Nom anglais: Jumonji Domain-Containing Histone Demethylases
Descriptor UI:D056484
Tree Number:D08.811.682.690.416.388
Termes MeSH sélectionnés :
Protein Processing, Post-Translational
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Jumonji Domain-Containing Histone Demethylases : Questions médicales les plus fréquentes",
"headline": "Jumonji Domain-Containing Histone Demethylases : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Jumonji Domain-Containing Histone Demethylases : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-10",
"dateModified": "2025-04-06",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Jumonji Domain-Containing Histone Demethylases"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Dioxygenases",
"url": "https://questionsmedicales.fr/mesh/D049308",
"about": {
"@type": "MedicalCondition",
"name": "Dioxygenases",
"code": {
"@type": "MedicalCode",
"code": "D049308",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.690.416"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Jumonji Domain-Containing Histone Demethylases",
"alternateName": "Jumonji Domain-Containing Histone Demethylases",
"code": {
"@type": "MedicalCode",
"code": "D056484",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Danica Galonić Fujimori",
"url": "https://questionsmedicales.fr/author/Danica%20Galoni%C4%87%20Fujimori",
"affiliation": {
"@type": "Organization",
"name": "Department of Cellular and Molecular Pharmacology, University of California San Francisco; San Francisco, CA 94158, USA; Department of Pharmaceutical Chemistry, University of California San Francisco; San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco; San Francisco, CA 94158, USA. Electronic address: danica.fujimori@ucsf.edu."
}
},
{
"@type": "Person",
"name": "James E Longbotham",
"url": "https://questionsmedicales.fr/author/James%20E%20Longbotham",
"affiliation": {
"@type": "Organization",
"name": "Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, Genentech Hall, San Francisco, California 94158, United States."
}
},
{
"@type": "Person",
"name": "Feng Li",
"url": "https://questionsmedicales.fr/author/Feng%20Li",
"affiliation": {
"@type": "Organization",
"name": "Department of Cell Biology, Key Laboratory of Cell Biology, National Health Commission of the PRC, Shenyang, China."
}
},
{
"@type": "Person",
"name": "Christopher J Schofield",
"url": "https://questionsmedicales.fr/author/Christopher%20J%20Schofield",
"affiliation": {
"@type": "Organization",
"name": "Chemistry Research Laboratory , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom."
}
},
{
"@type": "Person",
"name": "Anthony Tumber",
"url": "https://questionsmedicales.fr/author/Anthony%20Tumber",
"affiliation": {
"@type": "Organization",
"name": "Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford 12 Mansfield Road OX1 3TA Oxford UK christopher.schofield@chem.ox.ac.uk lennart.brewitz@chem.ox.ac.uk."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Persistence of significant secondary mitral regurgitation post-cardiac resynchronization therapy and survival: a systematic review and meta-analysis : Mitral regurgitation and mortality post-CRT.",
"datePublished": "2023-10-19",
"url": "https://questionsmedicales.fr/article/37855988",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s10741-023-10359-6"
}
},
{
"@type": "ScholarlyArticle",
"name": "Safety and tolerability of agalsidase beta infusions shorter than 90 min in patients with Fabry disease: post-hoc analysis of a Japanese post-marketing study.",
"datePublished": "2023-07-24",
"url": "https://questionsmedicales.fr/article/37488580",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13023-023-02803-5"
}
},
{
"@type": "ScholarlyArticle",
"name": "Magnitude and Time-Trends of Post-Endoscopy Esophageal Adenocarcinoma and Post-Endoscopy Esophageal Neoplasia in a Population-Based Cohort Study: The Nordic Barrett's Esophagus Study.",
"datePublished": "2023-06-04",
"url": "https://questionsmedicales.fr/article/37279832",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1053/j.gastro.2023.05.044"
}
},
{
"@type": "ScholarlyArticle",
"name": "Prognostic markers of post-stroke depression (PROMoSD): study protocol of a prospective single-center observational study on raphe hypoechogenicity as a predictor of post-stroke depression.",
"datePublished": "2022-12-09",
"url": "https://questionsmedicales.fr/article/36494874",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s42466-022-00225-5"
}
},
{
"@type": "ScholarlyArticle",
