questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Nucléoprotéines
Protéines chromosomiques nonhistones
Protéines de maintenance des minichromosomes
Protéines de maintenance des minichromosomes : Questions médicales fréquentes
Termes MeSH sélectionnés :
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Protéines de maintenance des minichromosomes : Questions médicales les plus fréquentes",
"headline": "Protéines de maintenance des minichromosomes : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Protéines de maintenance des minichromosomes : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-06",
"dateModified": "2025-04-02",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Protéines de maintenance des minichromosomes"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Protéines chromosomiques nonhistones",
"url": "https://questionsmedicales.fr/mesh/D002868",
"about": {
"@type": "MedicalCondition",
"name": "Protéines chromosomiques nonhistones",
"code": {
"@type": "MedicalCode",
"code": "D002868",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Composant-2 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 2",
"url": "https://questionsmedicales.fr/mesh/D064111",
"about": {
"@type": "MedicalCondition",
"name": "Composant-2 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064111",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.200"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Composant-3 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 3",
"url": "https://questionsmedicales.fr/mesh/D064126",
"about": {
"@type": "MedicalCondition",
"name": "Composant-3 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064126",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.300"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Composant-4 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 4",
"url": "https://questionsmedicales.fr/mesh/D064148",
"about": {
"@type": "MedicalCondition",
"name": "Composant-4 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064148",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.400"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Composant-5 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 5",
"url": "https://questionsmedicales.fr/mesh/D064150",
"about": {
"@type": "MedicalCondition",
"name": "Composant-5 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064150",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.500"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Composant-6 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 6",
"url": "https://questionsmedicales.fr/mesh/D064151",
"about": {
"@type": "MedicalCondition",
"name": "Composant-6 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064151",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.600"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Composant-7 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 7",
"url": "https://questionsmedicales.fr/mesh/D064168",
"about": {
"@type": "MedicalCondition",
"name": "Composant-7 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064168",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.700"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Composant-8 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 8",
"url": "https://questionsmedicales.fr/mesh/D064187",
"about": {
"@type": "MedicalCondition",
"name": "Composant-8 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064187",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.800"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Composant-9 du complexe de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Complex Component 9",
"url": "https://questionsmedicales.fr/mesh/D064188",
"about": {
"@type": "MedicalCondition",
"name": "Composant-9 du complexe de maintenance des minichromosomes",
"code": {
"@type": "MedicalCode",
"code": "D064188",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.664.235.750.900"
}
}
}
],
"about": {
"@type": "MedicalCondition",
"name": "Protéines de maintenance des minichromosomes",
"alternateName": "Minichromosome Maintenance Proteins",
"code": {
"@type": "MedicalCode",
"code": "D064110",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Qing Yang",
"url": "https://questionsmedicales.fr/author/Qing%20Yang",
"affiliation": {
"@type": "Organization",
"name": "Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China."
}
},
{
"@type": "Person",
"name": "Binhui Xie",
"url": "https://questionsmedicales.fr/author/Binhui%20Xie",
"affiliation": {
"@type": "Organization",
"name": "Department of Hepatobiliary Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China."
}
},
{
"@type": "Person",
"name": "Hui Tang",
"url": "https://questionsmedicales.fr/author/Hui%20Tang",
"affiliation": {
"@type": "Organization",
"name": "Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China."
}
},
{
"@type": "Person",
"name": "Wei Meng",
"url": "https://questionsmedicales.fr/author/Wei%20Meng",
"affiliation": {
"@type": "Organization",
"name": "Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China."
