Protéines de maintenance des minichromosomes : Questions médicales fréquentes
Nom anglais: Minichromosome Maintenance Proteins
Descriptor UI:D064110
Tree Number:D12.776.664.235.750
Termes MeSH sélectionnés :
Epidemiological Models
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie des protéines MCM ?",
"position": 1,
"acceptedAnswer": {
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"text": "Des tests génétiques et des analyses de protéines peuvent identifier des anomalies."
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les MCM ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'immunobuvardage et la PCR sont couramment utilisés pour évaluer les MCM."
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"@type": "Question",
"name": "Les niveaux de MCM peuvent-ils être mesurés ?",
"position": 3,
"acceptedAnswer": {
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"text": "Oui, les niveaux de MCM peuvent être mesurés par des techniques de biologie moléculaire."
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"@type": "Question",
"name": "Quels marqueurs sont associés aux MCM ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs de prolifération cellulaire, comme Ki-67, sont souvent associés aux MCM."
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"@type": "Question",
"name": "Les MCM sont-elles liées à des cancers spécifiques ?",
"position": 5,
"acceptedAnswer": {
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"text": "Oui, des niveaux élevés de MCM sont souvent associés à divers types de cancers."
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"@type": "Question",
"name": "Quels symptômes indiquent une dysfonction des MCM ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la réplication de l'ADN peuvent entraîner des symptômes variés."
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"@type": "Question",
"name": "Les symptômes sont-ils spécifiques aux MCM ?",
"position": 7,
"acceptedAnswer": {
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"text": "Non, les symptômes peuvent varier selon le type de maladie associée aux MCM."
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"@type": "Question",
"name": "Comment les MCM affectent-elles la santé cellulaire ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une mauvaise fonction des MCM peut entraîner des erreurs dans la réplication de l'ADN."
}
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"@type": "Question",
"name": "Les MCM sont-elles liées à des symptômes neurologiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent un lien entre les MCM et des troubles neurologiques."
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"@type": "Question",
"name": "Peut-on observer des symptômes précoces de dysfonction MCM ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des signes précoces peuvent inclure des anomalies de croissance cellulaire."
}
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"@type": "Question",
"name": "Peut-on prévenir les anomalies des MCM ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une bonne hygiène de vie et un suivi médical régulier peuvent aider à prévenir."
}
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"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour les MCM ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être proposés pour les personnes à risque élevé."
}
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"@type": "Question",
"name": "L'alimentation influence-t-elle les MCM ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut soutenir la santé cellulaire et la fonction des MCM."
}
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"@type": "Question",
"name": "Le stress affecte-t-il les MCM ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber la fonction cellulaire, y compris celle des MCM."
}
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"@type": "Question",
"name": "Les exercices physiques aident-ils les MCM ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la fonction des MCM."
}
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{
"@type": "Question",
"name": "Quels traitements ciblent les MCM ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques de MCM sont en cours de développement pour le cancer."
}
},
{
"@type": "Question",
"name": "Les thérapies géniques peuvent-elles aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique pourrait corriger les anomalies des MCM dans certains cas."
}
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"@type": "Question",
"name": "Y a-t-il des médicaments pour les MCM ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments ciblant la voie de réplication de l'ADN sont en développement."
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{
"@type": "Question",
"name": "Comment la chimiothérapie affecte-t-elle les MCM ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chimiothérapie peut perturber la fonction des MCM, affectant la réplication cellulaire."
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour les MCM ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des profils de MCM des patients."
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies MCM ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles de croissance et des maladies génétiques."
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"@type": "Question",
"name": "Les anomalies MCM sont-elles héréditaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies peuvent être héréditaires, augmentant le risque de maladies."
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"@type": "Question",
"name": "Comment les MCM affectent-elles le vieillissement ?",
"position": 23,
"acceptedAnswer": {
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"text": "Des dysfonctionnements des MCM peuvent accélérer le vieillissement cellulaire et tissulaire."
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"@type": "Question",
"name": "Les MCM sont-elles liées à des maladies auto-immunes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches suggèrent un lien potentiel entre les MCM et certaines maladies auto-immunes."
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"@type": "Question",
"name": "Les anomalies MCM peuvent-elles causer des troubles neurologiques ?",
"position": 25,
"acceptedAnswer": {
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"text": "Oui, des anomalies dans les MCM peuvent être associées à des troubles neurologiques."
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"@type": "Question",
"name": "Quels facteurs augmentent le risque d'anomalies MCM ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent augmenter le risque."
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"@type": "Question",
"name": "L'exposition à des toxines influence-t-elle les MCM ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines peut perturber la fonction des MCM."
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"@type": "Question",
"name": "Le tabagisme affecte-t-il les MCM ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme est un facteur de risque connu pour des anomalies dans la fonction des MCM."
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{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque pour les MCM ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la fonction des MCM et augmenter le risque de maladies."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils les MCM ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies liées aux MCM peuvent augmenter le risque."
}
}
]
}
]
}
Factors that may drive recommendations for operative intervention for patients with intramedullary spinal cord tumors (ISCTs) have yet to be extensively studied. The authors investigated racial and so...
The Surveillance, Epidemiology, and End Results registry was queried to identify all patients > 18 years of age with ISCTs diagnosed between 2000 and 2019. Univariable and multivariable logistic regre...
