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Protéines et peptides de signalisation intercellulaire
Cytokines
Interleukines
Interleukine-27
Interleukine-27 : Questions médicales fréquentes
Termes MeSH sélectionnés :
Complement Inactivating Agents
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"name": "Diagnostic",
"headline": "Diagnostic sur Interleukine-27",
"description": "Comment mesurer l'IL-27 dans le sang ?\nQuels tests sont utilisés pour évaluer l'IL-27 ?\nL'IL-27 est-elle mesurée dans des maladies spécifiques ?\nQuels biomarqueurs sont associés à l'IL-27 ?\nL'IL-27 peut-elle être un indicateur de gravité ?",
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"@type": "Question",
"name": "Comment mesurer l'IL-27 dans le sang ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IL-27 peut être mesurée par des tests ELISA dans des échantillons de sérum."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'IL-27 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests immunologiques comme l'ELISA et la cytométrie en flux sont utilisés."
}
},
{
"@type": "Question",
"name": "L'IL-27 est-elle mesurée dans des maladies spécifiques ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-27 est souvent mesurée dans des maladies auto-immunes et inflammatoires."
}
},
{
"@type": "Question",
"name": "Quels biomarqueurs sont associés à l'IL-27 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IL-27 est souvent associée à d'autres cytokines comme l'IL-6 et l'IL-10."
}
},
{
"@type": "Question",
"name": "L'IL-27 peut-elle être un indicateur de gravité ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux élevés d'IL-27 peuvent indiquer une inflammation sévère."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à une élévation de l'IL-27 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une élévation de l'IL-27 peut entraîner des symptômes d'inflammation comme la fièvre."
}
},
{
"@type": "Question",
"name": "L'IL-27 est-elle liée à des douleurs articulaires ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-27 peut contribuer à des douleurs articulaires dans les maladies inflammatoires."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques sont associés à l'IL-27 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les signes cliniques incluent fatigue, douleurs et symptômes systémiques d'inflammation."
}
},
{
"@type": "Question",
"name": "L'IL-27 influence-t-elle les symptômes respiratoires ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-27 peut exacerber les symptômes respiratoires dans certaines maladies pulmonaires."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes neurologiques liés à l'IL-27 ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés d'IL-27 peuvent être associés à des symptômes neurologiques dans certaines conditions."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir l'élévation de l'IL-27 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des modes de vie sains et une gestion du stress peuvent aider à prévenir l'élévation de l'IL-27."
}
},
{
"@type": "Question",
"name": "Y a-t-il des vaccins liés à l'IL-27 ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de vaccins spécifiquement ciblant l'IL-27."
}
},
{
"@type": "Question",
"name": "Comment l'alimentation influence-t-elle l'IL-27 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation anti-inflammatoire peut aider à réguler les niveaux d'IL-27."
}
},
{
"@type": "Question",
"name": "L'exercice physique affecte-t-il l'IL-27 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut réduire les niveaux d'IL-27 et améliorer la santé immunitaire."
}
},
{
"@type": "Question",
"name": "Le sommeil influence-t-il l'IL-27 ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un sommeil adéquat est crucial pour maintenir des niveaux sains d'IL-27 et une bonne santé."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent l'IL-27 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies biologiques ciblant l'IL-27 sont en développement pour les maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "L'IL-27 peut-elle être inhibée ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des inhibiteurs spécifiques de l'IL-27 sont à l'étude pour réduire l'inflammation."
}
},
{
"@type": "Question",
"name": "Quels médicaments affectent l'IL-27 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains médicaments anti-inflammatoires peuvent moduler les niveaux d'IL-27."
}
},
{
"@type": "Question",
"name": "L'IL-27 est-elle une cible pour l'immunothérapie ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-27 est une cible potentielle pour l'immunothérapie dans le cancer."
}
},
{
"@type": "Question",
"name": "Comment l'IL-27 influence-t-elle les traitements ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IL-27 peut influencer l'efficacité des traitements en modulant la réponse immunitaire."
}
},
{
"@type": "Question",
"name": "Quelles complications sont liées à l'IL-27 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés d'IL-27 peuvent entraîner des complications dans les maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "L'IL-27 est-elle impliquée dans des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IL-27 est associée à des maladies chroniques comme l'arthrite et le lupus."
}
},
{
"@type": "Question",
"name": "Comment l'IL-27 affecte-t-elle le cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IL-27 peut avoir un rôle double dans le cancer, favorisant ou inhibant la croissance tumorale."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques d'infection liés à l'IL-27 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés d'IL-27 peuvent augmenter le risque d'infections en modulant l'immunité."
}
},
{
"@type": "Question",
"name": "L'IL-27 est-elle liée à des troubles neurologiques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux anormaux d'IL-27 peuvent être associés à des troubles neurologiques comme la sclérose en plaques."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent l'IL-27 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress, l'obésité et les infections chroniques peuvent augmenter les niveaux d'IL-27."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il les niveaux d'IL-27 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les niveaux d'IL-27 peuvent augmenter avec l'âge, affectant la réponse immunitaire."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes atteintes de maladies auto-immunes présentent souvent des niveaux élevés d'IL-27."
