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"name": "Diagnostic",
"headline": "Diagnostic sur Calbindine-2",
"description": "Comment diagnostiquer une carence en calbindine-2 ?\nQuels examens sont utilisés pour évaluer la calbindine-2 ?\nLa calbindine-2 est-elle mesurable dans le sang ?\nQuels symptômes peuvent indiquer un problème avec la calbindine-2 ?\nY a-t-il des marqueurs spécifiques pour la calbindine-2 ?",
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"description": "Quelles complications peuvent survenir avec une carence en calbindine-2 ?\nLa calbindine-2 est-elle liée à des maladies chroniques ?\nDes troubles de l'humeur peuvent-ils être liés à la calbindine-2 ?\nLa calbindine-2 influence-t-elle le développement cognitif ?\nY a-t-il un risque accru de chutes ?",
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"description": "Quels facteurs augmentent le risque de carence en calbindine-2 ?\nLes troubles métaboliques sont-ils un facteur de risque ?\nLe mode de vie sédentaire influence-t-il la calbindine-2 ?\nLes régimes restrictifs sont-ils risqués ?\nLes antécédents familiaux jouent-ils un rôle ?",
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"@type": "Question",
"name": "Comment diagnostiquer une carence en calbindine-2 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins et des biopsies musculaires peuvent aider à évaluer les niveaux de calbindine-2."
}
},
{
"@type": "Question",
"name": "Quels examens sont utilisés pour évaluer la calbindine-2 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'électrophorèse des protéines et l'immunohistochimie sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "La calbindine-2 est-elle mesurable dans le sang ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, la calbindine-2 est principalement présente dans les tissus, pas dans le sang."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec la calbindine-2 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles neurologiques ou musculaires peuvent suggérer un dysfonctionnement de la calbindine-2."
}
},
{
"@type": "Question",
"name": "Y a-t-il des marqueurs spécifiques pour la calbindine-2 ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs comme la calmoduline peuvent être évalués en relation avec la calbindine-2."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en calbindine-2 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des spasmes musculaires, des tremblements et des troubles de la coordination."
}
},
{
"@type": "Question",
"name": "La calbindine-2 affecte-t-elle le système nerveux ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle joue un rôle crucial dans la transmission synaptique et la plasticité neuronale."
}
},
{
"@type": "Question",
"name": "Des douleurs musculaires peuvent-elles être liées à la calbindine-2 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une dysfonction de la calbindine-2 peut entraîner des douleurs musculaires et des crampes."
}
},
{
"@type": "Question",
"name": "La fatigue est-elle un symptôme associé à la calbindine-2 ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une fatigue excessive peut résulter d'une mauvaise régulation du calcium par la calbindine-2."
}
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{
"@type": "Question",
"name": "Peut-on observer des troubles cognitifs liés à la calbindine-2 ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles cognitifs peuvent survenir en raison de l'implication de la calbindine-2 dans le cerveau."
}
},
{
"@type": "Question",
"name": "Comment prévenir une carence en calbindine-2 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et des contrôles réguliers de la santé peuvent aider."
}
},
{
"@type": "Question",
"name": "Les suppléments de calcium sont-ils nécessaires ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être recommandés, surtout pour les personnes à risque de carence."
}
},
{
"@type": "Question",
"name": "Y a-t-il des groupes à risque pour la calbindine-2 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées et celles avec des troubles métaboliques sont plus à risque."
}
},
{
"@type": "Question",
"name": "L'exposition au soleil est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition au soleil aide à la synthèse de la vitamine D, essentielle pour la calbindine-2."
}
},
{
"@type": "Question",
"name": "Des tests réguliers sont-ils conseillés ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests réguliers peuvent aider à détecter précocement des anomalies."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en calbindine-2 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut inclure des suppléments de calcium et des thérapies ciblées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des médicaments pour réguler la calbindine-2 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de médicaments spécifiques pour la calbindine-2."
}
},
{
"@type": "Question",
"name": "La physiothérapie aide-t-elle en cas de dysfonction de la calbindine-2 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la physiothérapie peut améliorer la force musculaire et la coordination."
