Titre : Jumonji Domain-Containing Histone Demethylases

Jumonji Domain-Containing Histone Demethylases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Cellular Reprogramming
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diagnostiquer une dysfonction des Jumonji ?\nQuels marqueurs biologiques sont associés aux Jumonji ?\nLes biopsies sont-elles utiles pour le diagnostic ?\nQuels tests sanguins sont recommandés ?\nY a-t-il des tests d'imagerie pour ces enzymes ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=1000#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Jumonji Domain-Containing Histone Demethylases", "description": "Quels symptômes sont liés aux anomalies des Jumonji ?\nLes troubles neurologiques sont-ils associés ?\nY a-t-il des symptômes cutanés associés ?\nLes symptômes varient-ils selon le type de Jumonji ?\nLes symptômes sont-ils réversibles ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=1000#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Jumonji Domain-Containing Histone Demethylases", "description": "Peut-on prévenir les dysfonctionnements des Jumonji ?\nLes tests génétiques peuvent-ils aider à la prévention ?\nY a-t-il des vaccins pour prévenir ces dysfonctionnements ?\nL'éducation génétique est-elle importante ?\nLes conseils diététiques peuvent-ils aider ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=1000#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Jumonji Domain-Containing Histone Demethylases", "description": "Quels traitements sont disponibles pour les dysfonctionnements des Jumonji ?\nLes médicaments peuvent-ils cibler les Jumonji ?\nY a-t-il des traitements naturels recommandés ?\nLes traitements sont-ils personnalisés ?\nLes thérapies combinées sont-elles efficaces ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=1000#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Jumonji Domain-Containing Histone Demethylases", "description": "Quelles complications peuvent survenir avec les dysfonctionnements des Jumonji ?\nLes complications sont-elles graves ?\nY a-t-il des complications à long terme ?\nLes complications sont-elles réversibles ?\nLes complications varient-elles selon le type de Jumonji ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=1000#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Jumonji Domain-Containing Histone Demethylases", "description": "Quels sont les facteurs de risque pour les dysfonctionnements des Jumonji ?\nL'âge est-il un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?\nL'exposition à des toxines est-elle un facteur ?\nLe mode de vie influence-t-il le risque ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=1000#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des Jumonji ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses d'expression génique peuvent être utilisés." } }, { "@type": "Question", "name": "Quels marqueurs biologiques sont associés aux Jumonji ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les niveaux de méthylation des histones et l'expression des gènes sont des marqueurs clés." } }, { "@type": "Question", "name": "Les biopsies sont-elles utiles pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les biopsies peuvent aider à évaluer l'expression des Jumonji dans les tissus." } }, { "@type": "Question", "name": "Quels tests sanguins sont recommandés ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des tests pour mesurer les niveaux de protéines associées aux Jumonji peuvent être effectués." } }, { "@type": "Question", "name": "Y a-t-il des tests d'imagerie pour ces enzymes ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Non, l'imagerie ne permet pas de diagnostiquer directement les Jumonji." } }, { "@type": "Question", "name": "Quels symptômes sont liés aux anomalies des Jumonji ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des troubles de croissance, des anomalies développementales et des cancers peuvent survenir." } }, { "@type": "Question", "name": "Les troubles neurologiques sont-ils associés ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dysfonctionnements neurologiques peuvent être liés à des mutations des Jumonji." } }, { "@type": "Question", "name": "Y a-t-il des symptômes cutanés associés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Certaines anomalies cutanées peuvent être observées, notamment dans des syndromes spécifiques." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon le type de Jumonji ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, différents types de Jumonji peuvent entraîner des symptômes variés selon leur fonction." } }, { "@type": "Question", "name": "Les symptômes sont-ils réversibles ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Cela dépend de la gravité et de la nature de la dysfonction des Jumonji." } }, { "@type": "Question", "name": "Peut-on prévenir les dysfonctionnements des Jumonji ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention est difficile, mais un mode de vie sain peut réduire les risques." } }, { "@type": "Question", "name": "Les tests génétiques peuvent-ils aider à la prévention ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les tests génétiques peuvent identifier les individus à risque de dysfonctionnements." } }, { "@type": "Question", "name": "Y a-t-il des vaccins pour prévenir ces dysfonctionnements ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Non, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des Jumonji." } }, { "@type": "Question", "name": "L'éducation génétique est-elle importante ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'éducation sur les risques génétiques peut aider à la prévention et à la détection précoce." } }, { "@type": "Question", "name": "Les conseils diététiques peuvent-ils aider ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée peut soutenir la santé cellulaire, mais ne prévient pas directement." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les dysfonctionnements des Jumonji ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies géniques et des inhibiteurs spécifiques sont en cours d'étude." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils cibler les Jumonji ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments expérimentaux ciblent les Jumonji pour traiter des cancers." } }, { "@type": "Question", "name": "Y a-t-il des traitements naturels recommandés ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des approches nutritionnelles et phytothérapeutiques sont explorées, mais peu prouvées." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des Jumonji." } }, { "@type": "Question", "name": "Les thérapies combinées sont-elles efficaces ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des études montrent que les thérapies combinées peuvent améliorer les résultats cliniques." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec les dysfonctionnements des Jumonji ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des cancers, des troubles métaboliques et des anomalies développementales peuvent survenir." } }, { "@type": "Question", "name": "Les complications sont-elles graves ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines complications peuvent être potentiellement mortelles si non traitées." } }, { "@type": "Question", "name": "Y a-t-il des complications à long terme ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Des complications chroniques peuvent se développer, affectant la qualité de vie." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles." } }, { "@type": "Question", "name": "Les complications varient-elles selon le type de Jumonji ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications peuvent varier en fonction du type de Jumonji impliqué." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les dysfonctionnements des Jumonji ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains dysfonctionnements des Jumonji sont plus fréquents avec l'âge." } }, { "@type": "Question", "name": "Les antécédents familiaux jouent-ils un rôle ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de maladies génétiques augmentent le risque." } }, { "@type": "Question", "name": "L'exposition à des toxines est-elle un facteur ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certaines toxines peut augmenter le risque de dysfonctionnements." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie malsain peut accroître le risque de dysfonctionnements des Jumonji." } } ] } ] }