"name": "Vaccinia Virus Defective Particles Lacking the F17 Protein Do Not Inhibit Protein Synthesis: F17, a Double-Edged Sword for Protein Synthesis?",
"datePublished": "2024-01-23",
"url": "https://questionsmedicales.fr/article/38338659",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/ijms25031382"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Enzymes et coenzymes",
"item": "https://questionsmedicales.fr/mesh/D045762"
},
{
"@type": "ListItem",
"position": 3,
"name": "Enzymes",
"item": "https://questionsmedicales.fr/mesh/D004798"
},
{
"@type": "ListItem",
"position": 4,
"name": "Oxidoreductases",
"item": "https://questionsmedicales.fr/mesh/D010088"
},
{
"@type": "ListItem",
"position": 5,
"name": "Oxygénases",
"item": "https://questionsmedicales.fr/mesh/D010105"
},
{
"@type": "ListItem",
"position": 6,
"name": "Dioxygenases",
"item": "https://questionsmedicales.fr/mesh/D049308"
},
{
"@type": "ListItem",
"position": 7,
"name": "Jumonji Domain-Containing Histone Demethylases",
"item": "https://questionsmedicales.fr/mesh/D056484"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Jumonji Domain-Containing Histone Demethylases - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Jumonji Domain-Containing Histone Demethylases",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-06",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Jumonji Domain-Containing Histone Demethylases",
"description": "Comment diagnostiquer une dysfonction des Jumonji ?\nQuels marqueurs biologiques sont associés aux Jumonji ?\nLes biopsies sont-elles utiles pour le diagnostic ?\nQuels tests sanguins sont recommandés ?\nY a-t-il des tests d'imagerie pour ces enzymes ?",
"url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Protein+Processing,+Post-Translational&page=1000#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Jumonji Domain-Containing Histone Demethylases",
"description": "Quels symptômes sont liés aux anomalies des Jumonji ?\nLes troubles neurologiques sont-ils associés ?\nY a-t-il des symptômes cutanés associés ?\nLes symptômes varient-ils selon le type de Jumonji ?\nLes symptômes sont-ils réversibles ?",
"url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Protein+Processing,+Post-Translational&page=1000#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Jumonji Domain-Containing Histone Demethylases",
"description": "Peut-on prévenir les dysfonctionnements des Jumonji ?\nLes tests génétiques peuvent-ils aider à la prévention ?\nY a-t-il des vaccins pour prévenir ces dysfonctionnements ?\nL'éducation génétique est-elle importante ?\nLes conseils diététiques peuvent-ils aider ?",
"url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Protein+Processing,+Post-Translational&page=1000#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Jumonji Domain-Containing Histone Demethylases",
"description": "Quels traitements sont disponibles pour les dysfonctionnements des Jumonji ?\nLes médicaments peuvent-ils cibler les Jumonji ?\nY a-t-il des traitements naturels recommandés ?\nLes traitements sont-ils personnalisés ?\nLes thérapies combinées sont-elles efficaces ?",
"url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Protein+Processing,+Post-Translational&page=1000#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Jumonji Domain-Containing Histone Demethylases",
"description": "Quelles complications peuvent survenir avec les dysfonctionnements des Jumonji ?\nLes complications sont-elles graves ?\nY a-t-il des complications à long terme ?\nLes complications sont-elles réversibles ?\nLes complications varient-elles selon le type de Jumonji ?",
"url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Protein+Processing,+Post-Translational&page=1000#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Jumonji Domain-Containing Histone Demethylases",
"description": "Quels sont les facteurs de risque pour les dysfonctionnements des Jumonji ?\nL'âge est-il un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?\nL'exposition à des toxines est-elle un facteur ?\nLe mode de vie influence-t-il le risque ?",
"url": "https://questionsmedicales.fr/mesh/D056484?mesh_terms=Protein+Processing,+Post-Translational&page=1000#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des Jumonji ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses d'expression génique peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels marqueurs biologiques sont associés aux Jumonji ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les niveaux de méthylation des histones et l'expression des gènes sont des marqueurs clés."
