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"@type": "Question",
"name": "Comment identifier un système CRISPR-Cas ?",
"position": 1,
"acceptedAnswer": {
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"text": "L'identification se fait par séquençage génétique et analyse bioinformatique."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour détecter CRISPR ?",
"position": 2,
"acceptedAnswer": {
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"text": "Des tests PCR et des méthodes de séquençage ciblé sont couramment utilisés."
}
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{
"@type": "Question",
"name": "Peut-on détecter CRISPR dans des échantillons cliniques ?",
"position": 3,
"acceptedAnswer": {
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"text": "Oui, des échantillons de sang ou de tissus peuvent être analysés pour CRISPR."
}
},
{
"@type": "Question",
"name": "Quels marqueurs génétiques sont associés à CRISPR ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les gènes Cas et les séquences répétées sont des marqueurs clés."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'efficacité de CRISPR ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité est évaluée par des tests de modification génétique et d'expression."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent résulter d'une modification CRISPR ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes dépendent de la cible génétique, pouvant inclure des anomalies cellulaires."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires connus de CRISPR ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets secondaires peuvent inclure des réponses immunitaires ou des mutations off-target."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il causer des maladies ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des modifications non ciblées peuvent potentiellement induire des maladies génétiques."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une réponse immunitaire à CRISPR ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes incluent inflammation, douleur ou réactions allergiques au site d'injection."
}
},
{
"@type": "Question",
"name": "Comment surveiller les effets de CRISPR ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "La surveillance se fait par des examens cliniques réguliers et des tests génétiques."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il prévenir des maladies génétiques ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "CRISPR a le potentiel de prévenir des maladies en corrigeant des mutations héréditaires."
}
},
{
"@type": "Question",
"name": "Comment CRISPR peut-il être utilisé en prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il peut être utilisé pour modifier des embryons afin d'éliminer des gènes pathogènes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques dans l'utilisation préventive de CRISPR ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des risques incluent des modifications non intentionnelles et des effets à long terme inconnus."
}
},
{
"@type": "Question",
"name": "Quels protocoles de sécurité existent pour CRISPR ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des protocoles incluent des tests rigoureux et des évaluations éthiques avant l'application."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il être utilisé pour prévenir des infections ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches explorent l'utilisation de CRISPR pour cibler des virus et bactéries pathogènes."
}
},
{
"@type": "Question",
"name": "CRISPR est-il utilisé pour traiter des maladies ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, CRISPR est exploré pour traiter des maladies génétiques et certains cancers."
}
},
{
"@type": "Question",
"name": "Quels types de maladies peuvent être ciblés par CRISPR ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "CRISPR cible des maladies comme la drépanocytose, la fibrose kystique et certains cancers."
}
},
{
"@type": "Question",
"name": "Comment CRISPR est-il administré en traitement ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "CRISPR est généralement administré par injection dans les cellules ou tissus ciblés."
}
},
{
"@type": "Question",
"name": "Quels sont les résultats des essais cliniques avec CRISPR ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les essais montrent des résultats prometteurs, mais nécessitent encore des études approfondies."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il être utilisé en thérapie génique ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, CRISPR est une approche innovante en thérapie génique pour corriger des mutations."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec CRISPR ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des réponses immunitaires, des mutations off-target et des infections."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées à CRISPR ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion implique un suivi médical étroit et des traitements symptomatiques appropriés."
}
},
{
"@type": "Question",
"name": "CRISPR peut-il entraîner des cancers ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des modifications non ciblées par CRISPR pourraient théoriquement induire des cancers."
}
},
{
"@type": "Question",
"name": "Quels tests sont nécessaires après un traitement CRISPR ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des examens de santé réguliers sont recommandés après traitement."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets à long terme de CRISPR ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets à long terme sont encore mal compris et nécessitent des études approfondies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour l'utilisation de CRISPR ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents médicaux, des mutations génétiques et des conditions immunitaires."
