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Acides aminés, peptides et protéines
Protéines
Nucléoprotéines
Protéines chromosomiques nonhistones
Protéines de maintenance des minichromosomes
Protéines de maintenance des minichromosomes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Avoidant Restrictive Food Intake Disorder
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"name": "Comment diagnostiquer une anomalie des protéines MCM ?",
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"text": "Des tests génétiques et des analyses de protéines peuvent identifier des anomalies."
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les MCM ?",
"position": 2,
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"@type": "Question",
"name": "Quels marqueurs sont associés aux MCM ?",
"position": 4,
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"text": "Les marqueurs de prolifération cellulaire, comme Ki-67, sont souvent associés aux MCM."
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"@type": "Question",
"name": "Les MCM sont-elles liées à des cancers spécifiques ?",
"position": 5,
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"@type": "Question",
"name": "Quels symptômes indiquent une dysfonction des MCM ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la réplication de l'ADN peuvent entraîner des symptômes variés."
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"@type": "Question",
"name": "Les symptômes sont-ils spécifiques aux MCM ?",
"position": 7,
"acceptedAnswer": {
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"text": "Non, les symptômes peuvent varier selon le type de maladie associée aux MCM."
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{
"@type": "Question",
"name": "Comment les MCM affectent-elles la santé cellulaire ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une mauvaise fonction des MCM peut entraîner des erreurs dans la réplication de l'ADN."
}
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{
"@type": "Question",
"name": "Les MCM sont-elles liées à des symptômes neurologiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent un lien entre les MCM et des troubles neurologiques."
}
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{
"@type": "Question",
"name": "Peut-on observer des symptômes précoces de dysfonction MCM ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des signes précoces peuvent inclure des anomalies de croissance cellulaire."
}
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{
"@type": "Question",
"name": "Peut-on prévenir les anomalies des MCM ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une bonne hygiène de vie et un suivi médical régulier peuvent aider à prévenir."
}
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{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour les MCM ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être proposés pour les personnes à risque élevé."
}
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{
"@type": "Question",
"name": "L'alimentation influence-t-elle les MCM ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut soutenir la santé cellulaire et la fonction des MCM."
}
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{
"@type": "Question",
"name": "Le stress affecte-t-il les MCM ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber la fonction cellulaire, y compris celle des MCM."
}
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{
"@type": "Question",
"name": "Les exercices physiques aident-ils les MCM ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la fonction des MCM."
}
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{
"@type": "Question",
"name": "Quels traitements ciblent les MCM ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques de MCM sont en cours de développement pour le cancer."
}
},
{
"@type": "Question",
"name": "Les thérapies géniques peuvent-elles aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique pourrait corriger les anomalies des MCM dans certains cas."
}
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"@type": "Question",
"name": "Y a-t-il des médicaments pour les MCM ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments ciblant la voie de réplication de l'ADN sont en développement."
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"@type": "Question",
"name": "Comment la chimiothérapie affecte-t-elle les MCM ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chimiothérapie peut perturber la fonction des MCM, affectant la réplication cellulaire."
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour les MCM ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des profils de MCM des patients."
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies MCM ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles de croissance et des maladies génétiques."
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"@type": "Question",
"name": "Les anomalies MCM sont-elles héréditaires ?",
"position": 22,
"acceptedAnswer": {
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"text": "Certaines anomalies peuvent être héréditaires, augmentant le risque de maladies."
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"@type": "Question",
"name": "Comment les MCM affectent-elles le vieillissement ?",
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"acceptedAnswer": {
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"text": "Des dysfonctionnements des MCM peuvent accélérer le vieillissement cellulaire et tissulaire."
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"@type": "Question",
"name": "Les MCM sont-elles liées à des maladies auto-immunes ?",
"position": 24,
"acceptedAnswer": {
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"text": "Des recherches suggèrent un lien potentiel entre les MCM et certaines maladies auto-immunes."
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"@type": "Question",
"name": "Les anomalies MCM peuvent-elles causer des troubles neurologiques ?",
"position": 25,
"acceptedAnswer": {
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"text": "Oui, des anomalies dans les MCM peuvent être associées à des troubles neurologiques."
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"@type": "Question",
"name": "Quels facteurs augmentent le risque d'anomalies MCM ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent augmenter le risque."
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"@type": "Question",
"name": "L'exposition à des toxines influence-t-elle les MCM ?",
"position": 27,
"acceptedAnswer": {
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"text": "Oui, l'exposition à certaines toxines peut perturber la fonction des MCM."
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"@type": "Question",
"name": "Le tabagisme affecte-t-il les MCM ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme est un facteur de risque connu pour des anomalies dans la fonction des MCM."
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{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque pour les MCM ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la fonction des MCM et augmenter le risque de maladies."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils les MCM ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies liées aux MCM peuvent augmenter le risque."
}
}
]
}
]
}
To investigate the gut microbiota distribution and its functions in children with avoidant/restrictive food intake disorder (ARFID). A total of 135 children were enrolled in the study, including 102 c...
Exclusion diets for gastrointestinal symptom management have been hypothesized to be a risk factor for avoidant/restrictive food intake disorder (ARFID; a non-body image-based eating disorder). In a r...
