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"@type": "Question",
"name": "Comment le changement climatique affecte-t-il la santé ?",
"position": 1,
"acceptedAnswer": {
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"text": "Il augmente les maladies respiratoires, cardiovasculaires et les allergies."
}
},
{
"@type": "Question",
"name": "Quels tests diagnostiques pour les maladies liées au climat ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des évaluations de la qualité de l'air et des études épidémiologiques sont utilisées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des indicateurs de santé liés au climat ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les taux d'hospitalisation pour maladies respiratoires sont des indicateurs clés."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'impact du climat sur la santé ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par des études longitudinales et des analyses de données climatiques et sanitaires."
}
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{
"@type": "Question",
"name": "Quels sont les signes de stress thermique ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les signes incluent la déshydratation, la fatigue et les coups de chaleur."
}
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{
"@type": "Question",
"name": "Quels symptômes sont liés aux vagues de chaleur ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des maux de tête, des nausées et des évanouissements."
}
},
{
"@type": "Question",
"name": "Comment le changement climatique affecte-t-il les allergies ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il prolonge la saison des pollens, aggravant les symptômes allergiques."
}
},
{
"@type": "Question",
"name": "Quels symptômes respiratoires sont exacerbés par le climat ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'asthme et la bronchite peuvent s'aggraver avec la pollution de l'air."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes liés aux maladies infectieuses ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le paludisme peuvent se propager avec le changement climatique."
}
},
{
"@type": "Question",
"name": "Quels symptômes psychologiques peuvent survenir ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'anxiété et la dépression peuvent augmenter en raison des catastrophes climatiques."
}
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{
"@type": "Question",
"name": "Comment prévenir les maladies liées au changement climatique ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Promouvoir des modes de vie sains et réduire l'exposition aux polluants."
}
},
{
"@type": "Question",
"name": "Quelles mesures pour réduire les allergies ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les allergènes et utiliser des purificateurs d'air peuvent aider."
}
},
{
"@type": "Question",
"name": "Comment se protéger des vagues de chaleur ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Rester hydraté et éviter les activités physiques intenses pendant les pics de chaleur."
}
},
{
"@type": "Question",
"name": "Quelles stratégies pour la santé mentale face au climat ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Pratiquer la pleine conscience et se connecter avec la communauté sont bénéfiques."
}
},
{
"@type": "Question",
"name": "Comment sensibiliser aux risques climatiques ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éduquer le public sur les impacts du changement climatique sur la santé."
}
},
{
"@type": "Question",
"name": "Quels traitements pour les maladies respiratoires liées au climat ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les bronchodilatateurs et les corticostéroïdes sont couramment prescrits."
}
},
{
"@type": "Question",
"name": "Comment traiter les allergies exacerbées par le climat ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antihistaminiques et les immunothérapies sont des options de traitement."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements pour le stress thermique ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'hydratation et le repos dans un environnement frais sont essentiels."
}
},
{
"@type": "Question",
"name": "Comment gérer les maladies infectieuses liées au climat ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention par la vaccination et le traitement précoce sont cruciaux."
}
},
{
"@type": "Question",
"name": "Quels traitements pour les troubles mentaux liés au climat ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie cognitivo-comportementale et les médicaments peuvent aider."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le changement climatique ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des maladies chroniques aggravées et des décès prématurés."
}
},
{
"@type": "Question",
"name": "Comment le changement climatique affecte-t-il la santé mentale ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il peut entraîner des troubles anxieux et des dépressions sévères."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications pour les populations vulnérables ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les enfants et les personnes âgées sont plus à risque de complications."
}
},
{
"@type": "Question",
"name": "Quels impacts sur les maladies infectieuses ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le changement climatique peut favoriser la propagation de maladies infectieuses."
}
},
{
"@type": "Question",
"name": "Quelles complications respiratoires peuvent survenir ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'aggravation de l'asthme et des maladies pulmonaires chroniques est fréquente."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque liés au climat ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "La pollution de l'air, les vagues de chaleur et l'accès limité aux soins de santé."
}
},
{
"@type": "Question",
"name": "Comment l'urbanisation influence-t-elle les risques climatiques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'urbanisation augmente l'exposition aux vagues de chaleur et à la pollution."
}
},
{
"@type": "Question",
"name": "Quels groupes sont plus à risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées, les enfants et ceux avec des maladies préexistantes sont plus vulnérables."
}
},
{
"@type": "Question",
"name": "Quel rôle joue la pauvreté dans les risques climatiques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "La pauvreté limite l'accès aux soins et augmente la vulnérabilité aux impacts climatiques."
}
},
{
"@type": "Question",
"name": "Comment le changement climatique affecte-t-il les travailleurs ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les travailleurs en extérieur sont exposés à des risques accrus de chaleur et de maladies."
}
}
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Osteoarthritis (OA) is marked by the progressive degradation of joint cartilage and subchondral bone. The precise molecular mechanisms driving meniscus deterioration in OA, especially at the single-ce...
