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"@type": "Question",
"name": "Comment l'optogénétique est-elle diagnostiquée ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est diagnostiquée par des techniques d'imagerie et des tests fonctionnels sur des cellules modifiées."
}
},
{
"@type": "Question",
"name": "Quels outils sont utilisés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des microscopes à fluorescence et des systèmes de stimulation lumineuse sont utilisés."
}
},
{
"@type": "Question",
"name": "Peut-on diagnostiquer des troubles avec l'optogénétique ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à étudier des troubles neurologiques en ciblant des neurones spécifiques."
}
},
{
"@type": "Question",
"name": "L'optogénétique nécessite-t-elle des échantillons biologiques ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des échantillons de tissus ou de cellules sont souvent nécessaires pour l'analyse."
}
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{
"@type": "Question",
"name": "Quels types de cellules sont ciblées en optogénétique ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Principalement des neurones, mais aussi d'autres types cellulaires peuvent être modifiés."
}
},
{
"@type": "Question",
"name": "Quels symptômes l'optogénétique peut-elle aider à étudier ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle aide à étudier des symptômes comme l'anxiété, la dépression et les troubles moteurs."
}
},
{
"@type": "Question",
"name": "L'optogénétique peut-elle induire des symptômes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle ne provoque pas de symptômes, mais elle permet d'observer des réponses neuronales."
}
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{
"@type": "Question",
"name": "Comment l'optogénétique aide-t-elle à comprendre les symptômes ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet de manipuler des circuits neuronaux pour observer les effets sur le comportement."
}
},
{
"@type": "Question",
"name": "Peut-on mesurer des symptômes en temps réel ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'optogénétique permet des mesures en temps réel des réponses neuronales aux stimuli."
}
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{
"@type": "Question",
"name": "Quels symptômes sont liés aux troubles traités par l'optogénétique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme les convulsions, les troubles de l'humeur et les déficits cognitifs."
}
},
{
"@type": "Question",
"name": "L'optogénétique peut-elle aider à prévenir des maladies ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, en permettant une meilleure compréhension des mécanismes de la maladie."
}
},
{
"@type": "Question",
"name": "Comment l'optogénétique contribue-t-elle à la recherche préventive ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet d'étudier les facteurs de risque et les mécanismes sous-jacents des maladies."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser l'optogénétique pour des études épidémiologiques ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut être intégrée dans des études pour comprendre la propagation des maladies."
}
},
{
"@type": "Question",
"name": "Quels types de prévention sont envisagés avec l'optogénétique ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des stratégies de prévention basées sur la modulation des circuits neuronaux."
}
},
{
"@type": "Question",
"name": "L'optogénétique peut-elle aider à identifier des biomarqueurs ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut aider à identifier des biomarqueurs pour des maladies neurologiques."
}
},
{
"@type": "Question",
"name": "L'optogénétique est-elle utilisée comme traitement ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est principalement utilisée pour la recherche, mais a un potentiel thérapeutique."
}
},
{
"@type": "Question",
"name": "Quels types de maladies pourraient bénéficier de l'optogénétique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies comme la maladie de Parkinson, l'épilepsie et les troubles de l'humeur."
}
},
{
"@type": "Question",
"name": "Comment l'optogénétique est-elle administrée ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est administrée par l'insertion de gènes sensibles à la lumière dans des cellules cibles."
}
},
{
"@type": "Question",
"name": "Quels sont les résultats attendus des traitements optogénétiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Amélioration des symptômes neurologiques et modulation des circuits neuronaux."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires connus ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires sont encore à l'étude, mais peuvent inclure des réponses immunitaires."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec l'optogénétique ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications peuvent inclure des infections ou des réactions aux vecteurs utilisés."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques associés à l'optogénétique ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les risques incluent des effets indésirables liés à la manipulation génétique."
}
},
{
"@type": "Question",
"name": "Comment minimiser les complications en optogénétique ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "En suivant des protocoles stricts et en surveillant les patients après les interventions."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles fréquentes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles sont rares, mais la recherche continue d'évaluer la sécurité de la technique."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications à long terme ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications à long terme sont encore mal comprises et nécessitent des études approfondies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour l'optogénétique ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents médicaux, des maladies neurologiques et des traitements antérieurs."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il les résultats de l'optogénétique ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge peut affecter la réponse aux traitements optogénétiques et la récupération."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs environnementaux à considérer ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs comme le stress et l'exposition à des toxines peuvent influencer les résultats."
}
},
{
"@type": "Question",
"name": "Les facteurs génétiques jouent-ils un rôle ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les variations génétiques peuvent influencer la réponse aux interventions optogénétiques."
}
},
{
"@type": "Question",
"name": "Comment évaluer les facteurs de risque en optogénétique ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par des évaluations cliniques et des études génétiques pour identifier les vulnérabilités."
}
}
]
}
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Based on data from two large cohort studies, a label update became applicable for the class of interferon beta therapies in 9/2019, allowing interferons during pregnancy and breastfeeding....
To assess pregnancy outcomes of women with multiple sclerosis (MS) exposed to peginterferon beta-1a or intramuscular interferon beta-1a therapy (IFN)....
