Titre : Optogénétique

Optogénétique : Questions médicales fréquentes

Termes MeSH sélectionnés :

Free Tissue Flaps
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envisagés avec l'optogénétique ?\nL'optogénétique peut-elle aider à identifier des biomarqueurs ?", "url": "https://questionsmedicales.fr/mesh/D062308?mesh_terms=Free+Tissue+Flaps&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Optogénétique", "description": "L'optogénétique est-elle utilisée comme traitement ?\nQuels types de maladies pourraient bénéficier de l'optogénétique ?\nComment l'optogénétique est-elle administrée ?\nQuels sont les résultats attendus des traitements optogénétiques ?\nY a-t-il des effets secondaires connus ?", "url": "https://questionsmedicales.fr/mesh/D062308?mesh_terms=Free+Tissue+Flaps&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Optogénétique", "description": "Quelles complications peuvent survenir avec l'optogénétique ?\nY a-t-il des risques associés à l'optogénétique ?\nComment minimiser les complications en optogénétique ?\nLes complications sont-elles fréquentes ?\nQuelles sont les complications à long terme ?", "url": "https://questionsmedicales.fr/mesh/D062308?mesh_terms=Free+Tissue+Flaps&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Optogénétique", "description": "Quels sont les facteurs de risque pour l'optogénétique ?\nL'âge influence-t-il les résultats de l'optogénétique ?\nY a-t-il des facteurs environnementaux à considérer ?\nLes facteurs génétiques jouent-ils un rôle ?\nComment évaluer les facteurs de risque en optogénétique ?", "url": "https://questionsmedicales.fr/mesh/D062308?mesh_terms=Free+Tissue+Flaps&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment l'optogénétique est-elle diagnostiquée ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Elle est diagnostiquée par des techniques d'imagerie et des tests fonctionnels sur des cellules modifiées." } }, { "@type": "Question", "name": "Quels outils sont utilisés pour le diagnostic ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des microscopes à fluorescence et des systèmes de stimulation lumineuse sont utilisés." } }, { "@type": "Question", "name": "Peut-on diagnostiquer des troubles avec l'optogénétique ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle aide à étudier des troubles neurologiques en ciblant des neurones spécifiques." } }, { "@type": "Question", "name": "L'optogénétique nécessite-t-elle des échantillons biologiques ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des échantillons de tissus ou de cellules sont souvent nécessaires pour l'analyse." } }, { "@type": "Question", "name": "Quels types de cellules sont ciblées en optogénétique ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Principalement des neurones, mais aussi d'autres types cellulaires peuvent être modifiés." } }, { "@type": "Question", "name": "Quels symptômes l'optogénétique peut-elle aider à étudier ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Elle aide à étudier des symptômes comme l'anxiété, la dépression et les troubles moteurs." } }, { "@type": "Question", "name": "L'optogénétique peut-elle induire des symptômes ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Non, elle ne provoque pas de symptômes, mais elle permet d'observer des réponses neuronales." } }, { "@type": "Question", "name": "Comment l'optogénétique aide-t-elle à comprendre les symptômes ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Elle permet de manipuler des circuits neuronaux pour observer les effets sur le comportement." } }, { "@type": "Question", "name": "Peut-on mesurer des symptômes en temps réel ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'optogénétique permet des mesures en temps réel des réponses neuronales aux stimuli." } }, { "@type": "Question", "name": "Quels symptômes sont liés aux troubles traités par l'optogénétique ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme les convulsions, les troubles de l'humeur et les déficits cognitifs." } }, { "@type": "Question", "name": "L'optogénétique peut-elle aider à prévenir des maladies ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Indirectement, en permettant une meilleure compréhension des mécanismes de la maladie." } }, { "@type": "Question", "name": "Comment l'optogénétique contribue-t-elle à la recherche préventive ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Elle permet d'étudier les facteurs de risque et les mécanismes sous-jacents des maladies." } }, { "@type": "Question", "name": "Peut-on utiliser l'optogénétique pour des études épidémiologiques ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut être intégrée dans des études pour comprendre la propagation des maladies." } }, { "@type": "Question", "name": "Quels types de prévention sont envisagés avec l'optogénétique ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Des stratégies de prévention basées sur la modulation des circuits neuronaux." } }, { "@type": "Question", "name": "L'optogénétique peut-elle aider à identifier des biomarqueurs ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut aider à identifier des biomarqueurs pour des maladies neurologiques." } }, { "@type": "Question", "name": "L'optogénétique est-elle utilisée comme traitement ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Elle est principalement utilisée pour la recherche, mais a un potentiel thérapeutique." } }, { "@type": "Question", "name": "Quels types de maladies pourraient bénéficier de l'optogénétique ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des maladies comme la maladie de Parkinson, l'épilepsie et les troubles de l'humeur." } }, { "@type": "Question", "name": "Comment l'optogénétique est-elle administrée ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Elle est administrée par l'insertion de gènes sensibles à la lumière dans des cellules cibles." } }, { "@type": "Question", "name": "Quels sont les résultats attendus des traitements optogénétiques ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Amélioration des symptômes neurologiques et modulation des circuits neuronaux." } }, { "@type": "Question", "name": "Y a-t-il des effets secondaires connus ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Les effets secondaires sont encore à l'étude, mais peuvent inclure des réponses immunitaires." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec l'optogénétique ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications peuvent inclure des infections ou des réactions aux vecteurs utilisés." } }, { "@type": "Question", "name": "Y a-t-il des risques associés à l'optogénétique ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Les risques incluent des effets indésirables liés à la manipulation génétique." } }, { "@type": "Question", "name": "Comment minimiser les complications en optogénétique ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "En suivant des protocoles stricts et en surveillant les patients après les interventions." } }, { "@type": "Question", "name": "Les complications sont-elles fréquentes ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Elles sont rares, mais la recherche continue d'évaluer la sécurité de la technique." } }, { "@type": "Question", "name": "Quelles sont les complications à long terme ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Les complications à long terme sont encore mal comprises et nécessitent des études approfondies." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour l'optogénétique ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents médicaux, des maladies neurologiques et des traitements antérieurs." } }, { "@type": "Question", "name": "L'âge influence-t-il les résultats de l'optogénétique ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'âge peut affecter la réponse aux traitements optogénétiques et la récupération." } }, { "@type": "Question", "name": "Y a-t-il des facteurs environnementaux à considérer ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des facteurs comme le stress et l'exposition à des toxines peuvent influencer les résultats." } }, { "@type": "Question", "name": "Les facteurs génétiques jouent-ils un rôle ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les variations génétiques peuvent influencer la réponse aux interventions optogénétiques." } }, { "@type": "Question", "name": "Comment évaluer les facteurs de risque en optogénétique ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Par des évaluations cliniques et des études génétiques pour identifier les vulnérabilités." } } ] } ] }