We analyzed two datasets from the GEO database, GSE220243 and GSE98918, focusing on meniscus tissue sequencing data from OA and non-OA patients. The standard Seurat procedure was employed to process s...
After quality control, 34,763 cells from the OA patients and 34,145 cells from the healthy controls were analyzed. UMAP identified and SingleR annotated 14 cell clusters. The 10 largest cell clusters ...
This research highlights crucial genes in the OA meniscus and uncovers their differing regulatory patterns between chondrocytes and non-chondrocytes. These findings enhance our understanding of the mo...
(1) Purpose: Retrospective back-to-back comparisons were performed to evaluate the accuracy, effectiveness, and incremental yield of chromosome microarray analysis (CMA) and exome sequencing (ES) anal...
Down syndrome (DS) is the most common congenital cause of intellectual disability and also leads to numerous metabolic and structural problems. This study aims to explore the application value of chro...
The study recruited 1452 pregnant women with abnormal DS screening results including 493 with an enlarged nuchal translucency thickness (NT ≥ 2.5 mm) and 959 with an abnormal second-trimester maternal...
CMA identified 74/1452 abnormal results, which was more efficient than karyotyping (51/1452, P < 0.05.) CMA is equivalent to traditional karyotyping for identifying aneuploidies. Compared to karyotypi...
CMA and karyotyping have both advantages and disadvantages in prenatal diagnosis of pregnant women with abnormal DS screening results. However, there was not enough evidence to support routine CMA in ...
Though copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine...
We performed exome sequencing (ES) and CMA for 332 unrelated pediatric probands referred for evaluation of IEI. The analysis included primary, secondary, and incidental findings....
Of the 332 probands, 134 (40.4%) received molecular diagnoses. Of these, 116/134 (86.6%) were diagnosed by ES alone. An additional 15/134 (11.2%) were diagnosed by CMA alone, including two likely...
Pairing ES and CMA can provide a comprehensive evaluation to clarify the complex factors that contribute to both immune and non-immune phenotypes. Such a combined approach to genetic testing helps unt...
The aim of this study was to investigate the contribution of chromosomal microarray analysis (CMA) and next-generation sequencing (NGS) to genetic diagnosis in fetuses with normal karyotype who underw...
The results of invasive genetic testing performed at a tertiary center between September 2020 and March 2022 were retrospectively analyzed. Indications for invasive tests were classified as fetal stru...
A total of 830 invasive tests were performed and aneuploidy was detected in 11.2% of the fetuses. CMA was performed in 465 fetuses with normal karyotype, and pCNVs were detected in 6.9%. pCNVs were de...
pCNVs can be significantly detected not only in fetuses with structural malformations, but also in invasive testing with other indications. NGS significantly contributes to genetic diagnosis in fetuse...
Chromosomal microarray analysis (CMA) may detect variants of uncertain clinical significance (VUS) and susceptibility loci (SL) with incomplete penetrance for neurodevelopmental disorders. This qualit...
Semi-structured interviews were conducted with women who received a VUS and/or SL from prenatal CMA in the last 2-4 years and were analyzed using Grounded Theory....
The vast majority of women recalled being stressed by the findings. All women sought further advice and information to be able to decide whether to continue or terminate their pregnancy. The three pre...
Although uncertain/probabilistic information commonly involves a psychological burden, it may also be perceived as valuable and actionable. Pre-test parental choice regarding the disclosure of such in...
Aneuploidies are the most common chromosomal abnormality and the main genetic cause of adverse pregnancy outcomes. Since numerous studies have focused on common trisomies, relatively little is known a...
A total of 90 RAAs were detected, of which 83 cases were mosaic trisomies and 7 were non-mosaic trisomies. Chromosomes 16, 22, and 9 were identified as the major chromosomes involving RAAs. The four p...
Variable phenotypes and outcomes were observed, which were highly heterogeneous in cases of prenatal RAAs. Thus, a cautious and comprehensive strategy should be implemented during prenatal counseling ...
Alzheimer's disease is a prevalent health problem with a heavy global burden. Definitely diagnosed by autopsy, the clear mechanism of Alzheimer's disease pathogenesis process needs to be illustrated. ...
We attempted to discover the role of microRNA in Alzheimer's disease by microarray bioinformatics analysis using autopsy sample data from the GEO database. Temporal cortex samples were included in thi...
After filtering out significantly differential expressed microRNAs and genes, enrichment analyses of both microRNAs and genes were conducted, respectively. Then, we constructed a transcription factor-...
Hsa-miR-365b-5p act as a key target in Alzheimer's disease. It regulates Alzheimer's disease pathogenesis process via neuroinflammation, Wnt and oxidative stress pathway which provides a potential tar...
Background: There are few studies on the detection rate by chromosomal microarray analysis (CMA) of the prenatal diagnosis of talipes equinovarus (TE) compared to conventional karyotyping. We aimed to...
(1) Objective: To evaluate the application of chromosomal microarray analysis (CMA) in fetuses with pulmonary atresia (PA) and to explore the risk factors for predicting chromosomal imbalances and adv...