Non-interventional post-authorization safety study....
PRIMA was conducted from April to October 2021 in Germany. Retrospective pregnancy data were retrieved from adult female patients diagnosed with relapsing-remitting MS or clinically isolated syndrome,...
In total, 426 women reporting 542 pregnancies between December 2001 and July 2020 (14 pregnancies after the label update) were enrolled. Among patients with confirmed exposure during pregnancy (...
Overall, the prevalence of spontaneous abortions and congenital anomalies of females exposed to IFN exposure before or during pregnancy was within the range reported for the general population. Most m...
NCT04655222, EUPAS38347....
Cognitive dysfunction is common in multiple sclerosis and may worsen with reduced treatment adherence. We examined longitudinal relationships between anxiety, depression, fatigue, disability and adher...
The Confidence study is a prospective study in 165 people with MS with four visits (baseline/12/24/36 months). Physical and psychological symptoms were assessed using standardized questionnaires. Adhe...
At baseline, mean age was 35.7 ± 11 years and 66% were female (...
Our findings provide evidence for a longitudinal association between depression and low cognitive status in patients treated with interferon beta-1a in routine medical practice....
Interferon-beta (IFN-β) is a cytokine with a wide range of biological and pharmaceutical applications, including multiple sclerosis (MS), cancer, some autoimmune disorders, and viral infectious diseas...
The gene of IFN-β-1a was successfully sub-cloned into the pPICZA vector. The recombinant vector was transfected to...
The double digestion with...
Optimization of cultivation conditions for intracellular expression of IFN-β-1a was successfully performed. This approach can be generally applied to improve the production yield and quality of other ...
Results from several clinical trials suggest there is a dose-response effect for beta interferon-1a (INFβ1a) in multiple sclerosis (MS)....
Our objective was to confirm these results through a retrospective analysis of patients with MS who had breakthrough disease (BD) on intramuscular (IM) INFβ1a (Avonex®) once per week (QW), who were sw...
Among 92 patients on QW IM INFβ1a, 53 patients with BD were switched to BIW IM INFβ1a. Of these 53 patients, 44 had adequate follow-up for at least 2 years. Twenty-three of these had no further BD for...
For patients with MS having breakthrough disease on QW INFβ1a, switching to more frequently administered INFβ may be an option. Advantages to using IM INFβ1a for this include no skin reactions and a l...
Mendelian susceptibility to mycobacterial disease (MSMD) is caused by approximately 21 genetic defects, including a mutation in Interferon-Gamma Receptor 1 (IFNGR1). IFNGR1 deficiency leads to a loss ...
Effective therapeutics given early to high-risk ambulatory patients with coronavirus disease 2019 (COVID-19) could improve outcomes and reduce overall healthcare burden. However, conducting site visit...
To evaluate the feasibility of a purely remote (virtual) study in non-hospitalised patients with COVID-19; and the efficacy and safety of nebulised recombinant interferon-β1a (SNG001) in this setting....
Randomised, double-blind, parallel-group study, which was conducted remotely....
Eligible patients aged ≥65 years (or ≥50 years with risk factors) with COVID-19 and not requiring hospital admission were recruited remotely. They were randomised to SNG001 or placebo once-daily via n...
Of 114 patients treated, 111 (97.4%) completed 28 days of follow-up. Overall compliance to study medication was high, with ≥13 doses taken by 89.7% and 92.9% of treated patients in the placebo and SNG...
This study demonstrated that it is feasible to conduct a purely virtual study in community-based patients with COVID-19, when the study included detailed daily assessments and with medication administ...
Type I interferons (IFNs) play a pivotal role in immune response modulation, yet dysregulation is implicated in various disorders. Therefore, it is crucial to develop tools that facilitate the underst...
Knowledge within the field of multiple sclerosis treatment during pregnancy is vital to ensure the most optimal clinical practice. Immunomodulatory treatment in pregnancy could in theory affect the no...
This retrospective matched cohort study utilized data from the Danish Multiple Sclerosis Registry linked with national Danish registries to identify all children born of mothers with MS in Denmark fro...
We found no differences in childhood mortality, for hospital admissions the rate ratio compared to healthy controls was 0.79 (0.62-1.00). Regarding antibiotic prescriptions, the results were similar (...
Exposure to interferon-beta during gestation has little to no impact on the risk of acquiring significant infections during the first five years of childhood....
Evidence suggests that organizational models that provide care interventions including patient support programs may increase patient adherence to multiple sclerosis (MS) therapies by providing tailore...
The main objective of this study was to describe MS patients' self-reported experience of a nurse-led, telephone-based PSP and to explore its potential role in improving disease and therapy management...
Survey data were analyzed from a subset of patients relapsing-remitting MS (RRMS) using interferon beta-1a already registered in the adveva...
In total, 244 patient data at baseline were analyzed, of which 115 had a follow-up of at least 6 months. Results from this study provide an early view into the role of this PSP in improving the patien...
As such, it is reasonable to conclude that the involvement in the adveva...
Sugar beet (Beta vulgaris L.) is grown in temperate regions around the world as a source of sucrose. Sugar beet is susceptible to a number of viral diseases, but identification of the causal agent(s) ...