Sources (10000 au total)

A staged approach to oromandibular reconstruction using the iliac crest free flap in the setting of bilateral failed fibula free flaps.

While a single-stage free-flap reconstruction is the preferred approach for oromandibular defects, a multistaged approach may be necessary in rare cases. These patients can still be effectively restor... We report two cases with a history of bilateral failed fibula free flaps. We detail the multistaged reconstruction to repair these complex defects and discuss the considerations when planning such pro... Both patients successfully underwent a staged reconstruction with an iliac crest osteocutaneous flap following either a rectus abdominis or pectoralis major myocutaneous flap.... Oromandibular reconstruction is an expected outcome in the contemporary management of oral cavity cancer and osteoradionecrosis. However, complications do occur and can be devastating. In cases of bil...

The contribution of microvascular free flaps and pedicled flaps to successful chest wall surgery.

Pedicled flaps (PFs) have historically served as the preferred option for reconstruction of large chest wall defects. More recently, the indications for microvascular-free flaps (MVFFs) have increased... We retrospectively identified all patients who underwent chest wall resection at our institution from 2000 to 2022. Patients were stratified by flap reconstruction. End points were defect size, rate o... In total, 536 patients underwent chest wall resection, of whom 133 had flap reconstruction (MVFF, n = 28; PF, n = 105). The median (interquartile range) covered defect size was 172 cm... Patients with MVFFs had larger defects, a high rate of complete resection, and a low rate of local recurrence. MVFFs are a valid option for chest wall reconstructions....

Ultrathin Anterolateral Thigh Free Flap: An Adipocutaneous Flap with the Most Superficial Elevation Plane.

