Multiple cell types form the VIP amacrine cell population.

Amacrine Cells / cytology Animals Mice Mice, Transgenic Vasoactive Intestinal Peptide / metabolism Visual Pathways / cytology
AB_10058149 Confetti (Brainbow2.1) GABA RRID: AB_10013222 RRID: AB_11214092 RRID: AB_2187981 RRID: AB_2201526 RRID: AB_2209751 RRID: AB_2395389 RRID: AB_477483 RRID: AB_477652 RRID: AB_90764 VIP-ires-Cre recombinase amacrine cells mouse retina vasoactive intestinal peptide vision

Journal

The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041

Informations de publication

Date de publication:
01 01 2019
Historique:
received: 23 08 2016
revised: 21 04 2017
accepted: 27 04 2017
pubmed: 5 5 2017
medline: 17 4 2020
entrez: 5 5 2017
Statut: ppublish

Résumé

Amacrine cells are a heterogeneous group of interneurons that form microcircuits with bipolar, amacrine and ganglion cells to process visual information in the inner retina. This study has characterized the morphology, neurochemistry and major cell types of a VIP-ires-Cre amacrine cell population. VIP-tdTomato and -Confetti (Brainbow2.1) mouse lines were generated by crossing a VIP-ires-Cre line with either a Cre-dependent tdTomato or Brainbow2.1 reporter line. Retinal sections and whole-mounts were evaluated by quantitative, immunohistochemical, and intracellular labeling approaches. The majority of tdTomato and Confetti fluorescent cell bodies were in the inner nuclear layer (INL) and a few cell bodies were in the ganglion cell layer (GCL). Fluorescent processes ramified in strata 1, 3, 4, and 5 of the inner plexiform layer (IPL). All tdTomato fluorescent cells expressed syntaxin 1A and GABA-immunoreactivity indicating they were amacrine cells. The average VIP-tdTomato fluorescent cell density in the INL and GCL was 535 and 24 cells/mm

Identifiants

DOI: 10.1002/cne.24234 PMID: 28472856
pubmed: 28472856
doi: 10.1002/cne.24234
doi:

Substances chimiques

Vasoactive Intestinal Peptide 37221-79-7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

133-158

Subventions

Organisme : BLRD VA
ID : IK6 BX005230
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY004067
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY007026
Pays : United States
Organisme : NIH HHS
ID : P30 DK41301
Pays : United States

Informations de copyright

© 2017 Wiley Periodicals, Inc.

Auteurs

Luis Pérez de Sevilla Müller (L)

Department of Neurobiology, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.

Alexander Solomon (A)

Department of Neurobiology, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.

Kristopher Sheets (K)

Department of Neurobiology, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.

Hinekura Hapukino (H)

Department of Neurobiology, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.

Allen R Rodriguez (AR)

Department of Neurobiology, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.

Nicholas C Brecha (NC)

Department of Neurobiology, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.
Department of Medicine, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.
Department of Ophthalmology and the Stein Eye Institute, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.
CURE Digestive Diseases Research Center, David Geffen School of Medicine at Los Angeles, University of California at Los Angeles, Los Angeles, California, 90095-1763.
Veterans Administration Greater Los Angeles Health System, Los Angeles, California, 90073.
ORCID: 0000-0003-1395-245X

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Classifications MeSH

questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules amacrines › Multiple cell types form the VIP amacrine cell...
questionsmedicales.fr › Eucaryotes › Animaux › Multiple cell types form the VIP amacrine cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Multiple cell types form the VIP amacrine cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Multiple cell types form the VIP amacrine cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide vasoactif intestinal › Multiple cell types form the VIP amacrine cell...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Voies afférentes › Voies optiques › Multiple cell types form the VIP amacrine cell...