The authors identified 2325 patients (mean age 49 [SD 16] years; 48.8% female; 67.4% non-Hispanic White, 7.8% non-Hispanic Black, 16.2% Hispanic, 6.5% Asian/Pacific Islander, 0.6% Native American; 56....
In patients with spinal ependymomas and nonependymal spinal gliomas, recommendations for surgery appear to be unaffected by patient sex, race, or income. Survival disparities appear to exist among unm...
The metabolic score for insulin resistance index (METS-IR) is a novel non insulin-based marker that indicates the risk for metabolic syndrome and type 2 diabetes mellitus (T2DM). However, METS-IR has ...
Data were assessed from 30,164 Korean participants over 60 years of age from the Korean Genome and Epidemiology Study-Health Examinees (KoGES-HEXA) cohort data, linked with the death certificate datab...
During the mean 11.7 years of follow-up, 2,821 individuals expired. The HRs of mortality for METS-IR tertiles were 1.16 (95% CI, 1.01-1.34) in T3 after adjustment for metabolic parameters, but the T2 ...
The METS-IR may be a useful predictive marker for all-cause mortality and cancer mortality, but not for cardiovascular mortality in subjects over 60 years of age. This implies that early detection and...
Background There are several patterns of metastatic spread from endometrial cancer (EC). Although studies have been conducted to study the EC population with distant metastasis in the bone and lungs, ...
Working together, two major pharmaceutical companies have developed a Lyme disease vaccine consisting of recombinant-derived outer surface protein A (OspA) of the etiologic agent...
Predictors of health across the life-course do not maintain the same significance in very late life and the role of financial strain in health outcomes of very old adults remain unclear. Data from adu...
Respiratory viral infections significantly negatively impact animal welfare and have significant financial implications in the poultry industry. This study aimed to determine the frequency of the most...
Chickens from 359 broiler flocks in five different Egyptian governorates in the Nile Delta (Beheira, Gharbia, Giza, Monufiya, and Qalyoubia) at marketing time (33-38 days of age) were used in this stu...
Of the 359 flocks examined, 293 tested positive, whereas 66 were completely negative for the four viruses evaluated, with the highest positive results in Beheira. Out of 293 positive flocks, 211 were ...
From January to October 2022, prevalent respiratory viral infections (H5N1, NDV, H9N2, and IBV) were detected in broiler chickens across the Delta area governorate, according to the findings of the pr...
High-dose methotrexate (HDMTX) is administered for the treatment of some malignancies. Serious complications after the administration of HDMTX are rare, but occasionally MTX may precipitate in the ren...
Twelve haemato-oncology and pediatric oncology clinical experts from leading European hospitals participated in the study. A two-round Delphi methodology was used to gather data on different variables...
The total number of patients treated annually with HDMTX in France, Germany, Italy, and the UK is estimated in 7155. Of these, 16% are estimated to develop delayed MTX elimination and around 9% may de...
This report provides expert clinical practice experience and opinion of the incidence and management of HDMTX-delayed elimination in France, Germany, Italy and the UK, thereby contributing to the evid...
Methicillin-resistant Staphylococcus aureus (MRSA), is considered a potential and aggressive nosocomial pathogen. It accounts for 50% of S. aureus isolates in tertiary hospitals in Iran, however, ther...
Seventy-two non-duplicate MRSA isolates were collected from 3 referral hospitals in Tabriz, Ardebil, and Urmia cities. The antimicrobial susceptibility patterns were determined by disk diffusion test ...
The highest resistance was observed to erythromycin and clindamycin at a rate of 76.4%, followed by ciprofloxacin (61.1%), gentamicin (54.2%), rifampin (38.9%), and co-trimoxazole (27.8%). All isolate...
The ST numbers were non-repetitive. CC8 as a pandemic clone and an individual lineage and clinically significant clade was reported as the most prevalent clonal complex. It is essential periodic evalu...
Social determinants of health are consistently associated with systemic lupus erythematosus (SLE) outcomes. However, social determinants of health are typically measured with conventional socioeconomi...
In this cross-sectional analysis, data were derived from the California Lupus Epidemiology Study based in the San Francisco Bay Area, CA, USA. Participants were recruited between Feb 25, 2015, and Jan...
The final cohort included 252 participants. Mean age was 49·7 (SD 13·4) years, 228 (90%) of 252 were women and 24 (10%) were men. 80 (32%) individuals self-identified as Asian, 26 (10%) as Black, 101 ...
Having any economic insecurity was associated with worse outcomes for people with SLE regardless of poverty or education. The findings of this study provide insight into the relationship between econo...
US Centers for Disease Control, Rheumatology Research Foundation, and National Institute of Arthritis and Musculoskeletal and Skin Diseases....
The objective of the present study is to analyze the epidemiological, clinical and functional characteristics of patients admitted to the University Hospital of Navarra due to SARS-CoV-2 infection, as...
An observational, retrospective study was performed, including all hospitalized patients older than 75 years. Information has been obtained on multiple variables, among which it is worth mentioning pr...
Data have been obtained from a total of 426 patients with a mean age of 83.2 years (52.6% men). 34.7% died in hospital and 4.5% within 1 month after hospital discharge. The factors related to mortalit...
SARS-CoV-2 infection has caused high mortality rates in older adults. In this age group, the atypical presentation of this disease and functional deterioration during hospitalization are frequent. In ...