Although many efforts have been made to create thinner anterolateral thigh (ALT) flaps, their thickness varies among patients, and the flap may be still too thick to match shallow defects. The authors... All patients who underwent ALT free flap reconstruction for upper and lower distal extremity defects were divided retrospectively into groups by ALT flap elevation plane: thin, above the deep fascia; ... The average deep and superficial fascial depths were 16.7 and 10.8 mm, 12.5 and 8.2 mm, and 9.1 and 5.6 mm ( P < 0.05), and the average flap thickness was 5.8 mm, 7.9 mm, and 7.8 mm ( P = 0.29) in the... With precise preoperative planning, the most superficially elevated, ultrathin ALT flap can achieve optimal reconstructions of thin body areas. Female patients with thicker thighs and patients with a ... Therapeutic, IV....

Comparing outcomes of radial forearm free flaps and anterolateral thigh free flaps in oral cavity reconstruction: A systematic review and meta-analysis.

To compare surgical morbidity, functional and aesthetic restoration, and health-related quality of life among patients receiving anterolateral thigh (ALT) or radial forearm (RFF) free flaps for intra-... PubMed, Medline, EMBASE, CINAHL, and CDSR databases were searched from 2000 to 2022. Primary outcomes included flap survival, recipient site complications, donor site morbidity, recovery of oral funct... A total of 23 criteria-meeting studies with 685 ALT and 723 RFF patients were included. There were no differences between the two groups in flap survival or the likelihood of flap-related complication... The findings suggest that the ALT achieves equivalent flap survival rates and oral function with less donor site morbidity compared to the RFF for intra-oral reconstruction. Nonetheless, choice of fre...

Recipient bed perfusion as a predictor for postoperative complications in irradiated patients with microvascular free tissue transfer of the head and neck area: a clinical analysis of 191 microvascular free flaps.

Despite microvascular free tissue transfer being the mainstay of care in the reconstruction of larger maxillofacial defects, a significant number of patients experience postoperative complications due... We analyzed flap and recipient bed perfusion within the first 2 weeks after surgery by using the oxygen-to-see device. One hundred ninety-one patients who underwent free flap surgery in our department... Flow parameters were higher and postoperative complications were less frequent in radial forearm free flaps compared to any other type of flap. Flow parameters of the recipient bed were higher than tr... We conclude that monitoring of recipient bed perfusion is useful for detecting flap compromise of irradiated patients in the early postoperative period....

Outcomes of Free Muscle Flaps versus Free Fasciocutaneous Flaps for Lower Limb Reconstruction following Trauma: A Systematic Review and Meta-Analysis.

Free flap reconstruction of the lower limb following trauma often suffers higher complication rates than other areas of the body. The choice of muscle or fasciocutaneous free flap is an area of active... A systematic review of EMBASE, MEDLINE, PubMed, and Cochrane Register from inception to April 1, 2022 was performed. Articles were assessed using the methodological index for non-randomized studies in... Seventeen studies were included. All studies were retrospective in nature, of level three evidence, and published between 1986 and 2021. The most common muscle and fasciocutaneous free flaps used were... The rate of total flap failure, reoperation, or limb salvage is not significantly different between muscle and fasciocutaneous free flaps after lower limb reconstruction following trauma. Partial flap...

Medial sural artery perforator free flap versus radial forearm free flap in oral cavity reconstruction and donor site morbidity.

Radial Forearm Free flap (RFFF) is widely used in head and neck reconstruction, yet its donor site defect remains a significant drawback. The Medial Sural Artery Perforator Free Flap (MSAPFF) is consi... All patients who underwent oral cavity reconstruction using RFFF and MSAPFF between February 2017 and April 2023 were included in this study. Flap characteristics, outcomes and post-operative complica... The study included 76 patients: 37 underwent reconstruction with RFFF, and 39 with MSAPFF. There was no significance difference between the RFFF and MSAPFF regarding the success rate (97.2% vs 97.4%),... The MSAPFF is an excellent alternative to the RFFF for repairing oral cavity defects, with additional advantage of a well-hidden scar on the posterior calf, a larger flap thickness, accepted pedicle l... The study highlights the importance of the MSAPFF as an alternative option for RFFF with less donor site morbidity and high success rate in oral cavity reconstruction and improved patient Quality of l...