Sources (10000 au total)

SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes.

Cardiovascular complications significantly augment the overall COVID-19 mortality, largely due to the susceptibility of human cardiomyocytes (CMs) to SARS-CoV-2 virus. SARS-CoV-2 virus encodes 27 gene... CMs were derived from human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced pluripotent stem cells, using 2D and 3D differentiation methods. We overexpressed Nsp6, M, ... Nsp6, Nsp8, and M globally perturb the transcriptome and proteome of hPSC-CMs. SARS-CoV-2 infection and the overexpression of Nsp6, Nsp8, or M coherently upregulated genes associated with apoptosis an... Overall, our findings uncover the extensive damaging effects of Nsp6, Nsp8, and M on hPSC-CMs, underlining the crucial role of ATP homeostasis in CM death and functional abnormalities induced by these...

Humoral and cellular immune responses eleven months after the third dose of BNT162b2 an mRNA-based COVID-19 vaccine in people with HIV - a prospective observational cohort study.

We investigated long-term durability of humoral and cellular immune responses to third dose of BNT162b2 in people with HIV (PWH) and controls.... In 378 PWH with undetectable viral replication and 224 matched controls vaccinated with three doses of BNT162b2, we measured IgG-antibodies against the receptor binding domain of SARS-CoV-2 spike prot... Before the third dose the concentration of SARS-CoV-2 antibodies was lower in PWH than in controls (unadjusted geometric mean ratio (GMR): 0.68 (95% CI: 0.54-0.86, p = 0.002). We observed no differenc... We found no differences in antibody concentrations or cellular response between PWH and controls up to eleven months after third dose of BNT162b2. Our findings indicate that PWH with undetectable vira... This work was funded by the Novo Nordisk Foundation (NFF205A0063505, NNF20SA0064201), the Carlsberg Foundation (CF20-476 0045), the Svend Andersen Research Foundation (SARF2021), and Bio- and Genome B...

Discovery of New 2-Phenylamino-3-acyl-1,4-naphthoquinones as Inhibitors of Cancer Cells Proliferation: Searching for Intra-Cellular Targets Playing a Role in Cancer Cells Survival.

A series of 2-phenylamino-3-acyl-1,4-naphtoquinones were evaluated regarding their in vitro antiproliferative activities using DU-145, MCF-7 and T24 cancer cells. Such activities were discussed in ter...

New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry.

Cellular pharmacodynamic assays are crucial aspects of lead optimization programs in drug discovery. These assays are sometimes difficult to develop, oftentimes distal from the target and frequently l...

Longitudinal Analysis of Humoral and Cellular Immune Response Following SARS-CoV-2 Vaccination Supports Utilizing Point-Of-Care Tests to Enhance COVID-19 Booster Uptake.

Individuals with weaker neutralizing responses show reduced protection with SARS-CoV-2 variants. Booster vaccines are recommended for vaccinated individuals, but the uptake is low. We present the feas... SARS-CoV-2 point-of-care antibody tests are valuable and easy-to-access tools to inform inadequate humoral immunity and to support informed decision-making regarding the current and future booster vac...

Hybridization of triphenylamine to BODIPY dyes at the 3,5,8-positions: A facile strategy to construct near infra-red aggregation-induced emission luminogens with intramolecular charge transfer for cellular imaging.

A series of five BODIPY derivatives with triarylamine (TPA) moieties on their 3-, 5-, or 8-positions were reported, which showed wide-range fluorescence emissions across red and near infrared regions ...