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"description": "Comment diagnostiquer une dysfonction du PRC1 ?\nQuels tests sont utilisés pour évaluer le PRC1 ?\nLe diagnostic nécessite-t-il une biopsie ?\nQuels marqueurs sont associés au PRC1 ?\nLe diagnostic est-il basé sur des symptômes cliniques ?",
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"description": "Quels symptômes indiquent une anomalie du PRC1 ?\nLe PRC1 est-il lié à des cancers spécifiques ?\nLes troubles neurologiques sont-ils liés au PRC1 ?\nLe PRC1 affecte-t-il le métabolisme ?\nY a-t-il des symptômes généraux associés au PRC1 ?",
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"url": "https://questionsmedicales.fr/mesh/D063150?mesh_terms=Recovery+of+Function&page=5#section-prévention"
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"name": "Traitements",
"headline": "Traitements sur Complexe répresseur Polycomb-1",
"description": "Quels traitements ciblent le PRC1 ?\nLa chimiothérapie est-elle efficace contre les anomalies du PRC1 ?\nDes traitements expérimentaux existent-ils pour le PRC1 ?\nLe PRC1 peut-il être ciblé par des médicaments spécifiques ?\nLes thérapies combinées sont-elles efficaces pour le PRC1 ?",
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"description": "Quelles complications peuvent survenir avec le PRC1 ?\nLe PRC1 est-il lié à des maladies auto-immunes ?\nLes complications sont-elles réversibles ?\nLe PRC1 affecte-t-il la qualité de vie ?\nY a-t-il des complications neurologiques associées ?",
"url": "https://questionsmedicales.fr/mesh/D063150?mesh_terms=Recovery+of+Function&page=5#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Complexe répresseur Polycomb-1",
"description": "Quels sont les facteurs de risque pour le PRC1 ?\nL'âge est-il un facteur de risque pour le PRC1 ?\nLes facteurs environnementaux influencent-ils le PRC1 ?\nLe sexe joue-t-il un rôle dans le risque de PRC1 ?\nLe mode de vie influence-t-il le risque de PRC1 ?",
"url": "https://questionsmedicales.fr/mesh/D063150?mesh_terms=Recovery+of+Function&page=5#section-facteurs de risque"
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction du PRC1 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur des analyses génétiques et des études d'expression génique."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer le PRC1 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de séquençage et des analyses de chromatine sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Le diagnostic nécessite-t-il une biopsie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une biopsie peut être nécessaire pour analyser les tissus affectés par le PRC1."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont associés au PRC1 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs épigénétiques comme les modifications des histones sont souvent analysés."
}
},
{
"@type": "Question",
"name": "Le diagnostic est-il basé sur des symptômes cliniques ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes cliniques peuvent orienter le diagnostic, mais des tests spécifiques sont nécessaires."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une anomalie du PRC1 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies de développement et des troubles de la différenciation cellulaire peuvent survenir."
}
},
{
"@type": "Question",
"name": "Le PRC1 est-il lié à des cancers spécifiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations dans le PRC1 sont associées à divers types de cancers, notamment le cancer du sein."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques sont-ils liés au PRC1 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent un lien entre le PRC1 et des troubles neurologiques, mais les recherches sont en cours."
}
},
{
"@type": "Question",
"name": "Le PRC1 affecte-t-il le métabolisme ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches indiquent que le PRC1 peut influencer le métabolisme cellulaire et énergétique."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes généraux associés au PRC1 ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme la fatigue et des anomalies de croissance peuvent être observés."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les anomalies liées au PRC1 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais un mode de vie sain peut réduire certains risques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour le PRC1 ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de tests de dépistage standardisés pour les anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le risque ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers peuvent augmenter le risque d'anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Des conseils génétiques sont-ils disponibles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des conseils génétiques peuvent aider à évaluer le risque et à discuter des options de prévention."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans la prévention ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut contribuer à la santé cellulaire, mais ne prévient pas spécifiquement les anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent le PRC1 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs de la méthylation des histones et des thérapies géniques sont explorés."
}
},
{
"@type": "Question",
"name": "La chimiothérapie est-elle efficace contre les anomalies du PRC1 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chimiothérapie peut être utilisée, mais son efficacité dépend du type de cancer associé."