We conducted a chart review of 539 consecutive referrals (ages 6-90, 69% female) to adult (n = 410; January-December 2016) and pediatric (n = 129; January 2016-December 2018) neurogastroenterology cli...
Of 495 patients included, 194 (39%) had an exclusion diet history, and 118 (24%) had symptoms of ARFID. Of reported diets, dairy-free was the most frequent (45%), followed by gluten-free (36%). Where ...
History of following an exclusion diet was common and was most often patient-initiated among pediatric and adult neurogastroenterology patients. As patients with self-reported exclusion diet history w...
There is a paucity of validated diagnostic interviews for avoidant/restrictive food intake disorder (ARFID) to aid identification and classification of cases for both clinical and research purposes. T...
We used exploratory factor analysis to examine the factor structure of the PARDI in children, adolescents, and young adults with an ARFID diagnosis, the Kruskal-Wallis analysis of variance and Spearma...
Exploratory factor analysis yielded a 3-factor structure: (1) concern about aversive consequences of eating, (2) low appetite/low interest in food, and (3) sensory sensitivity. Participants with ARFID...
These data present evidence for the factor structure and validity of the PARDI diagnostic interview for diagnosing ARFID in children, adolescents, and young adults, supporting the use of this tool to ...
Due to the paucity of validated diagnostic interviews for avoidant/restrictive food intake disorder (ARFID), we evaluated the factor structure and validity of the Pica ARFID and Rumination Disorder In...
The COVID-19 pandemic has significantly increased the prevalence of psychiatric disorders within pediatric populations. However, only a limited number of studies have sought to understand the correlat...
This study explored the preliminary effectiveness of a partial hospitalization program (PHP) for children/adolescents with avoidant/restrictive food intake disorder (ARFID). We evaluated how ARFID sym...
Twenty-two children/adolescents with ARFID (77.3% White, 63.6% female) completed measures assessing ARFID symptomatology at admission and discharge from a PHP for eating disorders. Six months and twel...
Paired samples t tests indicated that participants demonstrated increases in weight and decreases in ARFID symptomatology from admission to discharge with medium to large effects. All participants rep...
Participants experienced symptom improvements from admission to discharge and appeared to maintain these gains after discharge. These results provide preliminary evidence that PHPs are an effective tr...
This study provides preliminary evidence that intensive, evidence-based PHPs are effective in treating ARFID. Our findings suggest that children and adolescents with ARFID who receive flexible, cognit...
Avoidant/restrictive food intake disorder (ARFID) was a new diagnosis in DSM-5. This systematic review explores what is known to date about the epidemiology of ARFID in children and adolescents....
Embase, Medline and PsycInfo were used to identify studies meeting inclusion criteria. PRISMA guidelines were followed....
Thirty studies met inclusion criteria, with most coming from specialised eating disorder services where prevalence rates were 5%-22.5%. Three studies from specialist feeding clinics showed the highest...
The current literature on the epidemiology of ARFID in children and adolescents is limited. Studies are heterogeneous with regard to setting and sample characteristics, with a wide range of prevalence...
Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder with known acute and longstanding physical health complications in children and young people (CYP) and commonly prese...
To systematically review the published literature on physical health complications in CYP with ARFID using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines....
A systematic search of PubMed, Embase, Web of Science, PsycINFO and Cochrane Library was performed on 14 February 2024. Studies reporting physical health complications in CYP ≤25 years with ARFID were...
Of 9058 studies found in searches, we included 132 studies. We found evidence for low weight, nutritional deficiencies and low bone mineral density. CYP with ARFID can present across the weight spectr...
There is a broad range of physical health complications associated with ARFID requiring clinical consideration. Many CYP with ARFID are not underweight yet still have complications. Less cardiovascula...
CRD42022376866....
The aim of the present study was to investigate whether the feeding style and core behavioral features of eating disorders of mothers are related to the symptoms of Avoidant/Restrictive Food Intake Di...
Individuals with Avoidant/Restrictive Food Intake Disorder (ARFID) experience restrictive or highly selective eating problems that interfere with growth and development. Despite the increasing number ...
Three cases of children with ARFID treated using PMT are presented: a 7-year-old, a 10-year-old, and a 12-year-old. These cases illustrate how a clinician delivers PMT interventions in the context of ...
PMT is a promising therapy for ARFID in school-age children. Challenges and strategies are discussed, including ways to address obstacles such as young age, comorbidities, and use of the virtual envir...
Avoidant/restrictive food intake disorder (ARFID) symptoms are common (up to 40%) among adults with disorders of gut-brain interaction (DGBI), but treatments for this population (DGBI + ARFID) have ye...
Patients (N = 14) received CBT as part of routine care in an outpatient gastroenterology clinic. A two-part investigation of the CBT included a retrospective evaluation of patients who were offered a ...
All feasibility and acceptability benchmarks were achieved (and qualitative feedback revealed high satisfaction with the treatment and outcomes). There were improvements in clinical outcomes across tr...
Initial development and testing of a brief 8-session CBT protocol for DGBI + ARFID showed high feasibility, acceptability, and promising clinical improvements. Findings will inform an NIH Stage 1B ran...
While cognitive-behavioral treatments (CBTs) for ARFID have been created in outpatient feeding and eating disorder clinics, they have yet to be developed and refined for other clinic settings or popul...