}
},
{
"@type": "Question",
"name": "Les personnes âgées sont-elles à risque avec CRISPR ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées peuvent avoir un risque accru en raison de la fragilité cellulaire."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes augmentent-elles les risques de CRISPR ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les maladies auto-immunes peuvent augmenter le risque de réactions indésirables."
}
},
{
"@type": "Question",
"name": "Comment les antécédents familiaux influencent-ils l'utilisation de CRISPR ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antécédents familiaux de maladies génétiques peuvent influencer les décisions thérapeutiques."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux affectent-ils CRISPR ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs environnementaux peuvent influencer l'efficacité et la sécurité de CRISPR."
}
}
]
}
]
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Non-invasive methods such as Transcranial Magnetic Stimulation (TMS) and magnetoencephalography (MEG) aid in the pre-surgical evaluation of patients with epilepsy or brain tumor to identify sensorimot...
Patients with multifocal or generalized epilepsies manifesting with drop attacks have severe refractory seizures and significant cognitive and behavioural abnormalities. It is unclear to what extent t...
Resting-state fMRI (rs-fMRI) data was available for 5 patients with epileptic drop attacks and 15 with refractory focal epilepsies undergoing presurgical evaluation. Functional connectivity was analyz...
Two clusters of reduced connectivity in the group with drop attacks (DA group) in relation to those with focal epilepsies were found in the between-group analysis: the precentral seed showed reduced c...
This pilot study shows differences in the cerebral connectivity in the sensorimotor cortex of patients with generalized epilepsies and drop attacks which should be further explored to better understan...
In complex regional pain syndrome (CRPS), the representation area of the affected limb in the primary sensorimotor cortex (SM1) reacts abnormally during sensory stimulation and motor actions. We recor...
Continuous theta-burst stimulation (cTBS) is a noninvasive repetitive brain stimulation protocol that suppresses the excitability of the primary motor cortex. It induces cerebral cortical inhibition b...
Tui Na (Chinese massage) is a relatively simple, inexpensive, and non-invasive intervention, and has been used to treat stroke patients for many years in China. Tui Na acts on specific parts of the bo...
Functional near-infrared spectroscopy (fNIRS) was used to explore the changes of sensorimotor cortical neural activity in patients with upper limb motor dysfunction of stroke and healthy control group...
Ten patients with unilateral upper limb motor dysfunction after stroke and eight healthy subjects received Tui Na. fNIRS was used to record the hemodynamic data in the sensorimotor cortex and the chan...
1. For hemodynamic response induced by Hegu acupoint Tui Na, a dominant increase in the contralesional primary sensorimotor cortex during Hegu point Tui Na of the less affected arm in stroke patients ...
The combination of Tui Na and fNIRS has the potential to reflect the functional status of sensorimotor neural circuits. The changes of neuroactivity in the sensorimotor cortex when Tui Na Hegu acupoin...
This study used functional magnetic resonance imaging (fMRI) to explore brain structural and related network changes in patients with spinal cord injury (SCI)....
Thirty-one right-handed SCI patients and 31 gender- and age-matched healthy controls (HC) were included. The gray matter volume (GMV) changes in SCI patients were observed using voxel-based morphometr...
GMV of the frontal, temporal, and insular cortices was lower in the SCI group than in the HC group. No GMV changes were found in the primary sensorimotor area in the SCI group. Besides, the altered FC...
This study demonstrated that gray matter and related network reorganization in patients with SCI occurred in higher cognitive regions. Future rehabilitation strategies should focus more on cognitive f...
Beta oscillations in human sensorimotor cortex are hallmark signatures of healthy and pathological movement. In single trials, beta oscillations include bursts of intermittent, transient periods of hi...
Human cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices to transmod...
Connectivity changes after spinal cord injury (SCI) appear as dynamic post-injury procedures. The present study aimed to investigate the alterations in the functional connectivity (FC) in different in...
It is hypothesized that disparate brain regions interact via synchronous activity to control behavior. The nature of these interconnected ensembles remains an area of active investigation, and particu...