, { "@type": "Question", "name": "Le suivi médical est-il important ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi régulier permet de surveiller l'évolution de la maladie et d'ajuster le traitement." } }, { "@type": "Question", "name": "Quels traitements sont utilisés pour cette maladie ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des corticostéroïdes et des immunosuppresseurs pour réduire l'inflammation." } }, { "@type": "Question", "name": "Les corticostéroïdes sont-ils efficaces ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils sont souvent efficaces pour contrôler l'inflammation et soulager les symptômes." } }, { "@type": "Question", "name": "Combien de temps dure le traitement ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La durée du traitement varie, mais peut durer plusieurs mois à plusieurs années." } }, { "@type": "Question", "name": "Y a-t-il des effets secondaires aux traitements ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les effets secondaires peuvent inclure des infections, des troubles digestifs et des problèmes osseux." } }, { "@type": "Question", "name": "Des traitements biologiques sont-ils disponibles ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des traitements biologiques comme le rituximab peuvent être utilisés dans certains cas." } }, { "@type": "Question", "name": "Quelles sont les complications possibles ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent l'insuffisance rénale, les infections et les problèmes pulmonaires." } }, { "@type": "Question", "name": "La polyangéite microscopique peut-elle être mortelle ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, sans traitement approprié, elle peut entraîner des complications graves et potentiellement mortelles." } }, { "@type": "Question", "name": "Comment prévenir les complications ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Un traitement précoce et un suivi régulier sont essentiels pour prévenir les complications." } }, { "@type": "Question", "name": "Les complications affectent-elles la qualité de vie ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications peuvent significativement affecter la qualité de vie des patients." } }, { "@type": "Question", "name": "Y a-t-il des complications à long terme ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des complications à long terme peuvent inclure des problèmes rénaux chroniques et des troubles pulmonaires." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque connus ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents familiaux, le tabagisme et certaines infections." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la polyangéite microscopique est plus fréquente chez les adultes âgés de 50 à 70 ans." } }, { "@type": "Question", "name": "Les infections peuvent-elles déclencher la maladie ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines infections virales ou bactériennes peuvent être des déclencheurs." } }, { "@type": "Question", "name": "Le sexe joue-t-il un rôle dans le risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la maladie est légèrement plus fréquente chez les hommes que chez les femmes." } }, { "@type": "Question", "name": "Des facteurs environnementaux sont-ils impliqués ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certains produits chimiques ou médicaments peut augmenter le risque." } } ] } ] }

Sources (1780 au total)

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease (MOGAD) are autoimmune inflammatory demyelinating diseases of the central ... In this observational study, data from 73 aquaporin-4 antibodies (AQP4-IgG) positive NMOSD patients and 22 MOG-IgG positive MOGAD patients were collected retrospectively. Demographics, clinical charac... The ages of onset were later in the AQP4-IgG positive NMOSD group and females predominated, which differed from the MOGAD group, whose ages were younger and with a slight male preponderance. The AQP4-... During the acute phase of NMOSD and MOGAD, plasma C3 and C4 may become potential biomarkers for distinguishing the two diseases and reflecting the NMOSD BBB damage....

Variations of C3 and C4 Before and During Pregnancy in Systemic Lupus Erythematosus: Association With Disease Flares and Obstetric Outcomes.

To analyze complement level variations in systemic lupus erythematosus (SLE) pregnancies, focusing on disease flares and obstetric complications.... SLE pregnancies prospectively followed by multidisciplinary teams from 1987 to 2018 in 2 Italian rheumatology centers were retrospectively analyzed. As reference, pregnancy-modified ranges of normal l... Two hundred forty-six pregnancies in 172 patients with SLE were analyzed. Eighty-nine percent were live births. Thirty-five flares were recorded in 30 pregnancies (12.2%) and obstetric complications o... Low C4 at preconception was found to be an independent risk factor for SLE flare during pregnancy. Not only C3 and C4 levels but also their variations should be observed, as their failure to increase ...

Analysis of the complement component C4 gene with schizophrenia subphenotypes.

The complement component C4 gene has been identified as a strong marker for schizophrenia (SCZ) risk. The C4 gene has a complex genetic structure consisting of variable structural elements (C4A, C4B, ... A total of 613 patients with DSM-IV SCZ or schizoaffective disorder (SCZ-AFF) were recruited to investigate the relationship between C4 gene variants and clinical characteristics of SCZ (age of onset,... We observed associations between C4 and clinical characteristics of SCZ (age of onset, symptom severity, GAF) and found significant differences when males and females were examined separately.... Overall, our preliminary findings encourage future investigations of C4 in SCZ-related phenotypes, including antipsychotic response and side effects. The study sample was of moderate size; therefore, ...

Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis.

It is not known why only some hepatitis C virus (HCV) infected patients develop glomerulonephritis (GN). Therefore, we investigated the role of soluble complement regulators in the development of HCV ... Patients with HCV associated GN who were admitted to our nephrology unit between July 2016 and July 2018 were recruited to the study (group 1). Two other age and sex matched groups were studied as con... Serum levels of complement 4 binding protein (C4BP) were significantly lower in group 1 (median 70 ng/ml) than in groups 2 (median 88.8 ng/ml) and 3 (median 82.8 ng/ml) with p value of 0.007. The mino... Low C4BP levels are associated with GN in HCV infected patients. In addition, rs800292 SNP in CFH protects against GN in patients with HCV....

The Role of Complement System's C3 and C4 Fractions in the Pathogenesis of Uveitis.

To study the role of the complement system's C3 and C4 fractions in the pathogenesis of different types of uveitis.... A prospective case-control study. 118 patients were enrolled. The control group comprised 60 patients who were otherwise healthy people undergoing cataract or pterygium surgery, whereas the uveitis pa... No statistically significant differences were found in the levels of the C3 and C4 fractions in the blood between the groups. However, a statistically significant difference was observed in the levels... Our findings are in line with our initial hypothesis, that the complement system's C3 and C4 fractions may have a role in the pathogenesis of uveitis....

Serum concentrations of complement C3 and C4 in dogs with idiopathic epilepsy.

High concentrations of complement factors are presented in serum of animal epilepsy models and human patients with epilepsy.... To determine whether complement dysregulation occurs in dogs with idiopathic epilepsy (IE).... The study included 49 dogs with IE subgrouped into treatment (n = 19), and nontreatment (n = 30), and 29 healthy dogs.... In this case-control study, the serum concentrations of the third (C3) and fourth (C4) components of the complement system were measured using a canine-specific ELISA kit.... Serum C3 and C4 concentrations were significantly higher in dogs with IE (C3, median; 4.901 [IQR; 3.915-6.673] mg/mL, P < .001; C4, 0.327 [0.134-0.557] mg/mL, P = .03) than in healthy control dogs (C3... Dysregulation of classical complement pathway was identified in IE dogs. Serum C3 and C4 concentrations could be diagnostic biomarkers for IE in dogs with higher seizure frequency....