La calbindine-2 est-elle liée à des maladies chroniques ?
Oui, des maladies comme l'ostéoporose peuvent être exacerbées par une carence en calbindine-2.
OstéoporoseMaladies chroniques
#3
Des troubles de l'humeur peuvent-ils être liés à la calbindine-2 ?
Oui, des déséquilibres de calcium peuvent affecter l'humeur et le comportement.
Troubles de l'humeurDéséquilibres de calcium
#4
La calbindine-2 influence-t-elle le développement cognitif ?
Oui, une déficience peut nuire au développement cognitif, surtout chez les enfants.
Développement cognitifEnfants
#5
Y a-t-il un risque accru de chutes ?
Oui, une faiblesse musculaire due à une carence en calbindine-2 augmente le risque de chutes.
ChutesFaiblesse musculaire
Facteurs de risque
5
#1
Quels facteurs augmentent le risque de carence en calbindine-2 ?
L'âge avancé, une mauvaise alimentation et certaines maladies augmentent le risque.
Âge avancéMauvaise alimentation
#2
Les troubles métaboliques sont-ils un facteur de risque ?
Oui, des troubles comme le diabète peuvent affecter les niveaux de calbindine-2.
Troubles métaboliquesDiabète
#3
Le mode de vie sédentaire influence-t-il la calbindine-2 ?
Oui, un mode de vie sédentaire peut contribuer à une faiblesse musculaire et à des carences.
Mode de vie sédentaireFaiblesse musculaire
#4
Les régimes restrictifs sont-ils risqués ?
Oui, les régimes restrictifs peuvent entraîner des carences en nutriments essentiels, y compris le calcium.
Régimes restrictifsCarences nutritionnelles
#5
Les antécédents familiaux jouent-ils un rôle ?
Oui, des antécédents familiaux de troubles musculaires ou neurologiques peuvent augmenter le risque.
Antécédents familiauxTroubles musculaires
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Calbindine-2 : Questions médicales les plus fréquentes",
"headline": "Calbindine-2 : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Calbindine-2 : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-06-21",
"dateModified": "2025-03-18",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Calbindine-2"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Calbindines",
"url": "https://questionsmedicales.fr/mesh/D064026",
"about": {
"@type": "MedicalCondition",
"name": "Calbindines",
"code": {
"@type": "MedicalCode",
"code": "D064026",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.157.125.090"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Calbindine-2",
"alternateName": "Calbindin 2",
"code": {
"@type": "MedicalCode",
"code": "D064032",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Eui-Man Jung",
"url": "https://questionsmedicales.fr/author/Eui-Man%20Jung",
"affiliation": {
"@type": "Organization",
"name": "Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea."
}
},
{
"@type": "Person",
"name": "Yeong-Min Yoo",
"url": "https://questionsmedicales.fr/author/Yeong-Min%20Yoo",
"affiliation": {
"@type": "Organization",
"name": "Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea."
}
},
{
"@type": "Person",
"name": "Eui-Bae Jeung",
"url": "https://questionsmedicales.fr/author/Eui-Bae%20Jeung",
"affiliation": {
"@type": "Organization",
"name": "Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea, ebjeung@chungbuk.ac.kr."
}
},
{
"@type": "Person",
"name": "Seon Young Park",
"url": "https://questionsmedicales.fr/author/Seon%20Young%20Park",
"affiliation": {
"@type": "Organization",
"name": "Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea."
