Titre : Jumonji Domain-Containing Histone Demethylases

Jumonji Domain-Containing Histone Demethylases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Cellular Reprogramming
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Demethylases", "description": "Comment diagnostiquer une dysfonction des Jumonji ?\nQuels marqueurs biologiques sont associés aux Jumonji ?\nLes biopsies sont-elles utiles pour le diagnostic ?\nQuels tests sanguins sont recommandés ?\nY a-t-il des tests d'imagerie pour ces enzymes ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=995#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Jumonji Domain-Containing Histone Demethylases", "description": "Quels symptômes sont liés aux anomalies des Jumonji ?\nLes troubles neurologiques sont-ils associés ?\nY a-t-il des symptômes cutanés associés ?\nLes symptômes varient-ils selon le type de Jumonji ?\nLes symptômes sont-ils réversibles ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=995#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Jumonji Domain-Containing Histone Demethylases", "description": "Peut-on prévenir les dysfonctionnements des Jumonji ?\nLes tests génétiques peuvent-ils aider à la prévention ?\nY a-t-il des vaccins pour prévenir ces dysfonctionnements ?\nL'éducation génétique est-elle importante ?\nLes conseils diététiques peuvent-ils aider ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=995#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Jumonji Domain-Containing Histone Demethylases", "description": "Quels traitements sont disponibles pour les dysfonctionnements des Jumonji ?\nLes médicaments peuvent-ils cibler les Jumonji ?\nY a-t-il des traitements naturels recommandés ?\nLes traitements sont-ils personnalisés ?\nLes thérapies combinées sont-elles efficaces ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=995#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Jumonji Domain-Containing Histone Demethylases", "description": "Quelles complications peuvent survenir avec les dysfonctionnements des Jumonji ?\nLes complications sont-elles graves ?\nY a-t-il des complications à long terme ?\nLes complications sont-elles réversibles ?\nLes complications varient-elles selon le type de Jumonji ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=995#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Jumonji Domain-Containing Histone Demethylases", "description": "Quels sont les facteurs de risque pour les dysfonctionnements des Jumonji ?\nL'âge est-il un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?\nL'exposition à des toxines est-elle un facteur ?\nLe mode de vie influence-t-il le risque ?", "url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Cellular+Reprogramming&page=995#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des Jumonji ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses d'expression génique peuvent être utilisés." } }, { "@type": "Question", "name": "Quels marqueurs biologiques sont associés aux Jumonji ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les niveaux de méthylation des histones et l'expression des gènes sont des marqueurs clés." } }, { "@type": "Question", "name": "Les biopsies sont-elles utiles pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les biopsies peuvent aider à évaluer l'expression des Jumonji dans les tissus." } }, { "@type": "Question", "name": "Quels tests sanguins sont recommandés ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des tests pour mesurer les niveaux de protéines associées aux Jumonji peuvent être effectués." } }, { "@type": "Question", "name": "Y a-t-il des tests d'imagerie pour ces enzymes ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Non, l'imagerie ne permet pas de diagnostiquer directement les Jumonji." } }, { "@type": "Question", "name": "Quels symptômes sont liés aux anomalies des Jumonji ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des troubles de croissance, des anomalies développementales et des cancers peuvent survenir." } }, { "@type": "Question", "name": "Les troubles neurologiques sont-ils associés ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dysfonctionnements neurologiques peuvent être liés à des mutations des Jumonji." } }, { "@type": "Question", "name": "Y a-t-il des symptômes cutanés associés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Certaines anomalies cutanées peuvent être observées, notamment dans des syndromes spécifiques." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon le type de Jumonji ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, différents types de Jumonji peuvent entraîner des symptômes variés selon leur fonction." } }, { "@type": "Question", "name": "Les symptômes sont-ils réversibles ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Cela dépend de la gravité et de la nature de la dysfonction des Jumonji." } }, { "@type": "Question", "name": "Peut-on prévenir les dysfonctionnements des Jumonji ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention est difficile, mais un mode de vie sain peut réduire les risques." } }, { "@type": "Question", "name": "Les tests génétiques peuvent-ils aider à la prévention ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les tests génétiques peuvent identifier les individus à risque de dysfonctionnements." } }, { "@type": "Question", "name": "Y a-t-il des vaccins pour prévenir ces dysfonctionnements ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Non, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des Jumonji." } }, { "@type": "Question", "name": "L'éducation génétique est-elle importante ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'éducation sur les risques génétiques peut aider à la prévention et à la détection précoce." } }, { "@type": "Question", "name": "Les conseils diététiques peuvent-ils aider ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée peut soutenir la santé cellulaire, mais ne prévient pas directement." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les dysfonctionnements des Jumonji ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies géniques et des inhibiteurs spécifiques sont en cours d'étude." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils cibler les Jumonji ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments expérimentaux ciblent les Jumonji pour traiter des cancers." } }, { "@type": "Question", "name": "Y a-t-il des traitements naturels recommandés ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des approches nutritionnelles et phytothérapeutiques sont explorées, mais peu prouvées." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des Jumonji." } }, { "@type": "Question", "name": "Les thérapies combinées sont-elles efficaces ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des études montrent que les thérapies combinées peuvent améliorer les résultats cliniques." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec les dysfonctionnements des Jumonji ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des cancers, des troubles métaboliques et des anomalies développementales peuvent survenir." } }, { "@type": "Question", "name": "Les complications sont-elles graves ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines complications peuvent être potentiellement mortelles si non traitées." } }, { "@type": "Question", "name": "Y a-t-il des complications à long terme ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Des complications chroniques peuvent se développer, affectant la qualité de vie." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles." } }, { "@type": "Question", "name": "Les complications varient-elles selon le type de Jumonji ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications peuvent varier en fonction du type de Jumonji impliqué." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les dysfonctionnements des Jumonji ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains dysfonctionnements des Jumonji sont plus fréquents avec l'âge." } }, { "@type": "Question", "name": "Les antécédents familiaux jouent-ils un rôle ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de maladies génétiques augmentent le risque." } }, { "@type": "Question", "name": "L'exposition à des toxines est-elle un facteur ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certaines toxines peut augmenter le risque de dysfonctionnements." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie malsain peut accroître le risque de dysfonctionnements des Jumonji." } } ] } ] }