}
},
{
"@type": "Person",
"name": "Changchang Jia",
"url": "https://questionsmedicales.fr/author/Changchang%20Jia",
"affiliation": {
"@type": "Organization",
"name": "Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol.",
"datePublished": "2022-12-20",
"url": "https://questionsmedicales.fr/article/36600424",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1136/bmjopen-2022-067251"
}
},
{
"@type": "ScholarlyArticle",
"name": "Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial.",
"datePublished": "2022-05-23",
"url": "https://questionsmedicales.fr/article/35617986",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/S2213-2600(22)00088-1"
}
},
{
"@type": "ScholarlyArticle",
"name": "Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial.",
"datePublished": "2024-08-14",
"url": "https://questionsmedicales.fr/article/39161682",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.2147/DDDT.S472651"
}
},
{
"@type": "ScholarlyArticle",
"name": "Efficacy of Liposomal Melatonin in sleep EEG in Childhood: A Double Blind Case Control Study.",
"datePublished": "2022-12-29",
"url": "https://questionsmedicales.fr/article/36612875",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/ijerph20010552"
}
},
{
"@type": "ScholarlyArticle",
"name": "Licogliflozin for nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a study.",
"datePublished": "2022-06-20",
"url": "https://questionsmedicales.fr/article/35725922",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41591-022-01861-9"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides aminés, peptides et protéines",
"item": "https://questionsmedicales.fr/mesh/D000602"
},
{
"@type": "ListItem",
"position": 3,
"name": "Protéines",
"item": "https://questionsmedicales.fr/mesh/D011506"
},
{
"@type": "ListItem",
"position": 4,
"name": "Nucléoprotéines",
"item": "https://questionsmedicales.fr/mesh/D009698"
},
{
"@type": "ListItem",
"position": 5,
"name": "Protéines chromosomiques nonhistones",
"item": "https://questionsmedicales.fr/mesh/D002868"
},
{
"@type": "ListItem",
"position": 6,
"name": "Protéines de maintenance des minichromosomes",
"item": "https://questionsmedicales.fr/mesh/D064110"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Protéines de maintenance des minichromosomes - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Protéines de maintenance des minichromosomes",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-13",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Protéines de maintenance des minichromosomes",
"description": "Comment diagnostiquer une anomalie des protéines MCM ?\nQuels tests sont utilisés pour évaluer les MCM ?\nLes niveaux de MCM peuvent-ils être mesurés ?\nQuels marqueurs sont associés aux MCM ?\nLes MCM sont-elles liées à des cancers spécifiques ?",
"url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Double-Blind+Method&page=3#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Protéines de maintenance des minichromosomes",
"description": "Quels symptômes indiquent une dysfonction des MCM ?\nLes symptômes sont-ils spécifiques aux MCM ?\nComment les MCM affectent-elles la santé cellulaire ?\nLes MCM sont-elles liées à des symptômes neurologiques ?\nPeut-on observer des symptômes précoces de dysfonction MCM ?",
"url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Double-Blind+Method&page=3#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Protéines de maintenance des minichromosomes",
"description": "Peut-on prévenir les anomalies des MCM ?\nY a-t-il des tests de dépistage pour les MCM ?\nL'alimentation influence-t-elle les MCM ?\nLe stress affecte-t-il les MCM ?\nLes exercices physiques aident-ils les MCM ?",
"url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Double-Blind+Method&page=3#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Protéines de maintenance des minichromosomes",
"description": "Quels traitements ciblent les MCM ?\nLes thérapies géniques peuvent-elles aider ?\nY a-t-il des médicaments pour les MCM ?\nComment la chimiothérapie affecte-t-elle les MCM ?\nLes traitements sont-ils personnalisés pour les MCM ?",
"url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Double-Blind+Method&page=3#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Protéines de maintenance des minichromosomes",
"description": "Quelles complications peuvent survenir avec des anomalies MCM ?\nLes anomalies MCM sont-elles héréditaires ?\nComment les MCM affectent-elles le vieillissement ?\nLes MCM sont-elles liées à des maladies auto-immunes ?\nLes anomalies MCM peuvent-elles causer des troubles neurologiques ?",
"url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Double-Blind+Method&page=3#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Protéines de maintenance des minichromosomes",
"description": "Quels facteurs augmentent le risque d'anomalies MCM ?\nL'exposition à des toxines influence-t-elle les MCM ?\nLe tabagisme affecte-t-il les MCM ?\nLe vieillissement est-il un facteur de risque pour les MCM ?\nLes antécédents familiaux influencent-ils les MCM ?",
"url": "https://questionsmedicales.fr/mesh/D064110?mesh_terms=Double-Blind+Method&page=3#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une anomalie des protéines MCM ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses de protéines peuvent identifier des anomalies."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les MCM ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'immunobuvardage et la PCR sont couramment utilisés pour évaluer les MCM."
}
},
{
"@type": "Question",
"name": "Les niveaux de MCM peuvent-ils être mesurés ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les niveaux de MCM peuvent être mesurés par des techniques de biologie moléculaire."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont associés aux MCM ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs de prolifération cellulaire, comme Ki-67, sont souvent associés aux MCM."
}
},
{
"@type": "Question",
"name": "Les MCM sont-elles liées à des cancers spécifiques ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux élevés de MCM sont souvent associés à divers types de cancers."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une dysfonction des MCM ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la réplication de l'ADN peuvent entraîner des symptômes variés."
}
},
{
"@type": "Question",
"name": "Les symptômes sont-ils spécifiques aux MCM ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, les symptômes peuvent varier selon le type de maladie associée aux MCM."