}
},
{
"@type": "Person",
"name": "Changhwan Ahn",
"url": "https://questionsmedicales.fr/author/Changhwan%20Ahn",
"affiliation": {
"@type": "Organization",
"name": "Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Use of connected injection device has a positive effect on catch-up growth in patients with growth disorders treated with growth hormone therapy.",
"datePublished": "2024-10-04",
"url": "https://questionsmedicales.fr/article/39429736",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3389/fendo.2024.1450573"
}
},
{
"@type": "ScholarlyArticle",
"name": "Shedding New Light: Novel Therapies for Achondroplasia and Growth Disorders.",
"datePublished": "2023-07-06",
"url": "https://questionsmedicales.fr/article/37704353",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.pcl.2023.05.008"
}
},
{
"@type": "ScholarlyArticle",
"name": "Integrated Digital Health Solutions in the Management of Growth Disorders in Pediatric Patients Receiving Growth Hormone Therapy: A Retrospective Analysis.",
"datePublished": "2022-06-30",
"url": "https://questionsmedicales.fr/article/35846336",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3389/fendo.2022.882192"
}
},
{
"@type": "ScholarlyArticle",
"name": "Effect of educational intervention based on health belief model on mothers monitoring growth of 6-12 months child with growth disorders.",
"datePublished": "2022-09-23",
"url": "https://questionsmedicales.fr/article/36151526",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12887-022-03593-8"
}
},
{
"@type": "ScholarlyArticle",
"name": "Development and validation of a nomogram to predict poor short-term response to recombinant human growth hormone treatment in children with growth disorders.",
"datePublished": "2022-12-08",
"url": "https://questionsmedicales.fr/article/36480094",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s40618-022-01979-0"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides aminés, peptides et protéines",
"item": "https://questionsmedicales.fr/mesh/D000602"
},
{
"@type": "ListItem",
"position": 3,
"name": "Protéines",
"item": "https://questionsmedicales.fr/mesh/D011506"
},
{
"@type": "ListItem",
"position": 4,
"name": "Protéines de transport",
"item": "https://questionsmedicales.fr/mesh/D002352"
},
{
"@type": "ListItem",
"position": 5,
"name": "Protéines de liaison au calcium",
"item": "https://questionsmedicales.fr/mesh/D002135"
},
{
"@type": "ListItem",
"position": 6,
"name": "Calbindines",
"item": "https://questionsmedicales.fr/mesh/D064026"
},
{
"@type": "ListItem",
"position": 7,
"name": "Calbindine-2",
"item": "https://questionsmedicales.fr/mesh/D064032"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Calbindine-2 - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Calbindine-2",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-08",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Calbindine-2",
"description": "Comment diagnostiquer une carence en calbindine-2 ?\nQuels examens sont utilisés pour évaluer la calbindine-2 ?\nLa calbindine-2 est-elle mesurable dans le sang ?\nQuels symptômes peuvent indiquer un problème avec la calbindine-2 ?\nY a-t-il des marqueurs spécifiques pour la calbindine-2 ?",
"url": "https://questionsmedicales.fr/mesh/D064032?mesh_terms=Growth+Disorders#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Calbindine-2",
"description": "Quels sont les symptômes d'une déficience en calbindine-2 ?\nLa calbindine-2 affecte-t-elle le système nerveux ?\nDes douleurs musculaires peuvent-elles être liées à la calbindine-2 ?\nLa fatigue est-elle un symptôme associé à la calbindine-2 ?\nPeut-on observer des troubles cognitifs liés à la calbindine-2 ?",
"url": "https://questionsmedicales.fr/mesh/D064032?mesh_terms=Growth+Disorders#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Calbindine-2",
"description": "Comment prévenir une carence en calbindine-2 ?\nLes suppléments de calcium sont-ils nécessaires ?\nY a-t-il des groupes à risque pour la calbindine-2 ?\nL'exposition au soleil est-elle importante ?\nDes tests réguliers sont-ils conseillés ?",
"url": "https://questionsmedicales.fr/mesh/D064032?mesh_terms=Growth+Disorders#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Calbindine-2",
"description": "Comment traiter une carence en calbindine-2 ?\nY a-t-il des médicaments pour réguler la calbindine-2 ?\nLa physiothérapie aide-t-elle en cas de dysfonction de la calbindine-2 ?\nDes changements alimentaires peuvent-ils aider ?\nLes exercices physiques sont-ils bénéfiques ?",
"url": "https://questionsmedicales.fr/mesh/D064032?mesh_terms=Growth+Disorders#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Calbindine-2",
"description": "Quelles complications peuvent survenir avec une carence en calbindine-2 ?\nLa calbindine-2 est-elle liée à des maladies chroniques ?\nDes troubles de l'humeur peuvent-ils être liés à la calbindine-2 ?\nLa calbindine-2 influence-t-elle le développement cognitif ?\nY a-t-il un risque accru de chutes ?",
"url": "https://questionsmedicales.fr/mesh/D064032?mesh_terms=Growth+Disorders#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Calbindine-2",
"description": "Quels facteurs augmentent le risque de carence en calbindine-2 ?\nLes troubles métaboliques sont-ils un facteur de risque ?\nLe mode de vie sédentaire influence-t-il la calbindine-2 ?\nLes régimes restrictifs sont-ils risqués ?\nLes antécédents familiaux jouent-ils un rôle ?",
"url": "https://questionsmedicales.fr/mesh/D064032?mesh_terms=Growth+Disorders#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une carence en calbindine-2 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins et des biopsies musculaires peuvent aider à évaluer les niveaux de calbindine-2."
}
},
{
"@type": "Question",
"name": "Quels examens sont utilisés pour évaluer la calbindine-2 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'électrophorèse des protéines et l'immunohistochimie sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "La calbindine-2 est-elle mesurable dans le sang ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, la calbindine-2 est principalement présente dans les tissus, pas dans le sang."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec la calbindine-2 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles neurologiques ou musculaires peuvent suggérer un dysfonctionnement de la calbindine-2."