}
},
{
"@type": "Question",
"name": "Des traitements expérimentaux existent-ils pour le PRC1 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des traitements expérimentaux sont en cours d'évaluation dans des essais cliniques."
}
},
{
"@type": "Question",
"name": "Le PRC1 peut-il être ciblé par des médicaments spécifiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches sont en cours pour développer des médicaments ciblant spécifiquement le PRC1."
}
},
{
"@type": "Question",
"name": "Les thérapies combinées sont-elles efficaces pour le PRC1 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les thérapies combinées peuvent améliorer l'efficacité des traitements contre les cancers liés au PRC1."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le PRC1 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers avancés et des troubles de développement sévères."
}
},
{
"@type": "Question",
"name": "Le PRC1 est-il lié à des maladies auto-immunes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études suggèrent un lien potentiel entre le PRC1 et certaines maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles."
}
},
{
"@type": "Question",
"name": "Le PRC1 affecte-t-il la qualité de vie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les anomalies du PRC1 peuvent significativement affecter la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications neurologiques associées ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies du PRC1 peuvent entraîner des complications neurologiques, comme des troubles cognitifs."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour le PRC1 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des mutations génétiques, des antécédents familiaux et des expositions environnementales."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le PRC1 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains types de cancers liés au PRC1 sont plus fréquents chez les personnes âgées."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils le PRC1 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des expositions à des agents cancérigènes peuvent augmenter le risque d'anomalies du PRC1."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque de PRC1 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains cancers liés au PRC1 montrent des différences de prévalence entre les sexes."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque de PRC1 ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie malsain, comme le tabagisme, peut augmenter le risque d'anomalies du PRC1."
}
}
]
}
]
}
Postoperative intestinal ileus is common after laparoscopic surgery, the incidence of those after hysterectomy was 9.2%. Anesthesia is one of the independent risk factors of postoperative ileus. Dexme...
What are the probability and underlying influence factors of intermittent ovarian function recovery in patients with idiopathic premature ovarian insufficiency (POI)?...
This was a retrospective cohort study conducted in tertiary hospitals recruiting 162 patients diagnosed with POI based on European Society of Human Reproduction and Embryology criteria from June 2015 ...
Among 162 POI patients, 48 (29.63%) presented intermittent ovarian function recovery, and 11 (6.79%) were natural pregnancies; 114 (70.37%) patients failed to show ovarian function recovery. No associ...
The incidence of intermittent ovarian function recovery in patients with idiopathic POI was 29.63%, and the natural pregnancy rate was 6.79%. Lower FSH concentration at diagnosis, no passive smoking a...
Physical therapy interventions play a crucial role in the daily care of patients recovering from severe stroke. However, the efficacy of these interventions and associated modalities, including durati...
We searched CENTRAL, MEDLINE, Web of Science, and three other relevant databases between December 2018 and March 2021 and updated the search between April 2021 and March 2023....
gov and ICTRP for searching trial registries helped to identify ongoing RCTs since 2023. We included individual and cluster randomized controlled trials in the English and German languages that compar...
The update identified 15 new studies, cumulating in a total of 30 studies (n = 2545 participants) meeting the eligibility criteria. These studies reported 54 outcomes and 20 physical therapy intervent...
There is conflicting evidence for the effectiveness of physical therapy interventions in patients with severe stroke. There is a need for additional high-quality studies that also systematically repor...
PROSPERO CRD42021244285....
High cervical spinal cord injury (SCI) results in complete loss of upper-limb function, resulting in debilitating tetraplegia and permanent disability. Spontaneous motor recovery occurs to varying deg...
A prospective cohort of high cervical SCI (C1-4) patients with American Spinal Injury Association Impairment Scale (AIS) grade A-D injury and enrolled in the Spinal Cord Injury Model Systems Database ...
Between 1992 and 2016, 405 high cervical SCI patients were included. At baseline, 97% of patients had impaired upper-limb function with total dependence in eating, bladder management, and transfers. A...
After high cervical SCI, patients who gained elbow extension (C7) and finger flexion (C8) had significantly greater independence in feeding, bladder management, and transfers than those with recovery ...