}
},
{
"@type": "Question",
"name": "Comment les MCM affectent-elles la santé cellulaire ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une mauvaise fonction des MCM peut entraîner des erreurs dans la réplication de l'ADN."
}
},
{
"@type": "Question",
"name": "Les MCM sont-elles liées à des symptômes neurologiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent un lien entre les MCM et des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Peut-on observer des symptômes précoces de dysfonction MCM ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des signes précoces peuvent inclure des anomalies de croissance cellulaire."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les anomalies des MCM ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une bonne hygiène de vie et un suivi médical régulier peuvent aider à prévenir."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour les MCM ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être proposés pour les personnes à risque élevé."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle les MCM ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut soutenir la santé cellulaire et la fonction des MCM."
}
},
{
"@type": "Question",
"name": "Le stress affecte-t-il les MCM ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber la fonction cellulaire, y compris celle des MCM."
}
},
{
"@type": "Question",
"name": "Les exercices physiques aident-ils les MCM ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la fonction des MCM."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent les MCM ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques de MCM sont en cours de développement pour le cancer."
}
},
{
"@type": "Question",
"name": "Les thérapies géniques peuvent-elles aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique pourrait corriger les anomalies des MCM dans certains cas."
}
},
{
"@type": "Question",
"name": "Y a-t-il des médicaments pour les MCM ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments ciblant la voie de réplication de l'ADN sont en développement."
}
},
{
"@type": "Question",
"name": "Comment la chimiothérapie affecte-t-elle les MCM ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chimiothérapie peut perturber la fonction des MCM, affectant la réplication cellulaire."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour les MCM ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des profils de MCM des patients."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies MCM ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles de croissance et des maladies génétiques."
}
},
{
"@type": "Question",
"name": "Les anomalies MCM sont-elles héréditaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies peuvent être héréditaires, augmentant le risque de maladies."
}
},
{
"@type": "Question",
"name": "Comment les MCM affectent-elles le vieillissement ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des dysfonctionnements des MCM peuvent accélérer le vieillissement cellulaire et tissulaire."
}
},
{
"@type": "Question",
"name": "Les MCM sont-elles liées à des maladies auto-immunes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches suggèrent un lien potentiel entre les MCM et certaines maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Les anomalies MCM peuvent-elles causer des troubles neurologiques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies dans les MCM peuvent être associées à des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'anomalies MCM ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines influence-t-elle les MCM ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines peut perturber la fonction des MCM."
}
},
{
"@type": "Question",
"name": "Le tabagisme affecte-t-il les MCM ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme est un facteur de risque connu pour des anomalies dans la fonction des MCM."
}
},
{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque pour les MCM ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la fonction des MCM et augmenter le risque de maladies."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils les MCM ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies liées aux MCM peuvent augmenter le risque."
}
}
]
}
]
}
Sepsis is a major cause of death among hospitalised patients. Accumulating evidence suggests that immune response during sepsis cascade lies within a spectrum of dysregulated host responses. On the on...
ImmunoSep is a randomised placebo-controlled phase 2 clinical trial with a double-dummy design in which the effect of precision immunotherapy on sepsis phenotypes with MALS and immunoparalysis is stud...
The protocol is approved by the German Federal Institute for Drugs and Medical Devices; the National Ethics Committee of Greece and by the National Organization for Medicines of Greece; the Central Co...
NCT04990232....
Baricitinib and dexamethasone have randomised trials supporting their use for the treatment of patients with COVID-19. We assessed the combination of baricitinib plus remdesivir versus dexamethasone p...
In this randomised, double-blind, double placebo-controlled trial, patients were enrolled at 67 trial sites in the USA (60 sites), South Korea (two sites), Mexico (two sites), Singapore (two sites), a...
Between Dec 1, 2020, and April 13, 2021, 1047 patients were assessed for eligibility. 1010 patients were enrolled and randomly assigned, 516 (51%) to baricitinib plus remdesivir plus placebo and 494 (...
In hospitalised patients with COVID-19 requiring supplemental oxygen by low-flow, high-flow, or non-invasive ventilation, baricitinib plus remdesivir and dexamethasone plus remdesivir resulted in simi...
National Institute of Allergy and Infectious Diseases....
This study aimed to establish the 95% effective dose (ED95) of esketamine in combination with propofol for hysteroscopy and then to evaluate its efficacy and safety profile....
This prospective, double-blind, randomized controlled trial consisted of two cohorts. In cohort 1, 45 women aged 18-65 years undergoing hysteroscopy were randomly assigned to either group E (esketamin...