}
},
{
"@type": "Question",
"name": "Y a-t-il des marqueurs spécifiques pour la calbindine-2 ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs comme la calmoduline peuvent être évalués en relation avec la calbindine-2."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une déficience en calbindine-2 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des spasmes musculaires, des tremblements et des troubles de la coordination."
}
},
{
"@type": "Question",
"name": "La calbindine-2 affecte-t-elle le système nerveux ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle joue un rôle crucial dans la transmission synaptique et la plasticité neuronale."
}
},
{
"@type": "Question",
"name": "Des douleurs musculaires peuvent-elles être liées à la calbindine-2 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une dysfonction de la calbindine-2 peut entraîner des douleurs musculaires et des crampes."
}
},
{
"@type": "Question",
"name": "La fatigue est-elle un symptôme associé à la calbindine-2 ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une fatigue excessive peut résulter d'une mauvaise régulation du calcium par la calbindine-2."
}
},
{
"@type": "Question",
"name": "Peut-on observer des troubles cognitifs liés à la calbindine-2 ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles cognitifs peuvent survenir en raison de l'implication de la calbindine-2 dans le cerveau."
}
},
{
"@type": "Question",
"name": "Comment prévenir une carence en calbindine-2 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et des contrôles réguliers de la santé peuvent aider."
}
},
{
"@type": "Question",
"name": "Les suppléments de calcium sont-ils nécessaires ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être recommandés, surtout pour les personnes à risque de carence."
}
},
{
"@type": "Question",
"name": "Y a-t-il des groupes à risque pour la calbindine-2 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées et celles avec des troubles métaboliques sont plus à risque."
}
},
{
"@type": "Question",
"name": "L'exposition au soleil est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition au soleil aide à la synthèse de la vitamine D, essentielle pour la calbindine-2."
}
},
{
"@type": "Question",
"name": "Des tests réguliers sont-ils conseillés ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests réguliers peuvent aider à détecter précocement des anomalies."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en calbindine-2 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut inclure des suppléments de calcium et des thérapies ciblées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des médicaments pour réguler la calbindine-2 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de médicaments spécifiques pour la calbindine-2."
}
},
{
"@type": "Question",
"name": "La physiothérapie aide-t-elle en cas de dysfonction de la calbindine-2 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la physiothérapie peut améliorer la force musculaire et la coordination."
}
},
{
"@type": "Question",
"name": "Des changements alimentaires peuvent-ils aider ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en calcium et en vitamine D peut soutenir la fonction de la calbindine-2."
}
},
{
"@type": "Question",
"name": "Les exercices physiques sont-ils bénéfiques ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des exercices réguliers peuvent améliorer la santé musculaire et nerveuse."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une carence en calbindine-2 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications neurologiques et musculaires graves peuvent se développer."
}
},
{
"@type": "Question",
"name": "La calbindine-2 est-elle liée à des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme l'ostéoporose peuvent être exacerbées par une carence en calbindine-2."
}
},
{
"@type": "Question",
"name": "Des troubles de l'humeur peuvent-ils être liés à la calbindine-2 ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres de calcium peuvent affecter l'humeur et le comportement."
}
},
{
"@type": "Question",
"name": "La calbindine-2 influence-t-elle le développement cognitif ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une déficience peut nuire au développement cognitif, surtout chez les enfants."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de chutes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une faiblesse musculaire due à une carence en calbindine-2 augmente le risque de chutes."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de carence en calbindine-2 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, une mauvaise alimentation et certaines maladies augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme le diabète peuvent affecter les niveaux de calbindine-2."
}
},
{
"@type": "Question",
"name": "Le mode de vie sédentaire influence-t-il la calbindine-2 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire peut contribuer à une faiblesse musculaire et à des carences."
}
},
{
"@type": "Question",
"name": "Les régimes restrictifs sont-ils risqués ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les régimes restrictifs peuvent entraîner des carences en nutriments essentiels, y compris le calcium."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de troubles musculaires ou neurologiques peuvent augmenter le risque."
}
}
]
}
]
}
Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea, ebjeung@chungbuk.ac.kr.
Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Human growth hormone (hGH) therapy in children can be administered by subcutaneous injection using either a manual non-connected device, which is a portable injection pen loaded with a pre-filled cart...
This retrospective study reports treatment of either GH deficiency or short stature secondary to birth size small for gestational age (SGA) in 174 pediatric patients attending Miguel Servet Hospital, ...
In total, 57% of subjects had GHD and 43% were SGA. Height standard deviation score (HSDS) at treatment start was higher (p<0.001) in the non-connected device group compared to the connected device gr...
