Titre : Inducteurs du cytochrome P-450 CYP2D6

Inducteurs du cytochrome P-450 CYP2D6 : Questions médicales fréquentes

Termes MeSH sélectionnés :

Robotics
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"https://questionsmedicales.fr/mesh/D065699?mesh_terms=Robotics&page=1000#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Inducteurs du cytochrome P-450 CYP2D6", "description": "Quels symptômes peuvent résulter d'une induction du CYP2D6 ?\nComment l'induction affecte-t-elle les médicaments ?\nY a-t-il des effets secondaires liés aux inducteurs ?\nQuels signes cliniques peuvent alerter sur une induction ?\nL'induction peut-elle causer des symptômes d'intoxication ?", "url": "https://questionsmedicales.fr/mesh/D065699?mesh_terms=Robotics&page=1000#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Inducteurs du cytochrome P-450 CYP2D6", "description": "Comment prévenir l'induction du CYP2D6 ?\nLes patients doivent-ils être informés des inducteurs ?\nQuelles précautions prendre lors de la prescription ?\nLes médecins doivent-ils surveiller les inducteurs ?\nY a-t-il des recommandations pour les prescripteurs ?", "url": "https://questionsmedicales.fr/mesh/D065699?mesh_terms=Robotics&page=1000#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Inducteurs du cytochrome P-450 CYP2D6", "description": "Comment gérer l'induction du CYP2D6 ?\nPeut-on utiliser des inhibiteurs du CYP2D6 ?\nQuels médicaments sont souvent ajustés ?\nY a-t-il des alternatives aux inducteurs ?\nComment surveiller l'efficacité du traitement ?", "url": "https://questionsmedicales.fr/mesh/D065699?mesh_terms=Robotics&page=1000#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Inducteurs du cytochrome P-450 CYP2D6", "description": "Quelles complications peuvent survenir avec l'induction ?\nL'induction peut-elle entraîner des hospitalisations ?\nQuels risques sont associés à l'induction ?\nComment gérer les complications liées à l'induction ?\nY a-t-il des complications à long terme ?", "url": "https://questionsmedicales.fr/mesh/D065699?mesh_terms=Robotics&page=1000#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Inducteurs du cytochrome P-450 CYP2D6", "description": "Quels sont les facteurs de risque d'induction ?\nL'âge influence-t-il l'induction du CYP2D6 ?\nLes habitudes de vie jouent-elles un rôle ?\nY a-t-il des prédispositions génétiques ?\nLes interactions médicamenteuses sont-elles un facteur ?", "url": "https://questionsmedicales.fr/mesh/D065699?mesh_terms=Robotics&page=1000#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment identifier un inducteur du CYP2D6 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "L'identification se fait par l'analyse des médicaments et leur effet sur le métabolisme." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer l'activité du CYP2D6 ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des dosages de médicaments peuvent être utilisés." } }, { "@type": "Question", "name": "Quels signes indiquent une induction du CYP2D6 ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Une diminution de l'efficacité des médicaments métabolisés par CYP2D6 peut indiquer une induction." } }, { "@type": "Question", "name": "Peut-on mesurer l'activité du CYP2D6 ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'activité peut être mesurée par des tests de métabolisme de médicaments spécifiques." } }, { "@type": "Question", "name": "Quels médicaments sont des inducteurs connus ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments comme la rifampicine et la carbamazépine sont des inducteurs connus." } }, { "@type": "Question", "name": "Quels symptômes peuvent résulter d'une induction du CYP2D6 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Une induction peut entraîner une réduction de l'efficacité des médicaments, causant des symptômes de maladie." } }, { "@type": "Question", "name": "Comment l'induction affecte-t-elle les médicaments ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut réduire la concentration plasmatique des médicaments, diminuant leur effet thérapeutique." } }, { "@type": "Question", "name": "Y a-t-il des effets secondaires liés aux inducteurs ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des effets secondaires peuvent survenir si les médicaments perdent leur efficacité." } }, { "@type": "Question", "name": "Quels signes cliniques peuvent alerter sur une induction ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des signes de non-réponse au traitement peuvent alerter sur une induction du CYP2D6." } }, { "@type": "Question", "name": "L'induction peut-elle causer des symptômes d'intoxication ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Indirectement, si des médicaments sont sous-dosés, cela peut entraîner des symptômes d'intoxication." } }, { "@type": "Question", "name": "Comment prévenir l'induction du CYP2D6 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Éviter les inducteurs connus et surveiller les interactions médicamenteuses." } }, { "@type": "Question", "name": "Les patients doivent-ils être informés des inducteurs ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'éducation des patients sur les inducteurs est cruciale pour éviter des complications." } }, { "@type": "Question", "name": "Quelles précautions prendre lors de la prescription ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Évaluer les antécédents médicamenteux et les interactions potentielles avant de prescrire." } }, { "@type": "Question", "name": "Les médecins doivent-ils surveiller les inducteurs ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une surveillance régulière des médicaments inducteurs est recommandée." } }, { "@type": "Question", "name": "Y a-t-il des recommandations pour les prescripteurs ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des lignes directrices existent pour éviter les interactions avec les inducteurs." } }, { "@type": "Question", "name": "Comment gérer l'induction du CYP2D6 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Il est essentiel d'ajuster les doses des médicaments affectés par l'induction." } }, { "@type": "Question", "name": "Peut-on utiliser des inhibiteurs du CYP2D6 ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des inhibiteurs peuvent être utilisés pour contrer l'effet des inducteurs." } }, { "@type": "Question", "name": "Quels médicaments sont souvent ajustés ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Les antidépresseurs et les antipsychotiques sont souvent ajustés en cas d'induction." } }, { "@type": "Question", "name": "Y a-t-il des alternatives aux inducteurs ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des médicaments non inducteurs peuvent être prescrits pour éviter l'interaction." } }, { "@type": "Question", "name": "Comment surveiller l'efficacité du traitement ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des suivis réguliers et des dosages de médicaments sont nécessaires pour évaluer l'efficacité." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec l'induction ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent une inefficacité thérapeutique et des effets indésirables." } }, { "@type": "Question", "name": "L'induction peut-elle entraîner des hospitalisations ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des hospitalisations peuvent être nécessaires en cas de complications graves." } }, { "@type": "Question", "name": "Quels risques sont associés à l'induction ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les risques incluent des interactions médicamenteuses et des effets secondaires graves." } }, { "@type": "Question", "name": "Comment gérer les complications liées à l'induction ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Il est crucial d'ajuster les traitements et de surveiller les patients de près." } }, { "@type": "Question", "name": "Y a-t-il des complications à long terme ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Des complications à long terme peuvent inclure des effets résiduels sur le métabolisme." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque d'induction ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent l'utilisation de certains médicaments et des variations génétiques." } }, { "@type": "Question", "name": "L'âge influence-t-il l'induction du CYP2D6 ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'âge peut affecter le métabolisme et la réponse aux inducteurs." } }, { "@type": "Question", "name": "Les habitudes de vie jouent-elles un rôle ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des habitudes comme l'alcool et le tabac peuvent influencer l'induction." } }, { "@type": "Question", "name": "Y a-t-il des prédispositions génétiques ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines variations génétiques peuvent augmenter le risque d'induction." } }, { "@type": "Question", "name": "Les interactions médicamenteuses sont-elles un facteur ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les interactions avec d'autres médicaments peuvent augmenter le risque d'induction." } } ] } ] }