}
},
{
"@type": "Question",
"name": "Les biopsies sont-elles utiles pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les biopsies peuvent aider à évaluer l'expression des Jumonji dans les tissus."
}
},
{
"@type": "Question",
"name": "Quels tests sanguins sont recommandés ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests pour mesurer les niveaux de protéines associées aux Jumonji peuvent être effectués."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests d'imagerie pour ces enzymes ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, l'imagerie ne permet pas de diagnostiquer directement les Jumonji."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés aux anomalies des Jumonji ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles de croissance, des anomalies développementales et des cancers peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques sont-ils associés ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des dysfonctionnements neurologiques peuvent être liés à des mutations des Jumonji."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes cutanés associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies cutanées peuvent être observées, notamment dans des syndromes spécifiques."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le type de Jumonji ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, différents types de Jumonji peuvent entraîner des symptômes variés selon leur fonction."
}
},
{
"@type": "Question",
"name": "Les symptômes sont-ils réversibles ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cela dépend de la gravité et de la nature de la dysfonction des Jumonji."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les dysfonctionnements des Jumonji ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais un mode de vie sain peut réduire les risques."
}
},
{
"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les individus à risque de dysfonctionnements."
}
},
{
"@type": "Question",
"name": "Y a-t-il des vaccins pour prévenir ces dysfonctionnements ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des Jumonji."
}
},
{
"@type": "Question",
"name": "L'éducation génétique est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'éducation sur les risques génétiques peut aider à la prévention et à la détection précoce."
}
},
{
"@type": "Question",
"name": "Les conseils diététiques peuvent-ils aider ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut soutenir la santé cellulaire, mais ne prévient pas directement."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les dysfonctionnements des Jumonji ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies géniques et des inhibiteurs spécifiques sont en cours d'étude."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils cibler les Jumonji ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments expérimentaux ciblent les Jumonji pour traiter des cancers."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements naturels recommandés ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des approches nutritionnelles et phytothérapeutiques sont explorées, mais peu prouvées."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des Jumonji."
}
},
{
"@type": "Question",
"name": "Les thérapies combinées sont-elles efficaces ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études montrent que les thérapies combinées peuvent améliorer les résultats cliniques."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec les dysfonctionnements des Jumonji ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des cancers, des troubles métaboliques et des anomalies développementales peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles graves ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines complications peuvent être potentiellement mortelles si non traitées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications à long terme ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications chroniques peuvent se développer, affectant la qualité de vie."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles."
}
},
{
"@type": "Question",
"name": "Les complications varient-elles selon le type de Jumonji ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent varier en fonction du type de Jumonji impliqué."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les dysfonctionnements des Jumonji ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains dysfonctionnements des Jumonji sont plus fréquents avec l'âge."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies génétiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines est-elle un facteur ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines peut augmenter le risque de dysfonctionnements."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie malsain peut accroître le risque de dysfonctionnements des Jumonji."
}
}
]
}
]
}
Cardiac resynchronization therapy (CRT) significantly reduces secondary mitral regurgitation (MR) in patients with severe left ventricular systolic dysfunction. However, uncertainty remains as to whet...
Agalsidase beta, an enzyme replacement therapy for Fabry disease, is dosed biweekly at 1 mg/kg body weight, with increasing infusion rates based on tolerability. The US label specifies ≥ 90-min infusi...