Sources (10000 au total)

Anti-Inflammatory Klotho Protein Serum Concentration Correlates with Interferon Gamma Expression Related to the Cellular Activity of Both NKT-like and T Cells in the Process of Human Aging.

Klotho is a beta-glucuronidase that reveals both anti-inflammatory and anti-oxidative properties that have been associated with mechanisms of aging. The study aimed to analyze the relationships betwee...

International Society for Cell & Gene Therapy Stem Cell Engineering Committee: Cellular therapies for the treatment of graft-versus-host-disease after hematopoietic stem cell transplant.

Allogeneic hematopoietic stem cell transplant is a curative approach for many malignant and non-malignant hematologic conditions. Despite advances in its prevention and treatment, the morbidity and mo... We conducted a search for scientific literature in PubMed® and ongoing clinical trials in clinicaltrial.gov with the keywords "Graft-versus-Host Disease (GVHD)," "Cellular Therapies," "Regulatory T ce... Although most of the existing clinical data focus on cellular therapies for GVHD prevention, there are observational and interventional clinical studies that explore the potential for cellular therapi... There are many ongoing clinical trials to date with the promise to expand our actual knowledge on the role of cellular therapies for GVHD treatment in an attempt to improve GVHD-related outcomes in th...

Administration of granulocyte-macrophage colony-stimulating factor enhanced chimeric antigen receptor T-cell expansion and cellular immunity recovery without inducing cytokine release syndrome.

Neutropenia and cytokine release syndrome (CRS) are two major toxicities of chimeric antigen receptor (CAR)-T cell therapy. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an ideal candid... Nine patients received GM-CSF therapy who displayed moderate neutropenia with absolute neutrophil counts (ANC) < 1,500 cells/mm... The median duration of GM-CSF intervention was 15 days (4-30). CAR T-cell expansion was observed in peripheral blood (PB) of seven patients (7/9). The median baseline and peak CAR T cells count in PB ... This study provides evidence for the clinical feasibility of combining CAR T-cell therapy with the GM-CSF to treat neutropenia patients with concomitant declination of circulating CAR T-cell....

Humoral and cellular immune response after severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid vaccination in heart transplant recipients: An observational study in France.

Heart transplant (HT) recipients have a high risk of developing severe COVID-19. Immunoglobulin G antibodies are considered to provide protective immunity and T-cell activity is thought to confer prot... In 96 HT patients, a IFN-γ release assay and an anti-Spike antibody test were used to evaluate the ability of SARS-CoV-2 mRNA vaccines to generate cellular and humoral immune response. Blood samples w... Three to five months after vaccination, three doses of vaccine induced a positive SARS-CoV-2 T-cell response in 47% of recipients and a positive humoral response in 83% of recipients, 11.1% of patient... Our study revealed that T and B immunity decreases over time, leading us to suggest the interest of a booster vaccination at 5 months after the third dose. Moreover, a close follow-up of immune respon...

High-throughput single cell metabolomics and cellular heterogeneity exploration by inertial microfluidics coupled with pulsed electric field-induced electrospray ionization-high resolution mass spectrometry.

Single cell metabolomics can obtain the metabolic profiles of individual cells and reveal cellular heterogeneity. However, high-throughput single-cell mass spectrometry (MS) analysis under physiologic...

Impact on Inpatient Length of Stay in Adults with Deep Partial-Thickness Burns: Comparing the Bioengineered Allogeneic Cellularized Construct Expanded-Access Trial with National Burn Repository Data.

To investigate the effect of StrataGraft (bioengineered allogeneic cellularized construct [BACC]) treatment on inpatient length of stay (LOS) as an indicator of hospital resource utilization.... Data from the single-arm StrataCAT trial for adult patients with deep partial-thickness (DPT) burns who received BACC were compared with data from a matched external control arm comprising patients wh... The BACC and NBR Autograft cohorts included 47 and 2641 patients, respectively. Following matching, the Autograft cohort had 137 patients and was weighted to 47 patients. Patients in the BACC and fina... The significantly reduced inpatient LOS observed with BACC compared to Autograft in adults with DPT burns may translate into reduced burden on the healthcare system, reduced costs for inpatient burn t...