Sources (10000 au total)

Impact of Liver Cirrhosis, Severity of Cirrhosis, and Portal Hypertension on the Difficulty and Outcomes of Laparoscopic and Robotic Major Liver Resections for Primary Liver Malignancies.

Minimally invasive liver resections (MILR) offer potential benefits such as reduced blood loss and morbidity compared with open liver resections. Several studies have suggested that the impact of cirr... A total of 2534 patients undergoing minimally invasive major hepatectomies (MIMH) for primary malignancies across 58 centers worldwide were retrospectively reviewed. Propensity score (PSM) and coarsen... A total of 1353 patients (53%) had no cirrhosis, 1065 (42%) had Child-Pugh A and 116 (4%) had Child-Pugh B cirrhosis. Matched comparison between non-cirrhotics vs Child-Pugh A cirrhosis demonstrated c... The presence and severity of cirrhosis affected the difficulty and impacted the outcomes of MIMH, resulting in higher blood transfusion rates, increased postoperative morbidity, and longer hospitaliza...

Permanent stoma rate and long-term stoma complications in laparoscopic, robot-assisted, and transanal total mesorectal excisions: a retrospective cohort study.

The surgical resection of rectal carcinoma is associated with a high risk of permanent stoma rate. Primary anastomosis rate is suggested to be higher in robot-assisted and transanal total mesorectal e... Patients undergoing total mesorectal excision for MRI-defined rectal cancer between 2015 and 2017 in 11 centers highly experienced in laparoscopic, robot-assisted or transanal total mesorectal excisio... In total, 1198 patients were included. Permanent stoma rate after low anterior resection (with anastomosis or with an end colostomy) was 40.1% in patients undergoing laparoscopic surgery, 21.3% in pat... The robot-assisted and transanal techniques are associated with a lower permanent stoma rate in patients who underwent a low anterior resection....

Study protocol for a randomised controlled trial to determine the efficacy of an intensive seated postural intervention delivered with robotic and rigid trunk support systems.

Children with cerebral palsy (CP) classified as gross motor function classification system (GMFCS) levels III-IV demonstrate impaired sitting and reaching control abilities that hamper their overall f... We will recruit 82 participants with CP, GMFCS III-IV, and aged 6-17 years. Randomisation using concealed allocation to either the TruST-support or static trunk-support intervention will be conducted ... The study was approved by the Columbia University Institutional Review Board (AAAS7804). This study is funded by the National Institutes of Health (1R01HD101903-01) and is registered at clinicaltrials... NCT04897347; clinicaltrials.gov....

Analysis of training pathway to reach expert performance levels based on proficiency-based progression in robotic-assisted minimally invasive esophagectomy (RAMIE).

