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Activation métabolique
Activation métabolique : Questions médicales fréquentes
Termes MeSH sélectionnés :
Platelet Glycoprotein GPIIb-IIIa Complex
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"description": "Comment diagnostiquer une activation métabolique ?\nQuels marqueurs sont utilisés pour le diagnostic ?\nLes imageries sont-elles utiles pour le diagnostic ?\nQuels symptômes peuvent indiquer une activation métabolique ?\nLes tests génétiques sont-ils pertinents ?",
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"headline": "Traitements sur Activation métabolique",
"description": "Quels traitements sont disponibles pour l'activation métabolique ?\nLes médicaments peuvent-ils aider ?\nQuel rôle joue l'alimentation dans le traitement ?\nL'exercice physique est-il recommandé ?\nDes thérapies alternatives sont-elles efficaces ?",
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"description": "Quelles complications peuvent survenir ?\nL'activation métabolique peut-elle causer des maladies ?\nY a-t-il des risques de déshydratation ?\nDes troubles psychologiques peuvent-ils survenir ?\nL'activation métabolique affecte-t-elle la fertilité ?",
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"@type": "Question",
"name": "Comment diagnostiquer une activation métabolique ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins et des analyses d'urine peuvent évaluer les niveaux métaboliques."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont utilisés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les niveaux de glucose, d'acides gras et d'hormones comme l'insuline sont analysés."
}
},
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"@type": "Question",
"name": "Les imageries sont-elles utiles pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques comme l'IRM peuvent évaluer les tissus et leur métabolisme."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer une activation métabolique ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, perte de poids inexpliquée et augmentation de l'appétit peuvent être des signes."
}
},
{
"@type": "Question",
"name": "Les tests génétiques sont-ils pertinents ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent identifier des anomalies métaboliques héréditaires."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une activation métabolique élevée ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Augmentation de la température corporelle, sudation excessive et nervosité."
}
},
{
"@type": "Question",
"name": "Comment l'activation métabolique affecte-t-elle l'appétit ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut entraîner une augmentation de l'appétit en raison d'une demande énergétique accrue."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes psychologiques associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, anxiété et irritabilité peuvent survenir avec une activation métabolique élevée."
}
},
{
"@type": "Question",
"name": "Les troubles du sommeil sont-ils liés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activation métabolique accrue peut perturber le sommeil et causer l'insomnie."
}
},
{
"@type": "Question",
"name": "Quels signes physiques peuvent apparaître ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Perte de poids rapide et augmentation de la fréquence cardiaque sont fréquents."
}
},
{
"@type": "Question",
"name": "Comment prévenir une activation métabolique excessive ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un mode de vie sain avec une alimentation équilibrée et de l'exercice régulier."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il l'activation métabolique ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut augmenter l'activation métabolique et perturber l'équilibre."
}
},
{
"@type": "Question",
"name": "Les bilans de santé réguliers sont-ils importants ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils permettent de détecter précocement des anomalies métaboliques."
}
},
{
"@type": "Question",
"name": "L'hydratation joue-t-elle un rôle ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une bonne hydratation est essentielle pour un métabolisme optimal."
}
},
{
"@type": "Question",
"name": "Les habitudes de sommeil affectent-elles le métabolisme ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un sommeil de qualité est crucial pour réguler le métabolisme."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour l'activation métabolique ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments, des changements alimentaires et de l'exercice."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des médicaments comme les bêta-bloquants peuvent réguler le métabolisme."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'alimentation dans le traitement ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut stabiliser le métabolisme et améliorer les symptômes."
}
},
{
"@type": "Question",
"name": "L'exercice physique est-il recommandé ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier aide à réguler le métabolisme et à maintenir un poids sain."
}
},
{
"@type": "Question",
"name": "Des thérapies alternatives sont-elles efficaces ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines thérapies comme l'acupuncture peuvent aider à équilibrer le métabolisme."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles endocriniens, des maladies cardiovasculaires et des troubles du métabolisme."
}
},
{
"@type": "Question",
"name": "L'activation métabolique peut-elle causer des maladies ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut contribuer à des maladies comme le diabète et l'hyperthyroïdie."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de déshydratation ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activation métabolique élevée peut augmenter le risque de déshydratation."
}
},
{
"@type": "Question",
"name": "Des troubles psychologiques peuvent-ils survenir ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'activation métabolique peut entraîner des troubles comme l'anxiété et la dépression."
}
},
{
"@type": "Question",
"name": "L'activation métabolique affecte-t-elle la fertilité ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres métaboliques peuvent nuire à la fertilité chez les deux sexes."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque d'activation métabolique ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité, le stress, une alimentation déséquilibrée et le manque d'exercice sont des facteurs."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le métabolisme ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le métabolisme a tendance à ralentir avec l'âge, augmentant les risques."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de troubles métaboliques augmentent le risque d'activation métabolique."