Rehabilitation medicine is facing a new development phase thanks to a recent wave of rigorous clinical trials aimed at improving the scientific evidence of protocols. This phenomenon, combined with ne...
We conducted a comprehensive search of five electronic databases using the Patient, Intervention, Comparison and Outcome (PICO) format. We extracted health conditions, population characteristics, outc...
A total of 19 primary studies were included. The predictors most frequently used belonged to the areas of demographic characteristics and stroke assessment through clinical examination. Regarding the ...
We identified several methodological limitations: small sample sizes, a limited number of external validation approaches, and high heterogeneity among input and output variables. Although these elemen...
The use of Impella support is increasingly adopted to "protect" patients with severe coronary artery disease (CAD) and left ventricle (LV) dysfunction undergoing percutaneous coronary intervention (PC...
To evaluate the impact of Impella-protected (Abiomed, Danvers, Massachusetts, USA) PCIs on myocardial function recovery....
Patients with significant LV dysfunction undergoing multi-vessel PCIs with pre-intervention Impella implantation were evaluated by echocardiography before PCI and at median follow up of 6 months: glob...
A total of 48 high surgical risk (mean EuroSCORE II 8) patients with median LVEF value of 30%, extensive wall motion abnormalities (median WMSI 2.16), and severe multi-vessel CAD (mean SYNTAX score 35...
In patients with extensive CAD and severe LV dysfunction, multi-vessel Impella-protected PCI was associated to an appreciable contractile recovery, mainly determined by regional wall motion improvemen...
Functional recovery as a consumer-centered approach is critical to recovery for community-dwelling people with schizophrenia. The current study investigated the mediating role of positive thinking in ...
To observe the effect of strength training of the nonhemiplegic side (NHS) on balance function, mobility, and muscle strength of patients with stroke....
A single-blinded (evaluator) randomized controlled trial....
A tertiary hospital rehabilitation center....
139 patients with first stroke (N=139) were recruited and randomly separated into a trial (n=69) or control group (n=70)....
The control group underwent usual rehabilitation training, including step training and trunk control training in standing position. The trial group underwent strength training of NHS on the basis of u...
Balance evaluation was done with the Berg Balance Scale (BBS); mobility assessment with the 6-minute walk test (6-MWT); activities of daily life was examined via the modified Barthel Index (MBI); musc...
The trial group performed better than control group in BBS scores (adjusted mean difference: 6.83; 95% confidence interval [CI]: 4.71-8.94) and 6-MWT (adjusted mean difference: 50.32; 95% CI: 40.58-60...
Strength training of the NHS can promote recovery of balance, mobility, and muscle strength of the paretic side of patients with stroke....
Knee osteoarthritis (KOA) is a common disease based on degenerative pathological changes. Total knee arthroplasty (TKA) is an effective treatment for end-stage of KOA. However, only volume adaptation ...
From October 2015 to June 2019, patients who underwent primary unilateral TKA were enrolled in this prospective cohort study with the same brand of knee prostheses. General data were collected from pa...
In total, 210 patients were eventually included in observation. All patients underwent postoperative follow-up for no less than two years. Multiple regression analysis showed that the course of the di...
All Patients underwent TKA had varying degrees of increased knee weight. The increased weight was 298.98 ± 63.77 g. Patients' body weight, K-L staging, and disease duration are important factors that ...
Robot technology to support upper limb (UL) rehabilitation poststroke has rapidly developed over the past 3 decades. We aimed to assess the effects of UL-robots (UL-RTs) on recovery of UL motor functi...
Randomized controlled trials (RCTs) comparing UL-RTs with any other intervention on patients with UL limitations poststroke were identified in electronic searches from PubMed, Wiley/Cochrane Libraries...
Ninety RCTs (N = 4,311) were included (median PEDro score 6 [6-7]). Meta-analyses of 86 trials (N = 4,240) showed small significant improvements in UL-muscle synergism (Fugl-Meyer Assessment of the UL...
The small significant effects found at the level of motor impairment do not show generalization to clinically meaningful effects at the level of UL-capacity. Meta-regressions suggest that selected par...
A prospectively registered study protocol is available in the PROSPERO database under ID CRD42020197450....