These results support the use of the connected device for hGH treatment of pediatric growth disorders....
Achondroplasia is the most common form of disproportionate severe short stature. Management of achondroplasia requires a multidisciplinary approach and has been largely symptomatic for medical complic...
Digital health has seen rapid advancements over the last few years in helping patients and their healthcare professionals better manage treatment for a variety of illnesses, including growth hormone (...
Maternal education is one of the main ways to improve children's nutritional behaviors and development. The purpose of this study is to investigate the effect of educational intervention based on Heal...
This quasi-experimental study was conducted on mothers of 6-12 months children with growth disorders of Ghirokarzin city, Fars province, Iran in 2021-2022. One hundred twenty mothers of 6-12 months ch...
A questionnaire beased on Health Belief Model constructs were used to collect information. The data was analyzed with SPSS 22 software using paired t-tests, Chi-square tests, and independent t-tests, ...
Three months after the educational intervention, the experimental group showed a significant increase in terms of knowledge, HBM constructs, weight of the children and feeding behavior....
This study showed the educational intervention based on the HBM improved the knowledge and feeding behavior of mothers and improved Growth Disorders of child. Hence, this model can act as a framework ...
The purpose of this study was to develop and validate a clinical predictive model for predicting the likelihood of a poor therapeutic response during the first year of recombinant human growth hormone...
A total of 627 pediatric patients with growth disorders (GHD, ISS, TS, SGA) from The LG Growth Study cohort were evaluated. Restricted cubic splines (RCS) were utilized to investigate the association ...
Two predictive models containing 8 baseline predictors (diagnosis, age, height SDS, bone age minus chronological age, rhGH dosage, distance from mid-parental height in SDS, weight SDS, IGF-1 SDS) and ...
The clinical predictive model for predicting the probability of poor short-term response of rhGH treatment in pediatric patients with growth disorders is useful and can assist physicians in making cli...
Many childhood-onset growth disorders (COGDs) require continued care into adulthood, and the time of transition between paediatric and adult providers carries a high risk for interruptions in medical ...
Research into best practices for healthcare transition (HCT) describes three distinct stages. Stage 1, transition planning and preparation, begins in the paediatric setting during early adolescence an...
This review covers general principles for ensuring smooth transition of adolescents and young adults (AYA) with COGD, disease-specific medical considerations for paediatric and adult endocrinologists ...
Growth hormone deficiency (GHD) is a rare disorder characterized by inadequate secretion of growth hormone (GH) from the anterior pituitary gland. One of the challenges in optimizing GH therapy is imp...
The MOOC entitled 'Telemedicine: Tools to Support Growth Disorders in a Post-COVID Era' was launched in 2021. It was designed to cover 4 weeks of online learning with an expected commitment of 2 h per...
Out of 219 learners enrolled in the MOOC, 31 completed both the pre- and post-course assessments. Of the evaluated learners, 74% showed improved scores in the post-course assessment, resulting in a me...
This "first-of-its-kind" MOOC can improve digital health literacy in the management of growth disorders. This is a crucial step toward improving the digital capability and confidence of healthcare pro...
Age estimation based on DNA methylation (DNAm) can be applied to children, adolescents and adults, but many CG dinucleotides (CpGs) exhibit different kinetics of age-associated DNAm across these age r...
Early diagnosis of childhood growth disorders, their timely and proper treatment are important for better outcomes.The aim of the present study was to assess the results of the first 18 months of the ...
In 2019, Partners4Growth started operation at 7 centres (4 experienced and 3 twin centres) with the main aim of aligning their practices in the shortest possible time. Education of twin centres' perso...
A total of 104 new patients were diagnosed compared to 30 in the previous year. Of those, 91 started rhGH treatment - 65 (64 %) GH deficient, 12 (12 %) Turner syndrome, 7 (7 %) Prader-Willi syndrome p...
Partners4Growth facilitated the alignment of the tertiary pediatric endocrinology centres competences thus leading to an improved diagnosis and treatment of growth disorders as well as better patients...
Severe short stature is a feature of acrodysostosis, but data on growth are sparse. Treatment with recombinant human growth hormone (rhGH) is used in some centers to increase final height, but no stud...
We present auxological data from individuals with genetically characterized iPPSD4, and participants with clinical features of iPPSD5....
We included 20 and 17 individuals with iPPSD4 and iPPSD5, respectively. The rhGH-treated iPPSD4 patients (n = 9) were smaller at birth than those who did not receive rhGH (median - 2.2 SDS vs. - 1.7 S...
Final height may be positively influenced by rhGH in patients with acrodysostosis/iPPSD. Our rhGH-treated cohort started therapy relatively late, which might explain, at least in part, the limited eff...
