Experimental models of demyelination and remyelination.
Modelos experimentales de desmielinización-remielinización.
Demyelination
Desmielinización
Encefalitis alérgica experimental
Esclerosis múltiple
Experimental allergic encephalitis
Experimental models
Mielina
Modelos experimentales
Multiple sclerosis
Myelin
Remielinización
Remyelination
Journal
Neurologia
ISSN: 2173-5808
Titre abrégé: Neurologia (Engl Ed)
Pays: Spain
ID NLM: 101778590
Informations de publication
Date de publication:
Historique:
received:
05
07
2017
accepted:
06
07
2017
pubmed:
3
9
2017
medline:
23
10
2020
entrez:
3
9
2017
Statut:
ppublish
Résumé
Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary. We reviewed the different in vitro and in vivo experimental models used in multiple sclerosis research. Concerning in vitro models, we analysed cell cultures and slice models. As for in vivo models, we examined such models of autoimmunity and inflammation as experimental allergic encephalitis in different animals and virus-induced demyelinating diseases. Furthermore, we analysed models of demyelination and remyelination, including chemical lesions caused by cuprizone, lysolecithin, and ethidium bromide; zebrafish; and transgenic models. Experimental models provide a deeper understanding of the different pathogenic mechanisms involved in multiple sclerosis. Choosing one model or another depends on the specific aims of the study.
Identifiants
pubmed: 28863829
pii: S0213-4853(17)30236-0
doi: 10.1016/j.nrl.2017.07.002
pmc: PMC7115679
pii:
doi:
Substances chimiques
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Review
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
32-39Informations de copyright
Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.
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