}
},
{
"@type": "Question",
"name": "Le tabagisme affecte-t-il l'IL-27 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut augmenter les niveaux d'IL-27 et aggraver l'inflammation."
}
},
{
"@type": "Question",
"name": "Y a-t-il un lien entre l'IL-27 et l'alimentation ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines habitudes alimentaires peuvent influencer les niveaux d'IL-27, notamment les régimes riches en sucres."
}
}
]
}
]
}
The objective of this study was to characterize the complement-inhibiting activity of SAR445088, a novel monoclonal antibody specific for the active form of C1s. Wieslab® and hemolytic assays were use...
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening, acquired disease in which blood cells lacking complement regulatory proteins are destroyed because of uncontrolled complement act...
Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is complement-mediated due to the lack of complement inhibitors in the hemopoietic cell membranes, making complement inhibition the best approach...
The expert recommendations presented here were created using a Delphi-like process by a group of expert PNH specialists across Central Europe. Based on an initial advisory board meeting discussion, re...
Using a systematic approach, literature databases were searched for relevant studies, and 50 articles were reviewed by the experts and included as supporting evidence....
Implementation of these recommendations uniformly across healthcare institutions will promote the best use of complement inhibition in managing PNH, and has the potential to positively impact patient ...
The efficacy and safety of complement inhibition in COVID-19 patients is unclear....
A multicenter randomized controlled, open-label trial. Hospitalized COVID-19 patients with signs of systemic inflammation and hypoxemia (PaO...
81 patients were randomly assigned to zilucoplan (n = 55) or the control group (n = 26). 78 patients were included in the safety and primary analysis. Most were men (87%) and the median age was 63 yea...
Administration of zilucoplan to COVID-19 patients in this proof-of-concept randomized trial was well tolerated under antibiotic prophylaxis. While not reaching statistical significance, indicators of ...
Enteroaggregative Escherichia coli (EAEC) is a predominant but neglected enteric pathogen implicated in infantile diarrhoea and nutrient malabsorption. There are no non-antibiotic approaches to dealin...
We used EAEC strains, 042 and MND005E in a medium-throughput crystal violet-based antibiofilm screen. Hits were confirmed in concentration-dependence, growth kinetic and time course assays and activit...
In all, five compounds (1.25%) reproducibly inhibited biofilm accumulation by at least one strain by 30-85% while inhibiting growth by under 10%. Hits exhibited potent antibiofilm activity at concentr...
This study identified five compounds, not previously described as anti-adhesins or Gram-negative antibacterials, with significant EAEC antibiofilm activity. Molecule, MMV687800 targets the EAEC Aap. I...
In the absence of head-to-head trials, this study compared treatment outcomes with the C3 complement inhibitor pegcetacoplan versus the C5 complement inhibitor eculizumab or ravulizumab in complement ...
A matching-adjusted indirect comparison was conducted using individual patient data from the pegcetacoplan arm of the PRINCE trial (NCT04085601; n = 34) and aggregate data from the ravulizumab (n = 12...
After weighting, treatment with pegcetacoplan was associated with statistically significant improvements in most clinical endpoints compared with ravulizumab or eculizumab treatment. These included: g...
Pegcetacoplan provides clinical benefits as first-line treatment for complement inhibitor-naïve patients with PNH....
ClinicalTrials.gov identifier, NCT04085601....
The Phase 3 single-arm COMMODORE 3 study (ClinicalTrials.gov, NCT04654468) evaluated efficacy and safety of crovalimab (novel C5 inhibitor) in complement inhibitor-naive patients with paroxysmal noctu...
We systematically reviewed the literature on the prevalence of geographic atrophy (GA) in Nordic populations, conducted meta-analyses on age-stratified estimates, and calculated current and future num...
A male in his teens with a history of liver transplant for biliary atresia (aged 2 years) and autoimmune haemolytic anaemia (AIHA, aged 6 years) presented with jaundice, dark urine, fatigue and chest ...
Although complement component 5 inhibitors (C5is) eculizumab and ravulizumab improve paroxysmal nocturnal hemoglobinuria (PNH) outcomes, patients may experience persistent anemia. This post hoc analys...
Patients with PNH and hemoglobin ≥10.0 g/dL at baseline of PADDOCK (N = 6), PRINCE (N = 8), and PEGASUS (N = 11) were included. Before receiving pegcetacoplan, PADDOCK and PRINCE patients were C5i-nai...
From baseline to week 16, mean (SD) hemoglobin concentrations increased in C5i-naive patients (PADDOCK: 10.5 [0.4] to 12.7 [1.1] g/dL; PRINCE: 11.3 [1.0] to 14.0 [1.3] g/dL) and those with suboptimal ...
Patients with PNH and mild/moderate anemia who were C5i-naive or who had suboptimal hemoglobin concentrations despite eculizumab treatment had improved hematologic outcomes and reduced fatigue after i...
Trial registration numbers: PADDOCK (NCT02588833), PRINCE (NCT04085601; EudraCT, 2018-004220-11), PEGASUS (NCT03500549)....