}
},
{
"@type": "Question",
"name": "Le mode de vie sédentaire est-il un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire contribue à une activation métabolique déséquilibrée."
}
},
{
"@type": "Question",
"name": "Les déséquilibres hormonaux sont-ils un facteur ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres hormonaux, comme ceux de la thyroïde, peuvent affecter le métabolisme."
}
}
]
}
]
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The protein tyrosine phosphatase SHP2 (PTPN11) is a negative regulator of glycoprotein VI (GPVI)-induced platelet signal under certain conditions. Clinical trials with derivatives of the allosteric dr...
Washed human platelets were incubated with SHP099 and stimulated with collagen-related peptide (CRP) for stirred aggregation and flow cytometric measurements. Whole-blood microfluidics assays using a ...
Pharmacological inhibition of SHP2 did not alter GPVI-dependent platelet aggregation under stirring, but it enhanced integrin αIIbβ3 activation in response to CRP. Using whole-blood microfluidics, SHP...
Pharmacological inhibition of SHP2 by the allosteric drug SHP099 enhances GPVI-induced platelet activation under shear conditions with a potential to improve platelet functions of Noonan syndrome pati...
Platelet glycoprotein (GP) IIb/IIIa antagonists have been employed in selective patients after endovascular therapy (EVT) for acute ischemic stroke (AIS), yet application in patients without EVT is de...
The glycoprotein Ib-IX (GPIb-IX) complex mediates initial platelet adhesion to von Willebrand factor (VWF) immobilized on subendothelial matrix and endothelial surfaces, and transmits VWF binding-indu...
Thrombophilic genetic polymorphisms of the platelet glycoproteins Ia (GpIa) and IIIa (GpIIIa) have been associated with an increased risk of recurrent miscarriages. The aim of this study was to invest...
This cross-sectional study comprised 196 unrelated nulliparous Greek women with a history of unexplained recurrent miscarriages. Patients were genotyped for the presence of the GpIa-C807T (rs1126643) ...
In the total population of women with recurrent miscarriages, the COL/EPI CT ranged from 70 to 160 seconds (median: 122 seconds, interquartile range (IQR): 102.3-138 seconds). In comparison with the d...
The GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms and more pronouncedly the combined carriers of the risk variants are associated with enhanced platelet reactivity expressed via shorter COL/EPI CT. Th...
Increased platelet activity is a risk factor of thrombotic events in cardiovascular patients. We studied the relationship between platelet function, platelet size, and the content of reticulated plate...
The safety of administration of tirofiban, a platelet glycoprotein IIb/IIIa inhibitor, followed by a clopidogrel loading dose in clopidogrel-naïve patients undergoing ad-hoc percutaneous coronary inte...
In a retrospective observational cohort analysis, clopidogrel-naïve patients undergoing ad-hoc PCI who received a high-dose bolus of tirofiban (25 μg/kg) followed by a 600-mg clopidogrel loading dose ...
A total of 1404 patients were included: 432 (31%) in group 1 and 972 (69%) in group 2. Median age was 69 years, and 28% were female. At 7‑day follow-up, MACE occurred in 1.4% in group 1 versus 3.0% in...
Ad-hoc PCI in clopidogrel-naïve patients who were treated with high-dose bolus of tirofiban followed by a clopidogrel loading dose immediately after the procedure appeared to be safe....
Patients with COVID-19 are at increased risk of thrombosis, which is associated with altered platelet function and coagulopathy, contributing to excess mortality....
To characterize the mechanism of altered platelet function in COVID-19 patients....
The platelet proteome, platelet functional responses, and platelet-neutrophil aggregates were compared between patients hospitalized with COVID-19 and healthy control subjects using tandem mass tag pr...
COVID-19 patients showed a different profile of platelet protein expression (858 altered of the 5773 quantified). Levels of COVID-19 plasma markers were enhanced in the platelets of COVID-19 patients....
Overall, our data suggest the presence of 2 platelet populations in patients with COVID-19: one of circulating platelets with an altered proteome and reduced functional responses and another of P-sele...
Activation of circulating platelets by receptor binding and subsequent coagulation events are defined by a well characterized physiological response. However, the growing prevalence of chronic kidney ...
Glycoprotein (GP) Ib-IX-V, a platelet surface receptor that plays a critical role in platelet adhesion and platelet-mediated immune responses, consists of GPIbα, GPIbβ, GPIX, and GPV in a stoichiometr...
Proteomics studies suggest that GPIbα, GPIbβ, GPIX, and GPV form the complex in a ratio of 1 : 2 : 1 : 1, which is supported by analysis of molecular weight of GPIb-IX-V and GPIb-IX and the structure ...
New studies challenge the traditional model for the organization of GPIb-IX-V as a complex and indicate the role of GPIb-IX-V in platelet production. Those studies provide insights for GPIb-IX-V in th...