}
},
{
"@type": "Question",
"name": "Des changements alimentaires peuvent-ils aider ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en calcium et en vitamine D peut soutenir la fonction de la calbindine-2."
}
},
{
"@type": "Question",
"name": "Les exercices physiques sont-ils bénéfiques ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des exercices réguliers peuvent améliorer la santé musculaire et nerveuse."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une carence en calbindine-2 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications neurologiques et musculaires graves peuvent se développer."
}
},
{
"@type": "Question",
"name": "La calbindine-2 est-elle liée à des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme l'ostéoporose peuvent être exacerbées par une carence en calbindine-2."
}
},
{
"@type": "Question",
"name": "Des troubles de l'humeur peuvent-ils être liés à la calbindine-2 ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres de calcium peuvent affecter l'humeur et le comportement."
}
},
{
"@type": "Question",
"name": "La calbindine-2 influence-t-elle le développement cognitif ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une déficience peut nuire au développement cognitif, surtout chez les enfants."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de chutes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une faiblesse musculaire due à une carence en calbindine-2 augmente le risque de chutes."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de carence en calbindine-2 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, une mauvaise alimentation et certaines maladies augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme le diabète peuvent affecter les niveaux de calbindine-2."
}
},
{
"@type": "Question",
"name": "Le mode de vie sédentaire influence-t-il la calbindine-2 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire peut contribuer à une faiblesse musculaire et à des carences."
}
},
{
"@type": "Question",
"name": "Les régimes restrictifs sont-ils risqués ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les régimes restrictifs peuvent entraîner des carences en nutriments essentiels, y compris le calcium."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de troubles musculaires ou neurologiques peuvent augmenter le risque."
}
}
]
}
]
}
Missed appointments (MAs) at child development centres (ChDCs) cause multiple problems: they preclude timely diagnosis and treatment of both the invited child and children whose appointment was delaye...
This nested case-control study included all children scheduled for initial appointments (N = 1143) at three centres during 1 year. Parents of children who missed their appointment and a sample of thos...
The rate of missed appointments was 26.6%, and the most frequent reasons were unexpected events (26.0%) and lack of insurance coverage (23.4%). Variables associated with lower MA rates were: having ha...
Encouraging physician's referral letters and personal-contact reminders can reduce missed appointments. Understanding the family's and the child's personal characteristics, and the organisational/admi...
To identify perceptions of primary care health professionals regarding the conceptual aspects of child development and propose strategies to address difficulties....
This descriptive-analytical study was conducted in a small municipality in the countryside of the State of São Paulo, Brazil. The primary health care in this region is comprised of Family Health Units...
Among the participants, 54% were nurses, and the average duration of working with the pediatric population was ten years. 80% reported never having undergone training in child development. The analysi...
The findings underscore the necessity of implementing health education initiatives and service projects in primary care settings. It is crucial to strengthen a comprehensive perspective of child healt...
Integrated Child Development Services (ICDS) scheme, a large public health program, addresses the needs of young children with Anganwadi Workers (AWWs) as frontline agents of delivery. A scalable prog...
This paper describes formative work done with AWWs, as part of ASPIRE to assess their understanding of early childhood development (ECD) and acceptability of a novel ECD intervention using digital tec...
Six focus group discussions (FGDs) were conducted with 31 AWWs, using a semi-structured guide....
Framework analysis of their responses from FGDs led to the identification of three themes: (1) time use, (2) understanding of ECD, and (3) delivering messages using videos. The findings suggest that A...
Integration of novel ECD interventions delivered by frontline workers needs to take into account their existing work schedules and associated challenges. Training on ECD interventions will need to bro...
Despite major improvements in child survival over the past decade, many children in low and middle-income countries (LMICs) remain at risk of not reaching their developmental potential due to malnutri...
We conducted a descriptive study using data from a prospective study in Kenya and Zambia. The study included three rounds of data collection. Children were on average 10 months old in round one, 25 mo...