Robotic-assisted minimally invasive esophagectomy (RAMIE) was first introduced in 2003 and has since then shown to significantly improve the postoperative course. Previous studies have shown that a st... All patients undergoing RAMIE performed by two experienced surgeons for esophageal cancer since the introduction of the robotic technique in 2017 was included in this analysis. Intraoperative outcomes... From 06/2017 to 03/2022, a total of 154 patients underwent RAMIE at our facility and were included in the analysis. An advancement in performance level was observed for total operating time after 70 c... Our data and analysis showed the progression from proficient to expert performance levels during the implementation of RAMIE at a European high-volume center. Further analysis of surgeons, especially ...

Impact of minimally invasive surgery on surgical outcomes for obese women with endometrial cancer following robotic surgery introduction; a single centre study.

The aim was to assess the surgical outcomes in obese women with endometrial cancer following robotic surgery introduction in a London tertiary gynaecological cancer unit.... Data was prospectively collected for 281 women undergoing endometrial cancer surgery in 2016, 2018 and 2019 (robotic surgery was introduced in November 2017).... The proportion of obese and morbidly obese patients undergoing minimally invasive surgery (MIS) significantly increased following robotic surgery introduction from 43.8% to 69.6% (p < 0.001). Overall ... Robotic surgery led to a significant rise in MIS and improved surgical outcomes for obese and morbidly obese women with endometrial cancer within 12 months of its introduction....

Propensity Score-Matching Analysis Comparing Robotic Versus Laparoscopic Limited Liver Resections of the Posterosuperior Segments: An International Multi-Center Study.

To compare the outcomes of robotic limited liver resections (RLLR) versus laparoscopic limited liver resections (LLLR) of the posterosuperior segments.... Both laparoscopic and robotic liver resections have been used for tumors in the posterosuperior liver segments. However, the comparative performance and safety of both approaches have not been well ex... This is a post hoc analysis of a multicenter database of 5,446 patients who underwent RLLR or LLLR of the posterosuperior segments (I, IVa, VII and VIII) at 60 international centers between 2008 and 2... A total of 3510 cases met the study criteria, of whom 3049 underwent LLLR (87%) and 461 underwent RLLR (13%). After PSM (1:1: and 1:2), RLLR was associated with a lower open conversion rate (10 of 449... RLLR for the posterosuperior segments was associated with superior perioperative outcomes in terms of decreased operative time, blood loss and open conversion rate when compared to LLLR....

Evaluation of the efficacy and safety of robot-assisted and video assisted thoracic surgery for early non-small cell lung cancer: A meta-analysis.

Radical resection of lung cancer and chemotherapy are the main methods for the treatment of early lung cancer, but surgical treatment is still the key and preferred method.... To evaluate the efficacy and safety of robotic-assisted thoracic surgery (RATS) and video assisted thoracic surgery (VATS) for non-small cell lung cancer (NSCLC).... The clinical cohort studies on the comparison of the effects of RATS and VATS in the treatment of NSCLC published in Web of Science, PubMed, The National Library of Medicine (NLM), China National Know... A total of 18 articles and 21,802 subjects were included. The results of the meta-analysis showed that the intraoperative blood loss of RATS was significantly less than that of VAS, and the difference... Compared with VATS, the number of lymph nodes dissected in RATS was significantly more, and the removal of lesions and lymph nodes was more thorough and accurate. More flexible and precise operation a...

Safety and accuracy of cannulated pedicle screw placement in scoliosis surgery: a comparison of robotic-navigation, O-arm-based navigation, and freehand techniques.

To compare the safety and accuracy of cannulated pedicle screw placement using a robotic-navigation technique, O-arm-based navigation technique, or freehand technique.... This study analyzed 106 consecutive patients who underwent scoliosis surgery. Thirty-two patients underwent robotic-navigation-assisted pedicle screw insertion (Group 1), 34 patients underwent O-arm-b... A total of 2035 cannulated pedicle screws were implanted in 106 patients. The accuracy rate of the first pedicle screw placement during operation was significantly greater in Group 1 (94.7%) than in G... The robotic-navigation and O-arm-based navigation techniques effectively increased the accuracy and safety of pedicle screw insertion alternative to the freehand technique in scoliosis surgery. Compar...

A comparison of robotic-assisted and manual techniques in restricted kinematically aligned total knee arthroplasty: coronal alignment improvement with no significant clinical differences.

The purpose of this study was to compare radiographic and clinical outcomes of robotic-assisted and conventional manual techniques in restricted kinematically aligned TKA.... Patients who underwent either manual or robotic-assisted restricted kinematically aligned TKA between 2019 and 2020 were included in this retrospective comparative study. Radiographic outcomes compris... The manual group consisted of 46 patients (38 females, eight males) with a mean age of 68.1 years, and the robotic group consisted of 70 patients (58 females, 12 males) with a mean age of 65.7 years (... The current study demonstrated that using robotic-assisted technique for restricted kinematically aligned total knee arthroplasty (TKA) resulted in significantly better outcomes compared to the conven... Level III (Retrospective cohort study)....