The ED95 of esketamine was 0.254 mg/kg (95% CI: 0.214-1.004), while that of alfentanil was 9.121 μg/kg (95% CI: 8.479-13.364). The anesthesia success rate was 93.0% in group E and 95.2% in group A (p ...
This study determined the ED 95 dose of esketamine for intravenous general anesthesia during hysteroscopy. Esketamine showed less respiratory and hemodynamic depression, as well as fewer adverse effec...
www.chictr.org.cn, (ChiCTR2300077283); registered November 3, 2023....
Electroencephalography (EEG) is pivotal in the clinical assessment of epilepsy, and sleep is known to improve the diagnostic yield of its recording. Sleep-EEG recording is generally reached by either ...
Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease that may advance to fibrosis and lead to mortality; however, no pharmacotherapy is currently available. We tested the hypothesis t...
Rescue of mitochondrial function is a promising neuroprotective strategy for Parkinson's disease (PD). Ursodeoxycholic acid (UDCA) has shown considerable promise as a mitochondrial rescue agent across...
To investigate the safety and tolerability of high-dose UDCA in PD and determine midbrain target engagement....
The UP (UDCA in PD) study was a phase II, randomized, double-blind, placebo-controlled trial of UDCA (30 mg/kg daily, 2:1 randomization UDCA vs. placebo) in 30 participants with PD for 48 weeks. The p...
UDCA was safe and well tolerated, and only mild transient gastrointestinal adverse events were more frequent in the UDCA treatment group. Midbrain...
High-dose UDCA is safe and well tolerated in early PD. Larger trials are needed to further evaluate the disease-modifying effect of UDCA in PD. © 2023 The Authors. Movement Disorders published by Wile...
To determine whether intravenous vitamin C compared with placebo, reduces vasopressor requirements in patients with vasoplegic shock....
Double-blinded, randomised clinical trial (RCT) conducted in two intensive care units in Perth, Australia. Vasopressor requirements at enrolment needed to be >10 μg/min noradrenaline after hypovolaemi...
Of the 71 patients randomised (35 vitamin C, 36 placebo group), the median vasopressor duration was 44 h [95% CI, 37-54 h] and 55 h [95% CI, 33-66 h]) in the vitamin C and placebo groups (p = 0.057). ...
In this RCT of patients with vasoplegic shock of at least moderate severity, the use of IV vitamin C compared with placebo did not significantly reduce the duration of vasopressors....
Prospective registration - trial number ACTRN12617001392358....
Fibrotic hypersensitivity pneumonitis (FHP) is an irreversible lung disease with high morbidity and mortality. We sought to evaluate the safety and effect of pirfenidone on disease progression in such...
We conducted a single-centre, randomised, double-blinded, placebo-controlled trial in adults with FHP and disease progression. Patients were assigned in a 2:1 ratio to receive either oral pirfenidone ...
After randomising 40 patients, enrolment was interrupted by the COVID-19 pandemic. There was no significant between-group difference in FVC% at week 52 (mean difference -0.76%, 95% CI -6.34 to 4.82). ...
The trial was underpowered to detect a difference in the primary end point. Pirfenidone was found to be safe and improved PFS in patients with FHP....
NCT02958917....
Pain after soft tissue injuries in and around the ankle is a troublesome process in terms of patient comfort and mobilization. The aim of this study was to compare the analgesic efficacy of intravenou...
We conducted a prospective, double-blind, randomized controlled study in a tertiary hospital. The patients were divided into two groups as those administered IV 400 mg ibuprofen and IV 20 mg tenoxicam...
One hundred and twenty-four patients were included in the study. There were 62 patients in the tenoxicam group and 62 patients in the ibuprofen group. When VAS scores were compared, it was found that ...
We hypothesize that synbiotic supplementation could modulate the intestinal microbiota and subsequently, improve the condition of hypothyroid patients....
Fifty-six adult hypothyroid patients were recruited to this double-blind, placebo-controlled, randomized clinical trial. The intervention was 10 weeks of synbiotic (500 mg of 109 CFU/g probiotics plus...
Analysis on 51 patients who completed the trial showed that TSH and depression (p> 0.05) did not change significantly, while serum FT4 significantly increased in both groups (p = 0.03 and p = 0.02 in ...
Ten-week supplementation with synbiotic had no favorable effect on depression and TSH, but it improved blood pressure and quality of life in patients with hypothyroidism. More trials are needed to sup...
IRCT20210926052583N1, Iranian Registry of Clinical Trials (IRCT), registered October 1st, 2021....