Higher maternal stimulation scores were associated with higher ASQ scores (effect size = 0.25; 95% CI: 0.19, 0.31) after adjusting for other confounders. For domain specific and child development (ASQ...
Our study findings suggest a strong positive link between maternal stimulation activities and children's developmental outcomes among communities in poor rural settings....
NA (not a clinical trial)....
Some children born to adolescent mothers may have developmental challenges, while others do not. Research focusing on which children of adolescent mothers are at the highest risk for cognitive delay i...
Cross-sectional data utilised within the analyses was drawn from a large cohort of adolescent mothers and their children residing in South Africa. Detailed study questionnaires were completed by adole...
The study included 954 adolescent mothers; 24.1% (230/954) were living with HIV, 12.6% (120/954) were classified as experiencing likely common mental disorder. After adjusting for covariates, maternal...
This study addresses a critical evidence gap relating to the understanding of possible risk factors for the cognitive development of children born to adolescent mothers affected by HIV. This group of ...
The present study aims to explore the association of maternal sleep disturbances during late pregnancy on child neuropsychological and behavioral development in preschool years. The study included 638...
Inequity in child development is found at early age, but limited evidence exists on whether these gaps change over time and what are the mediators....
We aim to (1) quantify wealth related gaps in cognitive and socio-emotional development in early and middle childhood; (2) examine how these gaps were mitigated by maternal, child factors and home env...
We assessed the offspring of women who participated in a randomized controlled trial of preconception micronutrient supplementation in Vietnam (n = 1599). Child development was measured by the Bayley ...
We found significant wealth gaps in cognitive development during early childhood (gaps between top and bottom quintiles: 0.5 SD); these gaps increased substantially in middle childhood (0.9 SD). Wealt...
Interventions focusing on improving quality of home environment, maternal education, wellbeing, and child nutrition status may help reduce developmental deficits associated with poverty....
Recent studies have reported the effect of neonicotinoid (NEO) exposures on development in human. However, information about the risk of childhood development delays due to NEO exposures is limited....
The study aimed to examine the association between NEO exposure and child development up to 4 years of age using data of the Japan Environment and Children's Study....
The study employed urinary NEO and metabolite concentrations in the first and second or third trimesters; the Japanese translation of the Ages and Stages Questionnaire (third edition; J-ASQ-3) scores ...
The determination rates of urinary acetamiprid-N-desmethyl (dm-ACE), clothianidin (CLO), dinotefuran (DIN) and thiamethoxam (THX) were greater than 50%. Median urinary dm-ACE, CLO, DIN and THX concent...
To identify and describe distinct trajectories of cognitive and socioemotional development during childhood and to examine their relationships with adolescent health....
We used group-based multitrajectory modeling applied to longitudinal data on 11 564 children up to age 14 years from the UK Millennium Cohort study to identify trajectories of cognitive and socioemoti...
Four child development trajectories were identified: "no problems" (76.5%); "late socio-emotional problems" (10.1%); "early cognitive and socioemotional problems" (8.6%); and "persistent cognitive and...
In a representative UK cohort, groups of distinct trajectories of cognitive and socioemotional development were identified. Adverse development, if unresolved, can have a negative impact on weight and...
Most studies on the effect of intimate partner violence (IPV) do not distinguish between the effects of the different types of IPVs on the various aspects of child development....
This study explores the effect of multiple dimensions of IPV, specifically physical violence, controlling behavior, and emotional abuse, on children's physical and cognitive development....
The study uses data from the Cebu Longitudinal Health and Nutritional Survey (CLHNS). The study uses a final sample of n = 1506 index children in Cebu, Philippines....
We use information pertaining to: (1) presence of IPV in the household, (2) demographic characteristics, (3) mother's status and autonomy, (4) anthropometric data, and (5) children's scores on mathema...
Maternal exposure to physical violence significantly reduces child's body mass index (BMI) (ATE: -0.344, p ≤ 0.05). On the other hand, mother's vulnerability to controlling behavior decreases children...
Our study shows that the deleterious effect of IPV on child development is IPV-specific. Exposure to physical violence tends to affect children's physical development while cognitive abilities are neg...