Data were available for 436 reduced-duration infusions (< 90 min) and 2242 standard infusions (≥ 90 min). SAEs were rare (0.6%), and the frequency of all safety events decreased over the treatment cou...
The results of this post-hoc analysis demonstrated no significant impact of infusion duration on safety outcomes, and no significant difference in outcomes between patients of different weights. These...
Post-endoscopy esophageal adenocarcinoma (PEEC) and post-endoscopy esophageal neoplasia (PEEN) undermine early cancer detection in Barrett's esophagus (BE). We aimed to assess the magnitude and conduc...
This population-based cohort study was conducted in Denmark, Finland, and Sweden between 2006 and 2020 and included 20,588 patients with newly diagnosed BE. PEEC and PEEN were defined as esophageal ad...
Among 293 patients diagnosed with EAC, 69 (23.5%) were categorized as PEEC, 43 (14.7%) as index EAC, and 181 (61.8%) as incident EAC. The IRs/100,000 person-years for PEEC and incident EAC were 392 (9...
Almost a quarter of all EACs are detected within a year after an ostensibly negative upper endoscopy in patients with newly diagnosed BE. Interventions to improve detection may reduce PEEC/PEEN rates....
Post-stroke depression (PSD) is an important and frequent non-motor complication after a stroke. As valid prediction of PSD occurrence is still not possible, the unselective use of preventive therapy ...
In the prognostic markers of post-stroke depression (PROMoSD) study, a prospective, observational, single-center, investigator-initiated study, we aim to include 100 patients with acute ischemic strok...
The results of PROMoSD will answer the question of whether screening of BRH after AIS improves the prediction of PSD occurrence. A positive result of this study could have direct consequences on psych...
Infection of cells with encephalomyocarditis virus type 1 (EMCV-1,...
To study the role of L and 2A «security» proteins in the suppression of translation of cellular proteins and the efficiency of translation and processing of viral proteins in infected cells....
Mutant variants of EMCV-1 were obtained to study the properties of L and 2A viral proteins:...
The functional inactivation of the 2A protein does not affect the inhibition of cellular protein synthesis. A direct correlation was found between the presence of active L protein and specific inactiv...
A study of the role of EMCV-1 L and 2A proteins during the translational processes of an infected cell, first performed using infectious viral pathogens lacking active L and 2A proteins in one experim...
To investigate the effects of conformational changes and thermal degradation of myofibrillar protein (MP), sarcoplasmic protein (SP), and collagen (CO) on the binding ability for aroma compounds durin...
The design of new protein variants is usually confined to slightly "fixing" an already existing protein, adapting it to certain conditions or to a new substrate. This is relatively easy to do if the f...
Plant-based protein supplements often contain lower amounts of leucine and other essential amino acids (EAAs), potentially making them less effective in stimulating muscle protein synthesis (MPS) than...
The aim of this study was to determine the effect of a novel plant-based blend protein (PBP), PBP with added leucine (PBP + Leu) to levels equivalent to whey protein isolate (WHEY) on aminoacidemia an...
We employed a randomized, double-blind, crossover study consisting of 3 separate study visits to compare PBP, PBP + Leu, and WHEY. To measure MPS response to ingestion of the supplements, a primed con...
All protein supplements increased mixed MPS above postabsorptive levels (...
Consumption of PBP isolate with added leucine stimulated MPS to a similar extent as whey protein in young men and women. PBPs containing higher leucine content promote anabolism to a similar extent as...
Predicting protein-protein interactions (PPIs) from sequence data is a key challenge in computational biology. While various computational methods have been proposed, the utilization of sequence embed...
Addressing this gap, we propose xCAPT5, a novel hybrid classifier that uniquely leverages the T5-XL-UniRef50 protein large language model for generating rich amino acid embeddings from protein sequenc...
This study represents one of the initial efforts to extract informative amino acid embeddings from a large protein language model using a deep and wide convolutional network. Experimental results show...